A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
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Yim, M.B. et al. A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide. Proc. Natal. Acad. Sci. USA 93, 5709–5714 (1996).
Wallace, D.C. Mitochondrial DMA Mutations and Bioenergetic Defects in Aging and Degenerative Diseases. in Molecular and Genetic Basis of Neurologic Disease (eds Rosenburg, D. N., Prusiner, S.B., DiMauro, S. & Barchi, R.L.) 237–269 (Butterworth Heinemann, Boston, 1996).
Szabo, C. Physiological and Pathophysiological Roles of Nitric Oxide in the Central Nervous System. Brain Research Bulletin 41, 131–141 (1996).
Schulz, J.B. & Seal, M.F. Neuroprotective effects of free radical scavengers and energy repletion in animal models of neurodegenerative disease. Ann. N.Y.Acad. Sci. 765, 100–118 (1995).
Simonian, N.A. & Coyle, J.T. Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36, 83106 (1996).
Turrens, J.F. & Boveris, A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 191, 421–427 (1980).
Turrens, J.F., Alexandre, A. & Lehninger, A.L. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch. Biochem. Biophys. 237, 408–414 (1985).
Li, Y. et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature Genet. 11, 376–381 (1995).
Day, B.J., Shawen, S., Liochev, S.I. & Crapo, J.D. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J. Pharmacol. Exp. Ther. 275, 1227–1232 (1995).
Day, B.J. & Crapo, J.D. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury in vivo. Toxicol. Appl. Pharmacol. 140, 94–100 (1996).
Szabo, C., Day, B.J. & Salzman, A.L. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett. 381, 82–86 (1996).
Zingarelli, B., Day, B.J., Crapo, J.D., Salzman, A.L. & Szabo, C. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock, Br. J. Pharmacol. 120, 259–267 (1997).
Lebovitz, R.M. et al Neurodegeneration, myocardial injury, and perinatal death in mitochondria! superoxide dismutase-deficient mice. Proc. Natal. Acad. Sci. USA 93, 9782–9787 (1996).
Hirano, A., Zimmerman, H.M. & Levine, S. Intramyelinic and extracellular spaces in triethyltin intoxication. J. Neuropathol. Exp. Neurol. 27, 571−580 (1968).
Kimura, S., Kobayashi, T. & Amemiya, F. Myelin splitting in the spongy lesion in Leigh encephalopathy. Pediatr. Neurol. 7, 56–58 (1991).
Adachi, M., Wallace, B.J. & Volk, B.W. Ultramicroscopic and histochemical studies of spongy degeneration (van Bogaert and Bertrand type). J. Neuropathol. Exp. Neurol. 26, 164–165 (1967).
Melov, S., Hinerfeld, D., Esposito, L. & Wallace, D.C. Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangments with age. Nucleic Acids Res. 25, 974–982 (1997).
Wong, P.C. et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14, 1105–1116 (1995).
Beal, M.F., ging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357–366 (1995).
Halliwell, B. Reactive oxygen species and the central nervous system. J Neurochem. 59, 1609−1623 (1992).
Hensley, K. et al. A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of molecular shrapnel for Alzheimers disease. Proc. West. Pharmacol. Soc. 38, 113–120 (1995).
Mattson, M.P. Calcium and neuronal injury in Alzheimers disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise. Ann. N.Y Acad. Sci. 747, 50–76 (1994).
Bancroft, J.D. & Stevens, A. Theory and Practice of Histological Techniques (Churchill Livingstone, New York, 1996).
