ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer

Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2013) GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide. IARC CancerBase 2012; No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer. Available from: http://globocan.iarc.fr. Accessed on 2019th Dec 2014 Pusztai L (2011) Anatomy and biology: two complementary sides of breast cancer prognostication. J Clin Oncol 29(33):4347–4348 Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, et al. (2011) Strategies for subtypes–dealing with the diversity of breast cancer: highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol 22(8):1736–1747 Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, et al. (2013) Personalizing the treatment of women with early breast cancer: highlights of the St gallen international expert consensus on the primary therapy of early breast cancer 2013. Ann Oncol 24(9):2206–2223 Zhang B, Beeghly-Fadiel A, Long J, Zheng W (2011) Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncol 12(5):477–488 Rafiq S, Khan S, Tapper W, Collins A, Upstill-Goddard R, et al. (2014) A genome wide meta-analysis study for identification of common variation associated with breast cancer prognosis. PLoS One 9(12):e101488 Sapkota Y (2014) Germline DNA variations in breast cancer predisposition and prognosis: a systematic review of the literature. Cytogenet Genome Res 144(2):77–91 Ribelles N, Santonja A, Pajares B, Llacer C, Alba E (2014) The seed and soil hypothesis revisited: current state of knowledge of inherited genes on prognosis in breast cancer. Cancer Treat Rev 40(2):293–299 Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, et al. (1987) Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science 238(4827):650–656 Hoffman BB, Taylor P (2001) Neurotransmission: the autonomic and somatic motor nervous systems. In: Hardman JG, Limbird LE, Gilman AG (eds) Goodman & Gilman’s the pharmacological basis of therapeutics. McGraw-Hill, New York, pp. 115–153 Lario S, Calls J, Cases A, Oriola J, Torras A, et al. (1997) MspI identifies a biallelic polymorphism in the promoter region of the alpha 2A-adrenergic receptor gene. Clin Genet 51(2):129–130 Lima JJ, Feng H, Duckworth L, Wang J, Sylvester JE, et al. (2007) Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations. Metabolism 56(6):757–765 Garenc C, Perusse L, Chagnon YC, Rankinen T, Gagnon J, et al. (2002) The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE family study. Mol Med 8(2):88–94 Kurnik D, Muszkat M, Li C, Sofowora GG, Friedman EA, et al. (2011) Genetic variations in the alpha(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine. Circ Cardiovasc Genet 4(2):179–187 Oppert JM, Tourville J, Chagnon M, Mauriege P, Dionne FT, et al. (1995) DNA polymorphisms in the alpha 2- and beta 2-adrenoceptor genes and regional fat distribution in humans: association and linkage studies. Obes Res 3(3):249–255 Ukkola O, Rankinen T, Weisnagel SJ, Sun G, Perusse L, et al. (2000) Interactions among the alpha2-, beta2-, and beta3-adrenergic receptor genes and obesity-related phenotypes in the Quebec family study. Metabolism 49(8):1063–1070 Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, et al. (2010) Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 327(5962):217–220 Bo S, Cassader M, Cavallo-Perin P, Durazzo M, Rosato R, et al. (2012) The rs553668 polymorphism of the ADRA2A gene predicts the worsening of fasting glucose values in a cohort of subjects without diabetes. A population-based study. Diabet Med 29(4):549–552 Talmud PJ, Cooper JA, Gaunt T, Holmes MV, Shah S, et al. (2011) Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia 54(7):1710–1719 Trentham-Dietz A, Newcomb PA, Storer BE, Longnecker MP, Baron J, et al. (1997) Body size and risk of breast cancer. Am J Epidemiol 145(11):1011–1019 van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, et al. (2000) Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 152(6):514–527 Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, et al. (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95(16):1218–1226 Sinicrope FA, Dannenberg AJ (2011) Obesity and breast cancer prognosis: weight of the evidence. J Clin Oncol 29(1):4–7 DeCensi A, Gennari A (2011) Insulin breast cancer connection: confirmatory data set the stage for better care. J Clin Oncol 29(1):7–10 Vazquez SM, Mladovan AG, Perez C, Bruzzone A, Baldi A, et al. (2006) Human breast cell lines exhibit functional alpha2-adrenoceptors. Cancer Chemother Pharmacol 58(1):50–61 Perez Pinero C, Bruzzone A, Sarappa MG, Castillo LF, Luthy IA (2012) Involvement of alpha2- and beta2-adrenoceptors on breast cancer cell proliferation and tumour growth regulation. Br J Pharmacol 166(2):721–736 Vazquez SM, Pignataro O, Luthy IA (1999) Alpha2-adrenergic effect on human breast cancer MCF-7 cells. Breast Cancer Res Treat 55(1):41–49 Chiesa IJ, Castillo LF, Luthy IA (2008) Contribution of alpha2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells. J Steroid Biochem Mol Biol 110(1–2):170–175 Bruzzone A, Pinero CP, Castillo LF, Sarappa MG, Rojas P, et al. (2008) Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol 155(4):494–504 Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, et al. (2000) Molecular portraits of human breast tumours. Nature 406(6797):747–752 Todd JH, Dowle C, Williams MR, Elston CW, Ellis IO, et al. (1987) Confirmation of a prognostic index in primary breast cancer. Br J Cancer 56(4):489–492 Sole X, Guino E, Valls J, Iniesta R, Moreno V (2006) SNPStats: a web tool for the analysis of association studies. Bioinformatics 22(15):1928–1929 Wirapati P, Sotiriou C, Kunkel S, Farmer P, Pradervand S, et al. (2008) Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 10(4):R65 El Saghir NS, Seoud M, Khalil MK, Charafeddine M, Salem ZK, et al. (2006) Effects of young age at presentation on survival in breast cancer. BMC Cancer 6:194 Bharat A, Aft RL, Gao F, Margenthaler JA (2009) Patient and tumor characteristics associated with increased mortality in young women (< or =40 years) with breast cancer. J Surg Oncol 100(3):248–251 Anders CK, Johnson R, Litton J, Phillips M, Bleyer A (2009) Breast cancer before age 40 years. Semin Oncol 36(3):237–249 Le Doussal V, Tubiana-Hulin M, Friedman S, Hacene K, Spyratos F, et al. (1989) Prognostic value of histologic grade nuclear components of scarff-bloom-Richardson (SBR). an improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer 64(9):1914–1921 Osborne CK, Yochmowitz MG, Knight 3rd WA, McGuire WL (1980) The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer 1980 46(12 Suppl):2884–2888 McGuire WL, Osborne CK, Clark GM, Knight 3rd WA (1982) Steroid hormone receptors and carcinoma of the breast. Am J Phys 243(2):E99–102 Clark GM, McGuire WL (1988) Steroid receptors and other prognostic factors in primary breast cancer. Semin Oncol 15(2 Suppl 1):20–25 Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, et al. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235(4785):177–182 Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98(19):10869–10874 Hugh J, Hanson J, Cheang MC, Nielsen TO, Perou CM, et al. (2009) Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J Clin Oncol 27(8):1168–1176 Boyle DP, McCourt CM, Matchett KB, Salto-Tellez M (2013) Molecular and clinicopathological markers of prognosis in breast cancer. Expert Rev Mol Diagn 13(5):481–498 Small KM, Brown KM, Seman CA, Theiss CT, Liggett SB (2006) Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proc Natl Acad Sci U S A 103(14):5472–5477 Lim E, Vaillant F, Wu D, Forrest NC, Pal B, et al. (2009) Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 15(8):907–913 Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, et al. (2008) Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14(5):518–527 Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, et al. (2003) Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A 100(18):10393–10398 Shkurnikov MY, Galatenko VV, Lebedev AE, Podol’skii VE, Tonevitskii EA, et al. (2014) On statistical relationship between ADRA2A expression and the risk of breast cancer relapse. Bull Exp Biol Med 157(4):454–458 Du Y, Zhou L, Wang Y, Yan T, Jiang Y, et al. (2014) Association of alpha2a and beta2 adrenoceptor expression with clinical outcome in breast cancer. Curr Med Res Opin 30(7):1337–1344 Lutgendorf SK, Sood AK, Antoni MH (2010) Host factors and cancer progression: biobehavioral signaling pathways and interventions. J Clin Oncol 28(26):4094–4099 Docherty JR (1998) Subtypes of functional alpha1- and alpha2-adrenoceptors. Eur J Pharmacol 361(1):1–15 Giessler C, Wangemann T, Silber RE, Dhein S, Brodde OE (2002) Noradrenaline-induced contraction of human saphenous vein and human internal mammary artery: involvement of different alpha-adrenoceptor subtypes. Naunyn Schmiedeberg's Arch Pharmacol 366(2):104–109 Bruckmaier RM, Wellnitz O, Blum JW (1997) Inhibition of milk ejection in cows by oxytocin receptor blockade, alpha-adrenergic receptor stimulation and in unfamiliar surroundings. J Dairy Res 64(3):315–325 Su F, Ouyang N, Zhu P, Jia W, Gong C, et al. (2005) Psychological stress induces chemoresistance in breast cancer by upregulating mdr1. Biochem Biophys Res Commun 329(3):888–897 Flint MS, Kim G, Hood BL, Bateman NW, Stewart NA, et al. (2009) Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway. Psychoneuroendocrinology 34(10):1533–1541