A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

Nano Research - Tập 13 Số 8 - Trang 2216-2225 - 2020
Hongwei Lu1, Yongjing Xu2, Ruirui Qiao3, Ziwei Lu4, Pin Wang5, Xindan Zhang6, An Chen1, Liming Zou2, Zhongling Wang1
1Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China
2State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
3ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
4Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China
5Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, 210029, China
6Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Liu, Y.; Zhen, W. Y.; Jin, L. H.; Zhang, S. T.; Sun, G. Y.; Zhang, T. Q.; Xu, X.; Song, S. Y.; Wang, Y. H.; Liu, J. H. et al. All-in-one theranostic nanoagent with enhanced reactive oxygen species generation and modulating tumor microenvironment ability for effective tumor eradication. ACS Nano2018, 12, 4886–4893.

Lv, R. C.; Yang, P. P.; He, F.; Gai, S. L.; Li, C. X.; Dai, Y. L.; Yang, G. X.; Lin, J. A yolk-like multifunctional platform for multimodal imaging and synergistic therapy triggered by a single near-infrared light. ACS Nano2015, 9, 1630–1647.

Song, X. R.; Wang, X. Y.; Yu, S. X.; Cao, J. B.; Li, S. H.; Li, J.; Liu, G.; Yang, H. H.; Chen, X. Y. Co9Se8 nanoplates as a new theranostic platform for photoacoustic/magnetic resonance dual-modal-imaging-guided chemo-photothermal combination therapy. Adv. Mater.2015, 27, 3285–3291.

Yu, J.; Yang, C.; Li, J. D. S.; Ding, Y. C.; Zhang, L.; Yousaf, M. Z.; Lin, J.; Pang, R.; Wei, L. B.; Xu, L. L. et al. Multifunctional Fe5C2 nanoparticles: A targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy. Adv. Mater.2014, 26, 4114–4120.

Tian, Q. W.; Wang, Q.; Yao, K. X.; Teng, B. Y.; Zhang, J. Z.; Yang, S. P.; Han, Y. Multifunctional polypyrrole@Fe3O4 nanoparticles for dual-modal imaging and in vivo photothermal cancer therapy. Small2014, 10, 1063–1068.

Dong, W. J.; Li, Y. S.; Niu, D. C.; Ma, Z.; Gu, J. L.; Chen, Y.; Zhao, W. R.; Liu, X. H.; Liu, C. S.; Shi, J. L. Facile synthesis of monodisperse superparamagnetic Fe3O4 Core@hybrid@Au shell nanocomposite for bimodal imaging and photothermal therapy. Adv. Mater.2011, 23, 5392–5397.

Bardhan, R.; Chen, W. X.; Perez-Torres, C.; Bartels, M.; Huschka, R. M.; Zhao, L. L.; Morosan, E.; Pautler, R. G.; Joshi, A.; Halas, N. J. Nanoshells with targeted simultaneous enhancement of magnetic and optical imaging and photothermal therapeutic response. Adv. Funct. Mater.2009, 19, 3901–3909.

Dang, X. N.; Bardhan, N. M.; Qi, J. F.; Gu, L.; Eze, N. A.; Lin, C. W.; Kataria, S.; Hammond, P. T.; Belcher, A. M. Deep-tissue optical imaging of near cellular-sized features. Sci. Rep.2019, 9, 3873.

Terreno, E.; Castelli, D. D.; Viale, A.; Aime, S. Challenges for molecular magnetic resonance imaging. Chem. Rev.2010, 110, 3019–3042.

Tromsdorf, U. I.; Bigall, N. C.; Kaul, M. G.; Bruns, O. T.; Nikolic, M. S.; Mollwitz, B.; Sperling, R. A.; Reimer, R.; Hohenberg, H.; Parak, W. J. et al. Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents. Nano Lett.2007, 7, 2422–2427.

Jang, J. T.; Nah, H.; Lee, J. H.; Moon, S. H.; Kim, M. G.; Cheon, J. Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles. Angew. Chem.2009, 121, 1260–1264.

Paquet, C.; de Haan, H. W.; Leek, D. M.; Lin, H. Y.; Xiang, B.; Tian, G. H.; Kell, A.; Simard, B. Clusters of superparamagnetic iron oxide nanoparticles encapsulated in a hydrogel: A particle architecture generating a synergistic enhancement of the T2 relaxation. ACS Nano2011, 5, 3104–3112.

Zhang, M.; Wang, W. T.; Wu, F.; Yuan, P.; Chi, C.; Zhou, N. L. Magnetic and fluorescent carbon nanotubes for dual modal imaging and photothermal and chemo-therapy of cancer cells in living mice. Carbon2017, 123, 70–83.

Mehra, N. K.; Palakurthi, S. Interactions between carbon nanotubes and bioactives: A drug delivery perspective. Drug Disco. Today2016, 21, 585–597.

Eatemadi, A.; Daraee, H.; Karimkhanloo, H.; Kouhi, M.; Zarghami, N.; Akbarzadeh, A.; Abasi, M.; Hanifehpour, Y.; Joo, S. W. Carbon nanotubes: Properties, synthesis, purification, and medical applications. Nanoscale Res. Lett.2014, 9, 393.

Meng, L. J.; Zhang, X. K.; Lu, Q. H.; Fei, Z. F.; Dyson, P. J. Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors. Biomaterials2012, 33, 1689–1698.

Liu, Y.; Muir, B. W.; Waddington, L. J.; Hinton, T. M.; Moffat, B. A.; Hao, X. J.; Qiu, J. S.; Hughes, T. C. Colloidally stabilized magnetic carbon nanotubes providing MRI contrast in mouse liver tumors. Biomacromolecules2015, 16, 790–797.

Li, R. B.; Wu, R. A.; Zhao, L.; Qin, H. Q.; Wu, J. L.; Zhang, J. W.; Bao, R. Y.; Zou, H. F. In vivo detection of magnetic labeled oxidized multi-walled carbon nanotubes by magnetic resonance imaging. Nanotechnology2014, 25, 495102.

Nguyen, T. D. T.; Pitchaimani, A.; Ferrel, C.; Thakkar, R.; Aryal, S. Nano-confinement-driven enhanced magnetic relaxivity of SPIONs for targeted tumor bioimaging. Nanoscale2018, 10, 284–294.

Peng, E.; Choo, E. S. G.; Chandrasekharan, P.; Yang, C. T.; Ding, J.; Chuang, K. H.; Xue, J. M. Synthesis of manganese ferrite/graphene oxide nanocomposites for biomedical applications. Small2012, 8, 3620–3630.

Deng, L. M.; Cai, X. J.; Sheng, D. L.; Yang, Y.; Strohm, E. M.; Wang, Z. G.; Ran, H. T.; Wang, D.; Zheng, Y. Y.; Li, P. et al. A laser-activated biocompatible theranostic nanoagent for targeted multimodal imaging and photothermal therapy. Theranostics2017, 7, 4410–4423.

Wang, Z. L.; Xue, X. D.; He, Y. X.; Lu, Z. W.; Jia, B.; Wu, H.; Yuan, Y.; Huang, Y.; Wang, H.; Lu, H. W. et al. Novel redox-responsive polymeric magnetosomes with tunable magnetic resonance property for in vivo drug release visualization and dual-modal cancer therapy. Adv. Funct. Mater.2018, 1802159.

Lartigue, L.; Hugounenq, P.; Alloyeau, D.; Clarke, S. P.; Lévy, M.; Bacri, J. C.; Bazzi, R.; Brougham, D. F.; Wilhelm, C.; Gazeau, F. Cooperative organization in iron oxide multi-core nanoparticles potentiates their efficiency as heating mediators and MRI contrast agents. ACS Nano2012, 6, 10935–10949.

Qiu, P. H.; Jensen, C.; Charity, N.; Towner, R.; Mao, C. B. Oil phase evaporation-induced self-assembly of hydrophobic nanoparticles into spherical clusters with controlled surface chemistry in an oil-in-water dispersion and comparison of behaviors of individual and clustered iron oxide nanoparticles. J. Am. Chem. Soc.2010, 132, 17724–17732.

Hayashi, K.; Nakamura, M.; Miki, H.; Ozaki, S.; Abe, M.; Matsumoto, T.; Sakamoto, W.; Yogo, T.; Ishimura, K. Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release. Theranostics2014, 4, 834–844.

Melancon, M. P.; Lu, W.; Zhong, M.; Zhou, M.; Liang, G.; Elliott, A. M.; Hazle, J. D.; Myers, J. N.; Li, C.; Stafford, R. J. Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer. Biomaterials2011, 32, 7600–7608.

Shen, S.; Wang, S.; Zheng, R.; Zhu, X. Y.; Jiang, X. G.; Fu, D. L.; Yang, W. L. Magnetic nanoparticle clusters for photothermal therapy with near-infrared irradiation. Biomaterials2015, 39, 67–74.

Liang, C.; Diao, S.; Wang, C.; Gong, H.; Liu, T.; Hong, G. S.; Shi, X. Z.; Dai, H. J.; Liu, Z. Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes. Adv. Mater.2014, 26, 5646–5652.

Fan, B.; Kang, L.; Chen, L. Q.; Sun, P.; Jin, M. J.; Wang, Q. M.; Bae, Y. H.; Huang, W.; Gao, Z. G. Systemic siRNA delivery with a dual pH-responsive and tumor-targeted nanovector for inhibiting tumor growth and spontaneous metastasis in orthotopic murine model of breast carcinoma. Theranostics2017, 7, 357–376.

Tsoukalas, C.; Geninatti-Crich, S.; Gaitanis, A.; Tsotakos, T.; Paravatou-Petsotas, M.; Aime, S.; Jiménez-Juárez, R.; Anagnostopoulos, C. D.; Djanashvili, K.; Bouziotis, P. Tumor targeting via sialic acid: [68Ga] DOTA-en-pba as a new tool for molecular imaging of cancer with PET. Mol. Imaging Biol.2018, 20, 798–807.

Deshayes, S.; Cabral, H.; Ishii, T.; Miura, Y.; Kobayashi, S.; Yamashita, T.; Matsumoto, A.; Miyahara, Y.; Nishiyama, N.; Kataoka, K. Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors. J. Am. Chem. Soc.2013, 135, 15501–15507.

Geninatti Crich, S.; Alberti, D.; Szabo, I.; Aime, S.; Djanashvili, K. MRI visualization of melanoma cells by targeting overexpressed sialic acid with a GdIII-dota-en-pba imaging reporter. Angew. Chem., Int. Ed.2013, 52, 1161–1164.

Lu, H. W.; Zou, L. M.; Xu, Y. J.; Li, Y. V. Controlled dispersion of multiwalled carbon nanotubes modified by hyperbranched polylysine. J. Appl. Polym. Sci.2018, 135, 46249.

Pramanik, S.; Ataollahi, F.; Pingguan-Murphy, B.; Oshkour, A. A.; Osman, N. A. A. In vitro study of surface modified poly(ethylene glycol)-impregnated sintered bovine bone scaffolds on human fibroblast cells. Sci. Rep.2015, 5, 9806.

Ai, H.; Flask, C.; Weinberg, B.; Shuai, X. T.; Pagel, M. D.; Farrell, D.; Duerk, J.; Gao, J. Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes. Adv. Mater.2005, 17, 1949–1952.

Kaittanis, C.; Shaffer, T. M.; Ogirala, A.; Santra, S.; Perez, J. M.; Chiosis, G.; Li, Y. M.; Josephson, L.; Grimm, J. Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nat. Commun.2014, 5, 3384.

Cao, J. T.; Zhang, P. H.; Liu, Y. M.; Abdel-Halim, E. S.; Zhu, J. J. Versatile microfluidic platform for the assessment of sialic acid expression on cancer cells using quantum dots with phenylboronic acid tags. ACS Appl. Mater. Interfaces2015, 7, 14878–14884.