A robust, integrated platform for comprehensive analyses of acyl-coenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development

Chen, 2019, Regulation of glucose and lipid metabolism in health and disease, Sci China Life Sci, 62, 1420, 10.1007/s11427-019-1563-3 Lam, 2013, Lipidomics as a principal tool for advancing biomedical research, J Genet Genomics, 40, 375, 10.1016/j.jgg.2013.06.007 Han, 2016, Lipidomics for studying metabolism, Nat Rev Endocrinol, 12, 668, 10.1038/nrendo.2016.98 Wang, 2020, Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression, J Genet Genomics, 47, 69, 10.1016/j.jgg.2019.11.009 Indiveri, 2011, The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology, Mol Aspects Med, 32, 223, 10.1016/j.mam.2011.10.008 Neely, 1974, Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle, Annu Rev Physiol, 36, 413, 10.1146/annurev.ph.36.030174.002213 Ramsay, 2001, Molecular enzymology of carnitine transfer and transport, Biochim Biophys Acta, 1546, 21, 10.1016/S0167-4838(01)00147-9 Snyder, 2014, Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme a thioesters, Rapid Commun Mass Spectrom, 28, 1840, 10.1002/rcm.6958 McCoin, 2015, Acylcarnitines–old actors auditioning for new roles in metabolic physiology, Nat Rev Endocrinol, 11, 617, 10.1038/nrendo.2015.129 Violante, 2013, Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines, FASEB J, 27, 2039, 10.1096/fj.12-216689 Ventura, 1998, Carnitine palmitoyltransferase II specificity towards beta-oxidation intermediates–evidence for a reverse carnitine cycle in mitochondria, Eur J Biochem, 253, 614, 10.1046/j.1432-1327.1998.2530614.x Morin-Rivron, 2017, Lipidomics analysis of long-chain fatty acyl-coenzyme as in liver, brain, muscle and adipose tissue by liquid chromatography/tandem mass spectrometry, Rapid Commun Mass Spectrom, 31, 344, 10.1002/rcm.7796 Neubauer, 2015, LC-MS/MS based analysis of coenzyme A and short-chain acyl-coenzyme a thioesters, Anal Bioanal Chem, 407, 6681, 10.1007/s00216-015-8825-9 Liu, 2015, High-resolution metabolomics with acyl-CoA profiling reveals widespread remodeling in response to diet, Mol Cell Proteomics, 14, 1489, 10.1074/mcp.M114.044859 Blachnio-Zabielska, 2011, Measuring long-chain acyl-coenzyme a concentrations and enrichment using liquid chromatography/tandem mass spectrometry with selected reaction monitoring, Rapid Commun Mass Spectrom, 25, 2223, 10.1002/rcm.5110 Zimmermann, 2013, Nontargeted profiling of coenzyme a thioesters in biological samples by tandem mass spectrometry, Anal Chem, 85, 8284, 10.1021/ac401555n Magnes, 2008, Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS, Anal Chem, 80, 5736, 10.1021/ac800031u Wang, 2017, Comprehensive analysis of short-, medium-, and long-chain acyl-coenzyme A by online two-dimensional liquid chromatography/mass spectrometry, Anal Chem, 89, 12902, 10.1021/acs.analchem.7b03659 Birse, 2010, High-fat-diet-induced obesity and heart dysfunction are regulated by the tor pathway in Drosophila, Cell Metab, 12, 533, 10.1016/j.cmet.2010.09.014 Carvalho, 2012, Effects of diet and development on the Drosophila lipidome, Mol Syst Biol, 8, 600, 10.1038/msb.2012.29 Heinrichsen, 2012, Role of high-fat diet in stress response of Drosophila, PLoS One, 7, 10.1371/journal.pone.0042587 Heinrichsen, 2014, Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster, Mol Metab, 3, 42, 10.1016/j.molmet.2013.10.003 Trindade de Paula, 2016, High-fat diet induces oxidative stress and MPK2 and HSP83 gene expression in Drosophila melanogaster, Oxid Med Cell Longev, 2016, 4018157, 10.1155/2016/4018157 Mancha, 1975, Fat metabolism in higher plants–determination of acyl-acyl carrier protein and acyl coenzyme A in a complex lipid mixture, Anal Biochem, 68, 600, 10.1016/0003-2697(75)90655-7 Lam, 2017, Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival, Redox Biol, 12, 967, 10.1016/j.redox.2017.05.002 Csardi, 2006, The igraph software package for complex network research, InterJournal Complex Systems, 1695 Williams, 2015, Database of gene co-regulation (dgcr): a web tool for analysing patterns of gene co-regulation across publicly available expression data, J Genomics, 3, 29, 10.7150/jgen.10888 Lu, 2019, High-coverage targeted lipidomics reveals novel serum lipid predictors and lipid pathway dysregulation antecedent to type 2 diabetes onset in normoglycemic Chinese adults, Diabetes Care, 42, 2117, 10.2337/dc19-0100 Kler, 1991, Quantitation of acyl-coA and acylcarnitine esters accumulated during abnormal mitochondrial fatty acid oxidation, J Biol Chem, 266, 22932, 10.1016/S0021-9258(18)54444-6 Jackson, 1999, Sequencing and functional expression of the malonyl-coA-sensitive carnitine palmitoyltransferase from Drosophila melanogaster, Biochem J, 341, 483, 10.1042/bj3410483 Price, 2010, Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues, J Biol Chem, 285, 7857, 10.1074/jbc.M109.072892 Bosveld, 2008, Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis, BMC Res Notes, 1, 75, 10.1186/1756-0500-1-75 Arduini, 1992, Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes, J Biol Chem, 267, 12673, 10.1016/S0021-9258(18)42330-7 Locasale, 2018, Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation, PLoS Biol, 16 Andrisic, 2018, Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer, Redox Biol, 14, 47, 10.1016/j.redox.2017.08.009 Nedic Erjavec, 2018, Short overview on metabolomic approach and redox changes in psychiatric disorders, Redox Biol, 14, 178, 10.1016/j.redox.2017.09.002 Lam, 2018, An integrated method for direct interrogation of sphingolipid homeostasis in the heart and brain tissues of mice through postnatal development up to reproductive senescence, Anal Chim Acta, 1037, 152, 10.1016/j.aca.2018.01.015