APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease
Tóm tắt
Từ khóa
Tài liệu tham khảo
Abondio, 2019, The genetic variability of APOE in different human populations and its implications for longevity, Genes, 10, E222, 10.3390/genes10030222
Adeosun, 2019, Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture, Neurobiol. Learn. Mem., 161, 106, 10.1016/j.nlm.2019.03.012
Altenburg, 2008, Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice, Arterioscler. Thromb. Vasc. Biol., 28, 1104, 10.1161/atvbaha.108.164863
Andrieu, 2017, Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial, Lancet Neurol., 16, 377, 10.1016/S1474-4422(17)30040-6
Arbones-Mainar, 2010, Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4, FASEB J., 24, 3809, 10.1096/fj.10-159517
Arbones-Mainar, 2008, Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice, Int. J. Obes., 32, 1595, 10.1038/ijo.2008.143
Arbones-Mainar, 2016, Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4, Int. J. Obes., 40, 1574, 10.1038/ijo.2016.93
Azevedo, 2014, Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice, PLoS One, 9, e89562, 10.1371/journal.pone.0089562
Babulal, 2019, Perspectives on ethnic and racial disparities in Alzheimer’s disease and related dementias: update and areas of immediate need, Alzheimers Dement., 15, 292, 10.1016/j.jalz.2018.09.009
Backman, 2015, 37 years of body mass index and dementia: effect modification by the apoe genotype: observations from the prospective population study of women in Gothenburg, Sweden, J. Alzheimers Dis., 48, 1119, 10.3233/jad-150326
Baitsch, 2011, Apolipoprotein E induces antiinflammatory phenotype in macrophages, Arterioscler. Thromb. Vasc. Biol., 31, 1160, 10.1161/ATVBAHA.111.222745
Barberger-Gateau, 2007, Dietary patterns and risk of dementia: the three-city cohort study, Neurology, 69, 1921, 10.1212/01.wnl.0000278116.37320.52
Bell, 2012, Apolipoprotein E controls cerebrovascular integrity via cyclophilin A, Nature, 485, 512, 10.1038/nature11087
Beydoun, 2007, Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the atherosclerosis risk in communities study, Am. J. Clin. Nutr., 85, 1103, 10.1093/ajcn/85.4.1103
Blanchard, 2018, Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study, J. Lipid Res., 59, 892, 10.1194/jlr.P083576
Blum, 1982, Dynamics of apolipoprotein E metabolism in humans, J. Lipid Res., 23, 1308, 10.1016/S0022-2275(20)38036-6
Boros, 2019, Dendritic spine remodeling accompanies Alzheimer’s disease pathology and genetic susceptibility in cognitively normal aging, Neurobiol. Aging, 73, 92, 10.1016/j.neurobiolaging.2018.09.003
Braun, 2006, Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells, J. Lipid Res., 47, 1176, 10.1194/jlr.m500503-jlr200
Brifault, 2017, Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation, J. Biol. Chem., 292, 18699, 10.1074/jbc.m117.798413
Burns, 2019, The TOMMORROW study: Design of an Alzheimer’s disease delay-of-onset clinical trial, Alzheimers Dement. (N Y), 5, 661, 10.1016/j.trci.2019.09.010
Carvalho-Wells, 2012, APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults, Am. J. Clin. Nutr., 96, 1447, 10.3945/ajcn.112.043240
Cataldo, 2000, Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations, Am. J. Pathol., 157, 277, 10.1016/s0002-9440(10)64538-5
Chang, 2016, Gray matter maturation and cognition in children with different APOE epsilon genotypes, Neurology, 87, 585, 10.1212/wnl.0000000000002939
Chawla, 2001, A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis, Mol. Cell, 7, 161, 10.1016/s1097-2765(01)00164-2
Chen, 2010, ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling, Proc. Natl. Acad. Sci. U S A, 107, 12011, 10.1073/pnas.0914984107
Chetty, 2017, Helical structure, stability and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry, Proc. Natl. Acad. Sci. U S A, 114, 968, 10.1073/pnas.1617523114
Conway, 2014, Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice, Prostaglandins Leukot. Essent. Fatty Acids, 91, 261, 10.1016/j.plefa.2014.09.007
Cui, 2011, Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels, Neurochem. Res., 36, 1910, 10.1007/s11064-011-0513-3
Cummings, 2016, Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease, Alzheimers Res. Ther., 8, 4, 10.1186/s13195-016-0173-2
Daiello, 2015, Association of fish oil supplement use with preservation of brain volume and cognitive function, Alzheimers Dement., 11, 226, 10.1016/j.jalz.2014.02.005
Dallongeville, 1992, Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis, J. Lipid Res., 33, 447, 10.1016/S0022-2275(20)41611-6
Di Cerbo, 2016, Mechanisms and therapeutic effectiveness of lactobacilli, J. Clin. Pathol., 69, 187, 10.1136/jclinpath-2015-202976
Dong, 1996, Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins, J. Biol. Chem., 271, 19053, 10.1074/jbc.271.32.19053
Elosua, 2003, Obesity modulates the association among APOE genotype, insulin and glucose in men, Obes. Res., 11, 1502, 10.1038/oby.2003.201
Espeland, 2017, Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment, Neurology, 88, 2026, 10.1212/WNL.0000000000003955
Fallaize, 2017, APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome, Sci. Rep., 7, 6274, 10.1038/s41598-017-05802-2
Fan, 2011, An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia, J. Lipid Res., 52, 1605, 10.1194/jlr.m014365
Farkas, 2003, The recycling of apolipoprotein E in primary cultures of mouse hepatocytes: evidence for a physiologic connection to high density lipoprotein metabolism, J. Biol. Chem., 278, 9412, 10.1074/jbc.m208026200
Farmer, 2019, Apolipoprotein E4 alters astrocyte fatty acid metabolism and lipid droplet formation, Cells, 8, E182, 10.3390/cells8020182
Farrer, 1997, Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis, JAMA, 278, 1349, 10.1001/jama.1997.03550160069041
Fernandez, 2019, The role of APOE4 in disrupting the homeostatic functions of astrocytes and microglia in aging and Alzheimer’s disease, Front. Aging Neurosci., 11, 14, 10.3389/fnagi.2019.00014
Finch, 2010, Evolution of the human lifespan and diseases of aging: roles of infection, inflammation and nutrition, Proc. Natl. Acad. Sci. U S A, 107, 1718, 10.1073/pnas.0909606106
Finch, 2016, Apolipoprotein E and sex bias in cerebrovascular aging of men and mice, Trends Neurosci., 39, 625, 10.1016/j.tins.2016.07.002
Finch, 2019, The Alzheimer’s disease exposome, Alzheimers Dement., 15, 1123, 10.1016/j.jalz.2019.06.3914
Flowers, 2020, O-glycosylation on cerebrospinal fluid and plasma apolipoprotein E differs in the lipid-binding domain, Glycobiology, 30, 74, 10.1093/glycob/cwz084
Gale, 2014, APOε4 is associated with enhanced in vivo innate immune responses in human subjects, J. Allergy Clin. Immunol., 134, 127.e9, 10.1016/j.jaci.2014.01.032
Ghebranious, 2011, A pilot study of gene/gene and gene/environment interactions in Alzheimer disease, Clin. Med. Res., 9, 17, 10.3121/cmr.2010.894
Gong, 2002, Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice, J. Biol. Chem., 277, 29919, 10.1074/jbc.m203934200
Griffin, 2018, APOE4 genotype exerts greater benefit in lowering plasma cholesterol and apolipoprotein B than wild type (E3/E3), after replacement of dietary saturated fats with low glycaemic index carbohydrates, Nutrients, 10, E1524, 10.3390/nu10101524
Haan, 2003, Prevalence of dementia in older latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors, J. Am. Geriatr. Soc., 51, 169, 10.1046/j.1532-5415.2003.51054.x
Halliday, 2013, Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown, JAMA Neurol., 70, 1198, 10.1001/jamaneurol.2013.3841
Hamilton, 2015, Aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimer’s disease, Cell Stem Cell, 17, 397, 10.1016/j.stem.2015.08.001
Hanson, 2015, Differential effects of meal challenges on cognition, metabolism and biomarkers for apolipoprotein E varepsilon4 carriers and adults with mild cognitive impairment, J. Alzheimers Dis., 48, 205, 10.3233/jad-150273
Heeren, 2003, Recycling of apoprotein E Is associated with cholesterol efflux and high density lipoprotein internalization, J. Biol. Chem., 278, 14370, 10.1074/jbc.m209006200
Heeren, 2004, Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation, J. Biol. Chem., 279, 55483, 10.1074/jbc.m409324200
Henderson, 2009, Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial, Nutr. Metab., 6, 31, 10.1186/1743-7075-6-31
Hu, , Simple and fast assay for apolipoprotein E phenotyping and glycotyping: discovering isoform-specific glycosylation in plasma and cerebrospinal fluid, J. Alzheimers Dis.
Huang, 2006, Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression, Arterioscler. Thromb. Vasc. Biol., 26, 157, 10.1161/01.atv.0000193627.12516.1d
Huang, 2005, Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4, Neurology, 65, 1409, 10.1212/01.wnl.0000183148.34197.2e
Hubin, 2019, Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation, FEBS Lett., 593, 1144, 10.1002/1873-3468.13428
Jansen, 2015, Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis, JAMA, 313, 1924, 10.1001/jama.2015.4668
Ji, 2003, Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer’s disease patients, Neuroscience, 122, 305, 10.1016/j.neuroscience.2003.08.007
Jofre-Monseny, 2007, Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression, Biochem. Biophys. Res. Commun., 357, 319, 10.1016/j.bbrc.2007.03.150
Johnson, 2011, The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE epsilon3/epsilon3 genotype, Alzheimers Dement., 7, 456, 10.1016/j.jalz.2010.11.012
Johnson, 2019, Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response, J. Cereb. Blood Flow Metab., 39, 770, 10.1177/0271678x17746186
Jones, 2019, Metabolic disturbances of a high-fat diet are dependent on APOE genotype and sex, eNeuro, 6, ENEURO.0267#x02013;19.2019, 10.1523/eneuro.0267-19.2019
Joo, 2018, Body mass index in mild cognitive impairment according to age, sex, cognitive intervention and hypertension and risk of progression to Alzheimer’s disease, Front. Psychiatry, 9, 142, 10.3389/fpsyt.2018.00142
Knopman, 2014, 18F-fluorodeoxyglucose positron emission tomography, aging and apolipoprotein E genotype in cognitively normal persons, Neurobiol. Aging, 35, 2096, 10.1016/j.neurobiolaging.2014.03.006
Konishi, 2018, Healthy versus entorhinal cortical atrophy identification in asymptomatic APOE4 carriers at risk for Alzheimer’s disease, J. Alzheimers Dis., 61, 1493, 10.3233/jad-170540
Krüger, 2009, Omega-3 fatty acids and risk of dementia: the Canadian study of health and aging, Am. J. Clin. Nutr., 90, 184, 10.3945/ajcn.2008.26987
Kulminski, 2019, Independent associations of TOMM40 and APOE variants with body mass index, Aging Cell, 18, e12869, 10.1111/acel.12869
Kulminski, 2020, APOE region molecular signatures of Alzheimer’s disease across races/ethnicities, Neurobiol. Aging, 87, 141.e1, 10.1016/j.neurobiolaging.2019.11.007
Laffitte, 2001, LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proc. Natl. Acad. Sci. U S A, 98, 507, 10.1073/pnas.021488798
Laitinen, 2006, Fat intake at midlife and risk of dementia and Alzheimer’s disease: a population-based study, Dement. Geriatr. Cogn. Disord., 22, 99, 10.1159/000093478
Lee, 2012, Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels, J. Biol. Chem., 287, 2032, 10.1074/jbc.M111.295451
Leonardini, 2009, Cross-talk between PPARγ and insulin signaling and modulation of insulin sensitivity, PPAR Res., 2009, 818945, 10.1155/2009/818945
Li, 2013, Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels, Arterioscler. Thromb. Vasc. Biol., 33, 687, 10.1161/atvbaha.112.301193
Lucotte, 1997, Pattern of gradient of apolipoprotein E allele *4 frequencies in western Europe, Hum. Biol., 69, 253
Lyall, 2014, Are APOE varepsilon genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?, Transl. Psychiatry, 4, e449, 10.1038/tp.2014.89
Marmillot, 1999, Desialylation of human apolipoprotein E decreases its binding to human high-density lipoprotein and its ability to deliver esterified cholesterol to the liver, Metabolism, 48, 1184, 10.1016/s0026-0495(99)90136-1
Mastana, 1998, Anthropology of the apoplipoprotein E (apo E) gene: low frequency of apo E4 allele in Basques and in tribal (Baiga) populations of India, Ann. Hum. Biol., 25, 137, 10.1080/03014469800005512
Morris, 2016, Association of seafood consumption, brain mercury level and APOE epsilon4 status with brain neuropathology in older adults, JAMA, 315, 489, 10.1001/jama.2015.19451
Morrow, 2002, Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease, J. Biol. Chem., 277, 50380, 10.1074/jbc.m204898200
Morrow, 2000, Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain, Biochemistry, 39, 11657, 10.1021/bi000099m
Mosconi, 2004, MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET, Neurology, 63, 2332, 10.1212/01.wnl.0000147469.18313.3b
Neu, 2017, Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis, JAMA Neurol., 74, 1178, 10.1001/jamaneurol.2017.2188
Ngandu, 2015, A 2 year multidomain intervention of diet, exercise, cognitive training and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial, Lancet, 385, 2255, 10.1016/S0140-6736(15)60461-5
Nieminen, 2008, Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease, Pharmacogenomics, 9, 1475, 10.2217/14622416.9.10.1475
Nishimura, 2017, Characterization of APOE and TOMM40 allele frequencies in the Japanese population, Alzheimers Dement., 3, 524, 10.1016/j.trci.2017.07.003
Nixon, 2005, Endosome function and dysfunction in Alzheimer’s disease and other neurodegenerative diseases, Neurobiol. Aging, 26, 373, 10.1016/j.neurobiolaging.2004.09.018
Nuriel, , Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology, Nat. Commun., 8, 1464, 10.1038/s41467-017-01444-0
Nuriel, , The endosomal-lysosomal pathway is dysregulated by APOE4 expression in vivo, Front. Neurosci., 11, 702, 10.3389/fnins.2017.00702
O’Bryant, 2013, Characterization of Mexican Americans with mild cognitive impairment and Alzheimer’s disease, J. Alzheimers Dis., 33, 373, 10.3233/JAD-2012-121420
Oriá, 2010, ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children, Braz. J. Med. Biol. Res., 43, 249, 10.1590/s0100-879x2010007500003
Parikh, 2020, Murine gut microbiome association with APOE alleles, Front. Immunol., 11, 200, 10.3389/fimmu.2020.00200
Pelletier, 2015, Mediterranean diet and preserved brain structural connectivity in older subjects, Alzheimers Dement., 11, 1023, 10.1016/j.jalz.2015.06.1888
Peng, 2019, Apolipoprotein E4 genotype compromises brain exosome production, Brain, 142, 163, 10.1093/brain/awy289
Prasad, 2018, Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH, Proc. Natl. Acad. Sci. U S A, 115, E6640, 10.1073/pnas.1801612115
Price, 2006, Apolipoprotein epsilon3 allele is associated with persistent hepatitis C virus infection, Gut, 55, 715, 10.1136/gut.2005.079905
Quinn, 2010, Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial, JAMA, 304, 1903, 10.1001/jama.2010.1510
Raffai, 2001, Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein E, Proc. Natl. Acad. Sci. U S A, 98, 11587, 10.1073/pnas.201279298
Rajabli, 2018, Ancestral origin of ApoE epsilon4 Alzheimer disease risk in Puerto Rican and African American populations, PLoS Genet., 14, e1007791, 10.1371/journal.pgen.1007791
Rajan, 2014, Gene-environment interaction of body mass index and apolipoprotein E ε4 allele on cognitive decline, Alzheimer Dis. Assoc. Disord., 28, 134, 10.1097/wad.0000000000000013
Rapp, 2017, Effect of a long-term intensive lifestyle intervention on cognitive function: action for health in diabetes study, J. Am. Geriatr. Soc., 65, 966, 10.1111/jgs.14692
Rawat, 2019, ApoE4 alters ABCA1 membrane trafficking in astrocytes, J. Neurosci., 39, 9611, 10.1523/jneurosci.1400-19.2019
Reger, 2004, Effects of β-hydroxybutyrate on cognition in memory-impaired adults, Neurobiol. Aging, 25, 311, 10.1016/S0197-4580(03)00087-3
Reiman, 2004, Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia, Proc. Natl. Acad. Sci. U S A, 101, 284, 10.1073/pnas.2635903100
Risner, 2006, Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease, Pharmacogenomics J., 6, 246, 10.1038/sj.tpj.6500369
Rönnemaa, 2012, Serum fatty-acid composition and the risk of Alzheimer’s disease: a longitudinal population-based study, Eur. J. Clin. Nutr., 66, 885, 10.1038/ejcn.2012.63
Roses, 2010, A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer’s disease, Pharmacogenomics J., 10, 375, 10.1038/tpj.2009.69
Roses, 2014, African-American TOMM40’523-APOE haplotypes are admixture of West African and Caucasian alleles, Alzheimers Dement., 10, 592.e2, 10.1016/j.jalz.2014.06.009
Shaw, 2007, Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study, Lancet Neurol., 6, 494, 10.1016/s1474-4422(07)70106-0
Singh, 2006, APOE distribution in world populations with new data from India and the UK, Ann. Hum. Biol., 33, 279, 10.1080/03014460600594513
Solomon, 2018, Effect of the apolipoprotein e genotype on cognitive change during a multidomain lifestyle intervention: a subgroup analysis of a randomized clinical trial, JAMA Neurol., 75, 462, 10.1001/jamaneurol.2017.4365
Stonehouse, 2013, DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial, Am. J. Clin. Nutr., 97, 1134, 10.3945/ajcn.112.053371
Sun, 2017, Hippocampal synaptic and neural network deficits in young mice carrying the human APOE4 gene, CNS Neurosci. Ther., 23, 748, 10.1111/cns.12720
Subramanian, 2017, The effects of PPARgamma on the regulation of the TOMM40-APOE-C1 genes cluster, Biochim. Biophys. Acta Mol. Basis Dis., 1863, 810, 10.1016/j.bbadis.2017.01.004
Tao, 2018, Association of chronic low-grade inflammation with risk of Alzheimer disease in ApoE4 carriers, JAMA Netw. Open, 1, e183597, 10.1001/jamanetworkopen.2018.3597
Tang, 1996, Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians and Hispanics in New York City, Am. J. Hum. Genet., 58, 574
Tejedor, 2014, The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men, PLoS One, 9, e108605, 10.1371/journal.pone.0108605
Tensaouti, 2018, ApoE regulates the development of adult newborn hippocampal neurons, eNeuro, 5, ENEURO.0155–18.2018, 10.1523/eneuro.0155-18.2018
Theendakara, 2016, Direct transcriptional effects of apolipoprotein E, J. Neurosci., 36, 685, 10.1523/JNEUROSCI.3562-15.2016
Theendakara, 2017, Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer’s disease, Mol. Cell. Neurosci., 83, 83, 10.1016/j.mcn.2017.07.002
Theendakara, 2018, Transcriptional effects of ApoE4: relevance to Alzheimer’s disease, Mol. Neurobiol., 55, 5243, 10.1007/s12035-017-0757-2
Tomaszewski, 2020, Effect of APOE genotype on plasma docosahexaenoic acid (DHA), eicosapentaenoic acid, arachidonic acid and hippocampal volume in the Alzheimer’s disease cooperative study-sponsored DHA clinical trial, J. Alzheimers Dis., 74, 975, 10.3233/jad-191017
Trumble, 2019, The exposome in human evolution: from dust to diesel, Q. Rev. Biol., 94, 333, 10.1086/706768
Trumble, 2017, Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden, FASEB J., 31, 1508, 10.1096/fj.201601084r
Tsivgoulis, 2013, Adherence to a Mediterranean diet and risk of incident cognitive impairment, Neurology, 80, 1684, 10.1212/wnl.0b013e3182904f69
Vamathevan, 2008, The role of positive selection in determining the molecular cause of species differences in disease, BMC Evol. Biol., 8, 273, 10.1186/1471-2148-8-273
van de Rest, 2008, Effect of fish oil on cognitive performance in older subjects A randomized, controlled trial, Neurology, 71, 430, 10.1212/01.wnl.0000324268.45138.86
van Exel, 2017, Effect of APOE epsilon4 allele on survival and fertility in an adverse environment, PLoS One, 12, e0179497, 10.1371/journal.pone.0179497
Vandal, 2014, Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2, J. Neurochem., 129, 516, 10.1111/jnc.12640
Venzi, 2017, Differential effect of APOE alleles on brain glucose metabolism in targeted replacement mice: an [18F]FDG-μPET study, J. Alzheimers Dis. Rep., 1, 169, 10.3233/adr-170006
Verghese, 2013, ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions, Proc. Natl. Acad. Sci. U S A, 110, E1807, 10.1073/pnas.1220484110
Volcik, 2006, Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants, Am. J. Epidemiol., 164, 342, 10.1093/aje/kwj202
Weisgraber, 1990, Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112, J. Lipid Res., 31, 1503, 10.1016/S0022-2275(20)42621-5
Weisgraber, 1982, Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site, J. Biol. Chem., 257, 2518, 10.1016/S0021-9258(18)34954-8
Westerterp, 2013, Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice, Circ. Res., 112, 1456, 10.1161/circresaha.113.301086
Whalley, 2008, n-3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood, Am. J. Clin. Nutr., 87, 449, 10.1093/ajcn/87.2.449
Williams, 2020, APOE alters glucose flux through central carbon pathways in astrocytes, Neurobiol. Dis., 136, 104742, 10.1016/j.nbd.2020.104742
Wolf, 2013, APOE and neuroenergetics: an emerging paradigm in Alzheimer’s disease, Neurobiol. Aging, 34, 1007, 10.1016/j.neurobiolaging.2012.10.011
Wolters, 2019, The impact of APOE genotype on survival: results of 38,537 participants from six population-based cohorts (E2-CHARGE), PLoS One, 14, e0219668, 10.1371/journal.pone.0219668
Wu, 2018, Human ApoE isoforms differentially modulate brain glucose and ketone body metabolism: implications for Alzheimer’s disease risk reduction and early intervention, J. Neurosci., 38, 6665, 10.1523/JNEUROSCI.2262-17.2018
Xu, 2016, Apolipoprotein E gene variants and risk of coronary heart disease: a meta-analysis, Biomed. Res. Int., 2016, 3912175, 10.1155/2016/3912175
Yassine, 2020, Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?, Neurobiol. Aging, 92, 61, 10.1016/j.neurobiolaging.2020.03.020
Yassine, , Association of docosahexaenoic acid supplementation With Alzheimer disease stage in apolipoprotein E epsilon4 carriers: a review, JAMA Neurol., 74, 339, 10.1001/jamaneurol.2016.4899
Yassine, , DHA brain uptake and APOE4 status: a PET study with [1–11 C]-DHA, Alzheimers Res. Ther., 9, 23, 10.1186/s13195-017-0250-1
Yassine, , Association of serum docosahexaenoic acid with cerebral amyloidosis, JAMA Neurol., 73, 1208, 10.1001/jamaneurol.2016.1924
Yassine, , The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease, Alzheimers Res. Ther., 8, 25, 10.1186/s13195-016-0194-x
Yu, 2017, APOE epsilon4-TOMM40 ’523 haplotypes and the risk of Alzheimer’s disease in older Caucasian and African Americans, PLoS One, 12, e0180356, 10.1371/journal.pone.0180356
Yue, 2004, Divergent effects of peroxisome proliferator-activated receptor γ agonists and tumor necrosis factor α on adipocyte ApoE expression, J. Biol. Chem., 279, 47626, 10.1074/jbc.M408461200
Zade, 2013, Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure, J. Stroke Cerebrovasc. Dis., 22, 119, 10.1016/j.jstrokecerebrovasdis.2011.06.020
Zhao, 2017, Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes, Neuron, 96, 115.e5, 10.1016/j.neuron.2017.09.003
Zhou, 2019, Non-coding variability at the APOE locus contributes to the Alzheimer’s risk, Nat. Commun., 10, 3310, 10.1038/s41467-019-10945-z