A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase

Journal of Flow Chemistry - Tập 11 Số 1 - Trang 31-36 - 2021
Mary E. Bayana1, A. John Blacker1, Adam D. Clayton1, Katherine E. Jolley1, Ricardo Labes1, Connor J. Taylor1, William R. Reynolds1
1Institute of Process Research and Development, School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK

Tóm tắt

AbstractDespite growing applications being reported both in academia and industry, continuous flow chemistry remains a relatively untaught field across most chemistry undergraduate courses. This is particularly true in laboratory practical classes, where it is often deemed simpler to carry out synthetic reactions in traditional batch mode using round-bottomed flasks. Herein, we report the development of an undergraduate project that utilises cheap and readily available materials to construct continuous flow reactors. The students compare the performance of different types of reactors and conditions in a biphasic selective acetylation of a symmetrical diamine. Throughout the investigation, the students can vary multiple parameters as they optimise the reaction, thus actively learning and readjusting them based on their improved understanding. The experiments give the students an appreciation of continuous flow techniques in comparison to batch.

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Thông tin xuất bản

Journal of Flow Chemistry

Tập 11 Số 1

31-36

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