Aberrant DNA methylation status of endometriosis: Epigenetics as the pathogenesis, biomarker and therapeutic target
Tóm tắt
Endometriosis, a common, benign, estrogen‐dependent disease affecting 3–10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue that is found primarily in the peritoneum, ovaries and rectovaginal septum. Recently, endometriosis has been alternatively described as an immune disease, a genetic disease and a disease caused by exposure to environmental factors, in addition to its usual description as a hormonal disease. In addition, accumulating evidence suggests that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. Epigenetic alterations reported to date in endometriosis include the genomic DNA methylation of progesterone receptor‐B, E‐cadherin, homeobox A10, estrogen receptor‐β, steroidogenic factor‐1 and aromatase. Aberrant expression of DNA methyltransferases, which attach a methyl group to the 5‐carbon position of cytosine bases in the CpG island of the promoter region and silence the corresponding gene expression, has also been demonstrated in endometriosis. This review summarizes the recent studies on the aberrant DNA methylation status and aberrant expression of DNA methyltransferases, which regulate DNA methylation, in endometriosis. We also discuss the recent information on the diagnostic and therapeutic implications of epigenetic alterations occurring in endometriosis.
Từ khóa
Tài liệu tham khảo
Hsieh CJ, 1998, Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long‐standing and extensive ulcerative colitis, Cancer Res, 58, 3942
Arimoto T, 2003, Genome‐wide cDNA microarray analysis of gene‐expression profiles involved in ovarian endometriosis, Int J Oncol, 22, 551
Lin X, 2001, Reversal of GSTP1 CpG island hypermethylation and reactivation of pi‐class glutathione S‐transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide, Cancer Res, 61, 8611
Korkmaz A, 2007, Epigenetic regulation: A new research area for melatonin?, J Pineal Res, 44, 41, 10.1111/j.1600-079X.2007.00509.x
Ushijima T, 2005, Detection and interpretation of altered methylation patterns in cancer cells, Nature, 5, 223
Fiegl H, 2004, Methylated DNA collected by tampons–a new tool to detect endometrial cancer, Cancer Epidemiol Biomarkers Prev, 13, 882, 10.1158/1055-9965.882.13.5