A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

Cancer Treatment Reviews - Tập 38 Số 6 - Trang 726-736 - 2012
Paul Cavuoto1, Michael Weinborn1
1CSIRO Food and Nutritional Sciences, P.O. Box 10041, Adelaide BC, SA 5000, Australia

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Stratton, 2009, The cancer genome, Nature, 458, 719, 10.1038/nature07943

World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of cancer: a global perspective, 2007. Available from: http://www.dietandcancerreport.org.

Cellarier, 2003, Methionine dependency and cancer treatment, Cancer Treat Rev, 29, 489, 10.1016/S0305-7372(03)00118-X

Zimmerman, 2003, Nutritional control of aging, Exp Gerontol, 38, 47, 10.1016/S0531-5565(02)00149-3

Finkelstein, 1990, Methionine metabolism in mammals, J Nutr Biochem, 1, 228, 10.1016/0955-2863(90)90070-2

Bolander-Gouaille, 2007

Zingg, 1997, Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis, Carcinogenesis, 18, 869, 10.1093/carcin/18.5.869

Sunden, 1997, Betaine–homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene, Arch Biochem Biophys, 345, 171, 10.1006/abbi.1997.0246

Anderson, 1998, Glutathione: an overview of biosynthesis and modulation, Chem Biol Interact, 111–112, 1, 10.1016/S0009-2797(97)00146-4

Thomas, 2001, Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications, Cell Mol Life Sci, 58, 244, 10.1007/PL00000852

Pirkov, 2008, A complete inventory of all enzymes in the eukaryotic methionine salvage pathway, FEBS J, 275, 4111, 10.1111/j.1742-4658.2008.06552.x

Quash, 1995, Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells, Biochem J, 305, 1017, 10.1042/bj3051017

Sugimura, 1959, Quantitative nutritional studies with water-soluble, chemically defined diets: VIII. The forced feeding of diets each lacking in one essential amino acid, Arch Biochem Biophys, 81, 448, 10.1016/0003-9861(59)90225-5

Buch, 1972, Inhibition of transfer ribonucleic acid methylase activity from several human tumors by nicotinamide and nicotinamide analogs, Biochemistry, 11, 393, 10.1021/bi00753a015

Halpern, 1974, The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture, Proc Natl Acad Sci USA, 71, 1133, 10.1073/pnas.71.4.1133

Breillout, 1990, Methionine dependency of malignant tumors: a possible approach for therapy, J Natl Cancer Inst, 82, 1628, 10.1093/jnci/82.20.1628

Hoffman, 1984, Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis, Biochim Biophys Acta, 738, 49

Lu, 2000, Molecular mechanisms of cell cycle block by methionine restriction in human prostate cancer cells, Nutr Cancer, 38, 123, 10.1207/S15327914NC381_17

Poirson-Bichat, 2000, Methionine depletion enhances the antitumoral efficacy of cytotoxic agents in drug-resistant human tumor xenografts, Clin Cancer Res, 6, 643

Guo, 1993, Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture, Cancer Res, 53, 2479

Hoffman, 1976, High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine, Proc Natl Acad Sci USA, 73, 1523, 10.1073/pnas.73.5.1523

Hoffman, 1978, Reversion to methionine independence by malignant rat and SV40-transformed human fibroblasts, Biochem Biophys Res Commun, 82, 228, 10.1016/0006-291X(78)90600-9

Hoffman, 1979, Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation, Proc Natl Acad Sci USA, 76, 1313, 10.1073/pnas.76.3.1313

Coalson, 1982, Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells, Proc Natl Acad Sci USA, 79, 4248, 10.1073/pnas.79.14.4248

Stern, 1983, Reduced free-methionine in methionine-dependent SV40-transformed human fibroblasts synthesizing apparently normal amounts of methionine, J Cell Physiol, 117, 9, 10.1002/jcp.1041170103

Behrmann, 2003, Characterization of methylthioadenosine phosphorylase (MTAP) expression in malignant melanoma, Am J Pathol, 163, 683, 10.1016/S0002-9440(10)63695-4

Garcia-Castellano, 2002, Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma, Clin Cancer Res, 8, 782

Komatsu, 2008, Identification of novel deletion polymorphisms in breast cancer, Int J Oncol, 33, 261

M’Soka, 2000, Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay, Leukemia, 14, 935, 10.1038/sj.leu.2401771

Nobori, 1991, Absence of methylthioadenosine phosphorylase in human gliomas, Cancer Res, 51, 3193

Schmid, 1998, Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC), Oncogene, 17, 2669, 10.1038/sj.onc.1202205

Nobori, 1994, Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers, Nature, 368, 753, 10.1038/368753a0

Nobori, 1996, Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers, Proc Natl Acad Sci USA, 93, 6203, 10.1073/pnas.93.12.6203

Brat, 1999, Molecular genetic alterations in radiation-induced astrocytomas, Am J Pathol, 154, 1431, 10.1016/S0002-9440(10)65397-7

Christopher, 2002, Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line, Cancer Res, 62, 6639

Tang, 2000, Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth, Cancer Res, 60, 5543

Lubin, 2009, Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy, PLoS One, 4, e5735, 10.1371/journal.pone.0005735

Kindler, 2009, A phase II multicenter study of l-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer, Invest New Drugs, 27, 75, 10.1007/s10637-008-9160-1

Basu, 2010, Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase, J Biol Chem, 286, 4902, 10.1074/jbc.M110.198374

Subhi, 2003, Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites, J Biol Chem, 278, 49868, 10.1074/jbc.M308451200

Kenyon, 2002, Methionine synthase activity and sulphur amino acid levels in the rat liver tumour cells HTC and Phi-1, Biochem Pharmacol, 63, 381, 10.1016/S0006-2952(01)00874-7

Stern, 1984, Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines, J Cell Physiol, 119, 29, 10.1002/jcp.1041190106

Drennan, 1994, How a protein binds B12: a 3.0A X-ray structure of B12-binding domains of methionine synthase, Science, 266, 1669, 10.1126/science.7992050

Beetstra, 2008, Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer, Cancer Epidemiol Biomarkers Prev, 17, 2565, 10.1158/1055-9965.EPI-08-0140

Tisdale, 1980, Methionine metabolism in Walker carcinosarcoma in vitro, Eur J Cancer, 16, 407, 10.1016/0014-2964(80)90360-6

Kimura, 2004, Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes, J Nutr, 134, 48, 10.1093/jn/134.1.48

McNulty, 2006, Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C→T polymorphism, Circulation, 113, 74, 10.1161/CIRCULATIONAHA.105.580332

Fiskerstrand, 1994, Development and reversion of methionine dependence in a human glioma cell line: relation to homocysteine remethylation and cobalamin status, Cancer Res, 54, 4899

Liteplo, 1991, Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells, J Cell Physiol, 149, 332, 10.1002/jcp.1041490222

Loewy, 2009, Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence, Mol Genet Metab, 96, 261, 10.1016/j.ymgme.2008.12.011

Watkins, 1998, Cobalamin metabolism in methionine-dependent human tumour and leukemia cell lines, Clin Invest Med, 21, 151

Ma, 2009, Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women, BMC Cancer, 9, 122, 10.1186/1471-2407-9-122

Lu, 2010, Methionine synthase A2756G polymorphism and breast cancer risk: a meta-analysis involving 18,953 subjects, Breast Cancer Res Treat, 123, 213, 10.1007/s10549-010-0755-9

Sharp, 2004, Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review, Am J Epidemiol, 159, 423, 10.1093/aje/kwh066

Linnebank, 2005, The methionine synthase polymorphism c.2756A right curved arrow G (D919G) is relevant for disease-free longevity, Int J Mol Med, 16, 759

Dhillon, 2009, Effect of common polymorphisms in folate uptake and metabolism genes on frequency of micronucleated lymphocytes in a South Australian cohort, Mutat Res, 665, 1, 10.1016/j.mrfmmm.2009.02.007

Bergstrom, 1987, PET study of methionine accumulation in glioma and normal brain tissue: competition with branched chain amino acids, J Comput Assist Tomogr, 11, 208, 10.1097/00004728-198703000-00002

Stern, 1984, Elevated overall rates of transmethylation in cell lines from diverse human tumors, In Vitro, 20, 663, 10.1007/BF02619617

Judde, 1989, Biochemical analysis of the role of transmethylation in the methionine dependence of tumor cells, Cancer Res, 49, 4859

Hoshiya, 1995, Human tumors are methionine dependent in vivo, Anticancer Res, 15, 717

Tang, 2009, Methionine-deficient diet induces post-transcriptional downregulation of cystathionine beta-synthase, Nutrition, 26, 1170, 10.1016/j.nut.2009.10.006

Epner, 2002, Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction, Nutr Cancer, 42, 158, 10.1207/S15327914NC422_2

Breillout, 1987, Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet, Anticancer Res, 7, 861

Guo, 1993, Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo, Cancer Res, 53, 5676

Komninou, 2006, Methionine restriction inhibits colon carcinogenesis, Nutr Cancer, 54, 202, 10.1207/s15327914nc5402_6

Theuer, 1971, Effect of essential amino acid restriction on the growth of female C57BL mice and their implanted BW10232 adenocarcinomas, J Nutr, 101, 223, 10.1093/jn/101.2.223

McCarty, 2009, The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy, Med Hypotheses, 72, 125, 10.1016/j.mehy.2008.07.044

Davey, 2003, EPIC-Oxford: lifestyle characteristics and nutrient intakes in a cohort of 33883 meat-eaters and 31546 non meat-eaters in the UK, Public Health Nutr, 6, 259, 10.1079/PHN2002430

Ornish, 2005, Intensive lifestyle changes may affect the progression of prostate cancer, J Urol, 174, 1065, 10.1097/01.ju.0000169487.49018.73

Caro, 2009, Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria, Rejuvenation Res, 12, 421, 10.1089/rej.2009.0902

Li, 2010, Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression, FASEB J, 24, 1442, 10.1096/fj.09-149328

Fenech, 2010, Nutriomes and nutrient arrays – the key to personalised nutrition for DNA damage prevention and cancer growth control, Genome Integr, 1, 11, 10.1186/2041-9414-1-11

Orentreich, 1993, Low methionine ingestion by rats extends life span, J Nutr, 123, 269

Richie, 1994, Methionine restriction increases blood glutathione and longevity in F344 rats, FASEB J, 8, 1302, 10.1096/fasebj.8.15.8001743

Miller, 2005, Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance, Aging Cell, 4, 119, 10.1111/j.1474-9726.2005.00152.x

Kreis, 1973, Isolation and purification of l-methionine-alpha-deamino-gamma-mercaptomethane-lyase (l-methioninase) from Clostridium sporogenes, Cancer Res, 33, 1862

Kreis, 1973, Biological effects of enzymatic deprivation of l-methionine in cell culture and an experimental tumor, Cancer Res, 33, 1866

Esaki, 1987, l-Methionine gamma-lyase from Pseudomonas putida and Aeromonas, Methods Enzymol, 143, 459, 10.1016/0076-6879(87)43081-4

Tan, 1996, Anticancer efficacy of methioninase in vivo, Anticancer Res, 16, 3931

Tan, 1997, Overexpression and large-scale production of recombinant l-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy, Protein Expr Purif, 9, 233, 10.1006/prep.1996.0700

Sun, 2003, In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5′-phosphate supplementation, Cancer Res, 63, 8377

Yang, 2004, Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates, Clin Cancer Res, 10, 2131, 10.1158/1078-0432.CCR-03-0068

Tan, 2010, Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells in vitro, Anticancer Res, 30, 1041

Hoffman, 1980, Reversible growth arrest in simian virus 40-transformed human fibroblasts, Proc Natl Acad Sci USA, 77, 7306, 10.1073/pnas.77.12.7306

Stern, 1986, Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect, J Natl Cancer Inst, 76, 629, 10.1093/jnci/76.4.629

Machover, 2001, Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid, Biochem Pharmacol, 61, 867, 10.1016/S0006-2952(01)00560-3

Goseki, 1990, Thiol depletion and chemosensitization on nimustine hydrochloride by methionine-depleting total parenteral nutrition, Tohoku J Exp Med, 161, 227, 10.1620/tjem.161.227

Goseki, 1995, Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial, Jpn J Cancer Res, 86, 484, 10.1111/j.1349-7006.1995.tb03082.x

Durando, 2008, Optimal methionine-free diet duration for nitrourea treatment: a phase I clinical trial, Nutr Cancer, 60, 23, 10.1080/01635580701525877

Durando, 2010, Dietary methionine restriction with FOLFOX regimen as first line therapy of metastatic colorectal cancer: a feasibility study, Oncology, 78, 205, 10.1159/000313700

Goldberg, 2005, Advances in the treatment of metastatic colorectal cancer, Oncologist, 10, 40, 10.1634/theoncologist.10-90003-40

Jagasia, 1996, Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas, Cancer Lett, 105, 91, 10.1016/0304-3835(96)04274-7

Jagasia, 1996, Partial deletions of the CDKN2 and MTS2 putative tumor suppressor genes in a myxoid chondrosarcoma, Cancer Lett, 105, 77, 10.1016/0304-3835(96)04273-5

Powell, 2005, Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications, Am J Surg Pathol, 29, 1497, 10.1097/01.pas.0000170349.47680.e8

Kim, 2006, Array-based comparative genomic hybridization of circulating esophageal tumor cells, Oncol Rep, 16, 1053

Kim, 2011, Downregulation of methylthioadenosine phosphorylase by homozygous deletion in gastric carcinoma, Genes Chromosomes Cancer, 50, 421, 10.1002/gcc.20867

Huang, 2009, Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors, Clin Cancer Res, 15, 6963, 10.1158/1078-0432.CCR-09-1511

Suzuki, 2004, Genetic analysis of human glioblastomas using a genomic microarray system, Brain Tumor Pathol, 21, 27, 10.1007/BF02482174

Zhang, 1996, Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-alpha1, interferon-beta1, and other 9p21 markers in human malignant cell lines, Cancer Genet Cytogenet, 86, 22, 10.1016/0165-4608(95)00157-3

Perry, 1997, Detection of p16 gene deletions in gliomas: a comparison of fluorescence in situ hybridization (FISH) versus quantitative PCR, J Neuropathol Exp Neurol, 56, 999, 10.1097/00005072-199709000-00005

Olopade, 1992, Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas, Cancer Res, 52, 2523

Efferth, 2002, Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells, Blood Cells Mol Dis, 28, 47, 10.1006/bcmd.2002.0483

Bertin, 2003, CDKN2A, CDKN2B, and MTAP gene dosage permits precise characterization of mono- and bi-allelic 9p21 deletions in childhood acute lymphoblastic leukemia, Genes Chromosomes Cancer, 37, 44, 10.1002/gcc.10188

Kamath, 2008, Double-minute MYC amplification and deletion of MTAP, CDKN2A, CDKN2B, and ELAVL2 in an acute myeloid leukemia characterized by oligonucleotide-array comparative genomic hybridization, Cancer Genet Cytogenet, 183, 117, 10.1016/j.cancergencyto.2008.02.011

Usvasalo, 2010, Focal 9p instability in hematologic neoplasias revealed by comparative genomic hybridization and single-nucleotide polymorphism microarray analyses, Genes Chromosomes Cancer, 49, 309, 10.1002/gcc.20741

Hori, 1998, The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia, Int J Cancer, 75, 51, 10.1002/(SICI)1097-0215(19980105)75:1<51::AID-IJC9>3.0.CO;2-0

Mirebeau, 2006, The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951, Haematologica, 91, 881

Marce, 2006, Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy, Clin Cancer Res, 12, 3754, 10.1158/1078-0432.CCR-05-2780

Dreyling, 1998, Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin’s lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma, Genes Chromosomes Cancer, 22, 72, 10.1002/(SICI)1098-2264(199805)22:1<72::AID-GCC10>3.0.CO;2-K

Krasinskas, 2010, CDKN2A and MTAP deletions in peritoneal mesotheliomas are correlated with loss of p16 protein expression and poor survival, Mod Pathol, 23, 531, 10.1038/modpathol.2009.186

Illei, 2003, Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas, Clin Cancer Res, 9, 2108

Mora, 2004, Comprehensive analysis of the 9p21 region in neuroblastoma suggests a role for genes mapping to 9p21–23 in the biology of favourable stage 4 tumours, Br J Cancer, 91, 1112, 10.1038/sj.bjc.6602094

Brownhill, 2007, Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT, Br J Cancer, 96, 1914, 10.1038/sj.bjc.6603819

Hustinx, 2005, Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy, Cancer Biol Ther, 4, 83, 10.4161/cbt.4.1.1380

Hustinx, 2005, Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion, Mod Pathol, 18, 959, 10.1038/modpathol.3800377

Chen, 1996, Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy, Cancer Res, 56, 1083

Wang, 2010, Tumor suppressor gene alterations of spontaneously malignant transformed cells from human embryonic muscle in vitro, Oncol Rep, 24, 555

Worsham, 2006, Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma, Arch Otolaryngol Head Neck Surg, 132, 409, 10.1001/archotol.132.4.409

Conway, 2010, Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma, Genes Chromosomes Cancer, 49, 425, 10.1002/gcc.20753