Huimin Zhang1,2,3, Zhenzhen Wang2,3, Xi′an Fu4,2,3, Yonghu Sun2,3, Zihao Mi2,3, Gongqi Yu5,2,3, Lele Sun2,3, Na Wang4,2,3, Chuan Wang2,3, Qing Zhao4,2,3, Shengli Chen2,3, Zhenming Yue4,2,3, Hong Liu6,2,3, Furen Zhang7,8,5,6,2,3
1Binzhou Medical University, Yantai, Shandong, China
2Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China
3Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, Shandong, China
4School of Medicine, Shandong University, Jinan, Shandong, China
5School of Medicine and Life Science, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China
6Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, Shandong, China
7National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong, China
8School of Medicine and Life Science University of Jinan‐Shandong Academy of Medical Sciences Jinan Shandong China
Tóm tắt
AbstractThe nuclear transcription factor‐κB (NF‐κB) plays a pivotal role in controlling both innate and adaptive immunity and regulates the expressions of many immunological mediators. Abundant evidences have showed the importance of NF‐κB pathway in the host immune responses against Mycobacterium leprae in the development of leprosy. However, no particular association study between leprosy and NF‐κB pathway‐related gene polymorphisms was reported. Here, we performed a large‐scale and two‐stage candidate association study to investigate the association between 94 NF‐κB pathway‐related genes and leprosy. Our results showed that rs58744688 was significantly associated with leprosy (P = 7.57 × 10−7, OR = 1.12) by combining the previous genomewide association data sets and four independent validation sample series, consisting of a total of 4631 leprosy cases and 6413 healthy controls. This founding implicated that MAP3K14 and FMNL1 were susceptibility genes for leprosy, which suggested the involvement of macrophage targeting and NF‐κB pathway in the development of leprosy.
