A pilot study for colorectal carcinoma screening by instant metabolomic profiles using conductive polymer spray ionization mass spectrometry

Arnold, 2017, Global patterns and trends in colorectal cancer incidence and mortality, Gut, 66, 683, 10.1136/gutjnl-2015-310912 Levin, 2002, Promoting early detection tests for colorectal carcinoma and adenomatous polyps: a framework for action: the strategic plan of the National Colorectal Cancer Roundtable, Cancer, 95, 1618, 10.1002/cncr.10890 Simon, 2016, Colorectal cancer development and advances in screening, Clin. Interv. Aging, 11, 967, 10.2147/CIA.S109285 He, 2020, Long-term risk of colorectal cancer after removal of conventional adenomas and serrated polyps, Gastroenterology, 158, 852, 10.1053/j.gastro.2019.06.039 Mandel, 2000, The effect of fecal occult-blood screening on the incidence of colorectal cancer, N. Engl. J. Med., 343, 1603, 10.1056/NEJM200011303432203 Gupta, 2013, Comparative effectiveness of fecal immunochemical test outreach, colonoscopy outreach, and usual care for boosting colorectal cancer screening among the underserved: a randomized clinical trial, JAMA Intern. Med., 173, 1725 Brown, 2004, Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging?, Br. J. Cancer, 91, 23, 10.1038/sj.bjc.6601871 Fijten, 1995, Predictive value of signs and symptoms for colorectal cancer in patients with rectal bleeding in general practice, Fam. Pract., 12, 279, 10.1093/fampra/12.3.279 Wauters, 2000, Rectal bleeding and colorectal cancer in general practice: diagnostic study, BMJ (Clin. Res. Ed.), 321, 998, 10.1136/bmj.321.7267.998 Nikpour, 2008, Colonoscopic evaluation of minimal rectal bleeding in average-risk patients for colorectal cancer, World J. Gastroenterol., 14, 6536, 10.3748/wjg.14.6536 Simon, 1985, Occult blood screening for colorectal carcinoma: a critical review, Gastroenterology, 88, 820, 10.1016/0016-5085(85)90158-1 Zhang, 2014, Metabolomics in diagnosis and biomarker discovery of colorectal cancer, Cancer Lett., 345, 17, 10.1016/j.canlet.2013.11.011 Brown, 2016, Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool, Cancer Metab., 4, 11, 10.1186/s40170-016-0151-y Bathe, 2014, From genotype to functional phenotype: unraveling the metabolomic features of colorectal cancer, Genes, 5, 536, 10.3390/genes5030536 Satoh, 2017, Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC, Proc. Natl. Acad. Sci. U. S. A., 114, E7697, 10.1073/pnas.1710366114 Zhang, 2017, Metabolomics for biomarker discovery in the diagnosis, prognosis, survival and recurrence of colorectal cancer: a systematic review, Oncotarget, 8, 35460, 10.18632/oncotarget.16727 Tan, 2013, Metabonomics identifies serum metabolite markers of colorectal cancer, J. Proteome Res., 12, 3000, 10.1021/pr400337b Yusof, 2018, Metabolomics profiling on different stages of colorectal cancer: a systematic review, Malays. J. Med. Sci., 25, 16 Gubala, 2012, Point of care diagnostics: status and future, Anal. Chem., 84, 487, 10.1021/ac2030199 Liesenfeld, 2013, Review of mass spectrometry-based metabolomics in cancer research, Cancer Epidemiol. Biomark. Prev., 22, 2182, 10.1158/1055-9965.EPI-13-0584 Williams, 2013, Metabolomics of colorectal cancer: past and current analytical platforms, Anal. Bioanal. Chem., 405, 5013, 10.1007/s00216-013-6777-5 Ferreira, 2016, Ambient ionization mass spectrometry for point-of-care diagnostics and other clinical measurements, Clin. Chem., 62, 99, 10.1373/clinchem.2014.237164 Riboni, 2019, Solvent-assisted paper spray ionization mass spectrometry (SAPSI-MS) for the analysis of biomolecules and biofluids, Sci. Rep., 9, 10296, 10.1038/s41598-019-45358-x Yang, 2012, Paper spray ionization devices for direct, biomedical analysis using mass spectrometry, Int. J. Mass Spectrom., 312, 201, 10.1016/j.ijms.2011.05.013 Song, 2018, Conductive polymer spray ionization mass spectrometry for biofluid analysis, 90, 12878 Song, 2020, Oral squamous cell carcinoma diagnosed from saliva metabolic profiling, 117, 16167 He, 2018, MassImager: a software for interactive and in-depth analysis of mass spectrometry imaging data, Anal. Chim. Acta, 1015, 50, 10.1016/j.aca.2018.02.030 Song, 2019, 91, 2838 H., 1995, Controlling the false discovery rate: a practical and powerful approach to multiple testing, J R Statist. Soc. B, 1, 289 Chong, 2019, Using MetaboAnalyst 4.0 for comprehensive and integrative metabolomics data analysis, Curr. Protoc. Bioinformatics, 68, 10.1002/cpbi.86 Broadhurst, 2018, Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies, Metabolomics, 14, 72, 10.1007/s11306-018-1367-3 Sinha, 2016, Fecal microbiota, fecal metabolome, and colorectal cancer interrelations, PLoS One, 11, 10.1371/journal.pone.0152126 Yang, 2019, Integrated microbiome and metabolome analysis reveals a novel interplay between commensal bacteria and metabolites in colorectal cancer, Theranostics, 9, 4101, 10.7150/thno.35186 Eberlin, 2014, Molecular assessment of surgical-resection margins of gastric cancer by mass-spectrometric imaging, Proc. Natl. Acad. Sci. U. S. A., 111, 2436, 10.1073/pnas.1400274111 Margulis, 2018, Distinguishing malignant from benign microscopic skin lesions using desorption electrospray ionization mass spectrometry imaging, Proc. Natl. Acad. Sci. U. S. A., 115, 6347, 10.1073/pnas.1803733115 Banerjee, 2017, Diagnosis of prostate cancer by desorption electrospray ionization mass spectrometric imaging of small metabolites and lipids, Proc. Natl. Acad. Sci. U. S. A., 114, 3334, 10.1073/pnas.1700677114 Schulze, 2012, How cancer metabolism is tuned for proliferation and vulnerable to disruption, Nature, 491, 364, 10.1038/nature11706 Pavlova, 2016, The emerging hallmarks of cancer metabolism, Cell Metab., 23, 27, 10.1016/j.cmet.2015.12.006 Zhu, 2019, Metabolic regulation of cell growth and proliferation, 20, 436 Altman, 2016, From Krebs to clinic: glutamine metabolism to cancer therapy, Nat. Rev. Cancer, 16, 619, 10.1038/nrc.2016.71 Perera, 2015, Pancreatic cancer metabolism: breaking it down to build it back up, Cancer Discov., 5, 1247, 10.1158/2159-8290.CD-15-0671 Wang, 2017, Purine synthesis promotes maintenance of brain tumor initiating cells in glioma, 20, 661 Yin, 2018, Potential mechanisms connecting purine metabolism and cancer therapy, Front. Immunol., 9, 1697, 10.3389/fimmu.2018.01697 Camici, 2019, Purine-metabolising enzymes and apoptosis in cancer, Cancers, 11, 10.3390/cancers11091354 Carrassa, 2017, DNA damage response inhibitors: mechanisms and potential applications in cancer therapy, Cancer Treat. Rev., 60, 139, 10.1016/j.ctrv.2017.08.013 Fasullo, 2015, Nucleotide salvage deficiencies, DNA damage and neurodegeneration, Int. J. Mol. Sci., 16, 9431, 10.3390/ijms16059431 Kurmi, 2020, Nitrogen metabolism in cancer and immunity, Trends Cell Biol., 30, 408, 10.1016/j.tcb.2020.02.005 Geiger, 2016, L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity, Cell, 167, 829, 10.1016/j.cell.2016.09.031 Rath, 2014, Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages, Front. Immunol., 5, 532, 10.3389/fimmu.2014.00532 Marcinkiewicz, 2014, Taurine and inflammatory diseases, Amino Acids, 46, 7, 10.1007/s00726-012-1361-4 Ogretmen, 2018, Sphingolipid metabolism in cancer signalling and therapy, Nat. Rev. Cancer, 18, 33, 10.1038/nrc.2017.96 Glunde, 2015, Choline metabolism-based molecular diagnosis of cancer: an update, Expert. Rev. Mol. Diagn., 15, 735, 10.1586/14737159.2015.1039515 Takyi-Williams, 2015, Application of paper spray-MS in PK studies using sunitinib and benzethonium as model compounds, Bioanalysis, 7, 413, 10.4155/bio.14.288 Michely, 2017, Paper spray ionization coupled to high resolution tandem mass spectrometry for comprehensive urine drug testing in comparison to liquid chromatography-coupled techniques after urine precipitation or dried urine spot workup, Anal Chem., 89, 11779, 10.1021/acs.analchem.7b03398