A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing

Epstein, 1999, Quality of life and oral function following radiotherapy for head and neck cancer, Head Neck, 21, 1, 10.1002/(SICI)1097-0347(199901)21:1<1::AID-HED1>3.0.CO;2-4 Valdez, 1993, Major salivary gland function in patients with radiation-induced xerostomia, Int J Radiat Oncol Biol Phys, 25, 41, 10.1016/0360-3016(93)90143-J Harrison, 1997, Detailed quality of life assessment in patients treated with primary radiotherapy for cancer of the base of tongue, Head Neck, 19, 169, 10.1002/(SICI)1097-0347(199705)19:3<169::AID-HED1>3.0.CO;2-0 Jha, 2003, Prevention of radiation induced xerostomia by surgical transfer of submandibular gland into the submental space, Radiother Oncol, 66, 283, 10.1016/S0167-8140(03)00023-9 Brizel, 2000, Phase III randomized trial of amifostine as a radioprotector in head and neck cancer, J Clin Oncol, 18, 3339, 10.1200/JCO.2000.18.19.3339 Chambers, 1995, Oral and dental management of the cancer patient; patient, Support Care Cancer, 3, 168, 10.1007/BF00368886 Dawes, 1987, Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man, J Dent Res, 66, 648, 10.1177/00220345870660S207 Eisbruch, 2001, Xerostomia and its predictors following parotid sparing irradiation of head and neck, Int J Radiat Oncol Biol Phys, 50, 695, 10.1016/S0360-3016(01)01512-7 Sonis, 1997, Oral complications, 3255 Scarantino, 2001, A Phase III study on the concurrent use of oral pilocarpine to reduce hyposalivation and mucositis associated with radiation therapy in head and neck cancer patients, Int J Radiat Oncol Biol Phys, 51, 85, 10.1016/S0360-3016(01)01981-2 Chao, 2001, Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma, Radiother Oncol, 61, 275, 10.1016/S0167-8140(01)00449-2 Tabak, 1995, In defense of the oral cavity, Ann Rev Physiol, 57, 547, 10.1146/annurev.ph.57.030195.002555 Eisbruch, 1999, Dose, volume, and function relationships in parotid salivary glands following conformal and intensity modulated irradiation of head and neck cancer, Int J Radiat Oncol Biol Phys, 45, 577, 10.1016/S0360-3016(99)00247-3 Ammoson, 2003, Dosimetric predictors for xerostomia for head and neck cancer patients treated with SMART (simultaneous modulated accelerated radiation therapy) boost technique, Int J Radiat Oncol Biol Phys, 56, 136, 10.1016/S0360-3016(03)00093-2 Koukourakis, 2000, Subcutaneous administration of amifostine during fractionated radiotherapy, J Clin Oncol, 18, 2226, 10.1200/JCO.2000.18.11.2226 Antonadou, 2002, Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head and neck cancer, Int J Radiat Oncol Biol Phys, 52, 739, 10.1016/S0360-3016(01)02683-9