A systematic review of predictive modeling for bronchiolitis

International Journal of Medical Informatics - Tập 83 - Trang 691-714 - 2014
Gang Luo1, Flory L. Nkoy2, Per H. Gesteland2, Tiffany S. Glasgow2, Bryan L. Stone2
1Department of Biomedical Informatics, University of Utah, Suite 140, 421 Wakara Way, Salt Lake City, UT, 84108, USA
2Department of Pediatrics, University of Utah, 100 N Mario Capecchi Drive, Salt Lake City, UT 84113, USA

Tài liệu tham khảo

Mansbach, 2005, Bronchiolitis in US emergency departments 1992 to 2000: epidemiology and practice variation, Pediatr. Emerg. Care, 21, 242, 10.1097/01.pec.0000161469.19841.86 Parker, 2009, Predictors of major intervention in infants with bronchiolitis, Pediatr. Pulmonol., 44, 358, 10.1002/ppul.21010 Shay, 1999, Bronchiolitis-associated hospitalizations among US children, 1980–1996, JAMA, 282, 1440, 10.1001/jama.282.15.1440 Ducharme, 2011, Management of acute bronchiolitis, BMJ, 342, d1658, 10.1136/bmj.d1658 Zorc, 2010, Bronchiolitis: recent evidence on diagnosis and management, Pediatrics, 125, 342, 10.1542/peds.2009-2092 Pelletier, 2006, Direct medical costs of bronchiolitis hospitalizations in the United States, Pediatrics, 118, 2418, 10.1542/peds.2006-1193 Carroll, 2008, Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan, Pediatrics, 122, 58, 10.1542/peds.2007-2087 Seiden, 2009, Bronchiolitis: an evidence-based approach to management, Clin. Pediatr. Emerg. Med., 10, 75, 10.1016/j.cpem.2009.03.006 American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis, 2006, Diagnosis and management of bronchiolitis, Pediatrics, 118, 1774, 10.1542/peds.2006-2223 Brand, 2000, Differences in management of bronchiolitis between hospitals in the Netherlands, Eur. J. Pediatr., 159, 343, 10.1007/s004310051284 Behrendt, 1998, International variation in the management of infants hospitalized with respiratory syncytial virus, Eur. J. Pediatr., 157, 215, 10.1007/s004310050798 Chamberlain, 2006, Association of emergency department care factors with admission and discharge decisions for pediatric patients, J. Pediatr., 149, 644, 10.1016/j.jpeds.2006.05.047 Johnson, 2002, Differences in admission rates of children with bronchiolitis by pediatric and general emergency departments, Pediatrics, 110, e49, 10.1542/peds.110.4.e49 Mallory, 2003, Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit, Pediatrics, 111, e45, 10.1542/peds.111.1.e45 Plint, 2004, Practice variation among pediatric emergency departments in the treatment of bronchiolitis, Acad. Emerg. Med., 11, 353, 10.1197/j.aem.2003.12.003 Vogel, 2003, Variations in bronchiolitis management between five New Zealand hospitals: can we do better?, J. Paediatr. Child Health, 39, 40, 10.1046/j.1440-1754.2003.00069.x Willson, 2001, Effect of practice variation on resource utilization in infants hospitalized for viral lower respiratory illness, Pediatrics, 108, 851, 10.1542/peds.108.4.851 Willson, 1996, Invasive monitoring in infants with respiratory syncytial virus infection, J. Pediatr., 128, 357, 10.1016/S0022-3476(96)70281-0 Wang, 1996, Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of admission and management variation in patients hospitalized with respiratory syncytial viral lower respiratory tract infection, J. Pediatr., 129, 390, 10.1016/S0022-3476(96)70071-9 Christakis, 2005, Variation in inpatient diagnostic testing and management of bronchiolitis, Pediatrics, 115, 878, 10.1542/peds.2004-1299 Mansbach, 2008, Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department, Pediatrics, 121, 680, 10.1542/peds.2007-1418 McBride, 2005, Preventable adverse events in infants hospitalized with bronchiolitis, Pediatrics, 116, 603, 10.1542/peds.2004-2387 Kotagal, 2002, Impact of a bronchiolitis guideline: a multisite demonstration project, Chest, 121, 1789, 10.1378/chest.121.6.1789 Walsh, 2004, A validated clinical model to predict the need for admission and length of stay in children with acute bronchiolitis, Eur. J. Emerg. Med., 11, 265, 10.1097/00063110-200410000-00005 Perlstein, 1999, Evaluation of an evidence-based guideline for bronchiolitis, Pediatrics, 104, 1334, 10.1542/peds.104.6.1334 Perlstein, 2000, Sustaining the implementation of an evidence-based guideline for bronchiolitis, Arch. Pediatr. Adolesc. Med., 154, 1001, 10.1001/archpedi.154.10.1001 Mittal, 2014, Inpatient bronchiolitis guideline implementation and resource utilization, Pediatrics, 133, e730, 10.1542/peds.2013-2881 Akenroye, 2014, Impact of a bronchiolitis guideline on ED resource use and cost: a segmented time-series analysis, Pediatrics, 133, e227, 10.1542/peds.2013-1991 Damore, 2008, Prospective multicenter bronchiolitis study: predicting intensive care unit admissions, Acad. Emerg. Med., 15, 887, 10.1111/j.1553-2712.2008.00245.x Houben, 2011, Clinical prediction rule for RSV bronchiolitis in healthy newborns: prognostic birth cohort study, Pediatrics, 127, 35, 10.1542/peds.2010-0581 Marlais, 2011, Clinical predictors of admission in infants with acute bronchiolitis, Arch. Dis. Child., 96, 648, 10.1136/adc.2010.201079 Norwood, 2010, Prospective multicenter study of bronchiolitis: predictors of an unscheduled visit after discharge from the emergency department, Acad. Emerg. Med., 17, 376, 10.1111/j.1553-2712.2010.00699.x Rietveld, 2006, Hospitalization for respiratory syncytial virus infection in young children: development of a clinical prediction rule, Pediatr. Infect. Dis. J., 25, 201, 10.1097/01.inf.0000202135.24485.f8 Shaw, 1991, Outpatient assessment of infants with bronchiolitis, Am. J. Dis. Child., 145, 151 Voets, 2006, Clinical predictors of the severity of bronchiolitis, Eur. J. Emerg. Med., 13, 134, 10.1097/01.mej.0000206194.85072.33 Walsh, 2004, An artificial neural network ensemble to predict disposition and length of stay in children presenting with bronchiolitis, Eur. J. Emerg. Med., 11, 259, 10.1097/00063110-200410000-00004 Weisgerber, 2011, Factors predicting prolonged hospital stay for infants with bronchiolitis, J. Hosp. Med., 6, 264, 10.1002/jhm.903 Steyerberg, 2009 Kuhn, 2013 Prodhan, 2011, Predictors of respiratory failure among previously healthy children with respiratory syncytial virus infection, Am. J. Emerg. Med., 29, 168, 10.1016/j.ajem.2009.08.020 Destino, 2012, Validity of respiratory scores in bronchiolitis, Hosp. Pediatr., 2, 202, 10.1542/hpeds.2012-0013 Laham, 2010, LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity, Pediatrics, 125, e225, 10.1542/peds.2009-0411 Corneli, 2012, Bronchiolitis: clinical characteristics associated with hospitalization and length of stay, Pediatr. Emerg. Care, 28, 99, 10.1097/PEC.0b013e3182440b9b Al-Shehri, 2005, Bronchiolitis in Abha, Southwest Saudi Arabia: viral etiology and predictors for hospital admission, West Afr. J. Med., 24, 299 Mansbach, 2012, Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study, Pediatr. Infect. Dis. J., 31, 767, 10.1097/INF.0b013e3182565eae Wang, 2012, Altitude and environmental climate effects on bronchiolitis severity among children presenting to the emergency department, J. Environ. Health, 75, 8 Nascimento, 2010, High rate of viral identification and coinfections in infants with acute bronchiolitis, Clinics (Sao Paulo), 65, 1133, 10.1590/S1807-59322010001100014 Marcone, 2013, Viral etiology of acute respiratory infections in hospitalized and outpatient children in Buenos Aires, Argentina, Pediatr. Infect. Dis. J., 32, e105, 10.1097/INF.0b013e31827cd06f Somech, 2006, Epidemiologic, socioeconomic, and clinical factors associated with severity of respiratory syncytial virus infection in previously healthy infants, Clin. Pediatr. (Phila), 45, 621, 10.1177/0009922806291012 Wang, 1992, Observer agreement for respiratory signs and oximetry in infants hospitalized with lower respiratory infections, Am. Rev. Respir. Dis., 145, 106, 10.1164/ajrccm/145.1.106 Wiler, 2011, National study of emergency department observation services, Acad. Emerg. Med., 18, 959, 10.1111/j.1553-2712.2011.01151.x Alpern, 2008, Utilization and unexpected hospitalization rates of a pediatric emergency department 23-hour observation unit, Pediatr. Emerg. Care, 24, 589, 10.1097/PEC.0b013e3181850c80 Sandweiss, 2010, Barriers to discharge from a 24-hour observation unit for children with bronchiolitis, Pediatr. Emerg. Care, 26, 892, 10.1097/PEC.0b013e3181fe911d Yusuf, 2012, Risk factors for admission in children with bronchiolitis from pediatric emergency department observation unit, Pediatr. Emerg. Care, 28, 1132, 10.1097/PEC.0b013e31827132ff Brooks, 1999, Predicting deterioration in previously healthy infants hospitalized with respiratory syncytial virus infection, Pediatrics, 104, 463, 10.1542/peds.104.3.463 Mandelberg, 2006, Lipopolysaccharide hyporesponsiveness as a risk factor for intensive care unit hospitalization in infants with respiratory syncitial virus bronchiolitis, Clin. Exp. Immunol., 144, 48, 10.1111/j.1365-2249.2006.03030.x García, 2010, Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis, Pediatrics, 126, e1453, 10.1542/peds.2010-0507 Hervás, 2012, Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis, Eur. J. Clin. Microbiol. Infect. Dis., 31, 1975, 10.1007/s10096-011-1529-y Richard, 2008, The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis, Pediatr. Infect. Dis. J., 27, 213, 10.1097/INF.0b013e31815b4935 Verger, 2012, Respiratory syncytial virus bronchiolitis in children, Crit. Care Nurs. Clin. North Am., 24, 555, 10.1016/j.ccell.2012.07.008 Langley, 2011, Epidemiology and prevention of respiratory syncytial virus infections among infants and young children, Pediatr. Infect. Dis. J., 30, 510, 10.1097/INF.0b013e3182184ae7 Aujard, 2002, Risk factors for severe respiratory syncytial virus infection in infants, Respir. Med., 96, S9, 10.1053/rmed.2002.1295 El Saleeby, 2010, Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population, J. Pediatr., 156, 409, 10.1016/j.jpeds.2009.09.043 Purcell, 2004, Driscoll Children's Hospital respiratory syncytial virus database: risk factors, treatment and hospital course in 3308 infants and young children, 1991 to 2002, Pediatr. Infect. Dis. J., 23, 418, 10.1097/01.inf.0000126273.27123.33 Chi, 2011, Epidemiological study of hospitalization associated with respiratory syncytial virus infection in Taiwanese children between 2004 and 2007, J. Formos. Med. Assoc., 110, 388, 10.1016/S0929-6646(11)60057-0 Dotan, 2013, Hospitalization for respiratory syncytial virus bronchiolitis and disease severity in twins, Isr. Med. Assoc. J., 15, 701 El Kholy, 2013, Morbidity and outcome of severe respiratory syncytial virus infection, Pediatr. Int., 55, 283, 10.1111/ped.12051 Hon, 2012, Respiratory syncytial virus morbidity, premorbid factors, seasonality, and implications for prophylaxis, J. Crit. Care, 27, 464, 10.1016/j.jcrc.2011.12.001 Mansbach, 2012, Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation, Pediatrics, 130, e492, 10.1542/peds.2012-0444 Al-Shawwa, 2007, Clinical and therapeutic variables influencing hospitalisation for bronchiolitis in a community-based paediatric group practice, Prim. Care Respir. J., 16, 93, 10.3132/pcrj.2007.00018 Schroeder, 2013, Apnea in children hospitalized with bronchiolitis, Pediatrics, 132, e1194, 10.1542/peds.2013-1501 Ralston, 2009, Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis: a systematic review, J. Pediatr., 155, 728, 10.1016/j.jpeds.2009.04.063 Kneyber, 1998, Risk factors for respiratory syncytial virus associated apnoea, Eur. J. Pediatr., 157, 331, 10.1007/s004310050822 Schiller, 2011, Central apnoeas in infants with bronchiolitis admitted to the paediatric intensive care unit, Acta Paediatr., 100, 216, 10.1111/j.1651-2227.2010.02004.x Willwerth, 2006, Identifying hospitalized infants who have bronchiolitis and are at high risk for apnea, Ann. Emerg. Med., 48, 441, 10.1016/j.annemergmed.2006.03.021 Evans, 2012, Clinical predictors of nasal continuous positive airway pressure requirement in acute bronchiolitis, Pediatr. Pulmonol., 47, 381, 10.1002/ppul.21549 Milési, 2013, 6 cmH2O continuous positive airway pressure versus conventional oxygen therapy in severe viral bronchiolitis: a randomized trial, Pediatr. Pulmonol., 48, 45, 10.1002/ppul.22533 Mayordomo-Colunga, 2009, Predictive factors of non invasive ventilation failure in critically ill children: a prospective epidemiological study, Intensive Care Med., 35, 527, 10.1007/s00134-008-1346-7 Najaf-Zadeh, 2011, Noninvasive positive pressure ventilation for acute respiratory failure in children: a concise review, Ann. Intensive Care, 1, 15, 10.1186/2110-5820-1-15 Abboud, 2012, Predictors of failure in infants with viral bronchiolitis treated with high-flow, high-humidity nasal cannula therapy, Pediatr. Crit. Care Med., 13, e343, 10.1097/PCC.0b013e31825b546f Javouhey, 2008, Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis, Intensive Care Med., 34, 1608, 10.1007/s00134-008-1150-4 Bernet, 2005, Predictive factors for the success of noninvasive mask ventilation in infants and children with acute respiratory failure, Pediatr. Crit. Care Med., 6, 660, 10.1097/01.PCC.0000170612.16938.F6 Kelly, 2013, High-flow nasal cannula use in children with respiratory distress in the emergency department: predicting the need for subsequent intubation, Pediatr. Emerg. Care, 29, 888, 10.1097/PEC.0b013e31829e7f2f Cavari, 2012, Non invasive positive pressure ventilation in infants with respiratory failure, Pediatr. Pulmonol., 47, 1019, 10.1002/ppul.22561 Ganu, 2012, Increase in use of non-invasive ventilation for infants with severe bronchiolitis is associated with decline in intubation rates over a decade, Intensive Care Med., 38, 1177, 10.1007/s00134-012-2566-4 Semple, 2011, Household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation: prospective cohort study, PLoS One, 6, e22425, 10.1371/journal.pone.0022425 Mai, 1995, Use of simple clinical parameters to assess severity of bronchiolitis, J. Paediatr. Child Health, 31, 465, 10.1111/j.1440-1754.1995.tb00859.x McCallum, 2013, Severity scoring systems: are they internally valid, reliable and predictive of oxygen use in children with acute bronchiolitis?, Pediatr. Pulmonol., 48, 797, 10.1002/ppul.22627 Bont, 2002, Immunological mechanisms of severe respiratory syncytial virus bronchiolitis, Intensive Care Med., 28, 616, 10.1007/s00134-002-1256-z Lebel, 1989, Respiratory failure and mechanical ventilation in severe bronchiolitis, Arch. Dis. Child., 64, 1431, 10.1136/adc.64.10.1431 Chan, 2000, Severe bronchiolitis in Malaysian children, J. Trop. Pediatr., 46, 234, 10.1093/tropej/46.4.234 DeVincenzo, 2005, Respiratory syncytial virus load predicts disease severity in previously healthy infants, J. Infect. Dis., 191, 1861, 10.1086/430008 Brand, 2013, CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection, Pediatr. Res., 73, 187, 10.1038/pr.2012.163 Bont, 2001, Local interferon-γ levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity, J. Infect. Dis., 184, 355, 10.1086/322035 Moynihan, 2003, Cardiac troponin I as a predictor of respiratory failure in children hospitalized with respiratory syncytial virus (RSV) infections: a pilot study, Am. J. Emerg. Med., 21, 479, 10.1016/S0735-6757(03)00163-3 Zachariah, 2011, Hospitalizations due to respiratory syncytial virus in children with congenital malformations, Pediatr. Infect. Dis. J., 30, 442, 10.1097/INF.0b013e318201813b van Beek, 2013, Increased risk of RSV infection in children with Down's syndrome: clinical implementation of prophylaxis in the European Union, Clin. Dev. Immunol., 2013, 801581, 10.1155/2013/801581 Prodhan, 2009, Chest radiological patterns predict the duration of mechanical ventilation in children with RSV infection, Pediatr. Radiol., 39, 117, 10.1007/s00247-008-1042-3 Flamant, 2005, Severe respiratory syncytial virus bronchiolitis in children: from short mechanical ventilation to extracorporeal membrane oxygenation, Eur. J. Pediatr., 164, 93, 10.1007/s00431-004-1580-0 Hsu, 2012, Design of a clinical decision support system for determining ventilator weaning using support sector machine, Int. J. Innovative Comput. Inform. Control, 8, 933 Stambouly, 1996, Complications of care in a pediatric intensive care unit: a prospective study, Intensive Care Med., 22, 1098, 10.1007/BF01699236 Thompson, 1992, Nosocomial bacterial infections in very low birth weight infants, Eur. J. Pediatr., 151, 451, 10.1007/BF01959362 Epstein, 1997, Effect of failed extubation on the outcome of mechanical ventilation, Chest, 112, 186, 10.1378/chest.112.1.186 Khan, 1996, Predictors of extubation success and failure in mechanically ventilated infants and children, Crit. Care Med., 24, 1568, 10.1097/00003246-199609000-00023 Kurachek, 2003, Extubation failure in pediatric intensive care: a multiple-center study of risk factors and outcomes, Crit. Care Med., 31, 2657, 10.1097/01.CCM.0000094228.90557.85 Randolph, 2002, Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial, JAMA, 288, 2561, 10.1001/jama.288.20.2561 Johnston, 2010, Risk factors for extubation failure in infants with severe acute bronchiolitis, Respir. Care, 55, 328 Manczur, 2000, Comparison of predictors of extubation from mechanical ventilation in children, Pediatr. Crit. Care Med., 1, 28, 10.1097/00130478-200007000-00005 Mueller, 2013, Can machine learning methods predict extubation outcome in premature infants as well as clinicians?, J. Neonatal Biol., 2, 118 Hsu, 2013, Clinical verification of a clinical decision support system for ventilator weaning, Biomed. Eng. Online, 12, S4, 10.1186/1475-925X-12-S1-S4 Purcell, 2007, Lack of usefulness of an abnormal white blood cell count for predicting a concurrent serious bacterial infection in infants and young children hospitalized with respiratory syncytial virus lower respiratory tract infection, Pediatr. Infect. Dis. J., 26, 311, 10.1097/01.inf.0000258627.23337.00 Antonow, 1998, Sepsis evaluations in hospitalized infants with bronchiolitis, Pediatr. Infect. Dis. J., 17, 231, 10.1097/00006454-199803000-00011 Bilavsky, 2008, A prospective study of the risk for serious bacterial infections in hospitalized febrile infants with or without bronchiolitis, Pediatr. Infect. Dis. J., 27, 269, 10.1097/INF.0b013e31815e85b1 Purcell, 2002, Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections, Arch. Pediatr. Adolesc. Med., 156, 322, 10.1001/archpedi.156.4.322 Bloomfield, 2004, Bacteraemia and antibiotic use in respiratory syncytial virus infections, Arch. Dis. Child., 89, 363, 10.1136/adc.2003.035105 Kneyber, 2001, Predictors of a normal chest X-ray in respiratory syncytial virus infection, Pediatr. Pulmonol., 31, 277, 10.1002/ppul.1039 Schuh, 2007, Evaluation of the utility of radiography in acute bronchiolitis, J. Pediatr., 150, 429, 10.1016/j.jpeds.2007.01.005 Meystre, 2008, Extracting information from textual documents in the electronic health record: a review of recent research, Yearb. Med. Inform., 128 Dublin, 2013, Natural language processing to identify pneumonia from radiology reports, Pharmacoepidemiol. Drug Saf., 22, 834, 10.1002/pds.3418 Durani, 2008, Clinical predictors of respiratory syncytial virus infection in children, Pediatr. Int., 50, 352, 10.1111/j.1442-200X.2008.02589.x Jhawar, 2003, Severe bronchiolitis in children, Clin. Rev. Allergy Immunol., 25, 249, 10.1385/CRIAI:25:3:249 Isaacs, 1991, Handwashing and cohorting in prevention of hospital acquired infections with respiratory syncytial virus, Arch. Dis. Child., 66, 227, 10.1136/adc.66.2.227 Levine, 2004, Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections, Pediatrics, 113, 1728, 10.1542/peds.113.6.1728 Titus, 2003, Prevalence of serious bacterial infections in febrile infants with respiratory syncytial virus infection, Pediatrics, 112, 282, 10.1542/peds.112.2.282 Randolph, 2004, Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit, Pediatr. Infect. Dis. J., 23, 990, 10.1097/01.inf.0000143647.88873.66 Riccetto, 2006, Respiratory syncytial virus (RSV) in infants hospitalized for acute lower respiratory tract disease: incidence and associated risks, Braz. J. Infect. Dis., 10, 357, 10.1590/S1413-86702006000500011 Moler, 1999, Severity of illness models for respiratory syncytial virus-associated hospitalization, Am. J. Respir. Crit. Care Med., 159, 1234, 10.1164/ajrccm.159.4.9807075 Kneyber, 2002, Prediction of duration of hospitalization in respiratory syncytial virus infection, Pediatr. Pulmonol., 33, 453, 10.1002/ppul.10099 El Saleeby, 2011, Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children, J. Infect. Dis., 204, 996, 10.1093/infdis/jir494 McMillan, 1988, Prediction of the duration of hospitalization in patients with respiratory syncytial virus infection: use of clinical parameters, Pediatrics, 81, 22, 10.1542/peds.81.1.22 Kristensen, 2012, Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based cohort study, Clin. Infect. Dis., 54, 810, 10.1093/cid/cir928 Broughton, 2005, Prospective study of healthcare utilisation and respiratory morbidity due to RSV infection in prematurely born infants, Thorax, 60, 1039, 10.1136/thx.2004.037853 Kott, 2008, Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4, Pediatr. Pulmonol., 43, 760, 10.1002/ppul.20853 Mella, 2013, Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis, J. Infect. Dis., 207, 564, 10.1093/infdis/jis721 Rietveld, 2004, Anticipated costs of hospitalization for respiratory syncytial virus infection in young children at risk, Pediatr. Infect. Dis. J., 23, 523, 10.1097/01.inf.0000129690.35341.8d Fieldston, 2013, Community household income and resource utilization for common inpatient pediatric conditions, Pediatrics, 132, e1592, 10.1542/peds.2013-0619 The IMpact-RSV Study Group, 1998, Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants, Pediatrics, 102, 531, 10.1542/peds.102.3.531 Carbonell-Estrany, 2010, Validation of a model to predict hospitalization due to RSV of infants born at 33-35 weeks’ gestation, J. Perinat. Med., 38, 411, 10.1515/jpm.2010.074 Smart, 2010, The cost effectiveness of palivizumab: a systematic review of the evidence, J. Med. Econ., 13, 453, 10.3111/13696998.2010.499749 Carbonell-Estrany, 2008, Clinical relevance of prevention of respiratory syncytial virus lower respiratory tract infection in preterm infants born between 33 and 35 weeks gestational age, Eur. J. Clin. Microbiol. Infect. Dis., 27, 891, 10.1007/s10096-008-0520-8 Hussman, 2012, A review of cost-effectiveness of palivizumab for respiratory syncytial virus, Expert Rev. Pharmacoecon. Outcomes Res., 12, 553, 10.1586/erp.12.45 McCormick, 2002, Readmission with respiratory syncytial virus (RSV) infection among graduates from a neonatal intensive care unit, Pediatr. Pulmonol., 34, 262, 10.1002/ppul.10169 Paes, 2009, Risk-scoring tool for respiratory syncytial virus prophylaxis in premature infants born at 33–35 completed weeks’ gestational age in Canada, Curr. Med. Res. Opin., 25, 1585, 10.1185/03007990902929112 Simões, 2008, A predictive model for respiratory syncytial virus (RSV) hospitalisation of premature infants born at 33–35 weeks of gestational age, based on data from the Spanish FLIP Study, Respir. Res., 9, 78, 10.1186/1465-9921-9-78 Law, 2004, The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestation, Pediatr. Infect. Dis. J., 23, 806, 10.1097/01.inf.0000137568.71589.bd Sampalis, 2008, Development and validation of a risk scoring tool to predict respiratory syncytial virus hospitalization in premature infants born at 33 through 35 completed weeks of gestation, Med. Decis. Making, 28, 471, 10.1177/0272989X08315238 Sampalis, 2003, Morbidity and mortality after RSV-associated hospitalizations among premature Canadian infants, J. Pediatr., 143, S150, 10.1067/S0022-3476(03)00513-4 Blanken, 2013, Prospective validation of a prognostic model for respiratory syncytial virus bronchiolitis in late preterm infants: a multicenter birth cohort study, PLoS One, 8, e59161, 10.1371/journal.pone.0059161 Simões, 2011, European risk factors’ model to predict hospitalization of premature infants born 33–35 weeks’ gestational age with respiratory syncytial virus: validation with Italian data, J. Matern. Fetal Neonatal Med., 24, 152, 10.3109/14767058.2010.482610 Stensballe, 2010, Population based external validation of a European predictive model for respiratory syncytial virus hospitalization of premature infants born 33 to 35 weeks of gestational age, Pediatr. Infect. Dis. J., 29, 374, 10.1097/INF.0b013e3181c810da Paes, 2009, Predictive value of the respiratory syncytial virus risk-scoring tool in the term infant in Canada, Curr. Med. Res. Opin., 25, 2191, 10.1185/03007990903126908 Choudhuri, 2006, Effect of altitude on hospitalizations for respiratory syncytial virus infection, Pediatrics, 117, 349, 10.1542/peds.2004-2795 Rossi, 2007, Risk factors for severe RSV-induced lower respiratory tract infection over four consecutive epidemics, Eur. J. Pediatr., 166, 1267, 10.1007/s00431-007-0418-y Reeve, 2006, Predicting respiratory syncytial virus hospitalisation in Australian children, J. Paediatr. Child Health, 42, 248, 10.1111/j.1440-1754.2006.00849.x Bulkow, 2012, Risk factors for hospitalization with lower respiratory tract infections in children in rural Alaska, Pediatrics, 129, e1220, 10.1542/peds.2011-1943 Goetghebuer, 2004, Familial susceptibility to severe respiratory infection in early life, Pediatr. Pulmonol., 38, 321, 10.1002/ppul.20069 Law, 2002, An update on respiratory syncytial virus epidemiology: a developed country perspective, Respir. Med., 96, S1, 10.1053/rmed.2002.1294 Figueras-Aloy, 2004, Case–control study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33–35 weeks in Spain, Pediatr. Infect. Dis. J., 23, 815, 10.1097/01.inf.0000136869.21397.6b Cilla, 2006, Risk factors for hospitalization due to respiratory syncytial virus infection among infants in the Basque Country, Spain, Epidemiol. Infect., 134, 506, 10.1017/S0950268805005571 Miller, 2011, Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness, J. Allergy Clin. Immunol., 127, 883, 10.1016/j.jaci.2010.11.041 Pezzotti, 2009, Incidence and risk factors of hospitalization for bronchiolitis in preterm children: a retrospective longitudinal study in Italy, BMC Pediatr., 9, 56, 10.1186/1471-2431-9-56 Liese, 2003, Incidence and risk factors of respiratory syncytial virus-related hospitalizations in premature infants in Germany, Eur. J. Pediatr., 162, 230, 10.1007/s00431-002-1105-7 Janssen, 2007, Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes, J. Infect. Dis., 196, 826, 10.1086/520886 Jansson, 2002, Socioeconomic environmental factors and hospitalization for acute bronchiolitis during infancy, Acta Paediatr., 91, 335, 10.1111/j.1651-2227.2002.tb01725.x Carroll, 2007, Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy, Pediatrics, 119, 1104, 10.1542/peds.2006-2837 Stensballe, 2006, Atopic disposition, wheezing, and subsequent respiratory syncytial virus hospitalization in Danish children younger than 18 months: a nested case–control study, Pediatrics, 118, e1360, 10.1542/peds.2006-0907 Simoes, 1993, Preterm twins and triplets. A high-risk group for severe respiratory syncytial virus infection, Am. J. Dis. Child., 147, 303, 10.1001/archpedi.1993.02160270065020 Weber, 1999, Risk factors for severe respiratory syncytial virus infection leading to hospital admission in children in the Western Region of The Gambia, Int. J. Epidemiol., 28, 157, 10.1093/ije/28.1.157 Karr, 2007, Effects of subchronic and chronic exposure to ambient air pollutants on infant bronchiolitis, Am. J. Epidemiol., 165, 553, 10.1093/aje/kwk032 Szabo, 2012, Respiratory distress syndrome at birth is a risk factor for hospitalization for lower respiratory tract infections in infancy, Pediatr. Infect. Dis. J., 31, 1245, 10.1097/INF.0b013e3182737349 Moore, 2012, Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery, Arch. Dis. Child., 97, 410, 10.1136/archdischild-2011-300607 Eick, 2008, The role of neutralizing antibodies in protection of American Indian infants against respiratory syncytial virus disease, Pediatr. Infect. Dis. J., 27, 207, 10.1097/INF.0b013e31815ac585 Kresfelder, 2011, Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African children, J. Med. Virol., 83, 1834, 10.1002/jmv.22179 Moyes, 2013, Epidemiology of respiratory syncytial virus-associated acute lower respiratory tract infection hospitalizations among HIV-infected and HIV-uninfected South African children, 2010–2011, J. Infect. Dis., 208, S217, 10.1093/infdis/jit479 Park, 2012, Epidemiology of respiratory syncytial virus infection in infants born at less than thirty-five weeks of gestational age, Pediatr. Infect. Dis. J., 31, e99, 10.1097/INF.0b013e318257f619 Joffe, 1999, Rehospitalization for respiratory syncytial virus among premature infants, Pediatrics, 104, 894, 10.1542/peds.104.4.894 Kristensen, 2009, Risk factors for respiratory syncytial virus hospitalisation in children with heart disease, Arch. Dis. Child., 94, 785, 10.1136/adc.2008.143057 Vardas, 1999, The epidemiology of respiratory syncytial virus (RSV) infections in South African children, S. Afr. Med. J., 89, 1079 Carbonell-Estrany, 2004, Identifying risk factors for severe respiratory syncytial virus among infants born after 33 through 35 completed weeks of gestation: different methodologies yield consistent findings, Pediatr. Infect. Dis. J., 23, S193, 10.1097/01.inf.0000144664.31888.53 Stensballe, 2009, Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze, J. Allergy Clin. Immunol., 123, 398, 10.1016/j.jaci.2008.10.043 Nielsen, 2003, Respiratory syncytial virus infection – risk factors for hospital admission: a case–control study, Acta Paediatr., 92, 1314, 10.1111/j.1651-2227.2003.tb00502.x Doering, 2006, The risk of respiratory syncytial virus-related hospitalizations in preterm infants of 29 to 35 weeks’ gestational age, Pediatr. Infect. Dis. J., 25, 1188, 10.1097/01.inf.0000246978.58565.b5 Welliver, 2007, Temperature, humidity, and ultraviolet B radiation predict community respiratory syncytial virus activity, Pediatr. Infect. Dis. J., 26, S29, 10.1097/INF.0b013e318157da59 Walton, 2010, Predicting the start week of respiratory syncytial virus outbreaks using real time weather variables, BMC Med. Inform. Decis. Making, 10, 68, 10.1186/1472-6947-10-68 Birkhaug, 2013, Infectious burden of respiratory syncytial virus in relation to time of birth modifies the risk of lower respiratory tract infection in infancy: the Norwegian Mother and Child Cohort, Pediatr. Infect. Dis. J., 32, e235, 10.1097/INF.0b013e31828ab9ff Langkamp, 2001, Factors predicting compliance with palivizumab in high-risk infants, Am. J. Perinatol., 18, 345, 10.1055/s-2001-17860 Frogel, 2010, A systematic review of compliance with palivizumab administration for RSV immunoprophylaxis, J. Manag. Care Pharm., 16, 46, 10.18553/jmcp.2010.16.1.46 Son, 2010, Application of support vector machine for prediction of medication adherence in heart failure patients, Healthc. Inform. Res., 16, 253, 10.4258/hir.2010.16.4.253 Mullins, 2003, Substantial variability in community respiratory syncytial virus season timing, Pediatr. Infect. Dis. J., 22, 857, 10.1097/01.inf.0000090921.21313.d3 Panozzo, 2007, Variation in timing of respiratory syncytial virus outbreaks: lessons from national surveillance, Pediatr. Infect. Dis. J., 26, S41, 10.1097/INF.0b013e318157da82 Hervás, 2012, Meteorologic conditions and respiratory syncytial virus activity, Pediatr. Infect. Dis. J., 31, e176, 10.1097/INF.0b013e31825cef14 Goddard, 2007, Timing of monoclonal antibody for seasonal RSV prophylaxis in the United Kingdom, Epidemiol. Infect., 135, 159, 10.1017/S0950268806006601 Vandini, 2013, Respiratory syncytial virus infection in infants and correlation with meteorological factors and air pollutants, Ital. J. Pediatr., 39, 1, 10.1186/1824-7288-39-1 du Prel, 2009, Are meteorological parameters associated with acute respiratory tract infections?, Clin. Infect. Dis., 49, 861, 10.1086/605435 Zachariah, 2009, Predictors of the duration of the respiratory syncytial virus season, Pediatr. Infect. Dis. J., 28, 772, 10.1097/INF.0b013e3181a3e5b6 Piippo-Savolainen, 2008, Wheezy babies–wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing, Acta Paediatr., 97, 5, 10.1111/j.1651-2227.2007.00558.x Hyvärinen, 2005, Teenage asthma after severe infantile bronchiolitis or pneumonia, Acta Paediatr., 94, 1378, 10.1080/08035250510046812 Larouch, 2000, Asthma and airway hyper-responsiveness in adults who required hospital admission for bronchiolitis in early childhood, Respir. Med., 94, 288, 10.1053/rmed.1999.0748 McConnochie, 1984, Bronchiolitis as a possible cause of wheezing in childhood: new evidence, Pediatrics, 74, 1, 10.1542/peds.74.1.1 Piippo-Savolainen, 2004, Asthma and lung function 20 years after wheezing in infancy: results from a prospective follow-up study, Arch. Pediatr. Adolesc. Med., 158, 1070, 10.1001/archpedi.158.11.1070 Sigurs, 2000, Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7, Am. J. Respir. Crit. Care Med., 161, 1501, 10.1164/ajrccm.161.5.9906076 Singh, 2007, Bronchiolitis to asthma: a review and call for studies of gene–virus interactions in asthma causation, Am. J. Respir. Crit. Care Med., 175, 108, 10.1164/rccm.200603-435PP Ruotsalainen, 2010, Adulthood asthma after wheezing in infancy: a questionnaire study at 27 years of age, Allergy, 65, 503, 10.1111/j.1398-9995.2009.02212.x Khaldi, 1999, Infant asthma in Tunisia, Pediatr. Pulmonol. Suppl., 18, 216, 10.1002/(SICI)1099-0496(1999)27:18+<216::AID-PPUL69>3.0.CO;2-O Mikalsen, 2013, Severe bronchiolitis in infancy: can asthma in adolescence be predicted?, Pediatr. Pulmonol., 48, 538, 10.1002/ppul.22675 Frey, 2009, The challenge of managing wheezing in infants, N. Engl. J. Med., 360, 2130, 10.1056/NEJMe0902242 Mansbach, 2009, Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma, Clin. Lab. Med., 29, 741, 10.1016/j.cll.2009.07.011 Shinohara, 2008, Presence of eosinophils in nasal secretion during acute respiratory tract infection in young children predicts subsequent wheezing within two months, Allergol. Int., 57, 359, 10.2332/allergolint.O-08-544 Bont, 2000, Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study, Am. J. Respir. Crit. Care Med., 161, 1518, 10.1164/ajrccm.161.5.9904078 Bont, 2001, Airflow limitation during respiratory syncytial virus lower respiratory tract infection predicts recurrent wheezing, Pediatr. Infect. Dis. J., 20, 277, 10.1097/00006454-200103000-00012 Chung, 2002, RANTES may be predictive of later recurrent wheezing after respiratory syncytial virus bronchiolitis in infants, Ann. Allergy. Asthma. Immunol., 88, 463, 10.1016/S1081-1206(10)62383-6 Kotaniemi-Syrjänen, 2002, Wheezing requiring hospitalization in early childhood: predictive factors for asthma in a six-year follow-up, Pediatr. Allergy Immunol., 13, 418, 10.1034/j.1399-3038.2002.02091.x Pifferi, 2001, Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing, Pediatr. Pulmonol., 31, 419, 10.1002/ppul.1069 Piippo-Savolainen, 2006, Early predictors for adult asthma and lung function abnormalities in infants hospitalized for bronchiolitis: a prospective 18- to 20-year follow-up, Allergy Asthma Proc., 27, 341, 10.2500/aap.2006.27.2912 Piippo-Savolainen, 2007, Does early exposure or sensitization to inhalant allergens predict asthma in wheezing infants? A 20-year follow-up, Allergy Asthma Proc., 28, 454, 10.2500/aap.2007.28.3022 Piippo-Savolainen, 2007, Does blood eosinophilia in wheezing infants predict later asthma? A prospective 18–20-year follow-up, Allergy Asthma Proc., 28, 163, 10.2500/app.2007.28.2946 Reijonen, 1997, Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis, Pediatr. Pulmonol., 23, 397, 10.1002/(SICI)1099-0496(199706)23:6<397::AID-PPUL1>3.0.CO;2-G Soferman, 2004, Soluble CD14 as a predictor of subsequent development of recurrent wheezing in hospitalized young children with respiratory syncytial virus-induced bronchiolitis, Ann. Allergy. Asthma. Immunol., 92, 545, 10.1016/S1081-1206(10)61762-0 Schuurhof, 2011, Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze, Respir. Res., 12, 121, 10.1186/1465-9921-12-121 Welliver, 1986, Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis, J. Pediatr., 109, 776, 10.1016/S0022-3476(86)80692-8 Yamada, 2010, Creola bodies in infancy with respiratory syncytial virus bronchiolitis predict the development of asthma, Allergol. Int., 59, 375, 10.2332/allergolint.09-OA-0165 Ruotsalainen, 2013, Adolescent asthma after rhinovirus and respiratory syncytial virus bronchiolitis, Pediatr. Pulmonol., 48, 633, 10.1002/ppul.22692 Ehlenfield, 2000, Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease, Pediatrics, 105, 79, 10.1542/peds.105.1.79 Cassimos, 2008, Asthma, lung function and sensitization in school children with a history of bronchiolitis, Pediatr. Int., 50, 51, 10.1111/j.1442-200X.2007.02509.x Bacharier, 2012, Determinants of asthma after severe respiratory syncytial virus bronchiolitis, J. Allergy Clin. Immunol., 130, 91, 10.1016/j.jaci.2012.02.010 Beigelman, 2013, The role of early life viral bronchiolitis in the inception of asthma, Curr. Opin. Allergy Clin. Immunol., 13, 211, 10.1097/ACI.0b013e32835eb6ef Escobar, 2010, Recurrent wheezing in the third year of life among children born at 32 weeks’ gestation or later: relationship to laboratory-confirmed, medically attended infection with respiratory syncytial virus during the first year of life, Arch. Pediatr. Adolesc. Med., 164, 915, 10.1001/archpediatrics.2010.177 Kuikka, 1994, Bronchial asthma after early childhood wheezing: a follow-up until 4.5–6 years of age, Acta Paediatr., 83, 744, 10.1111/j.1651-2227.1994.tb13131.x Midulla, 2012, Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up, Eur. Respir. J., 39, 396, 10.1183/09031936.00188210 Nuolivirta, 2012, Weight gain in infancy and post-bronchiolitis wheezing, Acta Paediatr., 101, 38, 10.1111/j.1651-2227.2011.02414.x Koponen, 2012, Preschool asthma after bronchiolitis in infancy, Eur. Respir. J., 39, 76, 10.1183/09031936.00040211 Kim, 2013, Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing, Biomarkers, 18, 230, 10.3109/1354750X.2013.773078 Valkonen, 2009, Recurrent wheezing after respiratory syncytial virus or non-respiratory syncytial virus bronchiolitis in infancy: a 3-year follow-up, Allergy, 64, 1359, 10.1111/j.1398-9995.2009.02022.x Castro-Rodríguez, 2000, A clinical index to define risk of asthma in young children with recurrent wheezing, Am. J. Respir. Crit. Care Med., 162, 1403, 10.1164/ajrccm.162.4.9912111 Oliveti, 1996, Pre- and perinatal risk factors for asthma in inner city African-American children, Am. J. Epidemiol., 143, 570, 10.1093/oxfordjournals.aje.a008787 Arruda, 2005, Risk factors for asthma and atopy, Curr. Opin. Allergy Clin. Immunol., 5, 153, 10.1097/01.all.0000162308.89857.6c Sherman, 1990, Early childhood predictors of asthma, Am. J. Epidemiol., 132, 83, 10.1093/oxfordjournals.aje.a115646 Voisin, 2010, Infant swimming in chlorinated pools and the risks of bronchiolitis, asthma and allergy, Eur. Respir. J., 36, 41, 10.1183/09031936.00118009 Karunasekera, 2001, Risk factors of childhood asthma: a Sri Lankan study, J. Trop. Pediatr., 47, 142, 10.1093/tropej/47.3.142 Korppi, 2010, Asthma predictive factors in infants with bronchiolitis: asthma risk at 13–20 years of age, Eur. Respir. J., 36, 221, 10.1183/09031936.00036710 Mansbach, 2008, Update on bronchiolitis, Emerg. Med. Crit. Rev., 4, 35 Howidi, 2007, The severity of respiratory syncytial virus bronchiolitis in young infants in the United Arab Emirates, J. Trop. Pediatr., 53, 22, 10.1093/tropej/fml045 Koehoorn, 2008, Descriptive epidemiological features of bronchiolitis in a population-based cohort, Pediatrics, 122, 1196, 10.1542/peds.2007-2231 Rakshi, 1994, Management of acute bronchiolitis, Arch. Dis. Child., 71, 463, 10.1136/adc.71.5.463 Ricart, 2013, Clinical risk factors are more relevant than respiratory viruses in predicting bronchiolitis severity, Pediatr. Pulmonol., 48, 456, 10.1002/ppul.22633 Martinello, 2002, Correlation between respiratory syncytial virus genotype and severity of illness, J. Infect. Dis., 186, 839, 10.1086/342414 Walsh, 1997, Severity of respiratory syncytial virus infection is related to virus strain, J. Infect. Dis., 175, 814, 10.1086/513976 Vieira, 2010, Correlation between inflammatory mediators in the nasopharyngeal secretion and in the serum of children with lower respiratory tract infection caused by respiratory syncytial virus and disease severity, J. Bras. Pneumol., 36, 59, 10.1590/S1806-37132010000100011 Semple, 2007, Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P, PLoS One, 2, e1038, 10.1371/journal.pone.0001038 Papoff, 2011, Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis, Acta Paediatr., 100, e17, 10.1111/j.1651-2227.2011.02181.x Flaherman, 2012, Frequency, duration and predictors of bronchiolitis episodes of care among infants ≥32 weeks gestation in a large integrated healthcare system: a retrospective cohort study, BMC Health Serv. Res., 12, 144, 10.1186/1472-6963-12-144 Wang, 1995, Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection, J. Pediatr., 126, 212, 10.1016/S0022-3476(95)70547-3 Akiyama, 2011, Bimodal effects of obesity ratio on disease duration of respiratory syncytial virus infection in children, Allergol. Int., 60, 305, 10.2332/allergolint.10-OA-0252 Tasker, 2000, Time course of severe respiratory syncytial virus infection in mechanically ventilated infants, Acta Paediatr., 89, 938, 10.1080/080352500750043387 Spaeder, 2011, Time series model to predict burden of viral respiratory illness on a pediatric intensive care unit, Med. Decis. Making, 31, 494, 10.1177/0272989X10388042 Houben, 2012, High concentrations of amniotic fluid proinflammatory cytokines in healthy neonates are associated with low risk of respiratory syncytial virus bronchiolitis, Pediatr. Infect. Dis. J., 31, 931, 10.1097/INF.0b013e31826366e3 Luo, 2014, A roadmap for designing a personalized search tool for individual healthcare providers, J. Med. Syst., 38, 6, 10.1007/s10916-014-0006-4 Morgan, 2007 Pearl, 2009 Markatou, 2012, Case-based reasoning in comparative effectiveness research, IBM J. Res. Dev., 56, 4, 10.1147/JRD.2012.2198311 Luo, 2013, Open issues in intelligent personal health record – an updated status report for 2012, J. Med. Syst., 37, 9943, 10.1007/s10916-013-9943-6 Conway, 2013, Using chief complaints for syndromic surveillance: a review of chief complaint based classifiers in North America, J. Biomed. Inform., 46, 734, 10.1016/j.jbi.2013.04.003 Guyon, 2003, An introduction to variable and feature selection, J. Mach. Learn. Res., 3, 1157 Neuvirth, 2011, Toward personalized care management of patients at risk: the diabetes case study, 395 Jiang, 2008 Wennberg, 1984, Dealing with medical practice variations: a proposal for action, Health Aff. (Millwood), 3, 6, 10.1377/hlthaff.3.2.6 Health Services Research Group, 1992, Small area variations: what are they and what do they mean?, Can. Med. Assoc. J., 146, 467 Wennberg, 1986, Which rate is right?, N. Engl. J. Med., 314, 310, 10.1056/NEJM198601303140509 Wiens, 2014, A study in transfer learning: leveraging data from multiple hospitals to enhance hospital-specific predictions, J. Am. Med. Inform. Assoc., 10.1136/amiajnl-2013-002162 Pan, 2010, A survey on transfer learning, IEEE Trans. Knowl. Data Eng., 22, 1345, 10.1109/TKDE.2009.191 A. Johnson, C. Hartling, C.J. Hoydu, J. Ballard, Adventure in bronchiolitis: respiratory outpatient clinic education & review, NACHRI 2009 Annual Meeting Poster Presentation, Available at http://www.childrenshospitals.net/AM/Template.cfm?Section=t&template=/CM/ContentDisplay.cfm&ContentID=48598 Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, PLoS Med., 6, e1000097, 10.1371/journal.pmed.1000097 Bonnie, 2001, Evaluating informatics applications – clinical decision support systems literature review, Int. J. Med. Inf., 64, 15, 10.1016/S1386-5056(01)00183-6