A study of elevated red cell distribution width (RDW) in early-onset neonatal sepsis
Tóm tắt
Neonatal sepsis is a serious infection occurring within the first 28 days of life. It is a significant cause of mortality and morbidity. Red cell distribution width (RDW) is estimated within the standard CBC profile and considered a simple tool for the diagnosis of neonatal sepsis without additional cost. Our aim in this study is to investigate the potential role of red cell distribution width (RDW) in the diagnosis of early-onset neonatal sepsis (EONS). The aim of our study is to detect the role of red cell distribution width (RDW) in the diagnosis and prognosis of early-onset neonatal sepsis (EONS). This case-control study was conducted at the NICU of Beni-Suef University Hospital and revealed that RDW% was highly significantly higher among cases than among controls (16.65 ± 4.28, 11.13 ± 0.62, respectively); regarding the severity of neonatal sepsis, we divided our cases into three groups (sepsis group includes 21 neonates, severe sepsis group includes 31 neonates, and septic shock group includes 48 neonates), there were statistically significant differences between the three groups (sepsis, severe sepsis, and septic shock) regarding RDW (15.15 ± 1.65, 16.78 ± 2.01, 17.02 ± 2.02, respectively) as P value (0.027). This study revealed that RDW is associated with the diagnosis and prognosis of early-onset neonatal sepsis, so further study is needed to prove causation as it is being simple, less expensive, available, and easily repeated as it is routinely done with CBC, so it will be a good indicator for prognosis of neonatal sepsis.
Tài liệu tham khảo
Sharma M, Yadav A, Yadav S, Goel N, Chudhary U (2008) Microbial profile of septicaemia in children. Indian J. 5(4):1–5
Money D, Allen VM (2016) The prevention of early-onset neonatal group B streptococcal disease. J Obstet Gynaecol Can 38(12):S326–S335
Nagao T, Hirokawa M (2017) Diagnosis and treatment of macrocytic anemias in adults. J Gen Fam Med. 18(5):200–204
Kim SH, Yeon JH, Park KN (2016) The association of red cell distribution width and hospital mortality in older adults admitted to the emergency department. Scand J Trauma Resusc Emerg Med. 24:81
Jandial A, Kumar S, Bhalla A, Sharma N, Varma N, Varma S (2017) Elevated red cell distribution width as a prognostic marker in severe sepsis: a prospective observational study. Indian J Crit Care Med. 21(9):552–562
Habibpour H, Torabi M, Mirzaee M (2019) The value of red cell (TASH) distribution width (RDW) and trauma-associated severe hemorrhage in predicting hospital mortality in multiple trauma patients. Bull Emerg Trauma 7(1):55–59
Mousa SO, Moustafa AN, Aly HM (2019) Prognostic value of red cell distribution width, platelet parameters, and the hematological scoring system in neonatal sepsis. Egypt J Haematol. 44:183–189
Goldestin B, Giroir B, Randolph A (2005) International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 6:2–8
Lott JW (2003) Neonatal bacterial sepsis. Crit Care Nurse Clin North AM. 15(1):35–65
Boskabadi A (2017) The evaluation of serum procalcitonin levels in neonatal infections. Int J Pediatr. 5(7):5287–5294
Chen J, Jin L, Yang T (2015) Clinical study of RDW and prognosis in sepsis new borns. Biomed Res 25(4):576–579
Förhécz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L (2009) Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 158:659–666
Chen PC, Sung FC, Chien KL, Hsu HC, Su TC, Lee YT (2010) Red blood cell distribution width and risk of cardiovascular events and mortality in a community cohort in Taiwan. Am J Epidemiol 171:214–220
Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC (2008) Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients. Scand J Clin Lab Investig 68:745–748
Saleh MA, Kasem YT, AMINHH (2017) Evaluation of neonatal sepsis and assessment of its severity by red cell distribution width indicator. Egypt J Commun Med 35(3):1–12
Kader A, Islam MS, Ferdoushi S, Chowdhury AA, Mortaz RE, Sultana T, Huda AQ, Nurullah A, Talukder SI, Ahmed AN (2015) Evaluation of red cell width in critically ill patients admitted in intensive care unit. Dinajpur Med Col J. 8(1):67–73
Hunziker S, Stevens J, Howell MD (2012) Red cell distribution width and mortality in newly hospitalized patients. Am J Med. 125:283–291