A randomised trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy

Ankum, 1993, Laparoscopy: a dispensable tool in the diagnosis of ectopic pregnancy?, Hum Reprod, 8, 1301, 10.1093/oxfordjournals.humrep.a138246 Ory, 1992, New options for the diagnosis and treatment of ectopic pregnancy, JAMA, 267, 534, 10.1001/jama.1992.03480040082035 Landström, 1998, Treatment failures and complications of ectopic pregnancy: changes over a 20 year period, Hum Reprod, 13, 203, 10.1093/humrep/13.1.203 Fylstra, 1998, Tubal pregnancy: a review of current diagnosis and treatment, Obstet Gynecol Surv, 53, 320, 10.1097/00006254-199805000-00024 Pisarska, 1998, Ectopic pregnancy, Lancet, 351, 1115, 10.1016/S0140-6736(97)11476-3 Yao, 1997, Current status of surgical and nonsurgical management of ectopic pregnancy, Fertil Steril, 67, 421, 10.1016/S0015-0282(97)80064-7 Fernandez, 1993, Methotrexate treatment of ectopic pregnancy: 100 cases treated by primary transvaginal injection under sonographic control, Fertil Steril, 59, 773, 10.1016/S0015-0282(16)55858-0 Pansky, 1992, Methotrexate local injection of unruptured tubal pregnancy, Int J Obstet Gynaecol, 37, 265, 10.1016/0020-7292(92)90327-F Stovall, 1991, Methotrexate treatment of unruptured ectopic pregnancy: a report of 100 cases, Obstet Gynecol, 77, 749 Lipscomb, 1998, Analysis of three hundred fifteen ectopic pregnancies treated with single dose methotrexate, Am J Obstet Gynecol, 178, 1354, 10.1016/S0002-9378(98)70343-6 Wolf, 1994, Completely non-surgical management of ectopic pregnancies, Gynecol Obstet Invest, 37, 232, 10.1159/000292566 Gross, 1995, Ectopic pregnancy: non-surgical, outpatient evaluation and single dose methotrexate treatment, J Reprod Med, 40, 371 Lui, 1997, Il management conservativo della gravidanza ectopica (conservative management of ectopic pregnancy), Minerva Ginecol, 49, 67 Saidi, 1999, Use of laparoscopic surgery for the treatment of ectopic pregnancy in the UK: a national survey, Gynaecol Endoscopy, 8, 81, 10.1046/j.1365-2508.1999.00239.x Garry, 1999, Towards evidence-based management of tubal ectopic pregnancy, Gynae Endoscopy, 8, 65, 10.1046/j.1365-2508.1999.00240.x American College of Obstetricians and Gynecologists. Ectopic pregnancy. Technical Bulletin No. 150. 1990. Sowter, 2000, An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy, Br J Obstet Gynaecol, 204 Ankum, 1993, Transvaginal sonography and human chorionic gonadotrophin measurements in suspected ectopic pregnancy: a detailed analysis of a diagnostic approach, Hum Reprod, 8, 1307, 10.1093/oxfordjournals.humrep.a138247 Ware, 1993 Spielberger, 1970 Radloff, 1977, Scale: a self report depression scale for research in the general population, Appl Psychol Measurement, 1, 385, 10.1177/014662167700100306 De Haes, 1996 Kimble R, Masters J, Farquhar C. The management of ectopic pregnancy at National Women's Hospital 1994-1996. Abstract presented at The Fertility Society of Australia 14th Annual Scientific Meeting, October 1996, Queenstown, New Zealand. Stovall, 1993, Single-dose methotrexate: an expanded clinical trial, Am J Obstet Gynecol, 168, 1759, 10.1016/0002-9378(93)90687-E Cacciatore, 1994, Early screening for ectopic pregnancy in high-risk symptom-free women, Lancet, 343, 517, 10.1016/S0140-6736(94)91464-8 Mol, 1999, Can non-invasive diagnostic tools predict tubal rupture or active bleeding in patients with tubal rupture?, Fert Steril, 71, 167, 10.1016/S0015-0282(98)00418-X Hajenius, 1997, Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy, Lancet, 350, 774, 10.1016/S0140-6736(97)05487-1 Saraj, 1998, Resolution of hormonal markers of ectopic gestation: a randomised trial comparing single dose intramuscular methotrexate with salpingostomy, Obstet Gynecol, 92, 989, 10.1016/S0029-7844(98)00324-X Fernandez, 1998, Randomized trial of conservative laparoscopic treatment and methotrexate administration in ectopic pregnancy and subsequent fertility, Hum Reprod, 13, 3239, 10.1093/humrep/13.11.3239 Corsan, 1995, Identification of hormonal parameters for the successful systemic single dose methotrexate therapy in ectopic pregnancy, Hum Reprod, 10, 2719, 10.1093/oxfordjournals.humrep.a135774 Mol, 1999, The treatment of ectopic pregnancy in the Netherlands: an economic evaluation of systemic methotrexate and laparoscopic salpingostomy, Am J Obstet Gynecol, 181, 945, 10.1016/S0002-9378(99)70330-3 Lipscomb, 1999, Management of separation pain after single dose methotrexate therapy for ectopic pregnancy, Obstet Gynecol, 93, 590, 10.1016/S0029-7844(98)00523-7 Nieuwkerk, 1998, Systemic methotrexate therapy versus laparoscopic salpingostomy in patients with tubal pregnancy Part 1. Impact on patients’ health-related quality of life, Fertility and Sterility, 70, 511, 10.1016/S0015-0282(98)00212-X Grudzinkas, 1997, Problems in Early Pregnancy, 284 Henshaw, 1994, Psychological responses following medical abortion (using mifepristone and gemprost) and surgical vacuum aspiration. A patient centred, partially randomised prospective study, Acta Obstet Gynecol Scand, 73, 812, 10.3109/00016349409072511 Stika, 1996, Single-dose methotrexate for the treatment of ectopic pregnancy: Northwestern Memorial Hospital three-year experience, Am J Obstet Gynecol, 174, 1840, 10.1016/S0002-9378(96)70219-3 Thoen, 1997, Medical treatment of ectopic pregnancy with methotrexate, Fertil Steril, 68, 727, 10.1016/S0015-0282(97)00284-7 Hahlin, 1995, The expectant management of early pregnancies of uncertain site, Hum Reprod, 10, 1223, 10.1093/oxfordjournals.humrep.a136123 Shalev, 1995, Spontaneous resolution of ectopic tubal pregnancy: natural history, Fertil Steril, 63, 15, 10.1016/S0015-0282(16)57289-6 Trio, 1995, Prognostic factors for successful expectant management of ectopic pregnancy, Fertil Steril, 63, 469, 10.1016/S0015-0282(16)57410-X Carp, 1986, Fertility after non-surgical treatment of ectopic pregnancy, J Reprod Med, 31, 119 Korhonen, 1996, Low-dose oral methotrexate with expectant management of ectopic pregnancy, Obstet Gynecol, 88, 775, 10.1016/0029-7844(96)00293-1 Hajenius, 1998 Glock, 1994, Efficacy and safety of single dose systemic methotrexate in the treatment of ectopic pregnancy, Fertil Steril, 62, 716, 10.1016/S0015-0282(16)56994-5 Henry, 1994, Single injection of methotrexate for treatment of ectopic pregnancies, Am J Obstet Gynecol, 171, 1584, 10.1016/0002-9378(94)90406-5 Schäfer, 1994, Systemic treatment of ectopic pregnancies with single dose methotrexate, J Am Assoc Gynecol Laparosc, 1, 213, 10.1016/S1074-3804(05)81012-6 Yao, 1996, Treatment of ectopic pregnancy by systemic methotrexate, transvaginal methotrexate, and operative laparoscopy, Int J Fertil Menopausal Stud, 41, 470 Hidlebaugh, 1997, Clinical and financial analyses of ectopic pregnancy management at a large health plan, J Am Assoc Gynecol Laparosc, 4, 207, 10.1016/S1074-3804(97)80011-4 Ransom, 1994, Serum progesterone as a predictor of methotrexate success in the treatment of ectopic pregnancy, Obstet Gynecol, 83, 1033, 10.1097/00006250-199406000-00026 Stovall, 1993, Single-dose methotrexate: an expanded clinical trial, Am J Obstet Gynecol, 168, 1759, 10.1016/0002-9378(93)90687-E Jiménez-Caraballo, 1998, A 6-year clinical trial of methotrexate therapy in the treatment of ectopic pregnancy, Eur J Obstets Gynecol Reprod Biol, 79, 167, 10.1016/S0301-2115(98)00036-0 Pietrzak, 1999, Efficacy of methotrexate in the treatment of nonruptured ectopic pregnancy, Acta Obstet Gynecol Scand, 78, 259, 10.1080/j.1600-0412.1999.780315.x