ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles

Journal of Hepatology - Tập 71 Số 5 - Trang 1000-1011 - 2019
Wonhyo Seo1, Yanhang Gao2,1, Yong He1, Jing Sun2, Hongqin Xu2, Dechun Feng1, Seol Hee Park1, Young-Eun Cho3, Adrien Guillot1, Tianyi Ren1, Ruihong Wu2, Jin-Yun Wang2, Seung-Jin Kim1, Seonghwan Hwang1, Suthat Liangpunsakul4,5,6, Yingzi Yang7, Junqi Niu2, Bin Gao1
1Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA
2Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China
3Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
4Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA
5Division of Gastroenterology and Hepatology, Department of Medicine, USA
6Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA
7Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA

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