A tale of many tumors and one endocrine site: A case series of pituitary metastases
Tóm tắt
Background: Metastases to the pituitary gland are extremely rare with an incidence rate reported from an autopsy series of 1.8%–12%, and only 20% was diagnosed clinically. Tumors that commonly metastasize are breast and lung tumors.
Case series: We present a series of five cases, including four female patients and one male patient with metastatic cancer. Two women had metastatic small lung cancer and presented with diabetes insipidus (DI). Two women had metastatic breast cancer, of which one presented with DI and the other with panhypopituitarism. The male patient had bronchogenic adenocarcinoma and presented with DI.
Conclusion: Our case series confirmed earlier reports that DI is the most common presentation of metastases to the pituitary gland.
Từ khóa
Tài liệu tham khảo
Intracranial metastatic disease rarely involves the pituitary: Retrospective analysis of 935 metastases in 155 patients and review of the literature, Pituitary, Volume 13:, 260–265
Clinical aspects of hypophyseal metastases, Onkologie, Volume 11, 66–69 1988
Pituitary metastasis: Incidence in cancer patients and clinical differentiation from pituitary adenoma, Neurology, Volume 31, 998–1002 1981
Metastatic tumors of the sella turcica masquerading as primary pituitary tumors, J Clin Endocrinol Metab, Volume 65, 469–474 1987
Hepatocellular carcinoma metastasis in the pituitary gland: Case report and review of the literature, J Neurooncol, Volume 63, 173–177
Follicular thyroid carcinoma with metastases to the pituitary causing pituitary insufficiency, Thyroid, Volume 21, 921–925
Symptomatic pituitary metastases from renal cell carcinoma, Pituitary, Volume 10, 251–259 2007
Clinical and biochemical characteristic features of metastatic cancer to the sella turcica: An analytical review, Pituitary, Volume 17, 575–587 2014
Metastases in carcinoma. Analysis of 1000 autopsied cases, Cancer, Volume 3, 74–85 1950
Metastatic cancer of the pituitary gland, Oncology, Volume 27, 533–542 1973
Metastatic lesions in the sella turcica and pituitary gland, Cancer, Volume 25, 478–480 1970
Diagnosis, treatment, and outcome of pituitary tumors and other abnormal intrasellar masses. Retrospective analysis of 353 patients, Medicine (Baltimore), Volume 78, 236–269 1999
Clinicopathologic review of 88 cases of carcinoma metastatic to the pituitary gland, Cancer, Volume 36, 216–220 1975
Symptomatic pituitary metastases, J Neurosurg, Volume 89, 69–73 1998
Endocrine organ metastases from breast carcinoma, Am J Pathol, Volume 114, 131–136 1984
Clinical features of tumor metastasis to the pituitary, Cancer, Volume 26, 656–659 1970
[Diabetes insipidus caused by metastasis to the hypothalamo-hypophyseal axis. Apropos of 4 cases], J Neuroradiol, Volume 22, 43–47 1995
Pituitary gland metastases, Ann Surg Oncol, Volume 3, 94–99 1996
Diabetes insipidus due to pituitary metastasis in a woman with lung adenocarcinoma: A case report, Cent Eur J Med, Volume 6, 475–479
Tumors metastatic to the pituitary gland: Case report and literature review, J Clin Endocrinol Metab, Volume 89, 574–580 2004
Metastasis within a pituitary adenoma presenting with bilateral abducens palsies: Case report and review of the literature, Neurosurgery, Volume 21, 383–386 1987