A twist in anti-inflammation: Annexin 1 acts via the lipoxin A4 receptor

F.N.E. Gavins1, P. Sawmynaden1, B.E. Chatterjee1, M. Perretti1
1Centre for Biochemical Pharmacology, William Harvey Research Institute, Bart's and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK

Tài liệu tham khảo

Gallin, 1992, Overview, 1 Panés, 1999, Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention, Br. J. Pharmacol., 126, 537, 10.1038/sj.bjp.0702328 Perretti, 1997, Endogenous mediators that inhibit the leukocyte-endothelium interaction, Trends Pharmacol. Sci., 18, 418 Mosser, 2003, The many faces of macrophage activation, J. Leukoc Biol., 73, 209, 10.1189/jlb.0602325 Liu, 1999, Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes, J. Immunol., 162, 3639 Gilroy, 2004, Inflammatory resolution: new opportunities for drug discovery, Nat. Rev. Drug Discov., 3, 401, 10.1038/nrd1383 Cronstein, 1995, Targets for antiinflammatory drugs, Ann. Rev. Pharmacol. Toxicol., 35, 449, 10.1146/annurev.pa.35.040195.002313 Gilroy, 1999, Inducible cyclooxygenase may have anti-inflammatory properties, Nat. Med., 5, 698, 10.1038/9550 Lawrence, 2001, Possible new role for NF-kappaB in the resolution of inflammation, Nat. Med., 7, 1291, 10.1038/nm1201-1291 Perretti, 2003, Annexin 1: an endogenous anti-inflammatory protein, News Physiol. Sci., 18, 60 Flower, 1988, Lipocortin and the mechanism of action of the glucocorticoids, Br. J. Pharmacol., 94, 987, 10.1111/j.1476-5381.1988.tb11614.x Perretti, 1998, Lipocortin 1 and chemokine modulation of granulocyte and monocyte accumulation in experimental inflammation, Gen. Pharmacol., 31, 545, 10.1016/S0306-3623(98)00039-1 Yang, 2003, Modulation of inflammation and response to dexamethasone by annexin-1 in antigen-induced arthritis, Arthritis Rheum. Hannon, 2003, Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse, FASEB J., 17, 253, 10.1096/fj.02-0239fje Minghetti, 1999, Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase by lipocortin 1, Br. J. Pharmacol., 126, 1307, 10.1038/sj.bjp.0702423 Croxtall, 1992, Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line, Proc. Natl. Acad. Sci. USA, 89, 3571, 10.1073/pnas.89.8.3571 De Caterina, 1993, Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids, J. Appl. Physiol., 75, 2368, 10.1152/jappl.1993.75.6.2368 Gerke, 2002, Annexins: from structure to function, Physiol. Rev., 82, 331, 10.1152/physrev.00030.2001 Francis, 1992, Human neutrophil annexin I promotes granule aggregation and modulates Ca2+− dependent membrane fusion, J. Clin. Invest., 90, 537, 10.1172/JCI115892 Goulding, 1990, Anti-inflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone, Lancet, 335, 1416, 10.1016/0140-6736(90)91445-G Ambrose, 1990, Corticosteroids increase lipocortin I in alveolar epithelial cells, Am. J. Respir. Cell Mol. Biol., 3, 349, 10.1165/ajrcmb/3.4.349 Christmas, 1991, Selective secretion of annexin I, a protein without a signal sequence, by the human prostate gland, J. Biol. Chem., 266, 2499, 10.1016/S0021-9258(18)52272-9 Perretti, 1996, Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration, Nat. Med., 22, 1259, 10.1038/nm1196-1259 Perretti, 2000, Annexin I is stored within gelatinase granules of human neutrophils and mobilised on the cell surface upon adhesion but not phagocytosis, Cell Biol. Int., 24, 163, 10.1006/cbir.1999.0468 Oliani, 2001, Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression, Am. J. Pathol., 158, 603, 10.1016/S0002-9440(10)64002-3 Mancuso, 1995, Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of endogenous lipocortin 1, J. Immunol., 155, 377 Perretti, 2002, Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor, Nat. Med., 8, 1296, 10.1038/nm786 Perretti, 1994, Lipocortin-derived peptides, Biochem. Pharmacol., 47, 931, 10.1016/0006-2952(94)90402-2 Le, 2002, Formyl-peptide receptors revisited, Trends Immunol., 23, 541, 10.1016/S1471-4906(02)02316-5 Walther, 2000, A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR, Mol. Cell, 5, 831, 10.1016/S1097-2765(00)80323-8 Ernst, 2004, An annexin 1 N-terminal Peptide activates leukocytes by triggering different members of the formyl Peptide receptor family, J. Immunol., 172, 7669, 10.4049/jimmunol.172.12.7669 Solito, 2003, A novel calcium-dependent pro-apoptotic effect of annexin 1 on human neutrophils, FASEB J., 17, 1544, 10.1096/fj.02-0941fje Maderna, 2005, Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac2-26, J. Immunol., 174, 3727, 10.4049/jimmunol.174.6.3727 Jozsef, 2002, Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes, Proc. Natl. Acad. Sci. USA, 99, 13266, 10.1073/pnas.202296999 Kenakin, 2002, Efficacy at g protein-coupled receptors, Nat. Rev. (Drug Discovery), 1, 103, 10.1038/nrd722 Migeotte, 2005, Identification and characterization of an endogenous chemotactic ligand specific for FPRL2, J. Exp. Med., 201, 83, 10.1084/jem.20041277 Fierro, 2003, Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells, J. Immunol., 170, 2688, 10.4049/jimmunol.170.5.2688 Srikrishna, 2001, Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells, J. Immunol., 166, 4678, 10.4049/jimmunol.166.7.4678 Lim, 1998, Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1, Proc. Natl. Acad. Sci. USA, 95, 14535, 10.1073/pnas.95.24.14535 Gavins, 2003, Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms, Blood, 101, 4140, 10.1182/blood-2002-11-3411 Cuzzocrea, 1997, Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration, J. Immunol., 159, 5089 D’Amico, 2000, Lipocortin 1 reduces myocardial ischaemia-reperfusion injury by affecting local leukocyte recruitment, FASEB J., 14, 1867, 10.1096/fj.99-0602fje La, 2001, Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action, FASEB J., 15, 2247, 10.1096/fj.01-0196com Gavins, 2005, Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct, FASEB J., 19, 100, 10.1096/fj.04-2178fje Chiang, 1999, Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion, J. Clin. Invest., 104, 309, 10.1172/JCI7016 Gao, 1998, Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse, Genomics, 51, 270, 10.1006/geno.1998.5376 Takano, 1997, Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors, J. Exp. Med., 185, 1693, 10.1084/jem.185.9.1693 Liang, 2000, Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils, Biochem. Biophys. Res. Commun., 270, 331, 10.1006/bbrc.2000.2416 Vaughn, 2002, Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene, J. Immunol., 169, 3363, 10.4049/jimmunol.169.6.3363 Gao, 1999, Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor, J. Exp. Med., 189, 657, 10.1084/jem.189.4.657 Le, 1999, Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation, J. Immunol., 163, 6777 Prossnitz, 1997, The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function, Pharmacol. Ther., 74, 73, 10.1016/S0163-7258(96)00203-3 Perretti, 2001, Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics, Am. J. Pathol., 158, 1969, 10.1016/S0002-9440(10)64667-6 Epstein, 1989, Tissue destruction by neutrophils, N. Engl. J. Med., 320, 365, 10.1056/NEJM198902093200606 Carden, 2000, Pathophysiology of ischaemia-reperfusion injury, J. Pathol., 190, 255, 10.1002/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6 Lefer, 2002, Do neutrophils contribute to myocardial reperfusion injury?, Basic Res. Cardiol., 97, 263, 10.1007/s00395-002-0363-x Baxter, 2002, The neutrophil as a mediator of myocardial ischemia-reperfusion injury: time to move on, Basic Res. Cardiol., 97, 268, 10.1007/s00395-002-0366-7 Ley, 1995, Gene-targeted mice in leukocyte adhesion research, Microcirculation, 2, 141, 10.3109/10739689509146762 Chiang, 2000, Activation of lipoxin A4 receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation, J. Exp. Med., 191, 1197, 10.1084/jem.191.7.1197 Rabb, 1997, Leukocytes, cell adhesion molecules and ischemic acute renale failure, Kidney Int., 51, 1463, 10.1038/ki.1997.200 Kieran, 2003, Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog, Kidney Int., 64, 480, 10.1046/j.1523-1755.2003.00106.x Ritchie, 2003, Cardioprotective actions of an N-terminal fragment of annexin-1 in rat myocardium in vitro, Eur. J. Pharmacol., 461, 171, 10.1016/S0014-2999(03)01314-1 Becker, 1998, Broad immunocytochemical localization of the formylpeptide receptor in human organs, tissues, and cells, Cell Tissue Res., 292, 129, 10.1007/s004410051042 Su, 1999, A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells, J. Exp. Med., 189, 395, 10.1084/jem.189.2.395 Le, 2001, Amyloid {beta}42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1, J. Neurosci., 21, RC123, 10.1523/JNEUROSCI.21-02-j0003.2001 Resnati, 2002, The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R, Proc. Natl. Acad. Sci. USA, 99, 1359, 10.1073/pnas.022652999 Harada, 2004, N-Formylated humanin activates both formyl peptide receptor-like 1 and 2, Biochem. Biophys. Res. Commun., 324, 255, 10.1016/j.bbrc.2004.09.046 Wang, 2002, Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice, Gene, 299, 57, 10.1016/S0378-1119(02)01012-0 John, 2001, Does annexin 1 act via the FPR receptor?, J. Endocrinol., 169, P150 Rosengarth, 2001, X-ray structure of full-length annexin 1 and implications for membrane aggregation, J. Mol. Biol., 306, 489, 10.1006/jmbi.2000.4423 Rosengarth, 2003, A calcium-driven conformational switch of the N-terminal and core domains of annexin A1, J. Mol. Biol., 326, 1317, 10.1016/S0022-2836(03)00027-5