A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development

Bookout, 2003, A quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways, NURSA e-Journal, 1 Cai, 2004, Interaction of monocytes with vascular smooth muscle cells regulates monocyte survival and differentiation through distinct pathways, Arterioscler. Thromb. Vasc. Biol., 24, 2263, 10.1161/01.ATV.0000146552.16943.5e Chawla, 2001, A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis, Mol. Cell, 7, 161, 10.1016/S1097-2765(01)00164-2 Colinayo, 2002, Genetic characterization of the Dyscalc locus, Mamm. Genome, 13, 283, 10.1007/s00335-001-2148-1 Collins, 2002, Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines, J. Med. Chem., 45, 1963, 10.1021/jm0255116 Cybulsky, 1991, Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis, Science, 251, 788, 10.1126/science.1990440 Dolber, 1987, Picrosirius red staining of cardiac muscle following phosphomolybdic acid treatment, Stain Technol., 62, 23, 10.3109/10520298709107961 Edwards, 2002, BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis, J. Lipid Res., 43, 2, 10.1016/S0022-2275(20)30180-2 Febbraio, 2000, Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice, J. Clin. Invest., 105, 1049, 10.1172/JCI9259 Feng, 2003, Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis, Proc. Natl. Acad. Sci. USA, 100, 10423, 10.1073/pnas.1732494100 Gebe, 1997, Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins, J. Biol. Chem., 272, 6151, 10.1074/jbc.272.10.6151 Geng, 2002, Progression of atheroma: a struggle between death and procreation, Arterioscler. Thromb. Vasc. Biol., 22, 1370, 10.1161/01.ATV.0000031341.84618.A4 Glass, 2001, Atherosclerosis. the road ahead, Cell, 104, 503, 10.1016/S0092-8674(01)00238-0 Groen, 2001, Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL, J. Clin. Invest., 108, 843, 10.1172/JCI200112473 Haruta, 2001, Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytotic function of macrophages, J. Biol. Chem., 276, 22910, 10.1074/jbc.M100324200 Herz, 1992, LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation, Cell, 71, 411, 10.1016/0092-8674(92)90511-A Janowski, 1996, An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha, Nature, 383, 728, 10.1038/383728a0 Joseph, 2003, Reciprocal regulation of inflammation and lipid metabolism by liver X receptors, Nat. Med., 9, 213, 10.1038/nm820 Joseph, 2004, LXR-dependent gene expression is important for macrophage survival and the innate immune response, Cell, 119, 299, 10.1016/j.cell.2004.09.032 Kelly, 2003, The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice, Mamm. Genome, 14, 692, 10.1007/s00335-003-2273-0 Kockx, 2000, Apoptosis in atherosclerosis: beneficial or detrimental?, Cardiovasc. Res., 45, 736, 10.1016/S0008-6363(99)00235-7 Kolodgie, 2000, Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death, Am. J. Pathol., 157, 1259, 10.1016/S0002-9440(10)64641-X Kuwata, 2003, AIM inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice, Am. J. Pathol., 162, 837, 10.1016/S0002-9440(10)63880-1 Laffitte, 2001, LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proc. Natl. Acad. Sci. USA, 98, 507, 10.1073/pnas.98.2.507 Li, 2002, The macrophage foam cell as a target for therapeutic intervention, Nat. Med., 8, 1235, 10.1038/nm1102-1235 Libby, 2002, Inflammation in atherosclerosis, Nature, 420, 868, 10.1038/nature01323 Libby, 1996, Macrophages and atherosclerotic plaque stability, Curr. Opin. Lipidol., 7, 330, 10.1097/00041433-199610000-00012 Littlewood, 2003, Apoptotic cell death in atherosclerosis, Curr. Opin. Lipidol., 14, 469, 10.1097/00041433-200310000-00007 Liu, 2005, Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice, Arterioscler. Thromb. Vasc. Biol., 25, 174, 10.1161/01.ATV.0000148548.47755.22 Lusis, 2000, Atherosclerosis, Nature, 407, 233, 10.1038/35025203 Mallat, 1999, Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity, Circulation, 99, 348, 10.1161/01.CIR.99.3.348 Maxwell, 2003, Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice, J. Lipid Res., 44, 2109, 10.1194/jlr.M300203-JLR200 Mehrabian, 2001, Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia, Circ. Res., 89, 125, 10.1161/hh1401.093458 Miyazaki, 1999, Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily, J. Exp. Med., 189, 413, 10.1084/jem.189.2.413 Paigen, 1989, Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice, Genetics, 122, 163, 10.1093/genetics/122.1.163 Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha, Cell, 93, 693, 10.1016/S0092-8674(00)81432-4 Plump, 1992, Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells, Cell, 71, 343, 10.1016/0092-8674(92)90362-G Repa, 2000, The role of orphan nuclear receptors in the regulation of cholesterol homeostasis, Annu. Rev. Cell Dev. Biol., 16, 459, 10.1146/annurev.cellbio.16.1.459 Salvayre, 2002, Oxidized low-density lipoprotein-induced apoptosis, Biochim. Biophys. Acta, 1585, 213, 10.1016/S1388-1981(02)00343-8 Suzuki, 1997, A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection, Nature, 386, 292, 10.1038/386292a0 Tabas, 2004, Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol, Cell Death Differ., 11, S12, 10.1038/sj.cdd.4401444 Tangirala, 1995, Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice, J. Lipid Res., 36, 2320, 10.1016/S0022-2275(20)39713-3 Tangirala, 2002, Identification of macrophage liver X receptors as inhibitors of atherosclerosis, Proc. Natl. Acad. Sci. USA, 99, 11896, 10.1073/pnas.182199799 Tontonoz, 2003, Liver X receptor signaling pathways in cardiovascular disease, Mol. Endocrinol., 17, 985, 10.1210/me.2003-0061 Tupin, 2004, CD1d-dependent activation of NKT cells aggravates atherosclerosis, J. Exp. Med., 199, 417, 10.1084/jem.20030997 Valledor, 2004, Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis, Proc. Natl. Acad. Sci. USA, 101, 17813, 10.1073/pnas.0407749101 Venkateswaran, 2000, Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha, Proc. Natl. Acad. Sci. USA, 97, 12097, 10.1073/pnas.200367697 Welch, 2001, Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model, Proc. Natl. Acad. Sci. USA, 98, 7946, 10.1073/pnas.141239098