Aberrant Expression of Long Noncoding RNAs in Autistic Brain

Springer Science and Business Media LLC - Tập 49 Số 3 - Trang 589-593 - 2013
Mark N. Ziats1, Owen M. Rennert2
1Laboratory of Clinical and Developmental Genomics, National Institute of Child Health and Human Development, National Institutes of Health, 49 Convent Drive, Building 49, Room 2C08, Bethesda, MD, 20814, USA
2Laboratory of Clinical and Developmental Genomics, National Institute of Child Health and Human Development, National Institutes of Health, 49 Convent Drive, Building 49, Room 2A08, Bethesda, MD, 20814, USA

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Abu-Elneel K, Liu T, Gazzaniga FS et al (2008) Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics 3:153–161

Amaral PP, Mattick JS (2008) Noncoding RNA in development. Mamm Genome 19:454–492

Bonati MT, Russo S, Finelli P et al (2007) Evaluation of autism traits in Angelman syndrome: A resource to unfold autism genes. Neurogenetics 8:169–178

Garbett K, Ebert PJ, Mitchell A et al (2008) Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol Dis 3:303–311

Geschwind DH, Levitt P (2007) Autism spectrum disorders: Developmental disconnection syndromes. Curr Opin Neurobiol 17:103–111

Geschwind DH (2008) Autism: Many genes, common pathways? Cell 3:391–395

Holt R, Monaco AP (2011) Links between genetics and pathophysiology in the autism spectrum disorders. EMBO Mol Med 8:438–450

Lintas C, Sacco R, Persico AM (2012) Genome-wide expression studies in autism spectrum disorder, Rett syndrome, and Down syndrome. Neurobiol Dis 1:57–68

Mclean CY, Bristor D, Hiller M et al (2010) GREAT improves functional interpretation of cis-regulatory regions. Nat Biotechnol 28:495–501

Mercer TR, Dinger ME, Sunkin SM, Mehler MF, Mattick JS (2008) Specific expression of long noncoding RNAs in the mouse brain. Proc Natl Acad Sci USA 105:716–721

Miles JH (2011) Autism spectrum disorders—a genetics review. Genet Med 4:278–294

Minshew NJ, Keller TA (2010) The nature of brain dysfunction in autism: Functional brain imaging studies. Curr Opin Neurol 2:124–130

Moncini S, Salvi A, Zuccotti P et al (2011) The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration. PLoS One 6:e20038

Nelson PT, Wang WX (2010) MiR-107 is reduced in Alzheimer’s disease brain neocortex: Validation study. J Alzheimer’s Dis 21:75–79

Ponting CP, Oliver PL, Reik W (2009) Evolution and functions of long noncoding RNAs. Cell 136:629–641

Purcell AE, Jeon OH, Zimmerman AW, Blue ME, Pevsner J (2001) Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology 9:1618–1628

Santarelli DM, Beveridge NJ, Tooney PA, Cairns MJ (2011) Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia. Biol Psychiatry 69:180–187

Sarachana T, Zhou R, Chen G, Manji HK, Hu VW (2010) Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines. Genome Med 2:23

Seno MM, Hu P, Gwadry FG et al (2011) Gene and miRNA expression profiles in autism spectrum disorders. Brain Res 1380:85–97

Talebizadeh Z, Butler MG, Theodoro MF (2008) Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism. Autism Res 4:240–250

Voineagu I, Wang X, Johnston P et al (2011) Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 474:380–384

Voineagu I (2012) Gene expression studies in autism: Moving from the genome to the transcriptome and beyond. Neurobiol Dis 1:69–75