A role for the androgen-receptor in clinically localized and advanced prostate cancer

Jemal, 2007, Cancer statistics, 2007, CA: A Cancer Journal for Clinicians, 57, 43, 10.3322/canjclin.57.1.43 Parkin, 2005, Global cancer statistics, 2002, CA: A Cancer Journal for Clinicians, 55, 74, 10.3322/canjclin.55.2.74 Denmeade, 1996, Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer, Prostate, 28, 251, 10.1002/(SICI)1097-0045(199604)28:4<251::AID-PROS6>3.0.CO;2-G Huggins, 2002, Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941, The Journal of Urology, 168, 9, 10.1016/S0022-5347(05)64820-3 Chang, 1988, Molecular cloning of human and rat complementary DNA encoding androgen receptors, Science, 240, 324, 10.1126/science.3353726 Lubahn, 1988, Cloning of human androgen receptor complementary DNA and localization to the X chromosome, Science, 240, 327, 10.1126/science.3353727 Lubahn, 1988, The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate, Molecular Endocrinology (Baltimore, Md.), 2, 1265, 10.1210/mend-2-12-1265 Chang, 1989, Prostate androgen receptor: immunohistological localization and mRNA characterization, Journal of Steroid Biochemistry, 34, 311, 10.1016/0022-4731(89)90099-X Bartsch, 1990, Enzymes of androgen formation and degradation in the human prostate, Annals of the New York Academy of Sciences, 595, 53, 10.1111/j.1749-6632.1990.tb34282.x Habib, 1986, Androgen receptors in cancer of the prostate. Correlation with the stage and grade of the tumor, Cancer, 57, 2351, 10.1002/1097-0142(19860615)57:12<2351::AID-CNCR2820571219>3.0.CO;2-F Masai, 1990, Immunohistochemical study of androgen receptor in benign hyperplastic and cancerous human prostates, Prostate, 17, 293, 10.1002/pros.2990170405 Brendler, 1984, The use of multiple variables to predict response to endocrine therapy in carcinoma of the prostate: a preliminary report, The Journal of Urology, 131, 694, 10.1016/S0022-5347(17)50585-6 Benson, 1985, Androgen receptor binding activity in human prostate cancer, Cancer, 55, 382, 10.1002/1097-0142(19850115)55:2<382::AID-CNCR2820550215>3.0.CO;2-2 Mohler, 1996, Androgen and glucocorticoid receptors in the stroma and epithelium of prostatic hyperplasia and carcinoma, Clinical Cancer Research, 2, 889 Henshall, 2001, Altered expression of androgen receptor in the malignant epithelium and adjacent stroma is associated with early relapse in prostate cancer, Cancer Research, 61, 423 Kim, 1999, Immunohistochemical quantitation of androgen receptor expression using color video image analysis, Cytometry, 35, 2, 10.1002/(SICI)1097-0320(19990101)35:1<2::AID-CYTO2>3.0.CO;2-Y Pertschuk, 1994, Immunocytochemical assay for androgen receptors in prostate cancer: a prospective study of 63 cases with long-term follow-up, Annals of surgical oncology, 1, 495, 10.1007/BF02303615 Ricciardelli, 2005, Androgen receptor levels in prostate cancer epithelial and peritumoral stromal cells identify non-organ confined disease, Prostate, 63, 19, 10.1002/pros.20154 Miyamoto, 1993, Immunohistochemistry of the androgen receptor in human benign and malignant prostate tissue, The Journal of Urology, 149, 1015, 10.1016/S0022-5347(17)36284-5 Zhang, 1998, Immunolocalization of apolipoprotein D, androgen receptor and prostate specific antigen in early stage prostate cancers, The Journal of Urology, 159, 548, 10.1016/S0022-5347(01)63981-8 Tilley, 1994, Detection of discrete androgen receptor epitopes in prostate cancer by immunostaining: measurement by color video image analysis, Cancer Research, 54, 4096 Chodak, 1992, Nuclear localization of androgen receptor in heterogeneous samples of normal, hyperplastic and neoplastic human prostate, The Journal of Urology, 147, 798, 10.1016/S0022-5347(17)37389-5 de Winter, 1990, Androgen receptor heterogeneity in human prostatic carcinomas visualized by immunohistochemistry, The Journal of Pathology, 160, 329, 10.1002/path.1711600409 Pertschuk, 1995, Immunostaining for prostate cancer androgen receptor in paraffin identifies a subset of men with a poor prognosis, Laboratory Investigation, 73, 302 Sadi, 1993, Image analysis of androgen receptor immunostaining in metastatic prostate cancer. Heterogeneity as a predictor of response to hormonal therapy, Cancer, 71, 2574, 10.1002/1097-0142(19930415)71:8<2574::AID-CNCR2820710823>3.0.CO;2-1 Grossfeld, 1998, The role of stroma in prostatic carcinogenesis, Endocrine-Related Cancer, 5, 253, 10.1677/erc.0.0050253 Thompson, 1993, Genetic predisposition and mesenchymal-epithelial interactions in ras+myc-induced carcinogenesis in reconstituted mouse prostate, Molecular Carcinogenesis, 7, 165, 10.1002/mc.2940070307 Rowley, 1998, What might a stromal response mean to prostate cancer progression?, Cancer Metastasis Reviews, 17, 411, 10.1023/A:1006129420005 Arnold, 2002, Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault, Endocrine-Related Cancer, 9, 61, 10.1677/erc.0.0090061 Olapade-Olaopa, 1999, Malignant transformation of human prostatic epithelium is associated with the loss of androgen receptor immunoreactivity in the surrounding stroma, Clinical Cancer Research, 5, 569 Guileyardo, 1980, Prevalence of latent prostate carcinoma in two U.S. populations, Journal of the National Cancer Institute, 65, 311 Sakr, 1993, The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients, The Journal of Urology, 150, 379, 10.1016/S0022-5347(17)35487-3 Ries, 2000, The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer, Cancer, 88, 2398, 10.1002/(SICI)1097-0142(20000515)88:10<2398::AID-CNCR26>3.0.CO;2-I Bouchardy, 1991, Ethnicity and cancer risk in Sao Paulo, Brazil, Cancer Epidemiology, Biomarkers and Prevention, 1, 21 Gaston, 2003, Racial differences in androgen receptor protein expression in men with clinically localized prostate cancer, The Journal of Urology, 170, 990, 10.1097/01.ju.0000079761.56154.e5 Li, 2004, High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate: cancer patients treated with radical prostatectomy, American Journal of Surgical Pathology, 28, 928, 10.1097/00000478-200407000-00013 Pollack, 2003, Ki-67 staining is a strong predictor of patient outcome for prostate cancer patients treated with androgen deprivation plus radiotherapy: An analysis of RTOG 92-02, International Journal of Radiation Oncology Biology Physics, 57, 200, 10.1016/S0360-3016(03)01003-4 Ricciardelli C, Jackson M, Choong C, et al. Elevated levels of HER-2/neu and androgen receptor in clinically localized prostate cancer identifies metastatic potential. Prostate, in press. Sadi, 1991, Immunohistochemical study of androgen receptors in metastatic prostate cancer. Comparison of receptor content and response to hormonal therapy, Cancer, 67, 3057, 10.1002/1097-0142(19910615)67:12<3057::AID-CNCR2820671221>3.0.CO;2-S Takeda, 1996, Androgen receptor content of prostate carcinoma cells estimated by immunohistochemistry is related to prognosis of patients with stage D2 prostate carcinoma, Cancer, 77, 934, 10.1002/(SICI)1097-0142(19960301)77:5<934::AID-CNCR20>3.0.CO;2-3 Prins, 1998, Image analysis of androgen receptor immunostaining in prostate cancer accurately predicts response to hormonal therapy, The Journal of Urology, 159, 641, 10.1016/S0022-5347(01)63692-9 Nabi, 2004, Computer based receptogram approach: an objective way of assessing immunohistochemistry of androgen receptor staining and its correlation with hormonal response in metastatic carcinoma of prostate, Journal of Clinical Pathology, 57, 146, 10.1136/jcp.2003.010520 Mohler, 2004, The androgen axis in recurrent prostate cancer, Clinical Cancer Research, 10, 440, 10.1158/1078-0432.CCR-1146-03 van der Kwast, 1991, Androgen receptors in endocrine-therapy-resistant human prostate cancer, International Journal of Cancer, 48, 189, 10.1002/ijc.2910480206 Visakorpi, 1995, In vivo amplification of the androgen receptor gene and progression of human prostate cancer, Nature Genetics, 9, 401, 10.1038/ng0495-401 Feldman, 2001, The development of androgen-independent prostate cancer, Nature Reviews. Cancer, 1, 34, 10.1038/35094009 Gelmann, 2002, Molecular biology of the androgen receptor, Journal of Clinical Oncology, 20, 3001, 10.1200/JCO.2002.10.018 Grossmann, 2001, Androgen receptor signaling in androgen-refractory prostate cancer, Journal of the National Cancer Institute, 93, 1687, 10.1093/jnci/93.22.1687 Sadar, 1999, Prostate cancer: molecular biology of early progression to androgen independence, Endocrine-Related Cancer, 6, 487, 10.1677/erc.0.0060487 Klocker, 2007, Androgen receptor function in prostate cancer progression Chen, 2004, Molecular determinants of resistance to antiandrogen therapy, Natural Medicines, 10, 33, 10.1038/nm972 Taplin, 1995, Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer, The New England Journal of Medicine, 332, 1393, 10.1056/NEJM199505253322101 Taplin, 1999, Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist, Cancer Research, 59, 2511 Linja, 2001, Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer, Cancer Research, 61, 3550 Ford, 2003, Androgen receptor gene amplification and protein expression in recurrent prostate cancer, The Journal of Urology, 170, 1817, 10.1097/01.ju.0000091873.09677.f4 Gregory, 2001, Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen, Cancer Research, 61, 2892 Gregory, 2001, A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy, Cancer Research, 61, 4315 Agoulnik, 2006, Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer, Cancer Research, 66, 10594, 10.1158/0008-5472.CAN-06-1023 Guo, 2006, Regulation of androgen receptor activity by tyrosine phosphorylation, Cancer Cell, 10, 309, 10.1016/j.ccr.2006.08.021 Mahajan, 2007, Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation, Proceedings of the National Academy of Sciences of the United States of America, 104, 8438, 10.1073/pnas.0700420104 Shi, 1991, Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections, The Journal of Histochemistry and Cytochemistry, 39, 741, 10.1177/39.6.1709656 Kim, 1994, Semiautomated nuclear shape analysis of prostatic carcinoma and benign prostatic hyperplasia, Analytical and Quantitative Cytology and Histology, 16, 400 Gaston, 2002, A novel method for the analysis of the androgen receptor, Current Urology Reports, 3, 67, 10.1007/s11934-002-0013-8 Kim, 2002, Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft, The American Journal of Pathology, 160, 219, 10.1016/S0002-9440(10)64365-9 Coggins, 1993 Kim, 1993 Pappolla, 1988, Computerized image-analysis microspectroscopy of tissue sections, Archives of Pathology & Laboratory Medicine, 112, 787 Mofidi, 2003, Objective measurement of breast cancer oestrogen receptor status through digital image analysis, European Journal of Surgical Oncology, 29, 20, 10.1053/ejso.2002.1373 Blatt, 2004, Automated quantitative analysis of angiogenesis in the rat aorta model using Image-Pro Plus 4.1, Computer Methods and Programs in Biomedicine, 75, 75, 10.1016/j.cmpb.2003.11.001 1990 Otsu, 1979, A threshold selection method from gray-level histograms, IEEE Transactions on Systems, Man, and Cybernetics, 9, 62, 10.1109/TSMC.1979.4310076 1992, 229