A retrospective analysis of surgical treatment for breast malignant tumors
Tóm tắt
Objective: To review the evolution of the current surgical treatment for breast malignant tumors over the past twenty years in the First Hospital of Jilin University (the former Bethune University of Medical Sciences). Methods: 1195 eligible patients with primary breast malignant tumor diagnosed and surgically treated at the First Teaching Hospital from January 1980 and December 2000 were retrospectively analyzed. Results: The peak frequency was in 40–49 years of age (40.00%), the age of the patients with breast malignant tumors trends to become young. The most common pTNM classification was Stage II. The most common histological type was infiltrating ductal carcinoma (398 patients, 33.31%), and simple carcinoma (279 patients, 23.53%). Modified radical mastectomy was the most common operation procedure performed (779 patients, 65.19%), and was increasingly used while radical mastectomy was adopted decreasingly in recent decade. Conclusion: The variation of operation procedures performed on patients with breast malignant tumors reflected the advance of our understanding of the biology of cancer and the progression of new treatment principles.
Tài liệu tham khảo
Caroline L, Jackson J, Jones A, et al. Relationship between tumor location relapse in 6,781 women with early invasive breast cancer [J]. J Clin Oncol 2000; 18: 2828.
Litcher AS, Lippman ME, Danfoth DN, et al. Mastectomy versus breast-conserving therapy in the treatment of stage I and stage II carcinoma of the breast: A randomized trial at the National Cancer Institute [J]. J Clin Oncol 1992; 10: 976.
Fisher B, Redmond C, Fisher ER, et al. Ten year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without irradiation [J]. N Engl J Med 1985; 312: 674.
Fisher B, Redmond C, Poisson R, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer [J]. N Engl J Med 1989; 320: 822.
Jacobson JA, Danforth DN, Cowan KH, et al. Ten year results of a comparison of conservation with mastectomy in the treatment of stage I and stage II breast cancer [J]. N Engl J Med 1995; 332: 907.
Jatoi I, Hilsenbeck SG, Clark GM, et al. Significance of axillary lymph node metastasis in primary breast cancer [J]. J Clin Oncol 1999; 17: 2334–2340.
Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast cancer and ovarian cancer susceptibility gene BRCA1 [J]. Science 1994; 266: 66.
Futreal A, Liu Q, ShattuckEidens D, et al. Mutations in primary breast and ovarian carcinomas [J]. Science 1994; 266:120.
Simard J, Tonin P, Durocher F, et al. Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families [J]. Nature Genet 1994; 8: 392.
Friedman L, Ostermeyer EA, Szabo CI, et al. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families [J]. Nature Genet 1994; 8: 399.
Wooster R, Neuhausen S, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12–13 [J]. Science 1994; 265:2088.
Silvestrini R, Daidone MG, Luisi A, et al. Cell proliferation in 3,800 node-negative breast cancers: Consistency over time of biological and clinical information provided by 3H-thymidine labeling index [J]. Int J Cancer 1997; 74:122.
Liljegren G, Holmberg L, Bergh J, et al. 10-year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: A randomized trial [J]. J Clin Oncol 1999; 17:2326.
Amadori D, Nanni O, Marangolo M, et al. Disease-free survival advantage of adjuvant Cyclophosphamide, Methotrexate, and Fluororacil in patients with node-negative, rapidly proliferating breast cancer: A randomized multicenter study [J]. J Clin Oncol 2000; 18:3125.
Kent Osborne C. Steroid hormone receptors in breast cancer management [J]. Breast Cancer Res Treat 1998; 51:227.
Sobin LH, Wittekind C. TNM classification of malignant tumors [M]. 5th ed. New York: John Wiley & Sons Inc. 1997; 123.
Lefall LD Jr. 100 years of breast cancer: Halsted to Fisher [J]. Am College Surg Bull 1994; 79:12.