A proteomic analysis of the mechanism of action of naphthoimidazoles in Trypanosoma cruzi epimastigotes in vitro

Moncayo, 2006, An update on Chagas' disease (human American trypanosomiasis), Ann Trop Med Parasitol, 100, 663, 10.1179/136485906X112248 Coura, 2002, A critical review on Chagas' disease chemotherapy, Mem Inst Oswaldo Cruz, 97, 3, 10.1590/S0074-02762002000100001 Jannin, 2007, An overview of Chagas' disease treatment, Mem Inst Oswaldo Cruz, 102, 95, 10.1590/S0074-02762007005000106 De Souza, 2002, From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality, Kinetoplastid Biol Dis, 1, 1, 10.1186/1475-9292-1-3 Soeiro, 2009, Trypanosoma cruzi targets for new chemotherapeutic approaches, Expert Opin Their Targets, 13, 105, 10.1517/14728220802623881 Pinto, 1997, Trypanocidal activity of synthetic heterocyclic derivatives of active quinones from Tabebuia sp, Arzneimittel-Forsch, 47, 74 Neves-Pinto, 2000, Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy, Arzneimittel-Forsch, 50, 1120 Moura, 2001, Synthesis and trypanocidal activity of naphthoquinones isolated from Tabebuia and heterocyclic derivatives: a review from an interdisciplinary study, J Braz Chem Soc, 12, 325, 10.1590/S0103-50532001000300003 Moura, 2004, Studies on the trypanocidal activity of semi-synthetic pyran[b-4, 3]naphtho[1, 2-d]imidazoles from β-lapachone, Eur J Med Chem, 39, 639, 10.1016/j.ejmech.2004.02.015 Menna-Barreto, 2005, Effect of a β-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles, J Antimicrob Chemother, 56, 1034, 10.1093/jac/dki403 Menna-Barreto, 2007, Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from β-lapachone, Parasitol Res, 101, 895, 10.1007/s00436-007-0556-1 Menna-Barreto, 2009, Naphthoimidazoles promote different death phenotypes in Trypanosoma cruzi, Parasitol, 136, 1, 10.1017/S0031182009005745 Ferella, 2008, Proteomics in Trypanosoma cruzi-localization of novel proteins to various organelles, Proteomics, 8, 2735, 10.1002/pmic.200700940 Parodi-Talice, 2004, Proteome analysis of the causative agent of Chagas' disease: Trypanosoma cruzi, Int J Parasitol, 34, 881, 10.1016/j.ijpara.2004.05.002 Andrade, 2008, Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole, J Proteome Res, 7, 2357, 10.1021/pr700659m Atwood, 2005, The Trypanosoma cruzi proteome, Science, 309, 473, 10.1126/science.1110289 Rabilloud T, Charmont S. Detection of proteins on two-dimensional electrophoresis gels. In: Rabilloud T (Ed.) Proteome Research: Two-Dimensional Gel Electrophoresis and Identification Methods. Springer, New York 2000, 107–126. Shevchenko, 1996, Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels, Proc Natl Acad Sci U S A, 93, 14440, 10.1073/pnas.93.25.14440 Keller, 2002, Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search, Anal Chem, 74, 5383, 10.1021/ac025747h Nesvizhskii, 2003, A statistical model for identifying proteins by tandem mass spectrometry, Anal Chem, 75, 4646, 10.1021/ac0341261 Beghini, 2004, Anti-sera raised in rabbits against crotoxin and phospholipase A2 from Crotalus durissus cascavella venom neutralize the neurotoxicity of the venom and crotoxin, Toxicon, 44, 141, 10.1016/j.toxicon.2004.05.011 Irigoín, 2008, Insights into the redox biology of Trypanosoma cruzi: trypanothione metabolism and oxidant detoxification, Free Radic Biol Med, 45, 733, 10.1016/j.freeradbiomed.2008.05.028 Piñeyro, 2008, Peroxiredoxins from Trypanosoma cruzi: virulence factors and drug targets for treatment of Chagas' disease?, Gene, 408, 45, 10.1016/j.gene.2007.10.014 Castro, 2008, Peroxidases of trypanosomatids, Antioxid Redox Signal, 10, 1593, 10.1089/ars.2008.2050 Borcsok, 1982, Mechanism of action of cystathionine synthase, Arch Biochem Biophys, 213, 695, 10.1016/0003-9861(82)90600-2 Pancholi, 2001, Multifunctional alpha-enolase: its role in diseases, Cell Mol Life Sci, 58, 902, 10.1007/PL00000910 Hannaert, 2003, Evolution of energy metabolism and its compartmentation in Kinetoplastida, Kinetoplastid Biol Dis, 2, 11, 10.1186/1475-9292-2-11 Brzezinski, 2008, Cytochrome c oxidase: exciting progress and remaining mysteries, J Bioenerg Biomembr, 40, 521, 10.1007/s10863-008-9181-7 Fang, 2003, Alternative oxidase present in procyclic Trypanosoma brucei may act to lower the mitochondrial production of superoxide, Arch Biochem Biophys, 414, 294, 10.1016/S0003-9861(03)00196-6 Kyoto Encyclopedia of Genes and Genomes. Trypanosoma cruzi database: 507689.50 (EC:3.4.-.). Website: http://www.genome.jp/kegg/ 2009. Menezes, 2006, Putrescine analogue cytotoxicity against Trypanosoma cruzi, Parasitol Res, 98, 99, 10.1007/s00436-005-0010-1 Urbina, 2009, Ergosterol biosynthesis inhibitors for the specific treatment of Chagas' disease: 20years after, does the promise holds? Urbina, 1995, Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by D24(25)-sterol methyltransferase inhibitors and their combinations with ketoconazole, Mol Biochem Parasitol, 73, 199, 10.1016/0166-6851(95)00117-J Wilson, 2004, New microtubule/tubulin-targeted anticancer drugs and novel chemotherapeutic strategies, J Chemother, 16, 83, 10.1179/joc.2004.16.Supplement-1.83 Sasse, 1988, Tubulin post-translational modifications and the construction of microtubular organelles in Trypanosoma brucei, J Cell Sci, 90, 577, 10.1242/jcs.90.4.577 Souto-Padron, 1993, Acetylated α-tubulin in Trypanosoma cruzi: immunocytochemical localization, Mem Inst Oswaldo Cruz, 8, 517, 10.1590/S0074-02761993000400004 Dietrich, 1992, Tyrosine aminotransferase: a transaminase among others?, Cel Mol Biol, 38, 95 Cazzulo, 1994, Intermediate metabolism in Trypanosoma cruzi, J Bioenerg Biomembr, 26, 157, 10.1007/BF00763064 Noble, 2008, Structural studies of elongation and release factors, Cell Mol Life Sci, 65, 1335, 10.1007/s00018-008-7495-6 Goijman, 1985, Effect of β-lapachone, a peroxide-generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi, Arch Biochem Biophys, 240, 273, 10.1016/0003-9861(85)90033-5 de Diego, 2001, The ubiquitin-proteasome pathway plays an essential role in proteolysis during Trypanosoma cruzi remodeling, Biochemistry, 40, 1053, 10.1021/bi001659k De Maio, 1999, Heat shock proteins: facts, thoughts, and dreams, Shock, 11, 1, 10.1097/00024382-199901000-00001 Dragon, 1987, The genome of Trypanosoma cruzi contains a constitutively expressed, tandemly arranged multicopy gene homologous to a major heat shock protein, Mol Cell Biol, 7, 1271 Papp, 2003, Molecular chaperones, stress proteins and redox homeostasis, Biofactors, 17, 249, 10.1002/biof.5520170124 Cheng, 1990, The mitochondrial chaperonin HSP60 is required for its own assembly, Nature, 348, 455, 10.1038/348455a0 Saraiva, 2009, Na(+)-ATPase and protein kinase C are targets to 1-O-hexadecylphosphocoline (miltefosine) in Trypanosoma cruzi, Arch Biochem Biophys, 481, 65, 10.1016/j.abb.2008.10.018 Almeida-Amaral, 2008, Leishmania amazonensis: characterization of an ouabain-insensitive Na+-ATPase activity, Exp Parasitol, 118, 165, 10.1016/j.exppara.2007.07.001 MacDonald, 1991, IgE-dependent histamine-releasing factors. A brief review, Int Arch Allergy Appl Immunol, 94, 144, 10.1159/000235347 MacDonald, 2001, Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo, Proc Natl Acad Sci U S A, 98, 10829, 10.1073/pnas.201191498 Burg, 1993, Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis, EMBO J, 12, 911, 10.1002/j.1460-2075.1993.tb05732.x El-Sayed, 2005, The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas' disease, Science, 309, 409, 10.1126/science.1112631 Poole, 2002, Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase, Methods Enzymol, 348, 122, 10.1016/S0076-6879(02)48632-6 Aumais, 2003, Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis, J Cell Sci, 116, 1991, 10.1242/jcs.00412