A study of methoxyflurane anaesthesia

Canadian Journal of Anaesthesia - Tập 8 - Trang 210-215 - 1961
R. A. Millar1, M. E. Morris1
1Department of Anaesthesia, Montreal Neurological Institute & McGill University, Montreal

Tóm tắt

Methoxyflurane anaesthesia in dogs produced respiratory depression, a gradual moderate decline in blood pressure with minimal changes in heart rate, and no significant effect on blood glucose or plasria adrenaline and noradrenaline levels. Hypercarbia induced an immediate hypotensive response-and caused sigruficant increases in both catecholamines; haemorrhage was followed by significant increases in plasma adrenaline. Blood glucose increased as a result of hypercarbia and haemorrhage during methoxyfluran0e anaesthesia.

Tài liệu tham khảo

Artusio, J. F., Poznak, A.;Hunt, R. E.;Tiers, F. M.; &Alexander, M. Methoxyflurane in Man. Anesthesiology21: 512 (1960). Poznak, A., Ray, B. S., &Artusio, J. F., Jr. Methoxyflurane as an Anesthetic for Neurological Surgery. J. Neurosurg.17: 477 (1960). Millar, R. A., Keener, E. B., &BeVfey, B. G. Plasma Adrenaline and Noradlrenaline After Phenoxybenzamine, and during Haemorrhagic Hypotension in Normal and Adrenal- ectomized Dogs. Brit. J. Pharmacol.14: 9 (1959). Somogyi, M. Determination of Blood Sugar. J. Biol. Chejin.160: 69 (1945). Somogyi, M. Notes on Sugar Determination. J.Biol. Chem.196: 19 (1952). Astrup, P. A Simple Electrometric Technique for the Determination of Carbon Dioxide Tension in Blood and Plasma, Total Content of Carbon Eioxide in Plasma, and Bicarbonate Content in “Separated” Plasma at a Fixed Carbon Dioxide Tension (40 mm. Hg). Scand. J. Clin. Lab. Invest.8: 33 (1956). Millar, R. A., &Morris, M. E. Induced Sympathetic Stimulation during Halothane Anaesthesia. Canad. Anaesth. Soc. J.7: 423 (1960). Millar, R. A., &Morris, M. E. To be published. Wasmuth, C. E.;Grieg, J. H.;Homi, J.;Moraca, P.;NiyIzi, H.;Bitte, E. M.; &Hale, D. Methoxyfiurane-A New Anesthetic Agent: A Clinical Evaluation Based onI 206 Cases. Cleveland Clinic Quarterly27: 174 (1960).