A two-transcript biomarker of host classifier genes for discrimination of bacterial from viral infection in acute febrile illness: a multicentre discovery and validation study

The Lancet Digital Health - Tập 3 - Trang e507-e516 - 2021
Nannan Xu1, Fanchang Hao2, Xiaomeng Dong1, Yongyuan Yao3, Yanyan Guan4, Lulu Yang1, Fengzhe Chen1, Feng Zheng1, Qingyan Li5, Wenguo Liu6, Cui Zhao6, Wen Li1, Elizabeth Palavecino7, Wei Wang8, Gang Wang1
1Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
2School of Computer Science and Technology, Shandong Jianzhu University, Jinan, China
3Department of Intensive Care Medicine, Rizhao People's Hospital, Rizhao, China
4Department of Infectious Disease, Rizhao People’s Hospital, Rizhao, China
5Department of Infectious Disease, Liaocheng People's Hospital, Liaocheng, China
6Department of Infectious Disease, Gaotang People's Hospital, Liaocheng, China
7Department of Pathology, Wake Forest Baptist Health, Winston-Salem, NC, USA
8Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA

Tài liệu tham khảo

Kapasi, 2016, Host biomarkers for distinguishing bacterial from non-bacterial causes of acute febrile illness: a comprehensive review, PLoS One, 11, 10.1371/journal.pone.0160278 Crump, 2011, Management of adolescents and adults with febrile illness in resource limited areas, BMJ, 343, 10.1136/bmj.d4847 Jain, 2015, Community-acquired pneumonia requiring hospitalization among US adults, N Engl J Med, 373, 415, 10.1056/NEJMoa1500245 Yan, 2016, Metagenomic analysis of sputum microbiome as a tool toward culture-independent pathogen detection of patients with ventilator-associated pneumonia, Am J Respir Crit Care Med, 194, 636, 10.1164/rccm.201601-0034LE Rook, 2017, Evolution, human-microbe interactions, and life history plasticity, Lancet, 390, 521, 10.1016/S0140-6736(17)30566-4 Brink, 2016, Antimicrobial stewardship across 47 South African hospitals: an implementation study, Lancet Infect Dis, 16, 1017, 10.1016/S1473-3099(16)30012-3 Mahajan, 2016, Association of RNA biosignatures with bacterial infections in febrile infants aged 60 days or younger, JAMA, 316, 846, 10.1001/jama.2016.9207 Hu, 2013, Gene expression profiles in febrile children with defined viral and bacterial infection, Proc Natl Acad Sci USA, 110, 12792, 10.1073/pnas.1302968110 Sweeney, 2016, Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis, Lancet Respir Med, 4, 213, 10.1016/S2213-2600(16)00048-5 Mejias, 2013, Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection, PLoS Med, 10, 10.1371/journal.pmed.1001549 Gliddon, 2018, Genome-wide host RNA signatures of infectious diseases: discovery and clinical translation, Immunology, 153, 171, 10.1111/imm.12841 Herberg, 2016, Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children, JAMA, 316, 835, 10.1001/jama.2016.11236 Bhattacharya, 2017, Transcriptomic biomarkers to discriminate bacterial from nonbacterial infection in adults hospitalized with respiratory illness, Sci Rep, 7, 10.1038/s41598-017-06738-3 Chang, 2002, Training nu-support vector regression: theory and algorithms, Neural Comput, 14, 1959, 10.1162/089976602760128081 Youden, 1950, Index for rating diagnostic tests, Cancer, 3, 32, 10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3 Newcombe, 1998, Two-sided confidence intervals for the single proportion: comparison of seven methods, Stat Med, 17, 857, 10.1002/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E DeLong, 1988, Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach, Biometrics, 44, 837, 10.2307/2531595 van Houten, 2017, A host-protein based assay to differentiate between bacterial and viral infections in preschool children (OPPORTUNITY): a double-blind, multicentre, validation study, Lancet Infect Dis, 17, 431, 10.1016/S1473-3099(16)30519-9 Oved, 2015, A novel host-proteome signature for distinguishing between acute bacterial and viral infections, PLoS One, 10, 10.1371/journal.pone.0120012 Meng, 2015, EPSTI1 is involved in IL-28A-mediated inhibition of HCV infection, Mediators Inflamm, 2015, 10.1155/2015/716315 Baranger, 2008, The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function, FEBS J, 275, 2008, 10.1111/j.1742-4658.2008.06355.x Roghanian, 2006, The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity, Am J Respir Cell Mol Biol, 34, 634, 10.1165/rcmb.2005-0405OC Havers, 2018, Outpatient antibiotic prescribing for acute respiratory infections during influenza seasons, JAMA Netw Open, 1, 10.1001/jamanetworkopen.2018.0243 Mullard, 2016, Tackling antimicrobial drug resistance, Nat Rev Drug Discov, 15, 375 ten Oever, 2016, Utility of immune response-derived biomarkers in the differential diagnosis of inflammatory disorders, J Infect, 72, 1, 10.1016/j.jinf.2015.09.007 Tsalik, 2018, New molecular diagnostic approaches to bacterial infections and antibacterial resistance, Annu Rev Med, 69, 379, 10.1146/annurev-med-052716-030320 Cardoso, 2016, 70-gene signature as an aid to treatment decisions in early-stage breast cancer, N Engl J Med, 375, 717, 10.1056/NEJMoa1602253 Crespo-Leiro, 2015, Performance of gene-expression profiling test score variability to predict future clinical events in heart transplant recipients, BMC Cardiovasc Disord, 15, 120, 10.1186/s12872-015-0106-1 Liew, 2006, The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool, J Lab Clin Med, 147, 126, 10.1016/j.lab.2005.10.005 Holcomb, 2017, Host-based peripheral blood gene expression analysis for diagnosis of infectious diseases, J Clin Microbiol, 55, 360, 10.1128/JCM.01057-16