A study of the immunohistochemical profile of bladder cancer in neuro-urological patients by the French Association of Urology
Tóm tắt
To establish whether the expression of markers of cell differentiation (CK7, CK14, CK20, GATA3), apoptosis (p53), proliferation (Ki67, STAG2) and peri-tumoural lymphocytes (CD3, CD8), provides specific information about urothelial carcinogenesis in neuro-urological patients with bladder cancer (NBC). Tissue samples from NBC were retrieved from 15 centres in France and compared to control samples from non neuro-urological patients with bladder cancer (NNBC) and from neuro-urological patients without bladder cancer (NB). The expression of CK7, CK14, CK20, GATA3, p53, Ki67, STAG2, CD3 and CD8 markers was analysed using immunohistochemistry of tissue microarray sections. Overall, tissue samples from 124 patients were included in the study (n = 72 NBC, n = 26 NNBC and n = 26 NB). Muscle invasive bladder cancer (MIBC) was found in 52 NBC patients (72.2%) and squamous cell differentiation in 9 (12.5%). In NBC samples, the expression of CK20 and GATA3 was significantly more frequent in NMIBC compared to MIBC (p = 0.015 and p = 0.004, respectively). CK20 and GATA3 were significantly more expressed in NBC compared to NNBC (p < 0.001 and p = 0.010, respectively). The expression of CK14, Ki67, CD3 and CD8 was significantly more frequent in NBC than in NNBC samples (p = 0.005, p < 0.001, p < 0.001 and p < 0.001, respectively). The expression of CD3 and CD8 was similar in NBC and NB samples. In NBC, markers of basal differentiation, proliferation and peri-tumoural lymphocytes were significantly more expressed compared to NNBC controls. These results suggest the aggressiveness of NBC and the role of chronic inflammation in the carcinogenesis of bladder cancer in neuro-urological patients.
Tài liệu tham khảo
IARC, Cancer Today (2021) Estimated number of new cases in 2020, worldwide, both sexes, all ages.
https://gco.iarc.fr/today/online-analysis-table
citation_journal_title=Eur Urol Oncol; citation_title=What Is the prognostic and clinical importance of urothelial and nonurothelial histological variants of bladder cancer in predicting oncological outcomes in patients with muscle-invasive and metastatic bladder cancer? A European Association of Urology muscle invasive and metastatic bladder cancer guidelines panel systematic review; citation_author=E Veskimäe, EL Espinos, HM Bruins, Y Yuan, R Sylvester, AM Kamat, SF Shariat, JA Witjes, EM Compérat; citation_volume=2; citation_publication_date=2019; citation_pages=625-642; citation_doi=10.1016/j.euo.2019.09.003; citation_id=CR2
citation_journal_title=Eur Urol; citation_title=Epidemiology of bladder cancer: a systematic review and contemporary update of risk factors in 2018; citation_author=MGK Cumberbatch, I Jubber, PC Black, F Esperto, JD Figueroa, AM Kamat, L Kiemeney, Y Lotan, K Pang, DT Silverman, A Znaor, JWF Catto; citation_volume=74; citation_publication_date=2018; citation_pages=784-795; citation_doi=10.1016/j.eururo.2018.09.001; citation_id=CR3
citation_journal_title=Neurourol Urodyn; citation_title=Prevalence, management, and prognosis of bladder cancer in patients with neurogenic bladder: a systematic review; citation_author=S Ismail, G Karsenty, E Chartier-Kastler, O Cussenot, E Compérat, M Rouprêt, V Phé; citation_volume=37; citation_publication_date=2018; citation_pages=1386-1395; citation_doi=10.1002/nau.23457; citation_id=CR4
citation_journal_title=Spinal Cord; citation_title=Bladder cancer in individuals with spinal cord injuries; citation_author=B Welk, A McIntyre, R Teasell, P Potter, E Loh; citation_volume=51; citation_publication_date=2013; citation_pages=516-521; citation_doi=10.1038/sc.2013.33; citation_id=CR5
citation_journal_title=Urol Ann; citation_title=Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: analysis of 125 cases; citation_author=B Arslan, IH Bozkurt, T Yonguc, E Vardar, T Degirmenci, Z Kozacioglu, B Gunlusoy, S Minareci; citation_volume=7; citation_publication_date=2015; citation_pages=177-182; citation_doi=10.4103/0974-7796.150533; citation_id=CR6
citation_journal_title=Urol Oncol; citation_title=Molecular pathways of urothelial development and bladder tumorigenesis; citation_author=M Castillo-Martin, J Domingo-Domenech, O Karni-Schmidt, T Matos, C Cordon-Cardo; citation_volume=28; citation_publication_date=2010; citation_pages=401-408; citation_doi=10.1016/j.urolonc.2009.04.019; citation_id=CR7
citation_journal_title=Virchows Arch; citation_title=Different immunohistochemical and ultrastructural phenotypes of squamous differentiation in bladder cancer; citation_author=NT Gaisa, T Braunschweig, N Reimer, J Bornemann, E Eltze, S Siegert, M Toma, L Villa, A Hartmann, R Knuechel; citation_volume=458; citation_publication_date=2011; citation_pages=301-312; citation_doi=10.1007/s00428-010-1017-2; citation_id=CR8
citation_journal_title=Cancer Cell; citation_title=Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy; citation_author=W Choi, S Porten, S Kim, D Willis, ER Plimack, J Hoffman-Censits, B Roth, T Cheng, M Tran, I-L Lee, J Melquist, J Bondaruk, T Majewski, S Zhang, S Pretzsch, K Baggerly, A Siefker-Radtke, B Czerniak, CPN Dinney, DJ McConkey; citation_volume=25; citation_publication_date=2014; citation_pages=152-165; citation_doi=10.1016/j.ccr.2014.01.009; citation_id=CR9
citation_journal_title=Can J Urol; citation_title=Analysis of bladder cancer subtypes in neurogenic bladder tumors; citation_author=Q Manach, O Cussenot, M Rouprêt, X Gamé, E Chartier-Kastler, C Reus, P Camparo, E Compérat, V Phé; citation_volume=25; citation_publication_date=2018; citation_pages=9161-9167; citation_id=CR10
citation_journal_title=Eur Urol; citation_title=A prognostic gene expression signature in the molecular classification of chemotherapy-naïve urothelial cancer is predictive of clinical outcomes from neoadjuvant chemotherapy: a phase 2 trial of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin with bevacizumab in urothelial cancer; citation_author=DJ McConkey, W Choi, Y Shen, I-L Lee, S Porten, SF Matin, AM Kamat, P Corn, RE Millikan, C Dinney, B Czerniak, AO Siefker-Radtke; citation_volume=69; citation_publication_date=2016; citation_pages=855-862; citation_doi=10.1016/j.eururo.2015.08.034; citation_id=CR11
citation_journal_title=J Buon; citation_title=Relationship of TP53 and Ki67 expression in bladder cancer under WHO 2004 classification; citation_author=L Wang, C Feng, G Ding, Z Zhou, H Jiang, Z Wu; citation_volume=18; citation_publication_date=2013; citation_pages=420-424; citation_id=CR12
citation_journal_title=Pathol Res Pract; citation_title=Relationship of Ki67, TP53, MDM-2 and BCL-2 expressions with WHO 1973 and WHO/ISUP grades, tumor category and overall patient survival in urothelial tumors of the bladder; citation_author=II Gönül, N Akyürek, A Dursun, B Küpeli; citation_volume=204; citation_publication_date=2008; citation_pages=707-717; citation_doi=10.1016/j.prp.2008.03.011; citation_id=CR13
citation_journal_title=Tumour Biol; citation_title=Ki67 and TP53 expressions predict recurrence of non-muscle-invasive bladder cancer; citation_author=L Wang, C Feng, G Ding, Q Ding, Z Zhou, H Jiang, Z Wu; citation_volume=35; citation_publication_date=2014; citation_pages=2989-2995; citation_doi=10.1007/s13277-013-1384-9; citation_id=CR14
citation_journal_title=Clin Cancer Res; citation_title=Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease; citation_author=V Margulis, SF Shariat, R Ashfaq, AI Sagalowsky, Y Lotan; citation_volume=12; citation_publication_date=2006; citation_pages=7369-7373; citation_doi=10.1158/1078-0432.CCR-06-1472; citation_id=CR15
citation_journal_title=N Engl J Med; citation_title=Accumulation of nuclear p53 and tumor progression in bladder cancer; citation_author=D Esrig, D Elmajian, S Groshen, JA Freeman, JP Stein, SC Chen, PW Nichols, DG Skinner, PA Jones, RJ Cote; citation_volume=331; citation_publication_date=1994; citation_pages=1259-1264; citation_doi=10.1056/NEJM199411103311903; citation_id=CR16
citation_journal_title=Nat Genet; citation_title=Frequent truncating mutations of STAG2 in bladder cancer; citation_author=DA Solomon, J-S Kim, J Bondaruk, SF Shariat, Z-F Wang, AG Elkahloun, T Ozawa, J Gerard, D Zhuang, S Zhang, N Navai, A Siefker-Radtke, JJ Phillips, BD Robinson, MA Rubin, B Volkmer, R Hautmann, R Küfer, PCW Hogendoorn, G Netto, D Theodorescu, CD James, B Czerniak, M Miettinen, T Waldman; citation_volume=45; citation_publication_date=2013; citation_pages=1428-1430; citation_doi=10.1038/ng.2800; citation_id=CR17
citation_journal_title=Hum Mol Genet; citation_title=Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes; citation_author=CF Taylor, FM Platt, CD Hurst, HH Thygesen, MA Knowles; citation_volume=23; citation_publication_date=2014; citation_pages=1964-1974; citation_doi=10.1093/hmg/ddt589; citation_id=CR18
citation_journal_title=Clin Cancer Res; citation_title=STAG2 is a biomarker for prediction of recurrence and progression in papillary non–muscle-invasive bladder cancer; citation_author=A Lelo, F Prip, BT Harris, D Solomon, DL Berry, K Chaldekas, A Kumar, J Simko, JB Jensen, P Bhattacharyya, C Mannion, J-S Kim, G Philips, L Dyrskjøt, T Waldman; citation_volume=24; citation_publication_date=2018; citation_pages=4145-4153; citation_doi=10.1158/1078-0432.CCR-17-3244; citation_id=CR19
citation_journal_title=Urology; citation_title=Role of chronic catheterization in the development of bladder cancer in patients with spinal cord injury; citation_author=DA West, JM Cummings, WE Longo, KS Virgo, FE Johnson, RO Parra; citation_volume=53; citation_publication_date=1999; citation_pages=292-297; citation_doi=10.1016/S0090-4295(98)00517-2; citation_id=CR20
citation_journal_title=J Urol; citation_title=B cell infiltration and lymphonodular hyperplasia in bladder submucosa of patients with persistent bacteriuria and recurrent urinary tract infections; citation_author=TA Schlager, R LeGallo, D Innes, JO Hendley, CA Peters; citation_volume=186; citation_publication_date=2011; citation_pages=2359-2364; citation_doi=10.1016/j.juro.2011.07.114; citation_id=CR21
citation_journal_title=PLoS ONE; citation_title=Presence of lymphocytic infiltrate cytotoxic T lymphocyte CD3+, CD8+, and immunoscore as prognostic marker in patients after radical cystectomy; citation_author=A Yu, JJ Mansure, S Solanki, DR Siemens, M Koti, ABT Dias, MM Burnier, F Brimo, W Kassouf; citation_volume=13; citation_publication_date=2018; citation_doi=10.1371/journal.pone.0205746; citation_id=CR22