AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Nature Genetics - Tập 24 Số 3 - Trang 245-250 - 2000
Seiji Satoh1, Yataro Daigo1, Yoichi Furukawa1, Tatsushi Kato1, Noriko Miwa1, Takeshi Nishiwaki1, Teru Kawasoe1, Hideyuki Ishiguro1, Manabu Fujita1, Takashi Tokino2, Yo Sasaki3, Shingi Imaoka3, Masaru Murata4, Takashi Shimano4, Yoshio Yamaoka5, Yusuke Nakamura1
1Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan
2Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo, Japan
3Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
4Municipal Ikeda Hospital, Osaka, Japan
5Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Tóm tắt

Từ khóa


Tài liệu tham khảo

Tsuda, M. et al. The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila. Nature 400, 276– 280 (1999).

Itoh, K., Krupnik, V.E. & Sokol, S.Y. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin. Curr. Biol. 8, 591–594 ( 1998).

Lee, Y.J., Swencki, B., Shoichet, S. & Shivdasani, R.A. A possible role for the high mobility group box transcription factor TCF4 in vertebrate gut epithelial cell differentiation. J. Biol. Chem. 274, 1566–1572 ( 1999).

Morin, P.J. et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275, 1787–1790 (1997).

He, T.C. et al. Identification of c-MYC as a target of the APC pathway. Science. 281, 1509–1512 (1998).

Tetsu, O. & McCormick, F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422–426 (1999).

Fukuchi, T. et al. β-catenin mutation in carcinoma of the uterine endometrium . Cancer Res. 58, 3526– 3528 (1998).

Chan, E.F., Gat, U., McNiff, J.M. & Fuchs, E. A common human skin tumour is caused by activating mutations in β-catenin. Nature Genet. 21, 410–413 ( 1999).

Miyoshi, Y. et al. Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res. 58, 2524–2527 ( 1998).

Voeller, H.J., Truica, C.I. & Gelmann, E.P. β-catenin mutations in human prostate cancer . Cancer Res. 58, 2520– 2523 (1998).

Zurawel, R.H., Chiappa, S.A., Allen, C. & Raffel, C. Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res. 58, 896–899 (1998).

Iwao, K. et al. Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res. 58, 1021– 1026 (1998).

de La Coste, A. et al. Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc. Natl Acad. Sci. USA 95, 8847–8851 ( 1998).

Ihara, A., Koizumi, H., Hashizume, R. & Uchikoshi, T. Expression of epithelial cadherin and α- and β-catenins in nontumoral livers and hepatocellular carcinomas. Hepatology 23 , 1441–1447 (1996).

Ding, S.F. et al. The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes. Cancer Detect. Prev. 17, 405–409 ( 1993).

Smalley, M.J. et al. Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J. 18, 2823–2835 (1999).

Hart, M.J., de los Santos, R., Albert, I.N., Rubinfeld, B. & Polakis, P. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β. Curr. Biol. 8, 573– 581 (1998).

Nakamura, T. et al. Axin, an inhibitor of the Wnt signalling pathway, interacts with β-catenin, GSK-3β and APC and reduces the β-catenin level . Genes Cells 3, 395–403 (1998).

Korinek, V. et al. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma. Science 275, 1784–1787 (1997).

Nakamura, Y. Cleaning up on β-catenin. Nature Med. 3, 499–500 (1997).

Orford, K., Orford, C.C. & Byers, S.W. Exogenous expression of β-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest. J. Cell Biol. 146, 855– 868 (1999).

Zhang, Z. et al. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698–702 (1998).

Morin, P.J., Vogelstein, B. & Kinzler, K.W. Apoptosis and APC in colorectal tumorigenesis. Proc. Natl Acad. Sci. USA 93, 7950– 7954 (1996).

Nagai, H. et al. Comprehensive allelotyping of human hepatocellular carcinoma . Oncogene 14, 2927–2933 (1997)

Polakis, P. The adenomatous polyposis coli (APC) tumor suppressor. Biochim. Biophys. Acta 1332, F127–F147 (1997).

Takahashi, M. et al. Long term correction of bilirubin-UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period. J. Biol. Chem. 271, 26536–26542 (1996).

McGrory, W.J., Bautista, D.S. & Graham, F.L. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology 163, 614–617 (1988).

Van de Wetering, M., Castrop, J., Korinek, V. & Clevers, H. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol. Cell. Biol. 16, 745–752 (1996).