Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features
Tóm tắt
End-stage kidney disease and mild cognitive impairment (ESKD-MCI) affect the quality of life and long-term treatment outcomes of patients affected by these diseases. Clarifying the morphological changes from brain injuries in ESKD-MCI and their relationship with clinical features is helpful for the early identification and intervention of MCI before it progresses to irreversible dementia. This study gathered data from 23 patients with ESKD-MCI, 24 patients with ESKD and non-cognitive impairment (NCI), and 27 health controls (HCs). Structural magnetic resonance studies, cognitive assessments, and general clinical data were collected from all participants. Voxel-based morphometry analysis was performed to compare grey matter (GM) volume differences between the groups. The patients’ GM maps and clinical features were subjected to univariate regression to check for possible correlations. Patients with ESKD-MCI displayed significantly more impairments in multiple cognitive domains, including global cognition, visuospatial and executive function, and memory, compared to patients with ESKD-NCI. Using a more liberal threshold (P < 0.001, uncorrected), we found that compared to patients with ESKD-NCI, patients with ESKD-MCI exhibited clusters of regions with lower GM volumes, including the right hippocampus (HIP), parahippocampal gyrus (PHG), Rolandic operculum, and supramarginal gyrus. The volumes of the right HIP and PHG were negatively correlated with serum calcium levels. ESKD-MCI was associated with a subtle volume reduction of GM in several brain areas known to be involved in memory, language, and auditory information processing. We speculate that these slight morphometric impairments may be associated with disturbed calcium metabolism.
Tài liệu tham khảo
Albert MS, DeKosky ST, Dickson D et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):270–279. https://doi.org/10.1016/j.jalz.2011.03.008
Alzheimer’s Association Calcium Hypothesis Workgroup (2017) Calcium hypothesis of Alzheimer’s disease and brain aging: a framework for integrating new evidence into a comprehensive theory of pathogenesis. Alzheimers Dement 13(2):178–182e17. https://doi.org/10.1016/j.jalz.2016.12.006
Bowie CR, Harvey PD (2006) Administration and interpretation of the trail making test. Nat Protoc 1(5):2277–2281. https://doi.org/10.1038/nprot.2006.390
Burgess N, Maguire EA, O’Keefe J (2002) The human hippocampus and spatial and episodic memory. Neuron 35(4):625–641. https://doi.org/10.1016/s0896-6273(02)00830-9
Chai C, Zhang M, Long M et al (2015) Increased brain iron deposition is a risk factor for brain atrophy in patients with haemodialysis: a combined study of quantitative susceptibility mapping and whole brain volume analysis. Metab Brain Dis 30(4):1009–1016. https://doi.org/10.1007/s11011-015-9664-2
Chiu YL, Tsai HH, Lai YJ et al (2019) Cognitive impairment in patients with end-stage renal disease: accelerated brain aging? J Formos Med Assoc 118(5):867–875. https://doi.org/10.1016/j.jfma.2019.01.011
Dalrymple-Alford JC, MacAskill MR, Nakas CT et al (2010) The MoCA: well-suited screen for cognitive impairment in Parkinson disease. Neurology 75(19):1717–1725. https://doi.org/10.1212/WNL.0b013e3181fc29c9
Ellis KA, Rowe CC, Szoeke CE et al (2011) Advances in structural and molecular neuroimaging in Alzheimer’s disease. Med J Aust 194(4):S20–S23. https://doi.org/10.5694/j.1326-5377.2011.tb02938.x
GBD Chronic Kidney Disease Collaboration (2020) Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the global burden of Disease Study 2017. Lancet (London England) 395(10225):709–733. https://doi.org/10.1016/S0140-6736(20)30045-3
Gu W, He R, Su H et al (2021) Changes in the shape and volume of subcortical structures in patients with end-stage renal disease. Front Hum Neurosci 15:778807. https://doi.org/10.3389/fnhum.2021.778807
Guo Q, Zhao Q, Chen M et al (2009) A comparison study of mild cognitive impairment with 3 memory tests among chinese individuals. Alzheimer Dis Assoc Disord 23(3):253–259. https://doi.org/10.1097/WAD.0b013e3181999e92
Jin M, Wang L, Wang H et al (2020) Structural and functional alterations in Hemodialysis Patients: a voxel-based morphometry and functional connectivity study. Front Hum Neurosci 14:80. https://doi.org/10.3389/fnhum.2020.00080
Julayanont P, Brousseau M, Chertkow H et al (2014) Montreal Cognitive Assessment Memory Index score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer’s disease. J Am Geriatr Soc 62(4):679–684. https://doi.org/10.1111/jgs.12742
Khachaturian ZS (1994) Calcium hypothesis of Alzheimer’s disease and brain aging. Ann N Y Acad Sci 747:1–11. https://doi.org/10.1111/j.1749-6632.1994.tb44398
Kim JW, Ha GY, Jung YW (2014) Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of αCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades. Kidney Res Clin Pract 33(3):132–138. https://doi.org/10.1016/j.krcp.2014.07.003
Kurella Tamura M, Yaffe K (2011) Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies. Kidney Int 79(1):14–22. https://doi.org/10.1038/ki.2010.336
Langa KM, Levine DA (2014) The diagnosis and management of mild cognitive impairment: a clinical review. JAMA 312(23):2551–2561. https://doi.org/10.1001/jama.2014.13806
Li A, Mu J, Huang M et al (2018) Altered amygdala-related structural covariance and resting-state functional connectivity in end-stage renal disease patients. Metab Brain Dis 33(5):1471–1481. https://doi.org/10.1007/s11011-018-0254-y
Lin JS, O’Connor E, Rossom RC et al (2013) Screening for cognitive impairment in older adults: an evidence update for the U.S. Preventive Services Task Force. Agency for Healthcare Research and Quality (US)
Lisman J, Buzsáki G, Eichenbaum H et al (2017) Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci 20(11):1434–1447. https://doi.org/10.1038/nn.4661
López-Arrieta JM, Birks J (2000) Nimodipine for primary degenerative, mixed and vascular dementia. Cochrane Database Syst Rev 2CD000147. https://doi.org/10.1002/14651858.CD000147
Mehra A, Suri V, Kumari S et al (2020) Association of mild cognitive impairment and metabolic syndrome in patients with hypertension. Asian J Psychiatr 53:102185. https://doi.org/10.1016/j.ajp.2020.102185
Nasreddine ZS, Phillips NA, Bédirian V et al (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr So 53(4):695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.x
Obi Y, Park C, Soohoo M et al (2018) Association of Pre-ESRD serum calcium with Post-ESRD mortality among Incident ESRD Patients: a Cohort Study. J Bone Miner Res 33(6):1027–1036. https://doi.org/10.1002/jbmr.3391
Petersen RC (2011) Clinical practice. Mild cognitive impairment. N Engl J Med 364(23):2227–2234. https://doi.org/10.1056/NEJMcp0910237
Pinto TCC, Machado L, Bulgacov TM et al (2019) Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) in the elderly? Int Psychogeriatr 31(4):491–504. https://doi.org/10.1017/S1041610218001370
Qiu Y, Lv X, Su H et al (2014) Structural and functional brain alterations in end stage renal disease patients on routine hemodialysis: a voxel-based morphometry and resting state functional connectivity study. PLoS ONE 9(5):e98346. https://doi.org/10.1371/journal.pone.0098346
Rapcsak SZ (2019) Face Recognition. Curr Neurol Neurosci Rep 19(7):41. https://doi.org/10.1007/s11910-019-0960-9
Schmahmann JD (2019) The cerebellum and cognition. Neurosci Lett 688:62–75. https://doi.org/10.1016/j.neulet.2018.07.005
Selden NR, Gitelman DR, Salamon-Murayama N et al (1998) Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain 121(Pt 12):2249–2257. https://doi.org/10.1093/brain/121.12.2249
Squire LR, Stark CE, Clark RE (2004) The medial temporal lobe. Annu Rev Neurosci 27:279–306. https://doi.org/10.1146/annurev.neuro.27.070203.144130
Stoeckel C, Gough PM, Watkins KE et al (2009) Supramarginal gyrus involvement in visual word recognition. Cortex 45(9):1091–1096. https://doi.org/10.1016/j.cortex.2008.12.004
Viggiano D, Wagner CA, Martino G et al (2020) Mechanisms of cognitive dysfunction in CKD. Nat Rev Nephrol 16(8):452–469. https://doi.org/10.1038/s41581-020-0266-9
Viggiano D, Wagner CA, Blankestijn PJ et al (2020a) Mild cognitive impairment and kidney disease: clinical aspects. Nephrol Dial Transplant 35(1):10–17. https://doi.org/10.1093/ndt/gfz051
Wada S, Honma M, Masaoka Y et al (2021) Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability. PLoS ONE 16(7):e0254623. https://doi.org/10.1371/journal.pone.0254623
Wang H, Huang L, Wu G et al (2022) Regional cerebral gray matter atrophy is associated with cognitive impairment in hemodialysis patients: a cross-sectional and longitudinal voxel-based morphological MRI study. Brain Imaging Behav 16(3):1284–1293. https://doi.org/10.1007/s11682-021-00602-9
Whitwell JL (2009) Voxel-based morphometry: an automated technique for assessing structural changes in the brain. J Neurosci 29(31):9661–9664. https://doi.org/10.1523/JNEUROSCI.2160-09.2009
Winblad B, Palmer K, Kivipelto M et al (2004) Mild cognitive impairment–beyond controversies, towards a consensus: report of the International Working Group on mild cognitive impairment. J Intern Med 256(3):240–246. https://doi.org/10.1111/j.1365-2796.2004.01380.x
Zhang LJ, Wen J, Ni L et al (2013) Predominant gray matter volume loss in patients with end-stage renal disease: a voxel-based morphometry study. Metab Brain Dis 28(4):647–654. https://doi.org/10.1007/s11011-013-9438-7
Zheng J, Jiao Z, Dai J et al (2022) Abnormal cerebral micro-structures in end-stage renal disease patients related to mild cognitive impairment. Eur J Radiol 157:110597. https://doi.org/10.1016/j.ejrad.2022.110597