Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

JCI insight - Tập 1 Số 7 - 2016
Keisuke Maeshima1, Stephanie M. Stanford2, Deepa Hammaker1, Cristiano Sacchetti2, Li‐Fan Zeng3, Rizi Ai4, Vida Zhang2, David L. Boyle1, German R. Aleman Muench2, Gen‐Sheng Feng5, John W. Whitaker6, Zhong‐Yin Zhang3, Wei Wang4, Nunzio Bottini2,1, Gary S. Firestein1
1Division of Rheumatology, Allergy and Immunology, University of California, San Diego School of Medicine, La Jolla, California, USA.
2Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
3Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
4Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA
5Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, California, USA
6Janssen Pharmaceuticals Companies of Johnson and Johnson, La Jolla, California, USA.

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