Một đánh giá hệ thống về giá trị tiện ích trạng thái sức khỏe cho ung thư tuyến giáp

Springer Science and Business Media LLC - Tập 30 - Trang 675-702 - 2020
Rachel Houten1, Nigel Fleeman1, Eleanor Kotas1,2, Angela Boland1, Tosin Lambe1, Rui Duarte1
1Liverpool Reviews and Implementation Group, University of Liverpool, Liverpool, UK
2York Health Economics Consortium, University of York, York, UK

Tóm tắt

Giá trị tiện ích trạng thái sức khỏe thường được sử dụng để thông báo đánh giá kinh tế và xác định hiệu quả chi phí của một can thiệp. Mục tiêu của đánh giá hệ thống này là tổng hợp các giá trị tiện ích có sẵn để đại diện cho chất lượng cuộc sống liên quan đến sức khỏe (HRQoL) của bệnh nhân mắc ung thư tuyến giáp. Tám cơ sở dữ liệu điện tử đã được tìm kiếm từ tháng 1 năm 1999 đến tháng 4 năm 2019 cho các nghiên cứu bao gồm việc đánh giá HRQoL cho bệnh nhân mắc ung thư tuyến giáp. Các ước lượng tiện ích được chiết xuất từ nhiều nguồn khác nhau (bảng hỏi EuroQol 5 chiều (EQ-5D), phương pháp trao đổi thời gian [TTO] và phương pháp đánh cược tiêu chuẩn [SG]). Ngoài ra, các ước lượng tiện ích được tạo ra bằng cách lập bản đồ từ SF-36 và EORTC QLQ-30 đến bộ giá trị EQ-5D-3L của Vương quốc Anh bằng cách sử dụng các thuật toán lập bản đồ đã được công bố. Các tìm kiếm đã xác định 33 nghiên cứu đủ điều kiện. Hai mươi sáu nghiên cứu báo cáo HRQoL cho bệnh nhân mắc ung thư tuyến giáp biệt hóa và bảy nghiên cứu cho bệnh nhân mắc ung thư tuyến giáp nói chung. Chúng tôi đã xác định các nghiên cứu sử dụng các phương pháp và công cụ khác nhau để định lượng HRQoL ở bệnh nhân mắc ung thư tuyến giáp, chẳng hạn như EQ-5D-3L, SF-36, EORTC QLQ-30 và các kỹ thuật SG và TTO để ước tính các giá trị tiện ích. Các ước lượng tiện ích dao động từ 0,205 (bệnh nhân mắc ung thư tuyến giáp biệt hóa nguy cơ thấp) đến các giá trị tiện ích gần như trung bình của dân số Vương quốc Anh (sau khi phẫu thuật cắt bỏ tuyến giáp thành công và điều trị bằng i-ốt phóng xạ). Các ước lượng tiện ích cho các trạng thái sức khỏe khác nhau, qua các phân loại ung thư tuyến giáp và các can thiệp được trình bày. Một danh mục các giá trị tiện ích được cung cấp để sử dụng khi thực hiện mô hình kinh tế cho ung thư tuyến giáp; bằng cách bao gồm các giá trị đã được lập bản đồ, cách tiếp cận này mở rộng phạm vi các trạng thái sức khỏe có thể được xem xét trong mô hình hiệu quả chi phí.

Từ khóa

#giá trị tiện ích #ung thư tuyến giáp #HRQoL #đánh giá kinh tế #mô hình hiệu quả chi phí

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