A split‐face study of intense pulsed light on photoaging skin in Chinese population

Lasers in Surgery and Medicine - Tập 42 Số 2 - Trang 185-191 - 2010
Yuan‐Hong Li1, Yan Wu2, John Z.S. Chen3, Xia Zhu2, Yuanyuan Xu2, Jing Chen2, Guang‐Hui Dong4, Xing‐Hua Gao2, Hong‐Duo Chen2
1Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, PR China.
2Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, PR China
3Sheftel Associates Dermatology, Tucson, Arizona
4Department of Biostatistics, China Medical University, Shenyang, PR China

Tóm tắt

AbstractBackground and ObjectivesIntense pulsed light (IPL) is regarded as the gold standard of nonablative photorejuvenation. Yet there is still a need to observe its efficacy and safety on dark skin using a split‐face module.Study Design/Materials and MethodsTwenty‐four Chinese women with photoaging were enrolled in this study. Patients were randomized to receive four IPL treatments at 3‐ to 4‐week intervals on one side of face, with the other side spared as control. Changes of photoaging were evaluated using a global evaluation, an overall self‐assessment, a Mexameter and a Corneometer. Skin biopsies were taken after four sessions of treatment on one side of face. The melanocyte density and the contents of melanin, collagen fibers, and elastic fibers were stained and used to evaluate the improvement on dyschromia and other signs of photoaging.ResultsThe global scores of photoaging on treated side decreased significantly from 3.02 to 1.22, while it remained unchanged on the untreated side. Twenty‐one of 24 patients (87.5%) rated their improvement as excellent or good. The difference on the values of melanin index and erythema index on treated side were significantly larger than those on untreated side after the 1st session, the 4th session and at 3‐month follow‐up (P<0.05). The melanin contents were significantly decreased and the collagen fibers were obviously increased only on treated side (P<0.05). Adverse effects of treated side were limited to mild pain and transient erythema.ConclusionUsing this split‐face module, IPL treatment is proved both clinically and histologically to be effective in treating photoaging skin in Chinese population. Adverse effects were minimal and acceptable. Lasers Surg. Med. 42:185–191, 2010. © 2010 Wiley‐Liss, Inc.

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Thông tin xuất bản

Lasers in Surgery and Medicine

Tập 42 Số 2

185-191

Thông tin tác giả