A role for bursa fabricii and bursin in the ontogeny of the pineal biosynthetic activity in the chicken

Journal of Pineal Research - Tập 21 Số 1 - Trang 35-43 - 1996
B.J. Youbicier‐Simo1, F. Boudard2, Mourad Mekaouche3, J.D. Baylé3, M. Bastide2
1Laboratoire de Physiologie Générale, Université de Montpellier II, France.
2Laboratoire d'Immunologie et Parasitologie (MESR‐EA696), Faculté de Pharmacie, Universite de Montpellier I, Flahault, Montpellier cedex 1, France
3Laboratoire de Physiologie Generale, Universite de Montpellier II, Montpellier cedex

Tóm tắt

Abstract: The tripeptide bursin (Lys‐His‐Gly‐NH2) is a B cell differentiation hormone derived from the bursa fabricii. The latter is a cloacal diverticulum and the site of B lymphocyte differentiation and selection in aves; also the bursa fabricii is involved in endocrine functions. Herein we demonstrate that in the chicken, the bursa fabricii and bursin are crucial to the ontogeny of both the pineal response to antigenic challenge and pineal circadian synthetic activity. In early embryonically bursectomized chickens, the plasma melatonin response to immunization by porcine thyroglobulin (Tg) was abolished. Also, the amplitudes of both plasma melatonin and pineal N‐acetyltransferase (NAT) circadian rhythms were reduced by 50%, whereas the activity of hydroxyindole‐O‐methyltransferase (HIOMT) remained unchanged. Conversely, administration of either minute amounts (100 pg, 100 fg) or highly dilute (5 × 10−27 g) bursin, with the exception of a highest dose (100 μg), to bursaless embryos induced recovery of normal antigen‐induced melatonin response and normal amplitudes of melatonin and NAT rhythms. These findings establish that early in embryonic life, the bursa fabricii and its derived signal (bursin) are essential for normal development of pineal synthetic activity and underline the efficacy of very dilute bursin as an informative signal.

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Tài liệu tham khảo

Abdul‐Karim A.K., 1987, Development of basal and stress‐induced adrenocortical function in early bursectomized embryos and chickens, Life Sci. Adv., 6, 121

10.1126/science.3484838

10.1016/0167-5699(85)90007-6

Bastide M., 1995, Forum on Immunomodulators, 303

Bastide M., 1992, The Paradigm of Signifiers

Besedovsky O.H., 1977, Network of immune‐neuroendocrine interactions, Clin. Exp. Immunol., 27, 1

10.3181/00379727-150-39057

10.1016/0016-6480(75)90063-5

10.1126/science.181.4096.273-a

10.1007/BF01923946

10.1126/science.180600

10.1007/BF00188110

10.1002/aja.1001620205

10.1016/0016-6480(87)90073-6

Demangeat J.L., 1992, Modification du temps de relaxation RMN a 4MHz des protons du solvant dans les tres hautes dilutions salines de silice/lactose, J. Med. Nucl. Biophys., 16, 135

Endler P.C., 1995, Non‐molecular information transfer from thyroxine to frogs with regard to homeopathic toxicology, Vet. Hum. Toxicol., 37, 259

10.1002/jez.1402320336

Hadji L., 1992, Effect of dilute histamine on coronary flow of guinea‐pig isolated heart. Inhibition by a magnetic field, FASEB J., 5, 1583

Jacobs L., 1994, A randomized clinical trial in Nicaragua: Treatment of acute childhood diarrhea with homeopathy, Pediatrics, 5, 719, 10.1542/peds.93.5.719

10.1016/0008-8749(89)90080-4

10.1111/j.1600-079X.1993.tb00478.x

Maestroni G.J.M., 1989, Melatonin, stress and the immune system, Pineal Res. Rev., 7, 203

10.1016/0016-6480(80)90172-0

10.3181/00379727-178-42037

Toivanen A., 1981, Avian Immunology, 45

10.1016/0024-3205(86)90326-7

10.1016/0169-328X(88)90018-6

10.1126/science.3317827

Wight P.A.L., 1971, Development of sympathetic innervation of the pineal of the domestic fowl, Acta Morphol. Neerl. Scand., 9, 47

10.1089/jir.1990.10.403

Youbicier‐Simo B.J., 1990, DiplSme d'Etudes Approfondies, 15

Yolbicier‐Semo B.J.(1994)Etude Cinétique et Chronobiologique de l'lnfluence de la Bursectomie et de la Bursine sur les Activités Corticotropes Épiphysaires et Immunitaires Chez le Poulet.Thése de Diplôme de Doctorat Université de Montpelliern pp.180.

Youbicier‐Simo B.J., 1993, Effects of embryonic bursectomy and in ovo administration of highly diluted bursin on adrenocorticotropic and immune responses of chickens, Int. J. Immunother., 9, 169

Youbicier‐Simo B.J., 1996, Specific abolition reversal of pituitary‐adrenal activity and control of the humoral immunity in bursectomized chickens through highly dilute bursin, Int. J. Immunopathol. Pharmacol., 9

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Journal of Pineal Research

Tập 21 Số 1

35-43

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