A prospective study on the dose dependency of cardiotoxicity induced by mitomycin C

Jaap Verweij1, Albert J. Funke-Küpper2, G. J. J. Teule3, H.M. Pinedo1
1Department of Medical Oncology, Free University Hospital, Amsterdam,
2Department of Cardiology, Free University Hospital, Amsterdam
3Department of Nuclear Medicine, Free University Hospital, Amsterdam

Tóm tắt

Từ khóa


Tài liệu tham khảo

Von Hoff D D, Rozencweig M, Picart M: The cardiotoxicity of anticancer agents.Semin Oncol 9, 23 (1982).

Fujita H: Comparative studies on the blood level, tissue distribution, excretion and inactivation of anticancer drugs.Jap J clin Oncol 12, 151 (1971).

Philips F S, Schwartz H S, Sternberg S S: Pharmacology of mitomycin C. I: toxicology and pathological effects.Cancer Res 20, 1354 (1960).

Levillain R, Cluzan R: Cardiac toxicity of anitmitotic drugs.Proc EACR 3, 100 (1973).

Verwey J, Kerpel-Fronius S, Stuurman M, van Triet A J, van Hattum A H, de Vries J, Pinedo H M: Mitomycin C-induced organ toxicity in Wistar rats: a study with special focus on the kidney.J Cancer Res clin Oncol, in press.

Monti E, Bossa R, Galatulas I, Favalli L, Villani F, Piccinini F: Interaction between doxorubicin and mitomycin C on mortality and myocardial contractility in guinea pig.Tumori 69, 113–116, 1983.

Suzuki Y, Nübe H: Radiation-induced heart injury: radiopathological study.Kitakanto Igaku 25, 395 (1975).

Buzdar A U, Legha S W, Tashina ChK, Hortyobagyi G N, Yap H Y, Krutchik A M, Luna M A, Blumenschein G R: Adriamycin and mitomycin C: possible synergistic cardiotoxicity.Cancer Treat Rep 62, 1005 (1978).

Creech R H, Catalano R B, Shah M K, Dayal H: An effective low-dose mitomycin regimen for hormonaland chemotherapy refractory patients with metastatic breast cancer.Cancer 51, 1034 (1983).

Ganz A, Gold B S, Tandron I, Lurie K: Angina pectoris after doxorubicin and mitomycin therapy.Cancer Treat Rep 67, 98 (1983).

Doyle L A, Ihde D C, Carney D N, Bunn P A, Cohen M H, Mattews M J, Puffenbarger R, Cordes R S, Minna J D: Combination chemotherapy with doxorubicin and mitomycin C in non-small cell bronchogenic carcinoma.Am J clin Oncol 7, 719 (1984).

Villani F, Comazzi R, Lacaita G, Guindani A, Genitoni V, Volonterio A, Brambilla M C: Possible enhancement of the cardiotoxicity of doxorubicin when combined with mitomycin C.Med Oncol Tumor Pharmacother 2, 93 (1985).

Verwey J, van Lingen A, Teule J J, Heidendal G A K, Pinedo H M: The cold pressor test during radionuclide ventriculography. A feasibility study in cancer patients.Med Oncol Tumor Pharmacother 3, 11 (1986).

MacDonald J S, Schein P S, Woolley R V, Smythe T, Ueno W, Hoth D, Smith F, Boiron M, Gisselbrecht Ch, Brunet R, Lagarde C: 5-Fluorouracil, doxorubicin and mitomycin C (FAM) combination chemotherapy for advanced gastric cancer.Ann intern Med 93, 533 (1980).

Doroshow J H: Mitomycin C-enhanced Superoxide and hydrogen peroxide formation in rat heart.J Pharmac exp Ther 218, 206, (1981).