AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target

Pharmacological Research - Tập 194 - Trang 106819 - 2023
Huan Zhang1,2, Jiaqi Liang1, Tao Lu1, Ming Li1, Guangyao Shan1, Guoshu Bi1, Mengnan Zhao1, Xing Jin1, Qun Wang1, Zhengcong Chen1, Cheng Zhan1,3
1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
2Division of Thoracic Surgery, Sichuan Cancer Hospital & Research Institute, School of Medicine, University of Electronic Science and Technology of China (UESTC), Chengdu, People’s Republic of China
3Department of Thoracic Surgery, ShangHai Geriatric Medicine Center, Shanghai, People’s Republic of China

Tài liệu tham khảo

Siegel, 2023, Cancer statistics, 2023, CA Cancer J. Clin., 73, 17, 10.3322/caac.21763 Chen, 2023, Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050, JAMA Oncol., 10.1001/jamaoncol.2022.7826 Travis, 2013, New pathologic classification of lung cancer: relevance for clinical practice and clinical trials, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol., 31, 992, 10.1200/JCO.2012.46.9270 Siegel, 2021, Cancer statistics, 2021, CA Cancer J. Clin., 71, 7, 10.3322/caac.21654 Pun, 1997, Agrin-deficient myotube retains its acetylcholine receptor aggregation ability when challenged with agrin, J. Neurochem., 69, 2555, 10.1046/j.1471-4159.1997.69062555.x Chakraborty, 2015, An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma, Nat. Commun., 6, 6184, 10.1038/ncomms7184 Ruivo, 2022, Extracellular vesicles from pancreatic cancer stem cells lead an intratumor communication network (EVNet) to fuel tumor progression, Gut, 71, 2043, 10.1136/gutjnl-2021-324994 Rivera, 2018, Agrin has a pathological role in the progression of oral cancer, Br. J. Cancer, 118, 1628, 10.1038/s41416-018-0135-5 Zhang, 2022, ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma, Transl. Oncol., 26, 10.1016/j.tranon.2022.101562 Ritchie, 2015, limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res., 43, 10.1093/nar/gkv007 Subramanian, 2005, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl. Acad. Sci. USA, 102, 15545, 10.1073/pnas.0506580102 Chen, 2021, Landscape and dynamics of single tumor and immune cells in early and advanced-stage lung adenocarcinoma, Clin. Transl. Med., 11, 10.1002/ctm2.350 Lu, 2020, Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules, Cell Discov., 6, 69, 10.1038/s41421-020-00200-x Zhang, 2021, Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma, Thorac. Cancer, 12, 3011, 10.1111/1759-7714.14170 Bi, 2022, miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways, Mol. Ther. Nucleic Acids, 28, 366, 10.1016/j.omtn.2022.03.020 Niu, 2020, Knockdown of SMAD3 inhibits the growth and enhances the radiosensitivity of lung adenocarcinoma via p21 in vitro and in vivo, Int. J. Biol. Sci., 16, 1010, 10.7150/ijbs.40173 Bi, 2021, Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo, Cancer Cell Int., 21, 181, 10.1186/s12935-021-01878-z Huang, 2021, HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer, J. Exp. Clin. Cancer Res. CR, 40, 398, 10.1186/s13046-021-02188-y Marui, 2022, Context-dependent roles of Hes1 in the adult pancreas and pancreatic tumor formation, Gastroenterology, 163, 1613, 10.1053/j.gastro.2022.08.048 Li, 2021, HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer, Int. J. Biol. Sci., 17, 247, 10.7150/ijbs.53477 Sonoshita, 2011, Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling, Cancer Cell, 19, 125, 10.1016/j.ccr.2010.11.008 Dong, 2021, Gamma-secretase inhibitor (DAPT), a potential therapeutic target drug, caused neurotoxicity in planarian regeneration by inhibiting Notch signaling pathway, Sci. Total Environ., 781, 10.1016/j.scitotenv.2021.146735 Hans, 2020, DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways, Clin. Sci., 1555, 10.1042/CS20200456 Grottkau, 2009, DAPT enhances the apoptosis of human tongue carcinoma cells, Int. J. Oral Sci., 1, 81, 10.4248/ijos.08025 Xie, 2020, Comprehensive review of targeted therapy for colorectal cancer, Signal Transduct. Target. Ther., 5, 22, 10.1038/s41392-020-0116-z Thatcher, 2015, Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial, Lancet Oncol., 16, 763, 10.1016/S1470-2045(15)00021-2 Tian, 2020, Cancer cell-derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma, Cancer Res., 80, 1461, 10.1158/0008-5472.CAN-19-2578 Burgess, 2000, Agrin isoforms with distinct amino termini: differential expression, localization, and function, J. Cell Biol., 151, 41, 10.1083/jcb.151.1.41 Chakraborty, 2017, Agrin as a mechanotransduction signal regulating YAP through the hippo pathway, Cell Rep., 18, 2464, 10.1016/j.celrep.2017.02.041 Gros, 2022, Neuronal agrin promotes proliferation of primary human myoblasts in an age-dependent manner, Int. J. Mol. Sci., 23, 10.3390/ijms231911784 Zhang, 2019, Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice, eLife, 8, 10.7554/eLife.45303 Chaffer, 2011, A perspective on cancer cell metastasis, Science, 331, 1559, 10.1126/science.1203543 Kalluri, 2009, The basics of epithelial-mesenchymal transition, J. Clin. Investig., 119, 1420, 10.1172/JCI39104 Liu, 2022, Mechanism of IDH1-R132H mutation in T cell acute lymphoblastic leukemia mouse model via the Notch1 pathway, Tissue Cell, 74, 10.1016/j.tice.2021.101674 Li, 2021, FOXP3 facilitates the invasion and metastasis of non-small cell lung cancer cells through regulating VEGF, EMT and the Notch1/Hes1 pathway, Exp. Ther. Med., 22, 958, 10.3892/etm.2021.10390 Matsumori, 2020, Hes1 is essential in proliferating ductal cell-mediated development of intrahepatic cholangiocarcinoma, Cancer Res., 80, 5305, 10.1158/0008-5472.CAN-20-1161 Liu, 2015, Hes1: a key role in stemness, metastasis and multidrug resistance, Cancer Biol. Ther., 16, 353, 10.1080/15384047.2015.1016662 Wang, 2021, GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma, Life Sci., 276, 10.1016/j.lfs.2021.119439 Lv, 2015, RBPJ inhibition impairs the growth of lung cancer, Tumor Biol. J. Int. Soc. Oncodev. Biol. Med., 36, 3751, 10.1007/s13277-014-3015-5 Zhang, 2020, RBPJ contributes to the malignancy of glioblastoma and induction of proneural-mesenchymal transition via IL-6-STAT3 pathway, Cancer Sci., 111, 4166, 10.1111/cas.14642 Liang, 2022, Signatures of malignant cells and novel therapeutic targets revealed by single-cell sequencing in lung adenocarcinoma, Cancer Med., 11, 2244, 10.1002/cam4.4547 Tanaka, 2018, Proteoglycans are attractive biomarkers and therapeutic targets in hepatocellular carcinoma, Int. J. Mol. Sci., 19, 10.3390/ijms19103070