A retrospective analysis of the prevalence of dental diseases in patients with digestive system cancers

Medicine (United States) - Tập 98 Số 13 - Trang e14771 - 2019
Hironori Sakai1,2,3,4, Shin‐ichi Yamada1,2,3,4, Takahiko Gibo1,2,3,4, Nobuhiko Yoshimura1,2,3,4, Fumihiro Nishimaki1,2,3,4, Eiji Kondo1,2,3,4, Takahiro Kamata1,2,3,4, Hiroshi Kurita1,2,3,4
1Abbreviation: CPI = community periodontal index.
2Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Nagano, Japan
3Supplemental Digital Content is available for this article.
4Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.md-journal.com).

Tóm tắt

Abstract The relationship between dental diseases and the prevalence of digestive system cancers remains unclear. The aim of the present study was to examine the prevalence of dental diseases in patients treated for digestive system cancers. The medical and dental records of patients treated for digestive system cancers were retrospectively reviewed, and the results obtained (decayed/filled/missing teeth [DMFT] indices and community periodontal index [CPI] codes) were compared with data from the national survey of dental diseases in order to investigate the relationship between oral health and digestive system cancers. DMFT, D, and F indices were significantly lower, while the M index was slightly higher in digestive system cancer patients than in the national survey. The proportions of individuals with more than 20 residual teeth and denture wearers were significantly lower in cancer patients than in the national survey. The prevalence of periodontitis (CPI codes 3 and 4) and severe periodontitis (CPI code 4) were significantly higher in cancer patients than in the national survey. The present results showed that digestive system cancers were closely associated with multi-tooth loss and/or a low denture-wearing rate. The prevalence of severe periodontitis was also found to be higher in cancer patients. These results suggest that periodontitis and associated multi-tooth loss play a potential role in digestive system cancers.

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Tài liệu tham khảo

Crall, 2009, Oral health policy development since the Surgeon General's Report on Oral Health, Acad Pediatr, 9, 476, 10.1016/j.acap.2009.09.017

Demirer, 1990, Diet and stomach cancer incidence. A case-control study in Turkey, Cancer, 65, 2344, 10.1002/1097-0142(19900515)65:10<2344::AID-CNCR2820651030>3.0.CO;2-H

Watabe, 1998, Lifestyle and gastric cancer: a case-control study, Oncol Rep, 5, 1191

Abnet, 2001, Prospective study of tooth loss and incident esophageal and gastric cancers in China, Cancer Causes Control, 12, 847, 10.1023/A:1012290009545

Abnet, 2005, Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort, Int J Epidemiol, 34, 467, 10.1093/ije/dyh375

Abnet, 2005, Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers, Scand J Gastroenterol, 40, 681, 10.1080/00365520510015430

Guha, 2007, Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies, Am J Epidemiol, 166, 1159, 10.1093/aje/kwm193

Hiraki, 2008, Teeth loss and risk of cancer at 14 common sites in Japanese, Cancer Epidemiol Biomarkers Prev, 17, 1222, 10.1158/1055-9965.EPI-07-2761

Ljung, 2011, Oral disease and risk of oesophageal and gastric cancer in a nationwide nested case-control study in Sweden, Eur J Cancer, 47, 2128, 10.1016/j.ejca.2011.03.012

Salazar, 2012, Association between oral health and gastric precancerous lesions, Carcinogenesis, 33, 399, 10.1093/carcin/bgr284

Fox, 1994, Periodontal disease among New England elders, J Periodontol, 65, 676, 10.1902/jop.1994.65.7.676

Locker, 1989, Prevalence of and factors associated with root decay in older adults in Canada, J Dent Res, 68, 768, 10.1177/00220345890680050301

Papas, 1992, Prevalence and intraoral distribution of coronal and root caries in middle-aged and older adults, Caries Res, 26, 459, 10.1159/000261487

Klein, 1938, Studies on dental caries vs. familial resemblance in the caries experience of siblings, Public Health Rep, 53, 1353, 10.2307/4582622

Ainamo, 1982, Development of the World Health Organization (WHO) community periodontal index of treatment needs (CPITN), Int Dent J, 32, 281

Petersen, 2005, The global burden of oral diseases and risks to oral health, Bull World Health Organ, 83, 661

Dye, 2007, Trends in oral health status: United States, 1988∗–∗1994 and 1999∗–∗2004, Vital Health Stat 11, 248, 1

Griffin, 2009, Oral health needs among adults in the United States with chronic diseases, J Am Dent Assoc, 140, 1266, 10.14219/jada.archive.2009.0050

Beck, 2000, Oral disease, cardiovascular disease and systemic inflammation, Periodontol, 23, 110, 10.1034/j.1600-0757.2000.2230111.x

Fouque, 2008, A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease, Kidney Int, 73, 391, 10.1038/sj.ki.5002585

Abnet, 2008, Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma, Cancer Epidemiol Biomarkers Prev, 17, 3062, 10.1158/1055-9965.EPI-08-0558

Shimazaki, 2003, Risk factors for tooth loss in the institutionalised elderly; a six-year cohort study, Community Dent Health, 20, 123

Coussens, 2002, Inflammation and cancer, Nature, 420, 860, 10.1038/nature01322

Meisel, 2012, Association of periodontitis with the risk of oral leukoplakia, Oral Oncol, 48, 859, 10.1016/j.oraloncology.2012.02.022

Tezal, 2015, Is periodontitis associated with oral neoplasms?, J Periodontol, 76, 406, 10.1902/jop.2005.76.3.406

Nair, 1996, Endogenous formation of nitrosamines and oxidative DNA-damaging agents in tobacco users, Crit Rev Toxicol, 26, 149, 10.3109/10408449609017928

Marshall, 1984, Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration, Lancet, 1, 1311, 10.1016/S0140-6736(84)91816-6

Parsonnet, 1991, Helicobacter pylori infection and the risk of gastric carcinoma, N Engl J Med, 325, 1127, 10.1056/NEJM199110173251603

Andersen, 1998, Helicobacter pylori adheres selectively to Fusobacterium spp, Oral Microbiol Immunol, 13, 51, 10.1111/j.1399-302X.1998.tb00751.x

Al Asqah, 2009, Is the presence of Helicobacter pylori in dental plaque of patients with chronic periodontitis a risk factor for gastric infection?, Can J Gastroenterol, 23, 177, 10.1155/2009/950527

Hu, 2016, Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation, Oncotarget, 7, 66700, 10.18632/oncotarget.11449

Zheng, 2015, Relation between periodontitis and Helicobacter pylori infection, Int J Clin Exp Med, 8, 16741

Käyser, 1987, Overtreatment with removable partial dentures in shortened dental arches, Aust Dent J, 32, 178, 10.1111/j.1834-7819.1987.tb01851.x

Sheiham, 2001, Does the condition of the mouth and teeth affect the ability to eat certain foods, nutrient and dietary intake and nutritional status amongst older people?, Public Health Nutr, 4, 797, 10.1079/PHN2000116

Helkimo, 1978, Chewing efficiency and state of dentition. A methodologic study, Acta Odontol Scand, 36, 33, 10.3109/00016357809026364

Miyatake, 1992, 8020 movement, J Jpn Dent Assoc, 45, 1

Yamanaka, 2008, Comparison of the health condition between the 8020 achievers and the 8020 non-achievers, Int Dent J, 58, 146, 10.1111/j.1875-595X.2008.tb00190.x

Galvão-Moreira, 2016, Oral microbiome, periodontitis and risk of head and neck cancer, Oral Oncol, 53, 17, 10.1016/j.oraloncology.2015.11.013

Holmes, 2009, Is dental care utilization associated with oral cavity cancer in a large sample of community-based United States residents?, Community Dent Oral Epidemiol, 37, 134, 10.1111/j.1600-0528.2008.00450.x

Ahrens, 2014, Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study, Oral Oncol, 50, 616, 10.1016/j.oraloncology.2014.03.001

Sheiham, 2000, The common risk factor approach: a rational basis for promoting oral health, Community Dent Oral Epidemiol, 28, 399, 10.1034/j.1600-0528.2000.028006399.x

Weyant, 1993, Oral health status of a long-term-care, veteran population, Community Dent Oral Epidemiol, 21, 227, 10.1111/j.1600-0528.1993.tb00762.x

Lawrence, 1996, Adjustment of the M-component of the DMFS index for prevalence studies of older adults, Community Dent Oral Epidemiol, 24, 322, 10.1111/j.1600-0528.1996.tb00870.x

ElSalhy, 2018, Caries reporting in studies that used the International Caries Detection and Assessment System: a scoping review, Community Dent Oral Epidemiol, 47, 92, 10.1111/cdoe.12430

Pitts, 2004, ICDAS – an international system for caries detection and assessment being developed to facilitate caries epidemiology, research and appropriate clinical management, Community Dent Health, 21, 193

Melgar, 2016, Differential impacts of caries classification in children and adults: a comparison of ICDAS and DMF-T, Braz Dent J, 27, 761, 10.1590/0103-6440201600990

Hong, 2010, A systematic review of dental disease in patients undergoing cancer therapy, Support Care Cancer, 18, 1007, 10.1007/s00520-010-0873-2

Toljanic, 1999, A prospective pilot study to evaluate a new dental assessment and treatment paradigm for patients scheduled to undergo intensive chemotherapy for cancer, Cancer, 85, 1843, 10.1002/(SICI)1097-0142(19990415)85:8<1843::AID-CNCR26>3.0.CO;2-R