Acceleration of burn wound healing by micronized amniotic membrane seeded with umbilical cord-derived mesenchymal stem cells

Yao, 2021, Recent trends on burn wound care: hydrogel dressings and scaffolds, Biomater. Sci., 9, 4523, 10.1039/D1BM00411E Burgess, 2022, The immune and regenerative response to burn injury, Cells, 11, 10.3390/cells11193073 M, 2022 Gurtner, 2008, Wound repair and regeneration, Nature, 453, 314, 10.1038/nature07039 Singh, 2007, The pathogenesis of burn wound conversion, Ann. Plast. Surg., 59, 109, 10.1097/01.sap.0000252065.90759.e6 Kwa, 2019, A systematic review on surgical and nonsurgical debridement techniques of burn wounds, J. Plast. Reconstr. Aesthetic Surg., 72, 1752, 10.1016/j.bjps.2019.07.006 Liu, 2020, Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway, Stem Cell Res. Ther., 11, 259, 10.1186/s13287-020-01756-x Wang, 2022, Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling, Regen. Med., 17, 219, 10.2217/rme-2021-0076 Yang, 2020, Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin regeneration, Int. J. Nanomed., 15, 5911, 10.2147/IJN.S249129 Guillamat-Prats, 2021, The role of MSC in wound healing, scarring and regeneration, Cells, 10, 10.3390/cells10071729 Zhang, 2015, Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4/β-catenin pathway, Stem Cells Transl Med, 4, 513, 10.5966/sctm.2014-0267 Zhao, 2022, Exosome derived from mesenchymal stem cells alleviates pathological scars by inhibiting the proliferation, migration and protein expression of fibroblasts via delivering miR-138-5p to target SIRT1, Int. J. Nanomed., 17, 4023, 10.2147/IJN.S377317 Surowiecka, 2022, Mesenchymal stem cells in burn wound management, Int. J. Mol. Sci., 23, 10.3390/ijms232315339 Wang, 2021, Mesenchymal stem cell-based therapy for burn wound healing, Burns Trauma, 9, 10.1093/burnst/tkab002 Huerta, 2023, Mesenchymal stem cell-based therapy for non-healing wounds due to chronic limb-threatening ischemia: a review of preclinical and clinical studies, Front Cardiovasc Med, 10, 10.3389/fcvm.2023.1113982 M.J. Saadh, A.A. Ramírez-Coronel, R.S. Saini, J.L. Arias-Gonzáles, A.H. Amin, J.C.O. Gavilán, I. Sârbu, Advances in mesenchymal stem/stromal cell-based therapy and their extracellular vesicles for skin wound healing, Hum. Cell (2023).doi: 10.1007/s13577-023-00904-8. Online ahead of print. Zhou, 2022, Efficacy of human adipose derived mesenchymal stem cells in promoting skin wound healing, J Healthc Eng, 2022 Kerstan, 2022, Translational development of ABCB5(+) dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers, Stem Cell Res. Ther., 13, 455, 10.1186/s13287-022-03156-9 Kouroupis, 2021, Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications, Front. Bioeng. Biotechnol., 9, 10.3389/fbioe.2021.621748 Shou, 2023, Mechano-responsive hydrogel for direct stem cell manufacturing to therapy, Bioact. Mater., 24, 387 Rybkowska, 2023, The metabolic changes between monolayer (2D) and three-dimensional (3D) culture conditions in human mesenchymal stem/stromal cells derived from adipose tissue, Cells, 12, 10.3390/cells12010178 Aguado, 2012, Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers, Tissue Eng., 18, 806, 10.1089/ten.tea.2011.0391 Mytsyk, 2021, Long-term severe in vitro hypoxia exposure enhances the vascularization potential of human adipose tissue-derived stromal vascular fraction cell engineered tissues, Int. J. Mol. Sci., 22, 10.3390/ijms22157920 Koh, 2020, Three dimensional microcarrier system in mesenchymal stem cell culture: a systematic review, Cell Biosci., 10, 75, 10.1186/s13578-020-00438-8 YekrangSafakar, 2018, Hollow microcarriers for large-scale expansion of anchorage-dependent cells in a stirred bioreactor, Biotechnol. Bioeng., 115, 1717, 10.1002/bit.26601 Chen, 2011, A modular approach to the engineering of a centimeter-sized bone tissue construct with human amniotic mesenchymal stem cells-laden microcarriers, Biomaterials, 32, 7532, 10.1016/j.biomaterials.2011.06.054 Fuentes, 2022, Dynamic culture of mesenchymal stromal/stem cell spheroids and secretion of paracrine factors, Front. Bioeng. Biotechnol., 10, 10.3389/fbioe.2022.916229 Kim, 2022, Bolstering the secretion and bioactivities of umbilical cord MSC-derived extracellular vesicles with 3D culture and priming in chemically defined media, Nano Converg, 9, 57, 10.1186/s40580-022-00349-z Zeng, 2015, Preformed gelatin microcryogels as injectable cell carriers for enhanced skin wound healing, Acta Biomater., 25, 291, 10.1016/j.actbio.2015.07.042 Mawji, 2022, Challenges and opportunities in downstream separation processes for mesenchymal stromal cells cultured in microcarrier-based stirred suspension bioreactors, Biotechnol. Bioeng., 119, 3062, 10.1002/bit.28210 Bennett, 1980, Treatment of chronic ulceration of the legs with human amnion, Lancet, 1, 1153, 10.1016/S0140-6736(80)91616-5 Faulk, 1980, Human amnion as an adjunct in wound healing, Lancet, 1, 1156, 10.1016/S0140-6736(80)91617-7 Garoufalis, 2018, Use of dehydrated human amnion/chorion membrane allografts in more than 100 patients with six major types of refractory nonhealing wounds, J. Am. Podiatr. Med. Assoc., 108, 84, 10.7547/17-039 Chen, 2021, Dehydrated human amnion/chorion membrane allografts for myelomeningocele and wound reconstruction, Childs Nerv Syst, 37, 3721, 10.1007/s00381-021-05352-z Jirsova, 2017, Amniotic membrane in ophthalmology: properties, preparation, storage and indications for grafting-a review, Cell Tissue Bank., 18, 193, 10.1007/s10561-017-9618-5 Nogami, 2016, A human amnion-derived extracellular matrix-coated cell-free scaffold for cartilage repair: in vitro and in vivo studies, Tissue Eng., 22, 680, 10.1089/ten.tea.2015.0285 Ilhan, 2015, Amniotic membrane: new concepts for an old dressing, Wound Repair Regen., 23, 145, 10.1111/wrr.12256 Cox, 2022, The amnion as a window into human pluripotency, Cell Stem Cell, 29, 661, 10.1016/j.stem.2022.04.014 Fairbairn, 2014, The clinical applications of human amnion in plastic surgery, J. Plast. Reconstr. Aesthetic Surg., 67, 662, 10.1016/j.bjps.2014.01.031 Bakhtiar, 2022, Human amniotic membrane extracellular matrix scaffold for dental pulp regeneration in vitro and in vivo, Int. Endod. J., 55, 374, 10.1111/iej.13675 Zheng, 2017, Topical administration of cryopreserved living micronized amnion accelerates wound healing in diabetic mice by modulating local microenvironment, Biomaterials, 113, 56, 10.1016/j.biomaterials.2016.10.031 Ji, 2011, An epidermal stem cells niche microenvironment created by engineered human amniotic membrane, Biomaterials, 32, 7801, 10.1016/j.biomaterials.2011.06.076 Ma, 2022, 3D printing of diatomite incorporated composite scaffolds for skin repair of deep burn wounds, Int J Bioprint, 8, 580, 10.18063/ijb.v8i3.580 Zaborowska, 2021, Immunomodulatory effects exerted by extracellular vesicles from Staphylococcus epidermidis and Staphylococcus aureus isolated from bone-anchored prostheses, Biomaterials, 278, 10.1016/j.biomaterials.2021.121158 Patel, 2022, Validation of automated fluorescent-based technology for measuring total nucleated cell viability of hematopoietic progenitor cell products, Transfusion, 62, 848, 10.1111/trf.16837 Eibes, 2010, Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system, J. Biotechnol., 146, 194, 10.1016/j.jbiotec.2010.02.015 Carter, 2019, Characterizing the impact of 2D and 3D culture conditions on the therapeutic effects of human mesenchymal stem cell secretome on corneal wound healing in vitro and ex vivo, Acta Biomater., 99, 247, 10.1016/j.actbio.2019.09.022 Duscher, 2016, Stem cells in wound healing: the future of regenerative medicine?, A Mini-Review, Gerontology., 62, 216, 10.1159/000381877 Kirby, 2015, Stem cells for cutaneous wound healing, BioMed Res. Int., 2015, 10.1155/2015/285869 Li, 2019, Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway, Stem Cell Res. Ther., 10, 247, 10.1186/s13287-019-1366-y Ha, 2020, Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration, Cells, 9, 10.3390/cells9051157 Yi, 2022, [Effects and mechanism of human umbilical vein endothelial cells-derived exosomes on wound healing in diabetic rabbits], Zhonghua Shaoshang Zazhi, 38, 1023 Yu, 2020, Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway, Stem Cell Res. Ther., 11, 350, 10.1186/s13287-020-01824-2 Kozhukharova, 2022, Paracrine and autocrine effects of VEGF are enhanced in human eMSC spheroids, Int. J. Mol. Sci., 23, 10.3390/ijms232214324 Su, 2017, Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: a new dimension in cell-material interaction, Biomaterials, 141, 74, 10.1016/j.biomaterials.2017.06.028 Hou, 2022, Human vascular endothelial cells promote the secretion of vascularization factors and migration of human skin fibroblasts under Co-culture and its preliminary application, Int. J. Mol. Sci., 23, 10.3390/ijms232213995 Guo, 2022, Beneficial effects of oleosomes fused with human fibroblast growth factor 1 on wound healing via the promotion of angiogenesis, Int. J. Mol. Sci., 23, 10.3390/ijms232113152 Holoubek, 2022 Zhang, 2022, GDF11 promotes wound healing in diabetic mice via stimulating HIF-1ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization, Acta Pharmacol. Sin., 44, 999, 10.1038/s41401-022-01013-2 Saharinen, 2017, Therapeutic targeting of the angiopoietin-TIE pathway, Nat. Rev. Drug Discov., 16, 635, 10.1038/nrd.2016.278 Wei, 2022, Mesenchymal stem cells promote wound healing and effects on expression of matrix metalloproteinases-8 and 9 in the wound tissue of diabetic rats, Stem Cell. Dev., 32, 25, 10.1089/scd.2021.0218 Fang, 2013, An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo, Cardiovasc. Res., 99, 146, 10.1093/cvr/cvt060