Abdominal aortic aneurysm

Golledge, 2006, Abdominal aortic aneurysm: pathogenesis and implications for management., Arterioscler Thromb Vasc Biol, 26, 2605, 10.1161/01.ATV.0000245819.32762.cb

Moll, 2011, Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery., Eur J Vasc Endovasc Surg, 41, S1, 10.1016/j.ejvs.2010.09.011

Anjum, 2012, Is the incidence of abdominal aortic aneurysm declining in the 21st century Mortality and hospital admissions for England Wales and Scotland., Eur J Vasc Endovasc Surg, 43, 161, 10.1016/j.ejvs.2011.11.014

Sidloff, 2014, Aneurysm global epidemiology study: public health measures can further reduce abdominal aortic aneurysm mortality., Circulation, 129, 747, 10.1161/CIRCULATIONAHA.113.005457

Robertson, 2014, Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with abdominal aortic aneurysm., Cochrane Database Syst Rev, 1, CD010447

Joergensen, 2014, Abdominal aortic diameter is increased in males with a family history of abdominal aortic aneurysms: results from the Danish VIVA-trial., Eur J Vasc Endovasc Surg, 48, 669, 10.1016/j.ejvs.2014.09.005

Morris, 2014, The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis., Heart, 100, 295, 10.1136/heartjnl-2013-304129

Jones, 2013, A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm., Hum Mol Genet, 22, 2941, 10.1093/hmg/ddt141

Biros, 2011, Meta-analysis of the association between single nucleotide polymorphisms in TGF-beta receptor genes and abdominal aortic aneurysm., Atherosclerosis, 219, 218, 10.1016/j.atherosclerosis.2011.07.105

Gretarsdottir, 2010, Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm., Nat Genet, 42, 692, 10.1038/ng.622

Elmore, 2009, Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association., J Vasc Surg, 49, 1525, 10.1016/j.jvs.2009.01.041

Bown, 2011, Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1., Am J Hum Genet, 89, 619, 10.1016/j.ajhg.2011.10.002

Galora, 2014, Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients., J Vasc Surg, 61, 787, 10.1016/j.jvs.2013.10.090

Bradley, 2013, A variant in LDLR is associated with abdominal aortic aneurysm., Circ Cardiovasc Genet, 6, 498, 10.1161/CIRCGENETICS.113.000165

Ryer, 2015, The potential role of DNA methylation in abdominal aortic aneurysms., Int J Mol Sci, 16, 11259, 10.3390/ijms160511259

Toghill, 2015, The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm., Atherosclerosis, 241, 121, 10.1016/j.atherosclerosis.2015.05.001

Sidloff, 2014, A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size., J Vasc Surg, 59, 528, 10.1016/j.jvs.2013.10.088

Stather, 2014, Meta-analysis and meta-regression analysis of biomarkers for abdominal aortic aneurysm., Br J Surg, 101, 1358, 10.1002/bjs.9593

Davis, 2014, Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies., Heart, 100, 1498, 10.1136/heartjnl-2014-305648

Michineau, 2014, Chemokine (C-X-C motif) receptor4 blockade by AMD3100 inhibits experimental abdominal aortic aneurysm expansion through anti-inflammatory effects., Arterioscler Thromb Vasc Biol, 34, 1, 10.1161/ATVBAHA.114.303913

Mellak, 2015, Angiotensin II mobilizes spleen monocytes to promote the development of abdominal aortic aneurysm in Apoe-- mice., Arterioscler Thromb Vasc Biol, 35, 378, 10.1161/ATVBAHA.114.304389

Xiao, 2012, Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses., Arterioscler Thromb Vasc Biol, 32, 386, 10.1161/ATVBAHA.111.242198

Yin, 2010, Deficient CD4CD25 T regulatory cell function in patients with abdominal aortic aneurysms., Arterioscler Thromb Vasc Biol, 30, 1825, 10.1161/ATVBAHA.109.200303

Ait-Oufella, 2013, Natural regulatory T cells limit angiotensin II-induced aneurysm formation and rupture in mice., Arterioscler Thromb Vasc Biol, 33, 2374, 10.1161/ATVBAHA.113.301280

Yodoi, 2015, Foxp3 regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice., Hypertension, 65, 889, 10.1161/HYPERTENSIONAHA.114.04934

Meng, 2014, Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice., Hypertension, 64, 875, 10.1161/HYPERTENSIONAHA.114.03950

Obama, 2015, Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model., Clin Sci (Lond), 128, 559, 10.1042/CS20140696

Johnston, 2013, Genetic and pharmacologic disruption of interleukin-1 beta signaling inhibits experimental aortic aneurysm formation., Arterioscler Thromb Vasc Biol, 33, 294, 10.1161/ATVBAHA.112.300432

Wei, 2014, Inhibiting the Th17IL-17A-related inflammatory responses with digoxin confers protection against experimental abdominal aortic aneurysm., Arterioscler Thromb Vasc Biol, 34, 2429, 10.1161/ATVBAHA.114.304435

Usui, 2015, Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm., Arterioscler Thromb Vasc Biol, 35, 127, 10.1161/ATVBAHA.114.303763

Doyle, 2015, Differential expression of HedgehogNotch and transforming growth factor- in human abdominal aortic aneurysms., J Vasc Surg, 62, 464, 10.1016/j.jvs.2014.02.053

Wang, 2010, TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice., J Clin Invest, 120, 422, 10.1172/JCI38136

Dai, 2015, SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model., Sci Rep, 5, 10180, 10.1038/srep10180

Krishna, 2015, A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse., Arterioscler Thromb Vasc Biol, 35, 389, 10.1161/ATVBAHA.114.304732

Hans, 2012, Inhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation., Arterioscler Thromb Vasc Biol, 32, 3012, 10.1161/ATVBAHA.112.254219

Zheng, 2013, Notch gamma-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms., PLoS One, 8, e83310, 10.1371/journal.pone.0083310

Cheng, 2014, Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model., J Am Heart Assoc, 3, e001064, 10.1161/JAHA.114.001064

Lei, 2014, Identification of Hic-5 as a novel scaffold for the MKK4p54 JNK pathway in the development of abdominal aortic aneurysms., J Am Heart Assoc, 3, e000747, 10.1161/JAHA.113.000747

Kigawa, 2014, NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice., Arterioscler Thromb Vasc Biol, 34, 2413, 10.1161/ATVBAHA.114.303086

Funk, 2005, Leukotriene modifiers as potential therapeutics for cardiovascular disease., Nat Rev Drug Discov, 4, 664, 10.1038/nrd1796

Zhao, 2004, The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm., Nature Med, 10, 966, 10.1038/nm1099

Ahluwalia, 2007, Inhibited aortic aneurysm formation in BLT1deficient mice., J Immunol, 179, 691, 10.4049/jimmunol.179.1.691

Cao, 2007, Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice., Prostaglandins Other Lipid Mediat, 84, 34, 10.1016/j.prostaglandins.2007.03.005

Bhamidipati, 2014, 5-Lipoxygenase pathway in experimental abdominal aortic aneurysms., Arterioscler Thromb Vasc Biol, 34, 2669, 10.1161/ATVBAHA.114.304016

Lu, 2012, Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms., Clin Sci, 123, 531, 10.1042/CS20120097

Kaschina, 2008, Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation., J Hypertens, 26, 2361, 10.1097/HJH.0b013e328313e547

Fujiwara, 2008, Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan., Int J Mol Med, 22, 703

Seto, 2014, Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model., Clin Sci (Lond), 127, 123, 10.1042/CS20130382

Liu, 2013, Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt., Arterioscler Thromb Vasc Biol, 33, 1568, 10.1161/ATVBAHA.112.300820

Golledge, 2013, Is there a new target in the renin-angiotensin system for aortic aneurysm therapy Arterioscler Thromb Vasc B, iol, 33, 1456

Linkermann, 2014, Necroptosis., N Engl J Med, 370, 455, 10.1056/NEJMra1310050

Wang, 2015, Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation., Circ Res, 116, 600, 10.1161/CIRCRESAHA.116.304899

Muratoglu, 2013, LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1., Arterioscler Thromb Vasc Biol, 33, 2137, 10.1161/ATVBAHA.113.301893

Davis, 2015, Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms., Arterioscler Thromb Vasc Biol, 35, 155, 10.1161/ATVBAHA.114.304683

Kadoglou, 2004, Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms., Curr Med Res Opin, 20, 419, 10.1185/030079904125003143

Lohoefer, 2014, Quantitative expression and localization of cysteine and aspartic proteases in human abdominal aortic aneurysms., Exp Mol Med, 46, e95, 10.1038/emm.2014.20

Lv, 2013, Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study., Atherosclerosis, 230, 100, 10.1016/j.atherosclerosis.2013.05.018

Sun, 2012, Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice., Arterioscler Thromb Vasc Biol, 32, 15, 10.1161/ATVBAHA.111.235002

Moran, 2005, Association of osteoprotegerin with human abdominal aortic aneurysm progression., Circulation, 111, 3119, 10.1161/CIRCULATIONAHA.104.464727

Moran, 2014, Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and rupture in the apolipoprotein E-knockout mouse., Arterioscler Thromb Vasc Biol, 34, 2609, 10.1161/ATVBAHA.114.304587

Maegdefessel, 2012, Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development., J Clin Invest, 122, 497, 10.1172/JCI61598

Maegdefessel, 2014, miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development., Nat Commun, 5, 5214, 10.1038/ncomms6214

Maegdefessel, 2012, MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion., Sci Transl Med, 4, 122ra22, 10.1126/scitranslmed.3003441

Kim, 2014, Prevention of abdominal aortic aneurysm by antimicroRNA-712 or antimicroRNA-205 in angiotensin II-infused mice., Arterioscler Thromb Vasc Biol, 34, 1412, 10.1161/ATVBAHA.113.303134

Cheuk, 2014, Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms., J Vasc Surg, 59, 202, 10.1016/j.jvs.2013.02.244

Zampetaki, 2014, Role of miR-195 in aortic aneurysmal disease., Circ Res, 115, 857, 10.1161/CIRCRESAHA.115.304361

Spear, 2015, Adventitial tertiary lymphoid organs as potential source of microRNA biomarkers for abdominal aortic aneurysm., Int J Mol Sci, 16, 11276, 10.3390/ijms160511276

van Rooij, 2012, MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles., Nat Rev Drug Discov, 11, 860, 10.1038/nrd3864

Takagi, 2009, Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis., Interact Cardiovasc Thorac Surg, 9, 437, 10.1510/icvts.2009.208835

Dilme, 2014, Influence of cardiovascular risk factors on levels of matrix metalloproteinases 2 and 9 in human abdominal aortic aneurysms., Eur J Vasc Endovasc Surg, 48, 374, 10.1016/j.ejvs.2014.05.023

Mata, 2015, Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms., Cardiovasc Pathol, 24, 110, 10.1016/j.carpath.2014.10.004

Meijer, 2013, Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial., Ann Intern Med, 159, 815, 10.7326/0003-4819-159-12-201312170-00007

Kortekaas, 2014, ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm., PLoS One, 9, e111952, 10.1371/journal.pone.0111952

Kristensen, 2015, Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in patients with abdominal aortic aneurysms: nation-wide cohort study., Arterioscler Thromb Vasc Biol, 35, 733, 10.1161/ATVBAHA.114.304428