Accelerated epigenetic aging in Werner syndrome

Aging - Tập 9 Số 4 - Trang 1143-1152 - 2017
Anna Maierhofer1, Julia Flunkert1, Junko Oshima2,3, George M. Martin4, Thomas Haaf1,5, Steve Horvath6,7,5
1Institute of Human Genetics, Julius Maximilians University, Würzburg, Germany
2Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
3Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Pathology, University of Washington, Seattle, WA 98105, USA
4Department of Pathology, University of Washington, Seattle, Wa. 98105, USA
5Joint last authors
6Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA
7Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Joint last authors

Tóm tắt

Từ khóa


Tài liệu tham khảo

Goto, 1997, Hierarchical deterioration of body systems in Werner’s syndrome: implications for normal ageing., Mech Ageing Dev, 9, 239, 10.1016/S0047-6374(97)00111-5

Hisama, 2014, Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome., Gerontology, 6, 239, 10.1159/000356030

Vilain, 2011, Epigenetic predictor of age., PLoS One, 6, e14821, 10.1371/journal.pone.0014821

Capri, 2012, Methylation of ELOVL2 gene as a new epigenetic marker of age., Aging Cell, 1, 1132, 10.1111/acel.12005

Rajapakse, 2013, Genome-wide methylation profiles reveal quantitative views of human aging rates., Mol Cell, 4, 359, 10.1016/j.molcel.2012.10.016

Horvath, 2013, DNA methylation age of human tissues and cell types., Genome Biol, 1, R115, 10.1186/gb-2013-14-10-r115

Wagner, 2016, DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy., Aging (Albany NY), 8, 394, 10.18632/aging.100908

Christensen, 2016, DNA methylation age is associated with mortality in a longitudinal Danish twin study., Aging Cell, 1, 149, 10.1111/acel.12421

Murphy, 2015, DNA methylation age of blood predicts all-cause mortality in later life., Genome Biol, 1, 25, 10.1186/s13059-015-0584-6

Giuliani, 2015, Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring., Aging (Albany NY), 7, 1159, 10.18632/aging.100861

Brenner, 2016, Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort., Clin Epigenetics, 8, 64, 10.1186/s13148-016-0228-z

Studenski, 2016, DNA methylation-based measures of biological age: meta-analysis predicting time to death., Aging (Albany NY), 8, 1844, 10.18632/aging.101020

Brenner, 2016, Frailty is associated with the epigenetic clock but not with telomere length in a German cohort., Clin Epigenetics, 8, 21, 10.1186/s13148-016-0186-5

Horvath, 2015, DNA methylation age of blood predicts future onset of lung cancer in the women’s health initiative., Aging (Albany NY), 7, 690, 10.18632/aging.100809

Murphy, 2015, The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936., Int J Epidemiol, 4, 1388, 10.1093/ije/dyu277

Horvath, 2015, Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning., Aging (Albany NY), 7, 1198, 10.18632/aging.100864

Coles, 2015, The cerebellum ages slowly according to the epigenetic clock., Aging (Albany NY), 7, 294, 10.18632/aging.100742

Franceschi, 2015, Accelerated epigenetic aging in Down syndrome., Aging Cell, 1, 491, 10.1111/acel.12325

Levine, 2015, HIV-1 infection accelerates age according to the epigenetic clock., J Infect Dis, 21, 1563, 10.1093/infdis/jiv277

Vinters, 2016, Huntington’s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels., Aging (Albany NY), 8, 1485, 10.18632/aging.101005

Sipos, 2014, Obesity accelerates epigenetic aging of human liver., Proc Natl Acad Sci USA, 11, 15538, 10.1073/pnas.1412759111

Brückl, 2015, Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling., Genome Biol, 1, 266, 10.1186/s13059-015-0828-5

Wong, 2016, Menopause accelerates biological aging., Proc Natl Acad Sci USA, 11, 9327, 10.1073/pnas.1604558113

Gonzalez, 2016, Specific increase of methylation age in osteoarthritis cartilage., Osteoarthritis Cartilage, 2, S63, 10.1016/j.joca.2016.01.140

Ritz, 2015, Increased epigenetic age and granulocyte counts in the blood of Parkinson’s disease patients., Aging (Albany NY), 7, 1130, 10.18632/aging.100859

Sansoni, 1996, Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians., Immunology, 8, 501, 10.1046/j.1365-2567.1996.d01-689.x

Sansoni, 2000, Shortage of circulating naïve CD8(+) T cells provides new insights on immunodeficiency in aging., Blood, 9, 2860

Sempowski, 2007, Immunosenescence of ageing., J Pathol, 21, 144, 10.1002/path.2104

Horvath, 2016, Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum., Nat Commun, 7, 10561, 10.1038/ncomms10561

Schellenberg, 1996, Positional cloning of the Werner’s syndrome gene., Science, 27, 258, 10.1126/science.272.5259.258

Bohr, 2010, Roles of Werner syndrome protein in protection of genome integrity., DNA Repair (Amst), 9, 331, 10.1016/j.dnarep.2009.12.011

Martin, 2016, How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative., Cold Spring Harb Perspect Med, 6, a025882, 10.1101/cshperspect.a025882

Karlseder, 2004, Defective telomere lagging strand synthesis in cells lacking WRN helicase activity., Science, 30, 1951, 10.1126/science.1103619

Kipling, 2000, Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts., Nat Genet, 2, 16, 10.1038/71630

Karlseder, 2007, Telomere dysfunction as a cause of genomic instability in Werner syndrome., Proc Natl Acad Sci USA, 10, 2205, 10.1073/pnas.0609410104

Kipling, 2004, Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells., Hum Mol Genet, 1, 1515, 10.1093/hmg/ddh159

Takubo, 2011, Accelerated in vivo epidermal telomere loss in Werner syndrome., Aging (Albany NY), 3, 417, 10.18632/aging.100315

Deary, 2016, The epigenetic clock and telomere length are independently associated with chronological age and mortality., Int J Epidemiol, 4, 424, 10.1093/ije/dyw041

Furuichi, 2013, Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~2008)., Biosci Trends, 7, 13

Oral, 2006, The spectrum of WRN mutations in Werner syndrome patients., Hum Mutat, 2, 558, 10.1002/humu.20337

Li, 2015, Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging., Science, 34, 1160, 10.1126/science.aaa1356

Doubal, 2006, A new approach to the concept and computation of biological age., Mech Ageing Dev, 12, 240, 10.1016/j.mad.2005.10.004

Li, 2016, An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease., Genome Biol, 1, 171, 10.1186/s13059-016-1030-0

Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, et al. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging (Albany NY). 2017.

Kelsey, 2012, DNA methylation arrays as surrogate measures of cell mixture distribution., BMC Bioinformatics, 1, 86, 10.1186/1471-2105-13-86