A prospective, randomized, double‐blind controlled trial of laparoscopic uterine nerve ablation in the treatment of pelvic pain associated with endometriosis

Wiley - Tập 10 Số 4 - Trang 217-222 - 2001
Chris Sutton1, Andrew S. Pooley2, Kevin Jones1, Richard W. Dover3, Patricia Haines1
1The Royal Surrey County Hospital Guildford Surrey UK
2Kingston General Hospital, Kingston‐upon‐Thames, UK
3Basingstoke District General Hospital, Basingstoke, UK

Tóm tắt

To determine the value of laparoscopic uterine nerve ablation (LUNA) as part of the laparoscopic laser treatment of painful endometriosis.A prospective randomized double‐blind controlled trial.A referral centre for the treatment of endometriosis.51 women with pelvic pain and pelvic endometriosis.All patients underwent laparoscopic laser ablation of their endometriosis and were then randomly allocated to receive LUNA or no further treatment.Dysmenorrhoea, dyspareunia and chronic non‐menstrual pelvic pain were assessed using visual analogue scales and structured questionnaires, preoperatively and at 3 and 6 months postoperatively.24 patients were randomly allocated to receive laser vaporization alone, and 27 to receive a LUNA procedure in addition. The mean age of the patients involved was 28 years (range 20–41), with no differences between the groups for stage of endometriosis. Comparisons were made between the two treatment groups at 3 and 6 months. Significant differences in favour of the non‐LUNA group were found at 3 months (P = 0.003), and at 6 months (P = 0.022) for dysmenorrhoea. A significant difference in favour of the non‐LUNA group also occurred at 6 months for chronic non‐menstrual pain (P = 0.323). There were no significant differences recorded for dyspareunia. Bonferroni's adjustment was applied, and the only difference which remained significant was for dysmenorrhoea at 3 months (P = 0.033) in favour of the non‐LUNA group. The preoperative and 6‐month pain scores for all the patients were combined. There was a significant improvement in the pain scores recorded at 6 months (P < 0.0001).Laparoscopic laser ablation of endometriosis is confirmed as an effective treatment, to which uterine nerve ablation adds no benefit.

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Wiley

Tập 10 Số 4

217-222

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