A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

Adams, 2000, The kelch repeat superfamily of proteins: propellers of cell function, Trends Cell Biol., 10, 17, 10.1016/S0962-8924(99)01673-6 Adegbite, 2019, Monitoring of efficacy, tolerability and safety of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial, Malar. J., 18, 1, 10.1186/s12936-019-3015-4 Amambua-Ngwa, 2017, Sustained ex vivo susceptibility of Plasmodium falciparum to artemisinin derivatives but increasing tolerance to artemisinin combination therapy partner quinolines in The Gambia, Antimicrob. Agents Chemother., 61, 10.1128/AAC.00759-17 Aninagyei, 2020, Characterization of putative drug resistant biomarkers in Plasmodium falciparum isolated from Ghanaian blood donors, BMC Infect. Dis., 20, 533, 10.1186/s12879-020-05266-2 Ariey, 2014, A molecular marker of artemisinin-resistant Plasmodium falciparum malaria, Nature, 505, 50, 10.1038/nature12876 Asua, 2020, Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda, J. Infect. Dis., 223, 985, 10.1093/infdis/jiaa687 Beavogui, 2020, Efficacy and safety of artesunate-amodiaquine and artemether-lumefantrine and prevalence of molecular markers associated with resistance, Guinea: an open-label two-arm randomised controlled trial, Malar. J., 19, 1, 10.1186/s12936-020-03290-w Bwire, 2020, Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in Southeast of Tanzania, Sci. Rep., 10, 3500, 10.1038/s41598-020-60549-7 Cortese, 2002, Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America, J. Infect. Dis., 186, 999, 10.1086/342946 Cowman, 1988, Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum, Proc. Natl. Acad. Sci. U. S. A., 85, 9109, 10.1073/pnas.85.23.9109 Dieckmann, 1986, Mechanisms of sulfadoxine resistance in Plasmodium falciparum, Mol. Biochem. Parasitol., 19, 143, 10.1016/0166-6851(86)90119-2 Dimbu, 2021, Continued low efficacy of artemether-lumefantrine in Angola, 2019, Antimicrob. Agents Chemother., 65, 10.1128/AAC.01949-20 Djimde, 2001, A molecular marker for chloroquine-resistant falciparum malaria, N. Engl. J. Med., 344, 257, 10.1056/NEJM200101253440403 Dondorp, 2009, Artemisinin resistance in Plasmodium falciparum malaria, N. Engl. J. Med., 361, 455, 10.1056/NEJMoa0808859 East African Network for Monitoring Antimalarial Treatment (EANMAT), 2001, Monitoring antimalarial drug resistance within National Malaria Control Programmes: the EANMAT experience, Trop. Med. Int. Health, 6, 10.1046/j.1365-3156.2001.00799.x East African Network for Monitoring Antimalarial Treatment (EANMAT), 2003, The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy, Trop. Med. Int. Health, 8, 10.1046/j.1360-2276.2003.01114.x Fidock, 2000, Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance, Mol Cell, 6, 861, 10.1016/S1097-2765(05)00077-8 Frosch, 2014, Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi, J. Infect. Dis., 210, 1110, 10.1093/infdis/jiu216 Gupta, 2020, Effect of mass dihydroartemisinin – piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance, PLoS ONE, 15, 10.1371/journal.pone.0240174 2013 Kamau, 2015, K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa, J. Infect. Dis., 211, 1352 Kayiba, 2020, Spatial and molecular mapping of Pfkelch13 gene polymorphism in Africa in the era of emerging Plasmodium falciparum resistance to artemisinin: a systematic review, Lancet Infect. Dis., 21, E82, 10.1016/S1473-3099(20)30493-X Kone, 2020, Different Plasmodium falciparum clearance times in two Malian villages following artesunate monotherapy, Int. J. Infect. Dis., 95, 399, 10.1016/j.ijid.2020.03.082 Laufer, 2006, Return of chloroquine antimalarial efficacy in Malawi, N. Engl. J. Med., 355, 1959, 10.1056/NEJMoa062032 Li, 2016, Limited artemisinin resistance-associated polymorphisms in Plasmodium falciparum K13-propeller and PfATPase6 gene isolated from Bioko Island, Equatorial Guinea, Int. J. Parasitol. Drugs Drug Resist., 6, 54, 10.1016/j.ijpddr.2015.11.002 Lo, 2017, Transmission dynamics of co-endemic Plasmodium vivax and P. falciparum in Ethiopia and prevalence of antimalarial resistant genotypes, PLoS Negl. Trop. Dis., 11, 1, 10.1371/journal.pntd.0005806 Mathieu, 2020, Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance, Elife, 9, 10.7554/eLife.51015 Matrevi, 2019, Plasmodium falciparum kelch propeller polymorphisms in clinical isolates from Ghana from 2007 to 2016, Antimicrob. Agents Chemother., 63, 10.1128/AAC.00802-19 Mayengue, 2018, No polymorphisms in K13-propeller gene associated with artemisinin resistance in Plasmodium falciparum isolated from Brazzaville, Republic of Congo, BMC Infect. Dis., 18, 538, 10.1186/s12879-018-3453-6 Miotto, 2015, Genetic architecture of artemisinin-resistant Plasmodium falciparum, Nat. Genet., 47, 226, 10.1038/ng.3189 Miotto, 2020, Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea, PLoS Pathog., 16, 10.1371/journal.ppat.1009133 Mita, 2007, Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia, Antimicrob. Agents Chemother., 51, 1071, 10.1128/AAC.01186-06 Moser, 2020, Describing the current status of Plasmodium falciparum population structure and drug resistance within mainland Tanzania using molecular inversion probes, Mol. Ecol., 30, 100, 10.1111/mec.15706 Mwai, 2009, Chloroquine resistance before and after its withdrawal in Kenya, Malar. J., 8, 106, 10.1186/1475-2875-8-106 Nag, 2019, Proof of concept: used malaria rapid diagnostic tests applied for parallel sequencing for surveillance of molecular markers of anti ‑ malarial resistance in Bissau, Guinea‑Bissau during 2014 – 2017, Malar. J., 18, 252, 10.1186/s12936-019-2894-8 Naidoo, 2011, Drug resistance maps to guide intermittent preventive treatment of malaria in African infants, Parasitology, 138, 1469, 10.1017/S0031182011000746 Noedl, 2008, Evidence of artemisinin-resistant malaria in western Cambodia, N. Engl. J. Med., 359, 2619, 10.1056/NEJMc0805011 Nzoumbou-Boko, 2020, Molecular assessment of kelch13 non-synonymous mutations in Plasmodium falciparum isolates from Central African Republic (2017-2019), Malar. J., 19, 1, 10.1186/s12936-020-03264-y Ogouyèmi-Hounto, 2016, Lack of artemisinin resistance in Plasmodium falciparum in northwest Benin after 10 years of use of artemisinin-based combination therapy, Parasite, 23, 28, 10.1051/parasite/2016028 Pacheco, 2019, Evolution and genetic diversity of the k13 gene associated with artemisinin delayed parasite clearance in Plasmodium falciparum, Antimicrob. Agents Chemother., 63, 10.1128/AAC.02550-18 Page, 2021, The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, BMJ, 372, n71, 10.1136/bmj.n71 Payne, 1987, Spread of chloroquine resistance in Plasmodium falciparum, Parasitol. Today, 3, 241, 10.1016/0169-4758(87)90147-5 Pearce, 2009, Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria, PLoS Med., 6, 10.1371/journal.pmed.1000055 Roper, 2004, Intercontinental spread of pyrimethamine-resistant malaria, Science, 305, 1124, 10.1126/science.1098876 Snow, 2017, The prevalence of Plasmodium falciparum in sub-Saharan Africa since 1900, Nature, 550, 515, 10.1038/nature24059 Snow, 2001, The past, present and future of childhood malaria mortality in Africa, Trends Parasitol., 17, 593, 10.1016/S1471-4922(01)02031-1 Straimer, 2015, Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates, Science, 347, 428, 10.1126/science.1260867 Talisuna, 2006, Pharmacovigilance of antimalarial treatment in Africa: is it possible?, Malar J., 5, 50, 10.1186/1475-2875-5-50 Tawe, 2018, Molecular surveillance of [lasmodium falciparum drug resistance markers in clinical samples from Botswana, Am. J. Trop. Med. Hyg., 99, 1499, 10.4269/ajtmh.18-0440 ter Kuile, 2007, Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review, J. Am. Med. Assoc., 297, 2603, 10.1001/jama.297.23.2603 Tun, 2015, Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker, Lancet Infect. Dis., 15, 415, 10.1016/S1473-3099(15)70032-0 Uwimana, 2020, Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda, Nat. Med., 26, 1602, 10.1038/s41591-020-1005-2 Uwimana, 2021, Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study, Lancet Infect. Dis., 10.1016/S1473-3099(21)00142-0 Wamae, 2019, No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites, Antimicrob. Agents Chemother., 63, 10.1128/AAC.01067-19 Wang, 2015, Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007-2012, Malar. J., 14, 168, 10.1186/s12936-015-0672-9 Wellems, 2001, Chloroquine-resistant malaria, J. Infect. Dis., 184, 770, 10.1086/322858 World Malaria report, 2020 Who Report on antimalarial efficacy, 2020 Who, 2012 Wwarn K13 Genotype-Phenotype Study Group, 2019, Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments-a WWARN individual patient data meta-analysis, BMC Med., 17, 1, 10.1186/s12916-018-1207-3 Yobi, 2020, The lack of K13-propeller mutations associated with artemisinin resistance in Plasmodium falciparum in Democratic Republic of Congo (DRC), PLoS ONE, 15, 10.1371/journal.pone.0237791