A robust coregistration method for <i>in vivo</i> studies using a first generation simultaneous PET/MR scanner

Medical Physics - Tập 37 Số 5 - Trang 1995-2003 - 2010
Thomas S.C. Ng1, Daniele Procissi1, Yue Wu2, Russell E. Jacobs1
1Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California 91125
2Department of Biomedical Engineering, University of California, Davis, Davis, California 95616

Tóm tắt

Purpose:Hybrid positron emission tomography (PET)/magnetic resonance (MR) imaging systems have recently been built that allow functional and anatomical information obtained from PET and MR to be acquired simultaneously. The authors have developed a robust coregistration scheme for a first generation small animal PET/MR imaging system and illustrated the potential of this system to study intratumoral heterogeneity in a mouse model.Methods:An alignment strategy to fuse simultaneously acquired PET and MR data, using the MR imaging gradient coordinate system as the reference basis, was developed. The fidelity of the alignment was evaluated over multiple study sessions. In order to explore its robustnessin vivo, the alignment strategy was applied to explore the heterogeneity of glucose metabolism in a xenograft tumor model, using to guide the acquisition of localized MR spectra within a single imaging session.Results:The alignment method consistently fused the PET/MR data sets with subvoxel accuracy (registration error voxels, ); this was independent of location within the field of view. When the system was used to study intratumoral heterogeneity within xenograft tumors, a correlation of high signal with high choline/creatine ratio was observed.Conclusions:The authors present an implementation of an efficient and robust coregistration scheme for multimodal noninvasive imaging using PET and MR. This setup allows time‐sensitive, multimodal studies of physiology to be conducted in an efficient manner.

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Medical Physics

Tập 37 Số 5

1995-2003

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