A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase
Tóm tắt
Despite growing applications being reported both in academia and industry, continuous flow chemistry remains a relatively untaught field across most chemistry undergraduate courses. This is particularly true in laboratory practical classes, where it is often deemed simpler to carry out synthetic reactions in traditional batch mode using round-bottomed flasks. Herein, we report the development of an undergraduate project that utilises cheap and readily available materials to construct continuous flow reactors. The students compare the performance of different types of reactors and conditions in a biphasic selective acetylation of a symmetrical diamine. Throughout the investigation, the students can vary multiple parameters as they optimise the reaction, thus actively learning and readjusting them based on their improved understanding. The experiments give the students an appreciation of continuous flow techniques in comparison to batch.
Từ khóa
Tài liệu tham khảo
Valera FE, Quaranta M, Moran A, Blacker J, Armstrong A, Cabral JT, Blackmond DG (2010) Angew Chem Int Ed 49:2478–2485
Adamo A, Beingessner RL, Behnam M, Chen J, Jamison TF, Jensen KF, Monbaliu J-CM, Myerson AS, Revalor EM, Snead DR, Stelzer T, Weeranoppanant N, Wong SY, Zhang P (2016) Science 352:61–67
White TD, Berglund KD, Groh JM, Johnson MD, Miller RD, Yates MH (2012) Org Process Res Dev 16:939–957
https://en.wikipedia.org/wiki/Schotten-Baumann_reaction (last accessed 23/0820)
Chapman MR, Kwan MH, King G, Jolley KE, Hussain M, Hussain S, Salama IE, González Nino C, Thompson LA, Bayana ME, Clayton A, Nguyen BN, Turner NJ, Kapur N, Blacker AJ (2017) Org Process Res Dev 21:1294–1301
Guan F, Kapur N, Sim L, Taylor CJ, Wen J, Zhang X, Blacker AJ (2020) React Chem Eng. https://doi.org/10.1039/D0RE00061B
www.freactor.com (last accessed 23/08/20)