A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

Liver International - Tập 31 Số s2 - Trang 30-60 - 2011
Andreas Erhardt1, Homie Razavi2, Alfredo Alberti3, Enos Bernasconi4, María Buti5,6, Curtis Cooper7, Olav Dalgård8, John F. Dillion9, Robert Flisiak10, Xavier Forns11, Soňa Fraňková12, Adrian Goldiș13, Ioannis Goulis14, Waldemar Halota15, Béla Hunyady16,17, Martin Lagging18, Angela Largen2, Michael Makara19, Spilios Manolakopoulos20, Patrick Marcellin21, Rui Tato Marinho22, Stanislas Pol23, Thierry Poynard24, Massimo Puoti25, Olga Sagalova26, Scott Sibbel2, Krzysztof Simon27, Carolyn Wallace2, Kendra A. Young2, Cihan Yurdaydın28, Eli Zuckerman29, Francesco Negro30, Stefan Zeuzem31
1Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
2Center for Disease Analysis, Kromite, Louisville, CO, USA
3Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
4Department of Internal Medicine, Regional Hospital, Lugano, Switzerland
5Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
6Hospital General Universitari Vall d´Hebron, Barcelona, Spain
7Department of Medicine, Division of Infectious Diseases, University of Ottawa, Ottawa, ON, Canada
8Medical Department, Oslo University Hospital, Rikshospitalet, Oslo, Norway
9Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
10Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland
11Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
12Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
13Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania
144th Department of Medicine, Medical School, Aristotelian University of Thessaloniki, Thessaloniki, Greece
15Department of Infectious Diseases and Hepatology, Nicolaus Copernicus University in Torun (Poland), L. Rydygier Medical University, Bydgoszcz, Poland
16Department of Medicine, Kaposi Mór Teaching Hospital, Kaposvár, Hungary
17First Department of Medicine, University of Pécs, Pécs, Hungary
18Department of Infectious Diseases/Virology, University of Gothenburg, Sweden
19Central Outpatient Clinic, Saint Laszlo Hospital, Budapest, Hungary
202nd Academic Department, Hippokration General Hospital, Athens, Greece
21Viral Hepatitis Research Unit, Hôpital Beaujon, University of Paris VII, Clichy, France
22Department of Gastroenterology and Hepatology, Hospital Santa Maria, Lisbon, Portugal
23Inserm U-1016 et Unité d'Hépatologie, Université Paris Descartes, Assistance Publique Hôpitaux de Paris, Paris, France
24Department of Hepatology, Université Pierre et Marie Curie Liver Center, Paris, France
25Department of Infectious Diseases, AO Ospedale Niguarda Ca Granda, Milano, Italy
26Department of Infectious Diseases, Clinic of the Chelyabinsk State Medical Academy, Chelyabinsk, Russia
27Department and Clinic of Infectious Diseases, Hepatology and Acquired Immune Deficiencies, Medical University Wroclaw, Wroclaw, Poland
28Department of Gastroenterology, School of Medicine, Ankara University, Tip Fakultesi Hastanesi, Ankara, Turkey
29Liver Unit, Carmel Medical Center, Haifa, Israel
30Services de Gastroenterologie et d'Hepatologie et de Pathologie Clinique, Hopitaux Universitaires, Genève, Switzerland
31Klinikum der Johann Wolfgang Goethe-Universität, Medizinische Klinik 1, Theodor-Stern-Kai 7, Frankfurt am Main, Germany

Tóm tắt

AbstractBackground and Aim: Decisions on public health issues are dependent on reliable epidemiological data. A comprehensive review of the literature was used to gather country‐specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel.Methodology: Data references were identified through indexed journals and non‐indexed sources. In this work, 13 000 articles were reviewed and 860 were selected based on their relevance.Results: Differences in prevalence were explained by local and regional variances in transmission routes or different public health measures. The lowest HCV prevalence (≤0.5%) estimates were from northern European countries and the highest (≥3%) were from Romania and rural areas in Greece, Italy and Russia. The main risk for HCV transmission in countries with well‐established HCV screening programmes and lower HCV prevalence was injection drug use, which was associated with younger age at the time of infection and a higher infection rate among males. In other regions, contaminated glass syringes and nosocomial infections continue to play an important role in new infections. Immigration from endemic countries was another factor impacting the total number of infections and the genotype distribution. Approximately 70% of cases in Israel, 37% in Germany and 33% in Switzerland were not born in the country. In summary, HCV epidemiology shows a high variability across Europe, Canada and Israel.Conclusion: Despite the eradication of transmission by blood products, HCV infection continues to be one of the leading blood‐borne infections in the region.

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Tài liệu tham khảo

10.1016/j.cgh.2010.09.014

Omland LH, 2010, Mortality in patients with chronic and cleared hepatitis C viral infection, a nationwide cohort study, 53, 36

Muhlberger N, 2009, HCV‐related burden of disease in Europe, a systematic assessment of incidence, prevalence, morbidity, and mortality, 9, 34

Davis GL, 2010, Aging of hepatitis C virus (HCV)‐infected persons in the United States, a multiple cohort model of HCV prevalence and disease progression, 138, 513

10.1093/eurpub/ckp001

10.1016/j.jhep.2007.07.033

Chiquete E, 2007, Low prevalence of anti‐hepatitis C virus antibodies in Mexico, a systematic review, 50, 1

10.1128/JCM.40.5.1656-1659.2002

10.1111/j.1478-3231.2011.02535.x

Rantala M, 2008, Surveillance and epidemiology of hepatitis B and C in Europe – a review, Euro Surveill, 13, 1, 10.2807/ese.13.21.18880-en

European Centre for Disease Prevention and Control., 2010, Annual Epidemiological Report on Communicable Diseases in Europe 2009. Report on the State of Communicable Diseases in Europe 2009, Revised Edition

Remis RS., 2009, Modelling the Incidence and Prevalence of Hepatitis C Infection and Its Sequelae in Canada, 2007: Final Report

Enhanced Hepatitis Strain Surveillance System., 2009, Health Canada. Epidemiology of Acute Hepatitis C Infection in Canada. Results from the Enhanced Hepatitis Strain Surveillance System (EHSSS)

Public Health Agency of Canada., 2008, Evaluation of the Hepatitis C Prevention, Support and Research Program 1999/2000–2005/2006

Remis Robert S., 2008, A Study to Characterize the Epidemiology of Hepatitis C Infection in Canada, 2002: Final Report/Prepared by Robert S. Remis Computer File

10.1111/j.1600-6143.2006.01607.x

Manuel DG, 1999, The prevalence of hepatitis C in a community‐based population, Ontario, 1996, Can Commun Dis Rep, 25, 193

Public Health Agency of Canada.Notifiable Diseases Online 2005 1991–2004. Available athttp://dsol‐smed.hc‐sc.gc.ca/dsol‐smed/ndis/c_inda‐eng.php

Marotta P, 2008, Impact of advanced fibrosis and cirrhosis on sustained virologic response of HCV G1‐infected patients: results of the Canadian power program (Abstract #1216). 58th annual meeting of the American Association for the Study of Liver Diseases, 31 October–4 November 2008. San Francisco, California, USA, Hepatology, 48, 849A

10.1128/JCM.43.10.5158-5163.2005

Chaudhary RK, 1999, Distribution of hepatitis C virus genotypes in Canada, results from the LCDC Sentinel Health Unit Surveillance System, 10, 53

Bernier L, 1996, Identification of numerous hepatitis C virus genotypes in Montreal, Canada, J Clin Microbiol, 34, 2815, 10.1128/jcm.34.11.2815-2818.1996

Murphy DG, 1995, Hepatitis C virus genotypes in patients and blood donors – Quebec, Can Commun Dis Rep, 21, 129

Andonov A, 1994, Genotyping of Canadian hepatitis C virus isolates by PCR, J Clin Microbiol, 32, 2031, 10.1128/jcm.32.8.2031-2034.1994

FrankovaS.Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic. Screening for hepatitis C in the Czech Republic. Conversation with Largen A Center for Disease Analysis Kromite Louisville CO USA 14 November 2010.

Krekulova L, 2009, Current situation and trends in the hepatitis C virus genotype distribution among injecting drug users in the Czech Republic, Epidemiol Mikrobiol Imunol, 58, 84

Urbanek P, 2002, Risk factors for transmission of hepatitis C in the the Czech population, Cas Lek Cesk, 141, 185

10.1086/323199

Hobstova J, 2007, Infectious diseases of drug users in the Czech Republic, Cas Lek Cesk, 146, 137

10.1159/000092117

Nemecek V, 2003, The 2001 serological survey in the Czech Republic – viral hepatitis, Cent Eur J Public Health, 11, S54

Klofera M, 1994, Hepatitis C antibodies (anti‐HCV) in blood donors at the transfusion department in Brno, Cas Lek Cesk, 133, 459

Nemecek V, 2009, Genotypic heterogeneity of hepatitis C virus (HCV) from blood donors in the Czech Republic, Epidemiol Mikrobiol Imunol, 58, 63

Delarocque‐Astagneau E, 2010, The impact of the prevention programme of hepatitis C over more than a decade, the French experience, 17, 435

Jullien‐Depradeux AM, 2002, National campaign against hepatitis C in France (1999–2002), Acta Gastroenterol Belg, 65, 112

Dubois F, 1997, Hepatitis C in a French population‐based survey, 1994, seroprevalence, frequency of viremia, genotype distribution, and risk factors. The Collaborative Study Group, 25, 1490

Meffre C, 2010, Prevalence of hepatitis B and hepatitis C virus infections in France in 2004, social factors are important predictors after adjusting for known risk factors, 82, 546

10.1093/eurpub/ckp112

Foucher J, 2009, FibroScan used in street‐based outreach for drug users is useful for hepatitis C virus screening and management, a prospective study, 16, 121

10.1016/j.annepidem.2007.05.007

10.1111/j.1365-2893.2006.00742.x

10.1016/S1246-7820(00)88945-4

Michault A, 2000, Prevalence of hepatitis A, B, C virus markers in Reunion (south hospital and Saint Pierre prison), Bull Soc Pathol Exot, 93, 34

Nalpas B, 2000, Prevalence of infection by hepatitis viruses in a rural area. Analysis according to risk factors and alcohol consumption, Gastroenterol Clin Biol, 24, 536

Ouzan D, 2000, Epidemiological information obtained from anti‐hepatitis C virus screening in blood donors and candidates for autologous transfusion from 1992 to 1996 in the Alpes‐Maritimes region, Gastroenterol Clin Biol, 24, 337

Pradat P, 2000, HCV, epidemiology, modes of transmission and prevention of spread, 14, 201

Frere T, 1999, Treatment of hepatitis C virus infection in the Poitou‐Charentes region, Gastroenterol Clin Biol, 23, 887

Merle V, 1999, Risk factors of contamination by hepatitis C virus. Case–control study in the general population, Gastroenterol Clin Biol, 23, 439

Raguin G, 1998, Hepatitis C in France, a national survey in the Departments of Internal Medicine and Infectious Diseases. The GERMIVIC (Joint Study Group on Hepatitis C virus of the French National Society of Internal Medicine and the French Society of Infectious Diseases), 14, 545

Bastie A, 1995, Hepatitis C virus infection. Epidemiology, Pathol Biol, 43, 674

Maisonneuve P, 1991, Serum antibodies to hepatitis C virus, analysis of risk factors of seropositivity in a population of blood donors in metropolitan France, 12, 416

Roudot‐Thoraval F., 1996, Epidemiology of infections linked to hepatitis C virus in France, Bull Acad Natl Med, 180, 1253

10.1016/S1246-7820(97)80045-6

French Institute for Public Health Surveillance (InVS).Institut de veille sanitaire. Hepatite C. Surveillance nationale de l'hepatite C a partir des poles de reference volontaires. Donnees 2001–2007.2010 Available athttp://www.invs.sante.fr/surveillance/hepatite_c/poleref_volontaire/2001_2007/web‐2007v2.pdf(accessed 28 September 2010).

Defossez G, 2008, Evaluation of the French national plan to promote screening and early management of viral hepatitis C, between 1997 and 2003, a comparative cross-sectional study in Poitou-Charentes region, 20, 367

Martinot‐Peignoux M, 1999, Hepatitis C virus genotypes in France, relationship with epidemiology, pathogenicity and response to interferon therapy. The GEMHEP, 6, 435

Payan C, 2005, Changing of hepatitis C virus genotype patterns in France at the beginning of the third millenium, The GEMHEP GenoCII Study, 12, 405

10.1023/A:1010902614443

Desenclos JC., 2000, Epidemiology of hepatitis C, Rev Prat, 50, 1066

10.1016/S1246-7820(97)80056-0

Jauffret‐Roustide M, 2009, A national cross‐sectional study among drug‐users in France, epidemiology of HCV and highlight on practical and statistical aspects of the design, 9, 113

Jauffret‐Roustide M, 2006, Limited impact of the harm‐reduction policy on HCV among drug‐users. The ANRS‐Coquelicot survey example, Rev Epidemiol Sante Publique, 54, 1S53

10.1016/S1246-7820(02)00263-X

10.1093/ndt/11.supp4.19

Aymard JP, 1993, Seroprevalence of hepatitis C antibodies among blood donors. Study of second generation ELISA and RIBA tests and surrogate markers, Pathol Biol, 41, 149

10.1007/978-3-7091-5633-9_55

Aymard JP, 1990, Serum antibodies against hepatitis C, study of 4,100 blood donors from the northeast of France, 33, 295

10.1136/gut.34.2_Suppl.S50

Larsen C, 2008, Prevalence of hepatitis C and hepatitis B infection in the HIV‐infected population of France, 2004, Euro Surveill, 13, 1, 10.2807/ese.13.22.18888-en

10.1093/eurpub/ckl233

Ouzan D, 2003, Modalities of care in anti HCV positive patients identified in General Medicine in the Alpes‐Maritimes district, Gastroenterol Clin Biol, 27, 376

Roudot‐Thoraval F, 2000, Strategies of hepatitis C screening in general practice. Results of a two‐center randomized trial, Gastroenterol Clin Biol, 24, 1037

Djeriri K, 1996, Seroprevalence of markers of viral hepatitis A, B and C in hospital personnel at the Clermont‐Ferrand University Hospital Center, Presse Med, 25, 145

Roudot‐Thoraval F, 1992, Prevalence of hepatitis C virus antibodies (tests ELISA 2 and RIBA 2) in a population of pregnant women in France, Gastroenterol Clin Biol, 16, 255

Bruandet A, 2006, Incidence and risk factors of HCV infection in a cohort of intravenous drug users in the North and East of France, Rev Epidemiol Sante Publique, 54, 1S15

10.1017/S095026880400247X

10.1038/ki.1994.301

10.1128/JCM.43.8.3624-3629.2005

10.1128/JCM.42.7.3030-3035.2004

Tamalet C, 2003, Genomic and phylogenetic analysis of hepatitis C virus isolates, a survey of 535 strains circulating in southern France, 71, 391

Bourliere M, 2002, Epidemiological changes in hepatitis C virus genotypes in France, evidence in intravenous drug users, 9, 62

Elghouzzi MH, 2000, Hepatitis C virus, routes of infection and genotypes in a cohort of anti-HCV-positive French blood donors, 79, 138

10.1046/j.1537-2995.1996.36696269516.x

10.1002/jmv.1890450408

10.1093/infdis/171.6.1607

Sarrazin C, 2010, Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection, the German guidelines on the management of HCV infection, 48, 289

Robert Koch Institute., 2010, Zur Situation wichtiger Infektionskrankheiten in Deutschland, virus hepatitis B, C und D im Jahr 2009, 20, 177

10.1055/s-2007-963691

Offergeld R, 2005, Human immunodeficiency virus, hepatitis C and hepatitis B infections among blood donors in Germany 2000–2002, risk of virus transmission and the impact of nucleic acid amplification testing, 10, 8

Deterding K, 2009, The German Hep‐Net acute hepatitis C cohort, impact of viral and host factors on the initial presentation of acute hepatitis C virus infection, 47, 531

10.1016/j.jinf.2005.04.004

10.1055/s-2005-858876

Ammon A, 2000, Hepatitis B and C among Berlin dental personnel, incidence, risk factors, and effectiveness of barrier prevention measures, 125, 407

10.1016/S0934-8840(11)80802-9

SchlosserB DomkeD MockelM.High prevalence of chronic hepatitis C virus (HCV) infection in a German metropolitan area: a prospective screening analysis of 13 823 patients. The International Liver Congress 2009 44th Annual Meeting of the European Association for the Study of the Liver 22–26 April 2009 Copenhagen Denmark Poster (PDF) 2009.

10.1111/j.1440-1746.2006.04358.x

10.1111/j.1469-0691.2004.00934.x

Backmund M, 2003, Hepatitis C virus infection in injection drug users in Bavaria, risk factors for seropositivity, 18, 563

10.3109/00365549509032726

Wiegand J, 2009, Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany, epidemiological benefit from established health resources, 16, 743

10.1046/j.1423-0410.1998.7440213.x

Seidl S, 1990, Hepatitis C virus (HCV) antibodies in German blood donors – a pilot study, Beitr Infusionsther, 26, 18

Zimmermann R, 1992, Examination of a Berlin blood donation branch for antibodies to hepatitis C virus with the anti‐HCV test and for circulating HCV‐RNA using polymerase chain reaction, Beitr Infusionsther, 30, 38

10.1097/00042737-199911000-00005

10.1023/A:1013792013184

10.1055/s-2008-1027157

The Hepatitis C Trust., 2006, University of Southampton. The UK vs. Europe: Losing the fight against hepatitis C

Schroter M, 2002, Epidemiological dynamics of hepatitis C virus among 747 German individuals, new subtypes on the advance, 40, 1866

Ross RS, 2000, Genotyping of hepatitis C virus isolates using CLIP sequencing, J Clin Microbiol, 38, 3581, 10.1128/JCM.38.10.3581-3584.2000

Berg T, 1997, Distribution of hepatitis C virus genotypes in German patients with chronic hepatitis C, correlation with clinical and virological parameters, 26, 484

10.1093/infdis/175.3.685

10.1007/BF01591485

10.1111/j.1365-2893.2005.00614.x

Katsoulidou A, 2006, Molecular epidemiology of hepatitis C virus (HCV) in Greece, temporal trends in HCV genotype-specific incidence and molecular characterization of genotype 4 isolates, 13, 19

10.1016/j.ejim.2006.09.008

10.1023/A:1024698715741

Raptopoulou M, 2011, Significant epidemiological changes in chronic hepatitis C infection, results of the nationwide HEPNET-GREECE cohort study, 15, 26

Goritsas C, 2000, HCV infection in the general population of a Greek island, prevalence and risk factors, 47, 782

10.1080/jmf.16.2.106.110

Zervou EK, 2003, Low prevalence of HCV, HIV, and HTLV‐I/II infection markers in northwestern Greece, results of a 3-year prospective donor study (1995–1997), 14, 39

10.1023/A:1015671627577

10.1046/j.1365-2893.1999.00155.x

10.1023/A:1010857128629

10.1016/S0168-8278(05)80428-3

10.1046/j.1365-2893.1997.00125.x

Koulentaki M, 2001, Prevalence of hepatitis B and C markers in high‐risk hospitalised patients in Crete, a five-year observational study, 1, 17

10.1023/A:1017951605272

10.1046/j.1365-2893.2000.00217.x

10.1002/jmv.21134

10.1023/A:1007378608773

Sypsa V, 2004, Reconstructing and predicting the hepatitis C virus epidemic in Greece, increasing trends of cirrhosis and hepatocellular carcinoma despite the decline in incidence of HCV infection, 11, 366

10.1111/j.1365-2893.2005.00588.x

10.1016/S1386-6532(00)00159-1

Barna TK, 1996, Hepatitis C virus antibody in the serum of blood donors, Orv Hetil, 137, 507

MerkinaiteS.HCV infection in Europe. Siauliu St. 5/1‐21 Vilnius 01133 Lithuania: Eurasian Harm Reduction Network (EHRN) formerly Central and Eastern European Harm Reduction Network (CEEHRN) 1 October 2007.

European Monitoring Centre for Drugs and Drug Addiction., 2010, EMCDDA 2010 Selected Issue‐Trends in Injecting Drug use in Europe European Union. Annual Report. Selected Issues/European Monitoring Centre for Drugs and Drug Addicton

10.1053/jhin.2001.1087

McOmish F, 1994, Geographical distribution of hepatitis C virus genotypes in blood donors, an international collaborative survey, 32, 884

Gervain J, 2001, Determination of the type and subtype of the hepatitis C virus in chronic viral hepatitis patients in Hungary, Orv Hetil, 142, 1315

SarvariC UjhelyiE SzlávikJ et alDetermination of hepatitis C virus genotypes in Hungary using the Trugene HCV 5'NC genotyping test. ISMD2010 Eighth International Symposium on Molecular Diagnostics 2010 Graz Austria De Gruyter 2010 A21.

10.1016/S1386-6532(02)00045-8

ZuckermanE.Liver Unit Carmel Medical Center Haifa Israel. Hepatitis C in Israel. Conversation with Razavi HA. Center for Disease Analysis Kromite Louisville CO USA 2 October 2010.

Kerzman H, 2007, Risk factors for hepatitis C virus infection among blood donors in Israel, a case–control study between native Israelis and immigrants from the former Soviet Union, 47, 1189

10.1097/00004836-199701000-00006

Lurie Y, 2007, Acute hepatitis C in Israel, a predominantly iatrogenic disease?, 22, 158

10.1007/BF02561531

Flatau E, 1993, Prevalence of markers of infection with hepatitis B and C viruses in immigrants of operation Solomon, 1991, Isr J Med Sci, 29, 387

Stern M, 1995, A study of Israeli blood donors, asymptomatic carriers of hepatitis C virus, in relation to liver disease, cryoglobulinemia and transmission, Isr J Med Sci, 31, 277

10.1111/j.1365-2893.1995.tb00019.x

10.1002/(SICI)1096-9071(199811)56:3<230::AID-JMV9>3.0.CO;2-8

ZuckermanE.Liver Unit Carmel Medical Center Haifa Israel. Sources for the epidemiology of hepatitis C in Israel. Conversation with Razavi HA. Center for Disease Analysis Kromite Louisville CO USA 2 August 2010.

Loebstein R, 2008, Hepatitis C, B, and human immunodeficiency virus infections in illicit drug users in Israel, prevalence and risk factors, 10, 775

10.1111/j.1365-2516.2006.01178.x

10.1086/501858

Bogomolski‐Yahalom V, 1997, Hepatitis C virus genotypes in patients with persistent infection – a preliminary report, Isr J Med Sci, 33, 18

Ministry of Health Israel, Department of Epidemiology., 2010, Infectious Diseases: Morbidity in Israel. Israel Morbidity Report

Cozzolongo R, 2009, Epidemiology of HCV infection in the general population, a survey in a southern Italian town, 104, 2740

10.1016/j.ejca.2008.01.025

Di Stefano R, 2002, Endemic hepatitis C virus infection in a Sicilian town, further evidence for iatrogenic transmission, 67, 339

10.1023/A:1024817417635

Fabris P, 2008, Changing epidemiology of HCV and HBV infections in Northern Italy, a survey in the general population, 42, 527

Beggio M, 2007, Prevalence of hepatitis virus A, B, and C markers according to the geographic origin of medical students, G Ital Med Lav Ergon, 29, 745

Petti S, 2006, Analysis of the shift of the transmission pattern for hepatitis C in a community in Central Italy, New Microbiol, 29, 207

10.1186/1745-0179-2-26

10.1002/jmv.20376

10.1007/s15010-005-4036-1

Pendino GM, 2005, Prevalence and etiology of altered liver tests, a population-based survey in a Mediterranean town, 41, 1151

10.1097/00008469-200302000-00013

Cecere A, 2003, High prevalence of hepatitis C virus infection in a southern Italian rural region. Clinical aspects and evidence of inapparent parenteral exposure, Panminerva Med, 45, 253

10.1023/B:EJEP.0000013250.54478.61

Proietti L, 2003, Prevalence of HCV in health care workers in Southern Italy, Clin Ter, 154, 159

10.1136/gut.52.7.1030

Bongiorno MR, 2002, Hepatitis B and hepatitis C virus infections in dermatological patients in west Sicily, a seroepidemiological study, 16, 43

10.1136/gut.50.5.693

Campello C, 2002, Seroprevalence, viremia and genotype distribution of hepatitis C virus, a community-based population study in northern Italy, 30, 7

10.1023/A:1010932832190

Baldo V, 2001, Prevalence of antibodies against hepatitis C virus in the elderly, a seroepidemiological study in a nursing home and in an open population. The Collaborative Group, 46, 194

Baldo V, 2000, Hepatitis C virus, hepatitis B virus and human immunodeficiency virus infection in pregnant women in North‐East Italy, a seroepidemiological study, 16, 87

10.1046/j.1365-2893.2000.00199.x

10.1002/hep.510310328

Maio G, 2000, Hepatitis C virus infection and alanine transaminase levels in the general population, a survey in a southern Italian town, 33, 116

10.1111/j.1478-3231.1999.tb00073.x

Osella AR, 1999, Molecular epidemiology of hepatitis C virus infection in an area of hyperendemicity in southern Italy, a population-based study, 37, 2371

10.1111/j.1469-0691.1999.tb00524.x

Bellentani S, 1999, Clinical course and risk factors of hepatitis C virus related liver disease in the general population, report from the Dionysos study, 44, 874

Comandini UV, 1998, Sporadic hepatitis C virus infection, a case–control study of transmission routes in a selected hospital sample of the general population in Italy, 30, 11

Guadagnino V, 1997, Prevalence, risk factors, and genotype distribution of hepatitis C virus infection in the general population, a community-based survey in southern Italy, 26, 1006

10.1023/A:1007374810981

10.1016/S0168-8278(97)80276-0

10.1111/j.1471-0528.1996.tb09736.x

10.2105/AJPH.85.9.1272

Stroffolini T, 1995, High prevalence of hepatitis C virus infection in a small central Italian town, lack of evidence of parenteral exposure, 27, 235

D'Amelio R, 1995, Low prevalence of anti‐HCV antibodies among Italian Air Force recruits, Scand J Infect Dis, 27, 12

10.1007/BF01715545

10.1007/BF01715541

Puro V, 1993, The seroprevalence of HIV, HBV and HCV infections in patients coming to the departments of general surgery of a public hospital (S. Camillo, Rome), Minerva Chir, 48, 349

Gessoni G, 1993, Prevalence of anti‐hepatitis C virus antibodies among teenagers in the Venetian area, a seroepidemiological study, 2, 79

10.1007/BF02033064

10.1002/jmv.1890370203

10.1007/BF00144820

10.1080/00365540903095358

10.1046/j.1365-2141.2002.03334.x

10.1016/j.jcv.2009.04.022

Pizzillo P, 2009, HCV genotypes in Sicily, is there any evidence of a shift?, 81, 1040

Cenci M, 2007, Prevalence of hepatitis C virus (HCV) genotypes and increase of type 4 in central Italy, an update and report of a new method of HCV genotyping, 27, 1219

Cenci M, 2003, Prevalence of hepatitis C virus (HCV) genotypes in central Italy, Anticancer Res, 23, 5129

10.1002/jmv.10210

10.1016/S0732-8893(01)00350-9

Dalgard O, 2003, Hepatitis C in the general adult population of Oslo, prevalence and clinical spectrum, 38, 864

Melum E, 2006, Liver TX for hepatitis C cirrhosis in a low prevalence population, risk factors and status at evaluation, 41, 592

Vik IS, 2008, Hepatitis C – a health problem also in Norway, Tidsskr Nor Laegeforen, 128, 563

Kristiansen MG, 2002, Hepatitis C in Northern Norway – an 8‐year material, Tidsskr Nor Laegeforen, 122, 1974

Eskild A, 2000, Hepatitis C virus among pregnant women in Norway – occurrence of antibodies and pregnancy outcome, Tidsskr Nor Laegeforen, 120, 1006

10.3109/00365529409090441

Dalgard O, 2009, Management of patients with hepatitis C virus genotype 2 or 3, comments on updated American Association for the Study of Liver Diseases practice guidelines, 50, 323

10.4045/tidsskr.09.35002

Kielland KB, 1991, Hepatitis A‐, B‐ and C‐markers among Norwegian drug addicts in the period 1975–89, Tidsskr Nor Laegeforen, 111, 821

DalgardO.Medical Department Oslo University Hospital Rikshospitalet Oslo Norway. Estimated incidence of hepatitis C in Norway. Conversation with Wallace C. Center for Disease Analysis Kromite Louisville CO USA 18 February 2011.

10.3109/00365549609037919

Warunek W, 1996, Epidemiologic and clinical characteristics of patients with hepatitis type C on the bases of selected parameters, Folia Med Cracov, 37, 71

Chlabicz S, 2006, Known and probable risk factors for hepatitis C infection, a case series in north-eastern Poland, 12, 141

Chlabicz S, 2004, Medical procedures and the risk of iatrogenic hepatitis C infection, case–controlled study in north-eastern Poland, 58, 204

Labedzka H, 2002, Clinical and epidemiological assessment of hepatitis C virus infection among voluntary blood donors, Med Sci Monit, 8, CR591

10.1016/S0168-8278(11)61156-2

10.1016/S0188-4409(00)00100-4

Borzecka B, 2007, The program of early detection of HCV infection, Przegl Epidemiol, 61, 733

Braczkowska B, 2006, Prevalence and basic determinants of hepatitis C antibodies in medical students in Katowice, Poland, Przegl Lek, 63, 539

Swincow G, 2006, Prevalence of HCV infection in infants – own clinical experience, Med Wieku Rozwoj, 10, 407

Seyfried H, 2005, Prevalence of hepatitis C virus markers in Polish blood donors in 1994–2003, Przegl Epidemiol, 59, 807

10.1016/j.hepres.2005.09.001

Stepien M, 2010, Hepatitis C in Poland in 2008, Przegl Epidemiol, 64, 245

Rosinska M, 2007, Hepatitis C in Poland in 2005, Przegl Epidemiol, 61, 281

Czarkowski MP., 2006, Hepatitis C in Poland in 2004, Przegl Epidemiol, 60, 481

Czarkowski MP, 2005, Hepatitis C in Poland in 2003, Przegl Epidemiol, 59, 303

Kuszewski K, 2004, Hepatitis C in Poland in 2002, Przegl Epidemiol, 58, 131

Bielak A., 2003, Hepatitis C in Poland in 2001, Przegl Epidemiol, 57, 125

Bobel D, 2008, Hepatitis C in Poland in 2006, Przegl Epidemiol, 62, 325

Mazurek J., 2002, Hepatitis C in Poland in 2000, Przegl Epidemiol, 56, 325

Laskus I, 2009, Hepatitis C in Poland in 2007, Przegl Epidemiol, 63, 251

10.1016/j.jcv.2008.02.001

10.1111/j.0041-1132.2004.04156.x

Areias J, 2006, Epidemiological characterization of chronic hepatitis C in Portugal, Gastroenterología y hepatología, 29, 147

Santos A, 1994, Epidemiology of hepatitis C in central Portugal. Prevalence of anti‐HCV in the population of the Coimbra District, Acta Med Port, 7, S3

10.1046/j.1440-1746.2001.2574a.x

10.1023/A:1005442317680

De Carvalho A, 2000, HCV genotypes. Liver histopathology and immunologic profile in four groups of patients, Acta Med Port, 13, 67

GoldisA.Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Prague Czech Republic. Comments on the Romania portion of HCV manuscript. Conversation with Largen A. Center for Disease Analysis Kromite Louisville CO USA 15 November 2010.

Grigorescu M., 2009, HCV genotype 1 is almost exclusively present in Romanian patients with chronic hepatitis C, J Gastrointestin Liver Dis, 18, 45

Gheorghe L, 2005, Effectiveness and tolerability of pegylated Interferon alpha‐2a and ribavirin combination therapy in Romanian patients with chronic hepatitis C, from clinical trials to clinical practice, 14, 109

Gheorghe L, 2007, Efficacy, tolerability and predictive factors for early and sustained virologic response in patients treated with weight‐based dosing regimen of PegIFN alpha‐2b ribavirin in real‐life healthcare setting, J Gastrointestin Liver Dis, 16, 23

Gheorghe L, 2008, Prevalence of hepatitis C in Romania, different from European rates?, 49, 661

Azoicai D, 2001, The prevalence of the owner of serologic markers for the hepatitis C virus, in a north‐eastern territory of Romania, Rev Med Chir Soc Med Nat Iasi, 105, 127

Ivan A, 1998, The epidemiological aspects and prevalence of markers in those with viral hepatitis C in some population categories in 1994–1997 in Iasi County, Bacteriol Virusol Parazitol Epidemiol, 43, 275

Ivan A, 1995, Seroepidemiological considerations of the incidence of viral hepatitis C in some population groups, Rev Med Chir Soc Med Nat Iasi, 99, 129

Molnar GB, 1994, A prevalence study of serum markers in hepatitis virus infection in the epidemiological anamnesis of the population, Bacteriol Virusol Parazitol Epidemiol, 39, 141

Paquet C, 1993, Viral hepatitis in Bucharest, Bull World Health Organ, 71, 781

Russian Federation MoH., 2000, Viral hepatitis prophylaxis, general rules of epidemiology surveillance for viral hepatitis

10.1258/095646202762226083

10.1023/A:1007486002349

Gaidarenko AD., 2009, Prediction of Epidemic of Hepatitis C through Computer Simulation

Zhiburt EB, 2005, The verification of the results of screening antibodies to hepatitis C virus in blood donors, Zh Mikrobiol Epidemiol Immunobiol, 5, 71

10.1136/sti.77.6.463

Kuzin SN, 1999, Spread of hepatitis C and separate genotypes of hepatitis C virus in a region with a moderately active epidemic process, Vopr Virusol, 44, 79

Ariamkina OL, 1998, The diagnosis of hepatitis C viral infection in blood donors and patients, Zh Mikrobiol Epidemiol Immunobiol, 1, 74

Lytsar BN, 1993, Detection of antibodies to hepatitis C virus in blood donors, Gematol Transfuziol, 38, 29

Sychev A, 1993, The hepatitis C virus infection of Moscow blood donors, Zh Mikrobiol Epidemiol Immunobiol, 4, 80

Zhiburt EB, 1995, Specific and substitute markers of hepatitis C in screening donor blood, Gematol Transfuziol, 40, 16

10.1016/j.jcv.2003.08.009

10.1017/S0950268898001940

Iashina TL, 1993, The spread of hepatitis C markers among the population of regions of Russia and Central Asia, Zh Mikrobiol Epidemiol Immunobiol, 5, 46

10.1007/BF01718286

Onishchenko GG, 2000, The current problems in the epidemiology and prevention of viral hepatitis B and C in the Russian Federation, Zh Mikrobiol Epidemiol Immunobiol, 1, 50

SagalovaO.Chelyabinsk State Medical Academy Chelyabinsk Russian Federation. Hepatitis C in Russia from the Ministry of Health and Social Development. Conversation with Razavi HA. Center for Disease Analysis Kromite Louisville CO USA 15 July 2010.

Asratian AA, 2005, Tendency and analysis of the epidemic situation in parenteral virus hepatitis B and C in the Russian Federation and a number of its regions, Zh Mikrobiol Epidemiol Immunobiol, 4, 40

10.1002/jmv.20467

MaksyutovRA GavrilovaEV KanevAN.The distribution of genotypes of hepatitis C in the Russian regions. Annual All‐Russian Congress on Infectious Diseases Moscow 29–31 March 2010 Moscow 186.

Ariamkina OL., 2005, HCV infection in Ulyanovsk region. Epidemiologiia i infektsionnye bolezni, Epidemiol Infect Dis, 4, 14

Kovalev SI, 2003, Genetic variations of hepatitis C virus circulating in the Ural region, Vopr Virusol, 48, 11

L'vov DK, 1995, Prevalence of genotypes of the hepatitis C virus, circulating in northwestern and central parts of Russia, Vopr Virusol, 40, 251

10.1157/13083370

10.1016/j.jhep.2007.07.031

10.1157/13090276

10.1128/JCM.43.10.5403-5404.2005

Sola R, 2002, Prevalence of hepatitis B and hepatitis C viruses in different counties of Catalonia, Spain, cross-sectional study, 119, 90

10.1002/jmv.2091

10.1002/hep.20515

10.1097/00042737-200105000-00003

10.1016/S0213-005X(02)72743-2

10.1157/13062888

10.1016/S0213-005X(04)73152-3

10.1016/S0025-7753(02)72417-2

Prieto Domingo JJ, 1997, Prevalence of hepatitis C virus and excessive consumption of alcohol in a nonhospital worker population, Gastroenterol Hepatol, 20, 479

Suarez A, 1997, The prevalence of hepatitis A, B and C viral markers in the population of Gijon between 26 and 65 years old, Gastroenterol Hepatol, 20, 347

Ferrer F, 1997, A comparative study of two third‐generation anti‐hepatitis C virus ELISAs, Haematologica, 82, 690

Munoz‐Gomez R, 1996, Hepatitis C virus infection in Spanish volunteer blood donors, HCV RNA analysis and liver disease, 8, 273

Garcia‐Bengoechea M, 1995, Antibodies to hepatitis C virus, a cross-sectional study in patients attending a trauma unit or admitted to hospital for elective surgery, 7, 237

Suarez A, 1994, The prevalence of anti‐HCV positivity among blood donors in Asturias. A clinical–epidemiologic study, Med Clin, 103, 606

10.1007/978-3-7091-5633-9_53

10.7326/0003-4819-115-6-443

Martinez JL, 1991, Hepatitis C virus infection in different risk groups and among blood donors, Enferm Infecc Microbiol Clin, 9, 345

Martin Y, 1990, Incidence of anti‐HCV and ALT in blood donors, Sangre, 35, 197

Salmeron J, 1998, Epidemiology and prevalence of seropositivity for hepatitis C virus in pregnant women in Granada, Rev Esp Enferm Dig, 90, 841

Sacristan B, 1996, Seroepidemiologic study of hepatitis C virus infection in a general population from the region of La Rioja, Spain, Med Clin, 107, 331

Gil Miguel A, 1996, Prevalence of hepatitis C virus infection in school children in an urban and suburban area of Madrid, Aten Primaria, 17, 521

Garcia‐Fulgueiras A, 1996, Prevalence of hepatitis B and C markers in the south‐east of Spain, an unlinked community-based serosurvey of 2,203 adults, 28, 17

Salleras L, 1994, Seroepidemiology of hepatitis C virus infection in pregnant women in Catalonia, Med Clin, 103, 721

Jaqueti J, 1991, Prevalence of antibodies against the hepatitis C virus among the staff of a general hospital, Rev Esp Enferm Dig, 80, 33

Muga R, 2006, Significant reductions of HIV prevalence but not of hepatitis C virus infections in injection drug users from metropolitan Barcelona, 1987–2001, 82, S29

Lumbreras B, 2006, Impact of hepatitis C infection on long‐term mortality of injecting drug users from 1990 to 2002, differences before and after HAART, 20, 111

Jimenez Fabrega X, 1999, The prevalence of infection by the hepatitis B, C and human immunodeficiency viruses in drug users, Aten Primaria, 24, 368

10.1023/A:1007410707801

10.1093/ije/25.1.204

Payeras Cifre A, 1992, Hepatitis C viral infection and the consumption of intravenous drugs, Rev Sanid Hig Publica, 66, 233

Ramos B, 2007, Changes in the distribution of hepatitis C virus (HCV) genotypes over time in Spain according to HIV serostatus, implications for HCV therapy in HCV/HIV-coinfected patients, 54, 173

Fernandez‐Arcas N, 2006, High prevalence of hepatitis C virus subtypes 4c and 4d in Malaga (Spain), phylogenetic and epidemiological analyses, 78, 1429

10.1016/j.transproceed.2005.02.050

10.1016/S0210-5705(03)70381-1

Duberg A, 2008, The epidemiology of hepatitis C virus infection in Sweden, Euro Surveill, 13, 1, 10.2807/ese.13.21.18882-en

10.1111/j.1365-2893.2010.01276.x

10.1007/BF01716280

Lidman C, 2009, Hepatitis C infection among injection drug users in Stockholm Sweden, prevalence and gender, 41, 679

10.1080/003655200750023246

10.1016/S0163-4453(95)80028-X

10.1097/00001721-199412003-00004

European Centre for Disease Prevention and Control., 2008, Annual Epidemiological Report on Communicable Diseases in Europe 2008. Report on the State of Communicable Diseases in the EU and EEA/EFTA Countries

10.1016/j.jcv.2005.02.002

Widell A, 2000, Hepatocellular carcinoma in Sweden, its association with viral hepatitis, especially with hepatitis C viral genotypes, 32, 147

Westin J, 1999, Chronic hepatitis C in Sweden, genotype distribution over time in different epidemiological settings, 31, 355

Widell A, 1994, Genotyping of hepatitis C virus isolates by a modified polymerase chain reaction assay using type specific primers, epidemiological applications, 44, 272

Prasad L, 2007, Cohort Profile, the Swiss Hepatitis C Cohort Study (SCCS), 36, 731

10.1111/j.1365-2893.2009.01113.x

Federal Office of Public Health (FOPH).Health in Switzerland Switzerland 27 August 2010.

10.1007/s10654-006-9023-z

10.1093/eurpub/11.4.425

Ladewig D., 2001, A reduction in HIV positive and an increase in hepatitis C positive subjects in methadone maintenance treatments, Swiss Med Wkly, 131, 422

10.1097/00002030-199815000-00018

10.1016/S0168-8278(97)80244-9

Russmann S, 2007, Prevalence and associated factors of viral hepatitis and transferrin elevations in 5036 patients admitted to the emergency room of a Swiss university hospital, cross-sectional study, 7, 5

Ambuhl PM, 2000, Epidemiology of chronic hepatitis B and C among dialysis patients in Switzerland, Schweiz Med Wochenschr, 130, 341

10.1099/00222615-41-4-220

Zucca E, 2000, Prevalence of Helicobacter pylori and hepatitis C virus infections among non‐Hodgkin's lymphoma patients in Southern Switzerland, Haematologica, 85, 147

10.1016/S0168-8278(01)00032-0

Lavanchy D, 1994, Evaluation of third‐generation assays for detection of anti‐hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100‐3 antigen, J Clin Microbiol, 32, 2272, 10.1128/jcm.32.9.2272-2275.1994

Prasad LR, 2007, Hepatitis C in a sample of pregnant women in Switzerland, seroprevalence and socio-demographic factors, 137, 27

10.1097/00042737-200201000-00006

NegroF.Divisions of Clinical Pathology and of Gastroenterology and Hepatology University Hospital Geneva Switzerland. Newly diagnosed case data from the Swiss Federal Office of Public Health. Conversation with Razavi HA. Center for Disease Analysis Kromite Louisville CO USA 5 November 2010.

Swiss Federal Statistical Office.The population of Switzerland 2009 Federal Office of Statistics Bern 2010 Statistics of Switzerland. 01 Population 16pp 30 cm.

10.1016/j.ijid.2008.07.005

Turhan V, 2005, Investigation of the genotype distribution of hepatitis C virus among Turkish population in Turkey and various European countries, Chin Med J, 118, 1392

Keskin F, 2010, Transmission routes for chronic hepatitis C and its relation with HCV genotypes, Turk J Gastroenterol, 21, 396, 10.4318/tjg.2010.0126

10.1159/000070757

Tozun N, 2010, A nationwide prevalence study and risk factors for hepatitis A, B, C,and D infections in Turkey (abstract), Hepatology, 52, 697A

Dursun M, 2004, Prevalence of Hepatitis C in adults in the south‐eastern region of Anatolia, a community-based study, 29, 75

Yildirim B, 2009, Seroprevalence of hepatitis B and C viruses in the province of Tokat in the Black Sea region of Turkey, a population-based study, 20, 27

Gunduz T, 2005, Evaluation of hepatitis B surface antigen, anti‐hepatitis C virus and anti‐human immunodeficiency virus antibodies and syphilis seropositivity in blood donors, six years' seropositivity, 25, 155

10.4103/0255-0857.42074

10.1007/s10654-006-0001-2

10.1177/147323000403200613

Mutlu B, 2004, Seroprevalence of hepatitis B and C virus, human immunodeficiency virus and syphilis in the blood donors, Mikrobiyol Bul, 38, 445

10.3748/wjg.v12.i42.6792

Sakarya S, 2004, Effect of preventive applications on prevalence of hepatitis B virus and hepatitis C virus infections in West Turkey, Saudi Med J, 25, 1070

Demirturk N, 2006, Hepatitis B and C virus in West‐Central Turkey, seroprevalence in healthy individuals admitted to a university hospital for routine health checks, 17, 267

10.1007/BF01715499

10.1016/j.contraception.2009.02.011

10.1007/s00404-009-1145-6

Alim A, 2009, Seroprevalence of hepatitis B and C viruses, HIV, and syphilis infections among engaged couples, Saudi Med J, 30, 541

Maral I, 2009, Hepatitis B virus and hepatitis C virus seroprevalence in the elderly living in nursing homes, J Investig Med, 57, 717, 10.2310/JIM.0b013e3181ab8cab

10.1016/j.ijid.2007.07.003

10.1007/s00705-004-0363-2

10.1111/j.1365-2893.1995.tb00045.x

Costella, Annastella and Health Protection Agency United Kingdom., 2008, Hepatitis C in the UK 2008. The Health Protection Agency Annual Report

Health Protection Scotland.Blood Borne Viruses and Sexually Transmitted Infections. Hepatitis C Reporting. Table 3: Persons in Scotland reported to be hepatitis C antibody positive by age group at time of earliest positive specimen and year of earliest positive specimen 2010 31 December 2009 Available athttp://www.documents.hps.scot.nhs.uk/bbvsti/annual‐data‐tables/2010/hcv‐table3‐2010‐05.pdf(accessed 17 September 2010).

Hutchinson SJ, 2006, Hepatitis C virus infection in Scotland, epidemiological review and public health challenges, 51, 8

10.1177/0962280208094691

Goldberg D, 2008, Hepatitis C Action Plan for Scotland: Phase II (May 2008–March 2011), Euro Surveill, 13, 1, 10.2807/ese.13.21.18876-en

Sweeting MJ, 2009, Hepatitis C infection among injecting drug users in England and Wales (1992–2006), there and back again?, 170, 352

10.1017/S0950268808001660

10.1093/pubmed/fdp067

10.1111/j.1365-2893.2007.00855.x

Roy KM, 2007, Hepatitis C virus infection among injecting drug users in Scotland, a review of prevalence and incidence data and the methods used to generate them, 135, 433

Judd A, 2005, Incidence of hepatitis C virus and HIV among new injecting drug users in London, prospective cohort study, 330, 24

10.1136/sti.79.4.301

Hope VD, 2001, Prevalence of hepatitis C among injection drug users in England and Wales, is harm reduction working?, 91, 38

Taylor A, 2000, Prevalence of hepatitis C virus infection among injecting drug users in Glasgow 1990–1996, are current harm reduction strategies working?, 40, 176

10.1093/pubmed/22.4.531

Lamden KH, 1998, Hepatitis B and hepatitis C virus infections, risk factors among drug users in Northwest England, 37, 260

Watson JP, 1996, Hepatitis C virus, epidemiology and genotypes in the north east of England, 38, 269

10.1111/j.1365-2893.1995.tb00071.x

10.1111/j.1423-0410.1992.tb01202.x

10.1017/S0950268809002143

Hutchinson SJ, 2004, Hepatitis C virus among childbearing women in Scotland, prevalence, deprivation, and diagnosis, 53, 593

10.1053/jinf.2002.1059

Goldberg D, 2001, Hepatitis C virus among high and low risk pregnant women in Dundee, unlinked anonymous testing, 108, 365

10.1136/gut.48.1.116

10.1017/S0950268800004696

10.1017/S0950268899004598

Ward C, 2000, Prevalence of hepatitis C among pregnant women attending an inner London obstetric department, uptake and acceptability of named antenatal testing, 47, 277

10.1017/S0950268800068539

10.1136/gut.48.5.707

10.1002/(SICI)1096-9071(199906)58:2<127::AID-JMV5>3.0.CO;2-K

Saiz dlH, 2011, Hepatitis C and B prevalence in Spanish prisons, Eur J Clin Microbiol Infect Dis, 10.1007/s10096-011-1166-5

10.1111/j.1478-3231.2011.02494.x

Gish RG, 2005, Management of hepatitis C virus in special populations, patient and treatment considerations, 3, 311

10.1016/j.cld.2005.05.003

10.1002/hep.510290311

10.1056/NEJM199212313272702

Gerlach JT, 2003, Acute hepatitis C, high rate of both spontaneous and treatment-induced viral clearance, 125, 80

10.1097/QAD.0b013e3281053a0c

10.1053/j.gastro.2009.02.006

Jauffret‐Roustide M, 2006, Impact of a harm‐reduction policy on HIV and hepatitis C virus transmission among drug users, recent French data – the ANRS-Coquelicot Study, 41, 1603

Garfein RS, 1996, Viral infections in short‐term injection drug users, the prevalence of the hepatitis C, hepatitis B, human immunodeficiency, and human T-lymphotropic viruses, 86, 655