Acacia nilotica polyphenol extract restores glucose homeostasis by upregulating the insulin secretion and lowering the oxidative stress through down regulation of c-Jun N-terminal kinase (JNK) signaling cascade

Agwaya, 2016, Hypoglycemic activity of aqueous root bark extract Zanthoxylum chalybeum in alloxan-induced diabetic rats, J. Diabetes Res., 1–5 Ahmed, 2014, Phenolic and flavonoid contents anti-oxidative potential of epicarp and mesocarp of Lageneriasiceraria fruit: a comparative study, Asian Pac. J. Trop. Med., 7, 249, 10.1016/S1995-7645(14)60241-8 Bancroft, J.D., Gamble, M. 2007. Theory and Practice of Histological Techniques. Philadelphia, Churchill, Livingstone, pp. 131–133. Ellman, 1959, Tissue sulfhydryl groups, Arch. Biochem. Biophys., 82, 70, 10.1016/0003-9861(59)90090-6 Eslami, H., Batavani, R.A., Asr, S. 2015. Changes of stress oxidative enzymes in rat mammary tissue, blood and milk after experimental mastitis induced by E. coli lipopolysaccharide. InVeterinary Research Forum, 6 (2) 131. Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Gandhi, 2012, Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats, Asian Pac. J. Trop. Biomed., 2, 281, 10.1016/S2221-1691(12)60023-9 Gao, 2018, NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis, J. Cell. Mol. Med., 22, 3408, 10.1111/jcmm.13617 Hassanin, 2018, Balanites aegyptiaca ameliorates insulin secretion and decreases pancreatic apoptosis in diabetic rats: Role of SAPK/JNK pathway, Biomed. Pharmacother., 102, 1084, 10.1016/j.biopha.2018.03.167 Kahkeshani, 2019, Pharmacological effects of gallic acid in health and diseases: A mechanistic review, Iran. J. Basic. Med. Sci., 22, 225 Kade, 2014, Influence of gallic acid on oxidative stress-linked streptozotocininduced pancreatic dysfunction in diabetic rats, J. Basic. Clin. Physiol. Pharmacol., 25, 35, 10.1515/jbcpp-2012-0062 Krishnaiah, 2011, A review of the antioxidant potential of medicinal plant species, Food Bioprod. Process., 89, 217, 10.1016/j.fbp.2010.04.008 Li, 2018, Intermittent high glucose exacerbates A-FABP activation and inflammatory response through TLR4-JNK signaling in THP-1 cells, J. Immunol. Res., 2018, 1 Li, 2019, Effects and underlying mechanisms of bioactive compounds on type 2 diabetes mellitus and Alzheimer’s disease, Oxid. Med. Cell. Longev, 2019, 25 Moonmun, 2017, Quantitative phytochemical estimation and evaluation of antioxidant and antibacterial activity of methanol and ethanol extracts of Heliconia rostrata, Indian J. Pharm. Sci., 79, 79, 10.4172/pharmaceutical-sciences.1000204 Mukundi, 2015, Antidiabetic effects of aqueous leaf extracts of acacia nilotica in alloxan induced diabetic mice, J. Diabetes Metab., 6, 1, 10.4172/2155-6156.1000568 Narasimhan, 2015, Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat, Appl. Physiol. Nutr. Metab., 40, 769, 10.1139/apnm-2015-0002 Ogurtsova, 2017, I.D.F. diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040, Diabetes Res. Clin. Pract., 128, 40, 10.1016/j.diabres.2017.03.024 Ohkawa, 1979, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal. Biochem., 95, 351, 10.1016/0003-2697(79)90738-3 Petersen, 2016, Brief communication: Plasma lipid oxidation predicts atherosclerotic status better than cholesterol in diabetic apolipoprotein E deficient mice, Exp. Biol. Med., 242, 88, 10.1177/1535370216650520 Prince, 2013, p-Coumaricacidattenuatesapoptosis in isoproterenol-induced myocardial infarcted rats by inhibiting oxidative stress, Int. J. Cardiol., 168, 3259, 10.1016/j.ijcard.2013.04.138 Rashid, 2012, Protective role of Dsaccharic acid-1, 4- lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway, Free Radic. Res., 46, 240, 10.3109/10715762.2011.650694 Roozbeh, 2017, Hypoglycemic effects of Acacia nilotica in type II diabetes: a research proposal, BMC. Res. Notes., 10, 1, 10.1186/s13104-017-2646-1 Rotruck, 1973, Selenium: Biochemical role as a component of glutathione peroxidase, Science, 179, 588, 10.1126/science.179.4073.588 Sabu, 2002, Anti-diabetic activityof green tea polyphenols and their role in reducing oxidative stress in experimental diabetes, J. Ethnopharmacol., 83, 109 Sadiq, 2017, In vitro antioxidant and antimalarial activities of leaves, pods and bark extracts of Acacia nilotica (L.) Del, BMC. Compl. Alternative. Med., 17, 372, 10.1186/s12906-017-1878-x Saxena, 2018, Evaluation of antidiabetic activity of a herbal formulation, EcPharmacol. Toxicol., 349 Seal, 2016, Quantitative HPLC analysis of phenolic acids, flavonoids and ascorbic acid in four different solvent extracts of two wild edible leaves, Sonchus arvensis and Oenanthe linearis of North-Eastern region in India, J. Appl. Pharma. Sci., 6, 157, 10.7324/JAPS.2016.60225 Sharma, B., Joshi, S.C., Jasuja, N.D., Singh, S.K., Sharma, G. 2016. Evaluation of anti-diabetic and heapatoprotectivity of coriandrum sativum in alloxan induced experimental animals: a histopathology study. Int. J. Pharm. Sci. Res. 7, 4510-4515. https://dx.doi.org/10.13040/IJPSR.0975-8232.7(11).1000-06. Taha, 2018, Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression, J. Appl. Biomed., 16, 263, 10.1016/j.jab.2018.05.004 Takahara, 1960, Hypocatalasemia: a new genetic carrier state, J. Clin. Investig., 39, 610, 10.1172/JCI104075 Van Doan, 2018, Antidiabetic activity, glucose uptake stimulation and α-glucosidase inhibitory effect of Chrysophyllum cainito L. stem bark extract, BMC Complement Altern. Med., 18, 267, 10.1186/s12906-018-2328-0 Volpe, 2018, Cellular death, reactive oxygen species (ROS) and diabetic complications, Cell Death Dis., 9, 119, 10.1038/s41419-017-0135-z Vieira, 2019, Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—Review of classical and new compounds: Part-I, Pharmaceuticals, 12, 152, 10.3390/ph12040152 Wu, 2016, Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt–GLUT4, GSK3β and mTOR–S6K1, J. Nutr. Biochem., 34, 126, 10.1016/j.jnutbio.2016.05.008 Yin, 2018, Hypoglycemic effects in alloxan-induced diabetic rats of the phenolic extract from mongolian oak cups enriched in ellagic acid, kaempferol and their derivatives, Molecules, 23, 1046, 10.3390/molecules23051046 Zhu, 2017, PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration, Stem. Cell. Res. Ther., 8, 1, 10.1186/s13287-017-0694-z