AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2

Journal of Ginseng Research - Tập 38 - Trang 16-21 - 2014
Min-Jung Kim1, Hee Yun1, Dong-Hyun Kim2, Insug Kang1, Wonchae Choe1, Sung-Soo Kim1, Joohun Ha1
1Department of Biochemistry and Molecular Biology, Medical Research Center and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
2Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea

Tài liệu tham khảo

Attele, 1999, Ginseng pharmacology: multiple constituents and multiple actions, Biochem Pharmacol, 58, 1685, 10.1016/S0006-2952(99)00212-9 Xie, 2005, Ginseng and diabetes, Am J Chin Med, 33, 397, 10.1142/S0192415X05003004 Hwang, 2007, Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte, Biochem Biophys Res Commun, 364, 1002, 10.1016/j.bbrc.2007.10.125 Cho, 2006, Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats, Eur J Pharmacol, 550, 173, 10.1016/j.ejphar.2006.08.056 Shang, 2008, Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes, J Endocrinol, 198, 561, 10.1677/JOE-08-0104 Song, 2003, Cytokine modulating effect of ginseng treatment in a mouse model of Pseudomonas aeruginosa lung infection, J Cyst Fibros, 2, 112, 10.1016/S1569-1993(03)00065-1 Lee, 2004, Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation, Int Immunopharmacol, 4, 235, 10.1016/j.intimp.2003.12.007 Han, 2005, Ginsan improved Th1 immune response inhibited by gamma radiation, Arch Pharm Res, 28, 343, 10.1007/BF02977803 Jia, 2004, Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy, Can J Physiol Pharmacol, 82, 431, 10.1139/y04-049 Choi, 2009, Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases, Pharm Res, 26, 2280, 10.1007/s11095-009-9944-9 Mochizuki, 1995, Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng, Biol Pharm Bull, 18, 1197, 10.1248/bpb.18.1197 Xu, 2007, Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer, Chin Med J (Engl), 120, 584, 10.1097/00029330-200704010-00011 Molnar, 2000, Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates, Anticancer Res, 20, 861 Fei, 2002, Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells, Acta Pharmacol Sin, 23, 315 Jin, 2000, Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells, J Biol Chem, 275, 30256, 10.1074/jbc.M001902200 Oh, 1999, Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells, Int J Oncol, 14, 869 Kim, 2004, Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells, Arch Pharm Res, 27, 429, 10.1007/BF02980085 Hardie, 2007, AMP-activated protein kinase as a drug target, Annu Rev Pharmacol Toxicol, 47, 185, 10.1146/annurev.pharmtox.47.120505.105304 Motoshima, 2006, AMPK and cell proliferation—AMPK as a therapeutic target for atherosclerosis and cancer, J Physiol, 574, 63, 10.1113/jphysiol.2006.108324 Luo, 2005, AMPK, the metabolic syndrome and cancer, Trends Pharmacol Sci, 26, 69, 10.1016/j.tips.2004.12.011 Kim, 2008, Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53, J Biol Chem, 283, 3731, 10.1074/jbc.M704432200 Kato, 2002, Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation, Oncogene, 21, 6082, 10.1038/sj.onc.1205737 Yang, 2009, Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice, Biol Pharm Bull, 32, 1710, 10.1248/bpb.32.1710 Oh, 2005, Caspase-3-dependent protein kinase C delta activity is required for the progression of ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells, Cancer Lett, 230, 228, 10.1016/j.canlet.2004.12.043 Cheng, 2005, Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells, Cancer Chemother Pharmacol, 55, 531, 10.1007/s00280-004-0919-6 Kim, 2004, Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and -3 and up-regulation of Bax in human neuroblastoma, Arch Pharm Res, 27, 834, 10.1007/BF02980175 Sandstrom, 2006, Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle, J Physiol, 575, 251, 10.1113/jphysiol.2006.110601 Choi, 2001, The regulation of AMP-activated protein kinase by H(2)O(2), Biochem Biophys Res Commun, 287, 92, 10.1006/bbrc.2001.5544 Ham, 2003, The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis, J Biol Chem, 278, 50330, 10.1074/jbc.M302997200 Yim, 2005, Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis, Cancer Res, 65, 1952, 10.1158/0008-5472.CAN-04-1740 Zhang, 2006, Ginsenoside Rg1 inhibits tumor necrosis factor-alpha (TNF-alpha)-induced human arterial smooth muscle cells (HASMCs) proliferation, J Cell Biochem, 98, 1471, 10.1002/jcb.20799 Jung, 2009, Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation, Exp Cell Res, 315, 2433, 10.1016/j.yexcr.2009.05.018 Fukushima, 2001, Inhibition by ginseng of colon carcinogenesis in rats, J Korean Med Sci, 16, S75, 10.3346/jkms.2001.16.S.S75 Helms, 2004, Cancer prevention and therapeutics: Panax ginseng, Altern Med Rev, 9, 259 Bae, 2002, Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities, Biol Pharm Bull, 25, 58, 10.1248/bpb.25.58 Park, 2012, Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced apoptosis in hepatoma cells through mitochondrial signaling pathways, Food Chem Toxicol, 50, 2736, 10.1016/j.fct.2012.05.027 Kim, 2011, Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans, Hepatology, 54, 1661, 10.1002/hep.24539 Wang, 2008, 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action, Br J Cancer, 98, 792, 10.1038/sj.bjc.6604227 Foller, 2009, Regulation of erythrocyte survival by AMP-activated protein kinase, FASEB J, 23, 1072, 10.1096/fj.08-121772 Hawley, 2003, Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade, J Biol, 2, 28 Hong, 2003, Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases, Proc Natl Acad Sci U S A, 100, 8839, 10.1073/pnas.1533136100 Inoki, 2003, TSC2 mediates cellular energy response to control cell growth and survival, Cell, 115, 577, 10.1016/S0092-8674(03)00929-2 Corradetti, 2004, Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz–Jeghers syndrome, Genes Dev, 18, 1533, 10.1101/gad.1199104 Liao, 2006, Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells, J Biomed Sci, 13, 613, 10.1007/s11373-006-9099-1 Jung, 2006, Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells, Int J Cancer, 118, 490, 10.1002/ijc.21356 Lemieux, 2003, The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle, FASEB J, 17, 1658, 10.1096/fj.02-1125com Lee, 2008, Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells, J Biol Chem, 283, 33969, 10.1074/jbc.M804469200 Berasi, 2006, Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase, J Biol Chem, 281, 27167, 10.1074/jbc.M602416200