A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage

Balami, 2012, Complications of intracerebral haemorrhage, Lancet Neurol., 11, 101, 10.1016/S1474-4422(11)70264-2 Cordonnier, 2018, Intracerebral haemorrhage: current approaches to acute management, Lancet, 392, 1257, 10.1016/S0140-6736(18)31878-6 Kreitzer, 2013, An update on surgical and medical management strategies for intracerebral hemorrhage, Semin. Neurol., 33, 462, 10.1055/s-0033-1364210 Adeoye, 2010, Advances in the management of intracerebral hemorrhage, Nat. Rev. Neurol., 6, 593, 10.1038/nrneurol.2010.146 Lan, 2017, Modulators of microglial activation and polarization after intracerebral haemorrhage, Nat. Rev. Neurol., 13, 420, 10.1038/nrneurol.2017.69 Keep, 2012, Intracerebral haemorrhage: mechanisms of injury and therapeutic targets, Lancet Neurol., 11, 720, 10.1016/S1474-4422(12)70104-7 Ideguchi, 2002, Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM, Biochem. J., 367, 87, 10.1042/bj20011851 Xu, 2016, USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage, J. Mol. Neurosci., 58, 16, 10.1007/s12031-015-0644-0 Sun, 2010, USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha, Cell. Signal., 22, 386, 10.1016/j.cellsig.2009.10.008 Ting, 2019, USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair, Nucleic Acids Res., 47, 9721, 10.1093/nar/gkz726 Lee, 2015, USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics, Cell Death Differ., 22, 1463, 10.1038/cdd.2014.234 Surget, 2013, Uncovering the role of p53 splice variants in human malignancy: a clinical perspective, OncoTargets Ther., 7, 57 Chao, 2015, Mechanisms of p53 degradation, Clin. Chim. Acta, 438, 139, 10.1016/j.cca.2014.08.015 Stevenson, 2007, The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2, EMBO J., 26, 976, 10.1038/sj.emboj.7601567 Li, 2002, Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization, Nature, 416, 648, 10.1038/nature737 Yuan, 2010, USP10 regulates p53 localization and stability by deubiquitinating p53, Cell, 140, 384, 10.1016/j.cell.2009.12.032 Yamaguchi, 2007, The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha), J. Biol. Chem., 282, 33943, 10.1074/jbc.M706282200 Ke, 2014, USP11 regulates p53 stability by deubiquitinating p53, J. Zhejiang Univ. Sci. B, 15, 1032, 10.1631/jzus.B1400180 Laptenko, 2006, Transcriptional regulation by p53: one protein, many possibilities, Cell Death Differ., 13, 951, 10.1038/sj.cdd.4401916 Lu, 2019, Kruppel-like factor 2 mediated anti-proliferative and anti-metastasis effects of simvastatin in p53 mutant colon cancer, Biochem. Biophys. Res. Commun., 511, 772, 10.1016/j.bbrc.2019.02.127 Kumar, 2011, p53 impairs endothelial function by transcriptionally repressing Kruppel-Like Factor 2, Arterioscler. Thromb. Vasc. Biol., 31, 133, 10.1161/ATVBAHA.110.215061 Zhou, 2014, Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation, Prog. Neurobiol., 115, 25, 10.1016/j.pneurobio.2013.11.003 Kim, 2016, Cholecalciferol inhibits lipid accumulation by regulating early adipogenesis in cultured adipocytes and zebrafish, Biochem. Biophys. Res. Commun., 469, 646, 10.1016/j.bbrc.2015.12.049 Vinjamur, 2014, Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation, Haematologica, 99, 1565, 10.3324/haematol.2014.104943 Li, 2016, Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats, J. Clin. Neurosci., 34, 264, 10.1016/j.jocn.2016.09.028 Gilmore, 2006, Introduction to NF-kappaB: players, pathways, perspectives, Oncogene, 25, 6680, 10.1038/sj.onc.1209954 Nayak, 2013, Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation, Am. J. Pathol., 182, 1696, 10.1016/j.ajpath.2013.01.029 Das, 2006, Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes, Proc. Natl. Acad. Sci. USA, 103, 6653, 10.1073/pnas.0508235103 Lingrel, 2012, Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis, Circ. Res., 110, 1294, 10.1161/CIRCRESAHA.112.267310 Hickenbottom, 1999, Nuclear factor-kappaB and cell death after experimental intracerebral hemorrhage in rats, Stroke, 30, 2472, 10.1161/01.STR.30.11.2472 Zeng, 2017, Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-kappaB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway, J Neuroinflammation, 14, 119, 10.1186/s12974-017-0895-5 Wagner, 2007, Modeling intracerebral hemorrhage: glutamate, nuclear factor-kappa B signaling and cytokines, Stroke, 38, 753, 10.1161/01.STR.0000255033.02904.db Badjatia, 2015, Inflammation, negative nitrogen balance, and outcome after aneurysmal subarachnoid hemorrhage, Neurology, 84, 680, 10.1212/WNL.0000000000001259 Wang, 2010, Preclinical and clinical research on inflammation after intracerebral hemorrhage, Prog. Neurobiol., 92, 463, 10.1016/j.pneurobio.2010.08.001 Ju, 2018, Increased BBB Permeability Enhances Activation of Microglia and Exacerbates Loss of Dendritic Spines After Transient Global Cerebral Ischemia, Front. Cell. Neurosci., 12, 236, 10.3389/fncel.2018.00236 Wu, 2008, Microglial activation and brain injury after intracerebral hemorrhage, Acta Neurochir. Suppl. (Wien), 105, 59, 10.1007/978-3-211-09469-3_13 Lu, 2019, Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage, Front. Immunol., 10, 1360, 10.3389/fimmu.2019.01360 Xie, 2016, OTUB1 attenuates neuronal apoptosis after intracerebral hemorrhage, Mol. Cell. Biochem., 422, 171, 10.1007/s11010-016-2817-8 Liu, 2017, Increased Expression of Ubiquitin-Specific Protease 4 Participates in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats, Cell. Mol. Neurobiol., 37, 427, 10.1007/s10571-016-0375-y Deng, 2018, Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses, Proc. Natl. Acad. Sci. USA, 115, 4678, 10.1073/pnas.1714938115 Yang, 2016, Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury, Neurobiol. Dis., 96, 216, 10.1016/j.nbd.2016.08.012 Li, 2018, Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway, J. Neuroinflammation, 15, 250, 10.1186/s12974-018-1271-9 Jha, 2017, KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation, Int. J. Mol. Sci., 18, 2383, 10.3390/ijms18112383 Ben-Neriah, 2011, Inflammation meets cancer, with NF-κB as the matchmaker, Nat. Immunol., 12, 715, 10.1038/ni.2060 Zhang, 2014, NF-κB activation and cell death after intracerebral hemorrhage in patients, Neurol. Sci., 35, 1097, 10.1007/s10072-014-1657-0 Zhou, 2018, Lactate potentiates angiogenesis and neurogenesis in experimental intracerebral hemorrhage, Exp. Mol. Med., 50, 1, 10.1038/s12276-018-0183-1