A phase II clinical trial of echinomycin in metastatic soft tissue sarcoma

Investigational New Drugs - Tập 13 Số 2 - Trang 171-174 - 1995
William J. Gradishar1, Nicholas J. Vogelzang2, Lary J. Kilton3, Steven J. Leibach4, Alfred Rademaker5, Suzanne French6, Al B. Benson6
1Division of Hematology/Medical Oncology, Department of Medicine, Northwestern University, Chicago, IL
2Section of Hematology/Medical Oncology, Department of Medicine, University of Chicago, Chicago
3Kilton Hematology/Oncology Practice, Elgin
4Northwest Oncology, P.C., Elk Grove Village, IL
5Biometry Section, Robert H. Lurie Cancer Center, Northwestern University, Chicago, IL
6Illinois Cancer Center, Chicago, IL, USA

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Corbaz R, Ettinger L, Gaumann E, Keller-Schierlein W, Kradolfer S, Neipp L, Prelog V, Reusser P, Zahner H: Metabolic products of actinomycetes. VII. Echinomycin. Helv Chim Acta 40:199–204, 1957

Martin DG, Misak SA, Biles C, Stewart JC, Baczynskyj L, Meulmann PA: Structure of quinomycin antibiotics. J Antibiot 28:332–336, 1975

Ward DC, Reich E, Goldberg IH: Base specificity in the interaction of polynucleotides with antibiotic drugs. Science 149:1259–1263, 1965

Wakelin LPG, Waring MJ: The binding of echinomycin to deoxyribonucleic acid. Biochem J 157:721–740, 1976

Lathan B, Von Hoff DD: Cytotoxin activity of echinomycin in a human tumor cloning system. Cancer Drug Delivery 1:191–198, 1984

Kuhn J, Von Hoff D, Hersh M: Phase I trial of echinomycin (NSC-526417), a bifunctional intercalating agent, administered by 24 hour continuous infusion. Eur J Cancer Clin Oncol 25:797–803, 1989

Pazdur R, Haas CD, Baker LH, Leichman CG, Decker D: Phase I study of echinomycin. Cancer Treat Rep 71:117–119, 1987

Harvey JH, McFadden M, Andrews WG, Byre PJ: Phase I study of echinomycin administered on an intermittent bolus schedule. Cancer Treat Rep 69:1365–1368, 1985

Wingo PA, Tong T, Bolder S: Cancer statistics, 1995. CA Cancer J Clin 5:8–30, 1995

Antman KH: Sarcoma of bone and soft tissue. In: Perry MC (ed). The Chemotherapy Sourcebook. Baltimore, Williams and Wilkins, pp. 1068–1093, 1992

Miller AB, Hoogstraten B, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer 47:207–214, 1981

Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481, 1958

Shevrin DH, Lad TE, Guinan P, Kilton LJ: Phase II trial of echinomycin in advanced hormone-resistant prostate cancer. An Illinois Cancer Council study. Invest New Drugs 12:65–66, 1994

Wadler S, Terteromano L, Cazenave L, Sparano JA: Phase II trial of echinomycin in patients with advanced or recurrent colorectal cancer. Cancer Chemother Pharmacol 34:266–269, 1994