A validated inherent stability indicating HPTLC method for estimation of cyclobenzaprine hydrochloride in tablets and use of MS–QTOF in characterization of its alkaline stress degradation product

Nibbelink, 1978, Cyclobenzaprine, diazepam and placebo in the treatment of skeletal muscle spasm of local origin, Clin Ther, 1, 409 Browning, 2001, Cyclobenzaprine and back pain: a meta-analysis, Arch Intern Med, 161, 1613, 10.1001/archinte.161.13.1613 Toth, 2004, Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride and metaxalone, Clin Ther, 26, 1355, 10.1016/j.clinthera.2004.09.008 Chou, 2004, Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review, J Pain Symptom Manage, 28, 140, 10.1016/j.jpainsymman.2004.05.002 Share, 1975, Cyclobenzaprine: a novel centrally acting skeletal muscle relaxant, Neuropharmacology, 14, 675, 10.1016/0028-3908(75)90091-X Katz, 1988, Cyclobenzaprine in the treatment of acute muscle spasm: review of a decade of clinical experience, Clin Ther, 10, 216 Malanga, 2009, Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design, Curr Med Res Opin, 25, 1179, 10.1185/03007990902851753 Tiwari, 2015, LC, MSn and LC–MS/MS studies for the characterization of degradation products of amlodipine, J Pharm Anal, 5, 33, 10.1016/j.jpha.2014.07.005 Faber, 1974, A thin-layer chromatographic method for determining carbamazepine in blood, J Chromatogr A, 93, 238, 10.1016/S0021-9673(00)83037-X Constanzer, 1985, Determination of cyclobenzaprine in plasma and urine using capillary gas chromatography with nitrogen-selective detection, J Chromatogr, 339, 414, 10.1016/S0378-4347(00)84673-3 Hwang, 1993, Quantitative determination of cyclobenzaprine in human plasma by high pressure liquid chromatography, J Liq Chromatogr, 16, 1163, 10.1080/10826079308019578 Constanzer, 1995, Development and comparison of high-performance liquid chromatographic methods with tandem mass spectrometric and ultraviolet absorbance detection for the determination of cyclobenzaprine in human plasma and urine, J Chromatogr B, 666, 117, 10.1016/0378-4347(94)00556-K Xiang, 2012, Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study, Biomed Chromatogr, 26, 1083, 10.1002/bmc.1751 Darwish, 2008, Single-dose pharmacokinetics of once-daily cyclobenzaprine extended release 30 mg versus cyclobenzaprine immediate release 10 mg three times daily in healthy young adults: a randomized, open-label, two-period crossover, single-centre study, Clin Drug Investig, 28, 793, 10.2165/0044011-200828120-00007 Brioschi, 2013, Pharmacokinetics and bioequivalence evaluation of cyclobenzaprine tablets, Biomed Res Int, 21, 281 Lam, 2010, Scrutiny of variance results for outliers: Cochran’s test optimized, Anal Chim Acta, 659, 68, 10.1016/j.aca.2009.11.032 ICH, 2005, Validation of Analytical Procedures: Text and Methodology, Q2(R1)