Ablation of the Pro-Apoptotic Protein Bax Protects Mice from Glucocorticoid-Induced Bone Growth Impairment

PLoS ONE - Tập 7 Số 3 - Trang e33168
Farasat Zaman1, Dionisios Chrysis1, Kirsten Huntjens1, Bengt Fadeel2, Lars Sävendahl1
1Pediatric Endocrinology Unit, Department of Women's and Children's Health, Astrid Lindgren Children's Hospital, Karolinska Institutet, Stockholm, Sweden.
2Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Tóm tắt

Từ khóa


Tài liệu tham khảo

T Mushtaq, 2002, The impact of corticosteroids on growth and bone health., Arch Dis Child, 87, 93, 10.1136/adc.87.2.93

TF Yeh, 2004, Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity., N Engl J Med, 350, 1304, 10.1056/NEJMoa032089

JJ Smink, 2003, Short-term glucocorticoid treatment of prepubertal mice decreases growth and IGF-I expression in the growth plate., J Endocrinol, 177, 381, 10.1677/joe.0.1770381

T Mushtaq, 2004, Insulin-like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid-mediated growth retardation in fetal mice metatarsal cultures., Endocrinology, 145, 2478, 10.1210/en.2003-1435

D Chrysis, 2005, Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3′-kinase signaling pathway., Endocrinology, 146, 1391, 10.1210/en.2004-1152

Y Oshima, 2004, Oxidative stress-associated mitochondrial dysfunction in corticosteroid-treated muscle cells., Muscle Nerve, 30, 49, 10.1002/mus.20036

Y Liu, 2004, Prevention of glucocorticoid-induced apoptosis in osteocytes and osteoblasts by calbindin-D28k., J Bone Miner Res, 19, 479, 10.1359/JBMR.0301242

JF Purton, 2004, Expression of the glucocorticoid receptor from the 1A promoter correlates with T lymphocyte sensitivity to glucocorticoid-induced cell death., J Immunol, 173, 3816, 10.4049/jimmunol.173.6.3816

MH Malone, 2004, The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis., J Biol Chem, 279, 52850, 10.1074/jbc.M408040200

O Frankfurt, 2004, Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates., Curr Opin Oncol, 16, 553, 10.1097/01.cco.0000142072.22226.09

ME Tome, 2004, Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance., Biochim Biophys Acta, 1693, 57, 10.1016/j.bbamcr.2004.05.004

WZ Li, 2010, Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice., Eur J Pharmacol, 628, 108, 10.1016/j.ejphar.2009.11.045

T Mushtaq, 2002, Glucocorticoid effects on chondrogenesis, differentiation and apoptosis in the murine ATDC5 chondrocyte cell line., J Endocrinol, 175, 705, 10.1677/joe.0.1750705

RP Rooman, 2003, Dexamethasone differentially inhibits thyroxine- or growth hormone-induced body and organ growth of Snell dwarf mice., Endocrinology, 144, 2553, 10.1210/en.2003-0062

AS Chagin, 2010, Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones., J Endocrinol, 204, 21, 10.1677/JOE-09-0307

L Savendahl, 2005, Hormonal regulation of growth plate cartilage., Horm Res, 64, 94

F Zaman, 2007, Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice., Cancer Res, 67, 10078, 10.1158/0008-5472.CAN-06-3982

B Fadeel, 2005, Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease., J Intern Med, 258, 479, 10.1111/j.1365-2796.2005.01570.x

G Kroemer, 2003, Mitochondrial control of apoptosis: an introduction., Biochem Biophys Res Commun, 304, 433, 10.1016/S0006-291X(03)00614-4

C Choi, 2004, Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses., Brain Res Brain Res Rev, 44, 65, 10.1016/j.brainresrev.2003.08.007

D Acehan, 2002, Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation., Mol Cell, 9, 423, 10.1016/S1097-2765(02)00442-2

NN Danial, 2004, Cell death: critical control points., Cell, 116, 205, 10.1016/S0092-8674(04)00046-7

AH Wyllie, 2010, “Where, o death, is thy sting?” a brief review of apoptosis biology., Mol Neurobiol, 42, 4, 10.1007/s12035-010-8125-5

SJ Gardai, 2004, Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils., J Biol Chem, 279, 21085, 10.1074/jbc.M400063200

CH Tsao, 2008, Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner., J Gen Virol, 89, 1930, 10.1099/vir.0.2008/000182-0

S Wesselborg, 1999, Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction., Blood, 93, 3053, 10.1182/blood.V93.9.3053

GI Perez, 2007, Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice., Proc Natl Acad Sci U S A, 104, 5229, 10.1073/pnas.0608557104

CM Knudson, 1995, Bax-deficient mice with lymphoid hyperplasia and male germ cell death., Science, 270, 96, 10.1126/science.270.5233.96

A Tivesten, 2004, Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats., J Bone Miner Res, 19, 1833, 10.1359/JBMR.040819

S Ishikawa, 1997, Osteoporosis due to testicular atrophy in male leprosy patients., Acta Med Okayama, 51, 279

T Siebler, 2002, Dexamethasone inhibits and thyroid hormone promotes differentiation of mouse chondrogenic ATDC5 cells., Bone, 31, 457, 10.1016/S8756-3282(02)00855-4

YC Lu, 2011, Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines., Arthritis Res Ther, 13, R142, 10.1186/ar3456

EB Hunziker, 1987, Quantitation of chondrocyte performance in growth-plate cartilage during longitudinal bone growth., J Bone Joint Surg Am, 69, 162, 10.2106/00004623-198769020-00002

M Liang, 2008, Bim, Bak, and Bax regulate osteoblast survival., J Bone Miner Res, 23, 610, 10.1359/jbmr.080106

J Milosevic, 2004, Spontaneous apoptosis in murine free-floating neurospheres., Exp Cell Res, 294, 9, 10.1016/j.yexcr.2003.10.033

B Espina, 2008, Regulation of bim in glucocorticoid-mediated osteoblast apoptosis., J Cell Physiol, 215, 488, 10.1002/jcp.21335

I Hilbers, 2003, Expression of the apoptosis accelerator Bax in rheumatoid arthritis synovium., Rheumatol Int, 23, 75, 10.1007/s00296-002-0255-2

CH Rundle, 2008, Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis., Bone, 43, 880, 10.1016/j.bone.2008.07.239

B Guo, 2003, Humanin peptide suppresses apoptosis by interfering with Bax activation., Nature, 423, 456, 10.1038/nature01627

F Luciano, 2005, Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL., J Biol Chem, 280, 15825, 10.1074/jbc.M413062200

G Del Poeta, 2008, Deregulation of the mitochondrial apoptotic machinery and development of molecular targeted drugs in acute myeloid leukemia., Curr Cancer Drug Targets, 8, 207, 10.2174/156800908784293640

M Takigawa, 1989, Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes., Cancer Res, 49, 3996

K Martensson, 2004, Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones., J Bone Miner Res, 19, 1805, 10.1359/JBMR.040805

AS Chagin, 2007, Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones., Bone, 40, 1415, 10.1016/j.bone.2006.12.066

D Chrysis, 2003, Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes., J Endocrinol, 176, 331, 10.1677/joe.0.1760331

AS Chagin, 2004, Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice., J Bone Miner Res, 19, 72, 10.1359/jbmr.0301203

J Schulze, 2010, Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2., PLoS One, 5, e10309, 10.1371/journal.pone.0010309

K Lehmann, 2006, A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2., Eur J Hum Genet, 14, 1248, 10.1038/sj.ejhg.5201708