Absorption and metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in Caco-2 cells in vitro
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Artursson P, Karlsson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Comm 175:880–885
Biasutto L, Marotta E, De Marchi U, Beltramello S, Bradaschia A, Garbisa S, Zoratti M, Paradisi C (2009) Heterogeneity and standardization of phase II metabolism in cultured cells. Cell Physiol Biochem 23:425–430
Brugger EM, Wagner J, Schumacher DM, Koch K, Podlech J, Metzler M, Lehmann L (2006) Mutagenicity of the mycotoxin alternariol in cultured mammalian cells. Toxicol Lett 164:221–230
Chelkowski J, Visconti A (1992) Alternaria. Biology, plant diseases and metabolites. Elsevier, Amsterdam
Fehr M, Pahlke G, Fritz J, Christensen MO, Boege F, Altemöller M, Podlech J, Marko D (2009) Alternariol acts as a topoisomerase poison, preferentially affecting the II alpha isoform. Mol Nutr Food Res 53:441–451
Grès M, Julian B, Bourriè M, Meunier V, Roques C, Berger M, Boulenc X, Berger Y, Fabre G (1998) Correlation between oral drug absorption in humans and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line. Pharmaceut Res 15:726–733
Koch K, Podlech J, Pfeiffer E, Metzler M (2005) Total synthesis of alternariol. J Org Chem 70:3275–3276
Lehmann L, Wagner J, Metzler M (2006) Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells. Food Chem Toxicol 44:398–408
Liu GT, Qian YZ, Zhang P, Dong WH, Qi YM, Guo HT (1992) Etiological role of Alternaria alternata in human esophageal cancer. Chin Med J 105:394–400
Pfeiffer E, Eschbach S, Metzler M (2007a) Alternaria toxins: DNA strand-breaking activity in mammalian cells in vitro. Mycotoxin Res 23:152–157
Pfeiffer E, Schebb NH, Podlech J, Metzler M (2007b) Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether. Mol Nutr Food Res 51:307–316
Pfeiffer E, Schmit C, Burkhardt B, Altemöller M, Podlech J, Metzler M (2009a) Glucuronidation of the mycotoxins alternariol and alternariol-9-methyl ether in vitro: chemical structures of the glucuronides and activities of human UDP-glucuronosyltransferase isoforms. Mycotox Res 25:3–10
Pfeiffer E, Herrmann C, Altemöller M, Podlech J, Metzler M (2009b) Oxidative in vitro metabolism of the Alternaria toxins altenuene and isoaltenuene. Mol Nutr Food Res 53:452–459
Press B, Di Grandi D (2008) Permeability for intestinal absorption: Caco-2 assays and related issues. Curr Drug Metab 9:893–900
Scott PM (2001) Analysis of agricultural commodities and foods for Alternaria mycotoxins. J AOAC International 84:1809–1817
Scott PM, Lawrence GA, Lau BPY (2006) Analysis of wines, grape juices and cranberry juices for Alternaria toxins. Mycotoxin Res 22:142–147
van Breemen RB, Li Y (2005) Caco-2 cell permeability assays to measure drug absorption. Expert Opin Drug Metab Toxicol 1:175–185