A novel cell-free intrathecal approach with PRP for the treatment of spinal cord multiple sclerosis in cats

citation_journal_title=Mult Scler; citation_title=Animal models of multiple sclerosis: from rodents to zebrafish; citation_author=DJ Burrows, A McGown, SA Jain, M Felice, TM Ramesh, B Sharrack, A Majid; citation_volume=25; citation_publication_date=2019; citation_pages=306-324; citation_doi=10.1177/1352458518805246; citation_id=CR1 citation_journal_title=Pathophysiology.; citation_title=The relevance of animal models in multiple sclerosis research; citation_author=A Denic, AJ Johnson, AJ Bieber, AE Warrington, M Rodriguez, I Pirko; citation_volume=18; citation_publication_date=2011; citation_pages=21-29; citation_doi=10.1016/j.pathophys.2010.04.004; citation_id=CR2 citation_journal_title=Acta Neuropathol; citation_title=Multiple sclerosis: experimental models and reality; citation_author=H Lassmann, M Bradl; citation_volume=133; citation_publication_date=2017; citation_pages=223-244; citation_doi=10.1007/s00401-016-1631-4; citation_id=CR3 citation_journal_title=Proc Natl Acad Sci U S A; citation_title=The adult oligodendrocyte can participate in remyelination; citation_author=ID Duncan, AB Radcliff, M Heidari, G Kidd, BK August, LA Wierenga; citation_volume=115; citation_publication_date=2018; citation_pages=E11807-E11816; citation_doi=10.1073/pnas.1808064115; citation_id=CR4 citation_journal_title=J Neurosci; citation_title=Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid; citation_author=J Widenfalk, K Lundströmer, M Jubran, S Brene, L Olson; citation_volume=21; citation_publication_date=2001; citation_pages=3457-3475; citation_doi=10.1523/JNEUROSCI.21-10-03457.2001; citation_id=CR5 citation_journal_title=Annu Rev Neurosci; citation_title=Molecular approaches to spinal cord repair; citation_author=S David, S Lacroix; citation_volume=26; citation_publication_date=2003; citation_pages=411-440; citation_doi=10.1146/annurev.neuro.26.043002.094946; citation_id=CR6 citation_journal_title=Acta Orthop Traumatol Turc; citation_title=Platelet rich plasma: effective treatment for repairing of spinal cord injury in rat; citation_author=R Salarinia, HR Sadeghnia, DH Alamdari, SJ Hoseini, A Mafinezhad, M Hosseini; citation_volume=51; citation_publication_date=2017; citation_pages=254-257; citation_doi=10.1016/j.aott.2017.02.009; citation_id=CR7 citation_journal_title=Res Vet Sci; citation_title=Evaluation of treatment of experimentally induced canine model of multiple sclerosis using laser activated non-expanded adipose derived stem cells; citation_author=AN Abdallah, AA Shamaa, OS El-Tookhy; citation_volume=125; citation_publication_date=2019; citation_pages=71-81; citation_doi=10.1016/j.rvsc.2019.05.016; citation_id=CR8 citation_journal_title=Curr Opin Neurol; citation_title=Experimental models of multiple sclerosis; citation_author=AR Pachner; citation_volume=24; citation_publication_date=2011; citation_pages=291-299; citation_doi=10.1097/WCO.0b013e328346c226; citation_id=CR9 citation_journal_title=Nat Neurosci; citation_title=Animal models of multiple sclerosis: the good, the bad and the bottom line; citation_author=RM Ransohoff; citation_volume=15; citation_publication_date=2012; citation_pages=1074-1077; citation_doi=10.1038/nn.3168; citation_id=CR10 citation_journal_title=Auton Neurosci; citation_title=Stem cell treatment trials of spinal cord injuries in animals; citation_author=MF Farid, YS Abouelela, H Rizk; citation_volume=238; citation_publication_date=2021; citation_doi=10.1016/j.autneu.2021.102932; citation_id=CR11 citation_journal_title=J Feline Med Surg; citation_title=Acute spinal cord injury in the cat: causes, treatment and prognosis; citation_author=S Eminaga, V Palus, GB Cherubini; citation_volume=13; citation_publication_date=2011; citation_pages=850-862; citation_doi=10.1016/j.jfms.2011.09.006; citation_id=CR12 citation_journal_title=J Curr Vet Res; citation_title=Ethidium bromide induced demyelination of the central nervous system in a dog model of secondary progressive multiple sclerosis; citation_author=AN Abdallah, AA Shamaa, O El-Tookhy; citation_volume=2; citation_publication_date=2020; citation_pages=57-67; citation_doi=10.21608/jcvr.2020.90224; citation_id=CR13 citation_journal_title=Aust Dent J; citation_title=Platelet-rich plasma and regenerative dentistry; citation_author=J Xu, L Gou, P Zhang, H Li, S Qiu; citation_volume=65; citation_publication_date=2020; citation_pages=131-142; citation_doi=10.1111/adj.12754; citation_id=CR14 citation_journal_title=Laryngoscope.; citation_title=Effect of neural-induced mesenchymal stem cells and platelet-rich plasma on facial nerve regeneration in an acute nerve injury model; citation_author=HH Cho, S Jang, SC Lee, HS Jeong, JS Park, JY Han; citation_volume=120; citation_publication_date=2010; citation_pages=907-913; citation_doi=10.1002/lary.20860; citation_id=CR15 citation_journal_title=Arch Plast Surg; citation_title=The efficacy and safety of platelet-rich plasma and adipose-derived stem cells: an update; citation_author=J Choi, KW Minn, H Chang; citation_volume=39; citation_publication_date=2012; citation_pages=585-592; citation_doi=10.5999/aps.2012.39.6.585; citation_id=CR16 citation_journal_title=Ann Dermatol; citation_title=Synergistic effect of bone marrow-derived mesenchymal stem cells and platelet-rich plasma in streptozotocin-induced diabetic rats; citation_author=Z Lian, X Yin, H Li, L Jia, X He, Y Yan; citation_volume=26; citation_publication_date=2014; citation_pages=1-10; citation_doi=10.5021/ad.2014.26.1.1; citation_id=CR17 citation_journal_title=Egypt J Histol; citation_title=Histological study on the possible ameliorating effect of platelet rich plasma on ischemia/reperfusion injury in testicular torsion model in adult albino rat; citation_author=M Gazia; citation_volume=43; citation_publication_date=2020; citation_pages=614-629; citation_doi=10.21608/ejh.2019.9860.1091; citation_id=CR18 citation_journal_title=Am J Sports Med; citation_title=Use of autologous platelet-rich plasma to treat muscle strain injuries; citation_author=JW Hammond, RY Hinton, LA Curl, JM Muriel, RM Lovering; citation_volume=37; citation_publication_date=2009; citation_pages=1135-1142; citation_doi=10.1177/0363546508330974; citation_id=CR19 citation_journal_title=Clin Podiatr Med Surg; citation_title=Bone and wound healing augmentation with platelet-rich plasma; citation_author=SE Smith, TS Roukis; citation_volume=26; citation_publication_date=2009; citation_pages=559-588; citation_doi=10.1016/j.cpm.2009.07.002; citation_id=CR20 citation_journal_title=Int Orthop; citation_title=The regenerative effect of platelet-rich plasma on healing in large osteochondral defects; citation_author=Y Sun, Y Feng, CQ Zhang, SB Chen, XG Cheng; citation_volume=34; citation_publication_date=2010; citation_pages=589-597; citation_doi=10.1007/s00264-009-0793-2; citation_id=CR21 citation_journal_title=Orthop Traumatol Surg Res; citation_title=Experimental study of tendon healing early phase: is IGF-1 expression influenced by platelet rich plasma gel?; citation_author=DN Lyras, K Kazakos, G Agrogiannis, D Verettas, A Kokka, G Kiziridis; citation_volume=96; citation_publication_date=2010; citation_pages=381-387; citation_doi=10.1016/j.otsr.2010.03.010; citation_id=CR22 citation_journal_title=Vet Med; citation_title=Adipose stem cell combined with plasma-based implant bone tissue differentiation in vitro and in a horse with a phalanx digitalis distalis fracture: a case report; citation_author=K Marycz, J Grzesiak, K Wrzeszcz, P Golonka; citation_volume=11; citation_publication_date=2012; citation_pages=610-617; citation_doi=10.17221/6469-VETMED; citation_id=CR23 citation_journal_title=Clin Appl Thromb Hemost; citation_title=Analyzing the effects of platelet gel on knee osteoarthritis in the rat model; citation_author=S Guner, O Buyukbebeci; citation_volume=19; citation_publication_date=2013; citation_pages=494-498; citation_doi=10.1177/1076029612452117; citation_id=CR24 citation_journal_title=Ann Rehabil Med; citation_title=The effects of intra-articular platelet-rich plasma injection according to the severity of collagenase-induced knee osteoarthritis in a rabbit model; citation_author=DR Kwon, GY Park, SU Lee; citation_volume=36; citation_publication_date=2012; citation_pages=458-465; citation_doi=10.5535/arm.2012.36.4.458; citation_id=CR25 citation_journal_title=Osteoarthr Cartil; citation_title=The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair; citation_author=Y Mifune, T Matsumoto, K Takayama, S Ota, H Li, LB Meszaros; citation_volume=21; citation_publication_date=2013; citation_pages=175-185; citation_doi=10.1016/j.joca.2012.09.018; citation_id=CR26 citation_journal_title=Thromb Haemost; citation_title=Platelet lysates stimulate angiogenesis, neurogenesis and neuroprotection after stroke; citation_author=Y Hayon, O Dashevsky, E Shai, D Varon, RR Leker; citation_volume=110; citation_publication_date=2013; citation_pages=323-330; citation_doi=10.1160/TH12-11-0875; citation_id=CR27 citation_journal_title=Front Neurosci; citation_title=Therapeutic effect of platelet-rich plasma in rat spinal cord injuries; citation_author=NF Chen, CS Sung, ZH Wen, CH Chen, CW Feng, HC Hung; citation_volume=12; citation_publication_date=2018; citation_pages=252; citation_doi=10.3389/fnins.2018.00252; citation_id=CR28 Unal M. Platelet-rich plasma in burn treatment. In S. P. Kartal, & D. Bayramgürler (Eds.), Hot Topics in Burn Injuries. IntechOpen. 2017. https://doi.org/10.5772/intechopen.70835 . citation_journal_title=Braz J Med Biol Res; citation_title=Ethidium bromide-induced demyelination of the sciatic nerve of adult Wistar rats; citation_author=G Riet-Correa, CG Fernandes, LAV Pereira, DL Graça; citation_volume=35; citation_publication_date=2002; citation_pages=99-104; citation_doi=10.1590/S0100-879X2002000100014; citation_id=CR30 citation_journal_title=Basic Clin Neurosci; citation_title=Focal injection of ethidium bromide as a simple model to study cognitive deficit and its improvement; citation_author=M Goudarzvand, S Choopani, A Shams, M Javan, Z Khodaii, F Ghamsari; citation_volume=7; citation_publication_date=2016; citation_pages=63-72; citation_id=CR31 citation_journal_title=Neurologia (Engl Ed); citation_title=Experimental models of demyelination and remyelination; citation_author=L Torre-Fuentes, L Moreno-Jiménez, V Pytel, JA Matías-Guiu, U Gómez-Pinedo, J Matías-Guiu; citation_volume=35; citation_publication_date=2020; citation_pages=32-39; citation_doi=10.1016/j.nrleng.2019.03.007; citation_id=CR32 citation_journal_title=Neuropathol Appl Neurobiol; citation_title=Ethidium bromide induced demyelination in the spinal cord of the cat; citation_author=WF Blakemore; citation_volume=8; citation_publication_date=1982; citation_pages=365-375; citation_doi=10.1111/j.1365-2990.1982.tb00305.x; citation_id=CR33 citation_journal_title=J Neurotrauma; citation_title=A sensitive and reliable locomotor rating scale for open field testing in rats; citation_author=DM Basso, MS Beattie, JC Bresnahan; citation_volume=12; citation_publication_date=1995; citation_pages=1-21; citation_doi=10.1006/exnr.1996.0098; citation_id=CR34 citation_journal_title=BMC Vet Res; citation_title=Effects of sodium citrate and acid citrate dextrose solutions on cell counts and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel; citation_author=CE Giraldo, ME Álvarez, JU Carmona; citation_volume=1; citation_publication_date=2015; citation_pages=1-7; citation_doi=10.1186/s12917-015-0370-4; citation_id=CR35 citation_journal_title=Biomed Res Int; citation_title=Platelet-rich plasma: the choice of activation method affects the release of bioactive molecules; citation_author=C Cavallo, A Roffi, B Grigolo, E Mariani, L Pratelli, G Merli; citation_volume=2016; citation_publication_date=2016; citation_pages=6591717; citation_doi=10.1155/2016/6591717; citation_id=CR36 citation_journal_title=J Tissue Eng Regen Med; citation_title=Photobiomodulation of freshly isolated human adipose tissue-derived stromal vascular fraction cells by pulsed light-emitting diodes for direct clinical application; citation_author=E Priglinger, J Maier, S Chaudary, C Lindner, C Wurzer, S Rieger; citation_volume=12; citation_publication_date=2018; citation_pages=1352-1362; citation_doi=10.1002/term.2665; citation_id=CR37 citation_journal_title=Fordham Urb LJ; citation_title=Thiopental in lethal injection; citation_author=S Vassallo; citation_volume=35; citation_publication_date=2008; citation_pages=957-986; citation_id=CR38 citation_title=Theory and practice of histological techniques. 6th Edition; citation_publication_date=2008; citation_id=CR39; citation_publisher=Churchill Livingstone, Elsevier citation_journal_title=Acta Histochem; citation_title=Ameliorative effects of bone marrow derived pancreatic progenitor cells on hyperglycemia and oxidative stress in diabetic rats; citation_author=H Rizk, AF Tohamy, WM Sayed, A Prince; citation_volume=120; citation_publication_date=2018; citation_pages=412-419; citation_doi=10.1016/j.acthis.2018.05.001; citation_id=CR40 citation_journal_title=Ital J Anim Sci; citation_title=Effects of probiotic feed additives (Biosol and Zemos) on growth and related genes in broiler chickens; citation_author=N Hassan, I Mostafa, MA Elhady, MA Ibrahim, H Amer; citation_volume=21; citation_publication_date=2022; citation_pages=62-73; citation_doi=10.1080/1828051X.2021.2016509; citation_id=CR41 citation_journal_title=Methods.; citation_title=Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method; citation_author=KJ Livak, TD Schmittgen; citation_volume=25; citation_publication_date=2001; citation_pages=402-408; citation_doi=10.1006/meth.2001.1262; citation_id=CR42 citation_journal_title=Microsurgery; citation_title=Platelet gel does not improve peripheral nerve regeneration: an electrophysiological, stereological, and electron microscopic study; citation_author=A Piskin, S Kaplan, A Aktas, M Ayyildiz, S Raimondo, T Alic; citation_volume=29; citation_publication_date=2009; citation_pages=144-153; citation_doi=10.1002/micr.20599; citation_id=CR43 citation_journal_title=J Arthroplast; citation_title=Intraoperative platelet-rich plasma does not improve outcomes of total knee arthroplasty; citation_author=M Morishita, K Ishida, T Matsumoto, R Kuroda, M Kurosaka, N Tsumura; citation_volume=29; citation_publication_date=2014; citation_pages=2337-2341; citation_doi=10.1016/j.arth.2014.04.007; citation_id=CR44 citation_journal_title=J Neuroimmunol; citation_title=The therapeutic effect of platelet-rich plasma on the experimental autoimmune encephalomyelitis mice; citation_author=M Borhani-Haghighi, Y Mohamadi; citation_volume=333; citation_publication_date=2019; citation_doi=10.1016/j.jneuroim.2019.04.018; citation_id=CR45 citation_journal_title=Future Neurol; citation_title=Growth factor regulation of remyelination: behind the growing interest in endogenous cell repair of the CNS; citation_author=RC Armstrong; citation_volume=2; citation_publication_date=2007; citation_pages=689-697; citation_doi=10.2217/14796708.2.6.689; citation_id=CR46 citation_journal_title=Exp Neurol; citation_title=Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord; citation_author=NJ Kuypers, KT James, GU Enzmann, DSK Magnuson, SR Whittemore; citation_volume=247; citation_publication_date=2013; citation_pages=615-622; citation_doi=10.1016/j.expneurol.2013.02.014; citation_id=CR47 Hollis E, Ishiko N, Tolentino K, Doherty E, Rodriguez M, Calcutt N, et al. A novel and robust conditioning lesion induced by ethidium bromide. Exp.neurol. 2015;265(30-9). https://doi.org/10.1016/j.expneurol.2014.12.004 . citation_journal_title=J Neurosci; citation_title=Functional redundancy of ventral spinal locomotor pathways; citation_author=DN Loy, DSK Magnuson, YP Zhang, SM Onifer, MD Mills, QL Cao; citation_volume=22; citation_publication_date=2002; citation_pages=315-323; citation_doi=10.1523/JNEUROSCI.22-01-00315.2002; citation_id=CR49 citation_journal_title=J Neurol Sci; citation_title=A comparison of autologous and allogenic bone marrow-derived mesenchymal stem cell transplantation in canine spinal cord injury; citation_author=DI Jung, J Ha, BT Kang, JW Kim, FS Quan, JH Lee; citation_volume=285; citation_publication_date=2009; citation_pages=67-77; citation_doi=10.1016/j.jns.2009.05.027; citation_id=CR50 citation_journal_title=Chin J Traumatol; citation_title=Control of demyelination for recovery of spinal cord injury; citation_author=B Wu, XJ Ren; citation_volume=11; citation_publication_date=2008; citation_pages=306-310; citation_doi=10.5555/cjt.1008-1275.11.05.p306.01; citation_id=CR51 citation_journal_title=Exp Neurol; citation_title=Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats; citation_author=Y Nishio, M Koda, K Kitajo, M Seto, K Hata, J Taniguchi, H Moriya, M Fujitani, T Kubo, T Yamashita; citation_volume=2; citation_publication_date=2006; citation_pages=392-397; citation_doi=10.1016/j.expneurol.2006.02.123; citation_id=CR52 citation_journal_title=Regen Med Res; citation_title=Pilot study: bone marrow stem cells as a treatment for dogs with chronic spinal cord injury; citation_author=CA Sarmento, MN Rodrigues, RZ Bocabello, AM Mess, MA Miglino; citation_volume=2; citation_publication_date=2014; citation_pages=9; citation_doi=10.1186/2050-490X-2-9; citation_id=CR53 citation_journal_title=Mult Scler; citation_title=Remyelination multiple sclerosis; citation_author=H Lassmann, B Wolfgang, C Lucchinetti, M Rodriguez; citation_volume=3; citation_publication_date=1997; citation_pages=133-136; citation_doi=10.1177/135245859700300213; citation_id=CR54 citation_journal_title=Acta Neuropathol; citation_title=Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach; citation_author=T Kuhlmann, H Lassmann, W Brück; citation_volume=115; citation_publication_date=2008; citation_pages=275-287; citation_doi=10.1007/s00401-007-0320-8; citation_id=CR55 Popescu BF, Lucchinetti CF. Neuropathology of multiple sclerosis. Mult Scler. 2016:181–200. https://doi.org/10.1016/B978-0-12-800763-1.00009-9 . citation_journal_title=PLoS One; citation_title=Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice; citation_author=SY Jeong, DR Crooks, H Wilson-Ollivierre, MC Ghosh, R Sougrat, J Lee; citation_volume=6; citation_publication_date=2011; citation_doi=10.1371/journal.pone.0025404; citation_id=CR57 citation_journal_title=Semin Pediatr Neurol; citation_title=Mitochondrial dysfunction in demyelinating diseases; citation_author=KS Carvalho; citation_volume=20; citation_publication_date=2013; citation_pages=194-201; citation_doi=10.1016/j.spen.2013.09.001; citation_id=CR58 citation_journal_title=Mol Ther Nucleic Acids; citation_title=Myelin basic protein and a multiple sclerosis-related MBP-peptide bind to oligonucleotides; citation_author=GT Rozenblum, T Kaufman, AD Vitullo; citation_volume=3; citation_publication_date=2014; citation_doi=10.1038/mtna.2014.43; citation_id=CR59 citation_journal_title=ACS Omega; citation_title=Myelin basic protein phospholipid complexation likely competes with deimination in experimental autoimmune encephalomyelitis mouse model; citation_author=AO Valdivia, PK Agarwal, SK Bhattacharya; citation_volume=5; citation_publication_date=2020; citation_pages=15454-15467; citation_doi=10.1021/acsomega.0c01590; citation_id=CR60 citation_journal_title=Brain; citation_title=Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination; citation_author=C Deboux, C Bachelin, ÃM Frah, C Kerninon, D Seilhean, M Weider, M Wegner; citation_volume=138; citation_publication_date=2015; citation_pages=120-135; citation_doi=10.1093/brain/awu375; citation_id=CR61 citation_journal_title=J Neurol; citation_title=Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis; citation_author=M Axelsson, C Malmeström, S Nilsson, S Haghighi, L Rosengren, J Lycke; citation_volume=258; citation_publication_date=2011; citation_pages=882-888; citation_doi=10.1007/s00415-010-5863-2; citation_id=CR62 citation_journal_title=Neurosci Lett; citation_title=GFAP in early multiple sclerosis: a biomarker for inflammation; citation_author=R Kassubek, M Gorges, M Schocke, VAM Hagenston, A Huss, AC Ludolph; citation_volume=657; citation_publication_date=2017; citation_pages=166-170; citation_doi=10.1016/j.neulet.2017.07.050; citation_id=CR63 citation_journal_title=Sci Rep; citation_title=Serum GFAP as a biomarker for disease severity in multiple sclerosis; citation_author=A Abdelhak, A Huss, J Kassubek, H Tumani, M Otto; citation_volume=8; citation_publication_date=2018; citation_pages=14798; citation_doi=10.1038/s41598-018-33158-8; citation_id=CR64 citation_journal_title=Int J Morphol; citation_title=Does neuroectodermal stem cells transplantation restore neural regeneration and locomotor functions in compressed spinal cord injury rat model?; citation_author=S Al-Karim, WS Ramadan, GA Abdel-Hamid, F Al-Qudsi; citation_volume=37; citation_publication_date=2019; citation_pages=349-357; citation_doi=10.4067/S0717-95022019000100349; citation_id=CR65 citation_journal_title=Brain Pathol; citation_title=Oligodendroglial fibroblast growth factor receptor 1 gene targeting protects mice from experimental autoimmune encephalomyelitis through ERK/AKT phosphorylation; citation_author=R Rajendran, M Giraldo-Velásquez, C Stadelmann, M Berghoff; citation_volume=28; citation_publication_date=2018; citation_pages=212-224; citation_doi=10.1111/bpa.12487; citation_id=CR66 citation_journal_title=Neurosci Lett; citation_title=Bax-ablation attenuates experimental autoimmune encephalomyelitis in mice; citation_author=N Lev, Y Barhum, E Melamed, D Offen; citation_volume=15; citation_publication_date=2004; citation_pages=139-142; citation_doi=10.1016/j.neulet.2004.01.076; citation_id=CR67 citation_journal_title=J Chem Neuroanat; citation_title=Combined use of platelet-rich plasma and adipose tissue-derived mesenchymal stem cells shows a synergistic effect in experimental spinal cord injury; citation_author=R Salarinia, M Hosseini, Y Mohamadi, A Ghorbani, DH Alamdari, A Mafinezhad, H Sadeghnia; citation_volume=110; citation_publication_date=2020; citation_doi=10.1016/j.jchemneu.2020.101870; citation_id=CR68 citation_journal_title=J Neurochem; citation_title=BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation; citation_author=Y Hu, SJ Russek; citation_volume=105; citation_publication_date=2008; citation_pages=1-17; citation_doi=10.1016/j.jchemneu.2020.101870; citation_id=CR69 citation_journal_title=Theranostics.; citation_title=Self-assembling peptide hydrogels functionalized with LN-and BDNF-mimicking epitopes synergistically enhance peripheral nerve regeneration; citation_author=S Yang, C Wang, J Zhu, C Lu, H Li, F Chen, J Lu, Z Zhang, X Yan, H Zhao, X Sun; citation_volume=10; citation_publication_date=2020; citation_pages=8227-8249; citation_doi=10.7150/thno.44276; citation_id=CR70 citation_journal_title=J Immunol; citation_title=Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia; citation_author=Y Mizoguchi, A Monji, T Kato, Y Seki, L Gotoh, H Horikawa, SO Suzuki, T Iwaki, M Yonaha, S Hashioka, S Kanba; citation_volume=183; citation_publication_date=2009; citation_pages=7778-7786; citation_doi=10.4049/jimmunol.0901326; citation_id=CR71 citation_journal_title=Acta Neuropathol; citation_title=Central nervous system rather than immune cell derived BDNF mediates axonal protective effects early in autoimmune demyelination; citation_author=DH Lee, E Geyer, AC Flach, K Jung, R Gold, A Flügel, RA Linker, F Lühder; citation_volume=123; citation_publication_date=2012; citation_pages=247-258; citation_doi=10.1007/s00401-011-0890-3; citation_id=CR72 citation_journal_title=Biochem Biophys Res Commun; citation_title=Autocrine activation of cultured macrophages by brain-derived neurotrophic factor; citation_author=T Asami, T Ito, H Fukumitsu, H Nomoto, Y Furukawa, S Furukawa; citation_volume=344; citation_publication_date=2006; citation_pages=941-947; citation_doi=10.1016/j.bbrc.2006.03.228; citation_id=CR73 citation_journal_title=Cytotherapy.; citation_title=Combined treatment with platelet-rich plasma and brain-derived neurotrophic factor-overexpressing bone marrow stromal cells supports axonal remyelination in a rat spinal cord hemi-section model; citation_author=T Zhao, W Yan, K Xu, Y Qi, X Dai, Z Shi; citation_volume=15; citation_publication_date=2013; citation_pages=792-804; citation_doi=10.1016/j.jcyt.2013.04.004; citation_id=CR74 citation_journal_title=Cell Mol Neurobiol; citation_title=Mesenchymal stem cells ameliorate cuprizone-induced demyelination by targeting oxidative stress and mitochondrial dysfunction; citation_author=E Shiri, P Pasbakhsh, M Borhani-Haghighi, Z Alizadeh, S Nekoonam, S Mojaverrostami, V Pirhajati Mahabadi, A Mehdi, K Zibara, IR Kashani; citation_volume=41; citation_publication_date=2021; citation_pages=1467-1481; citation_doi=10.1007/s10571-020-00910-6; citation_id=CR75 citation_journal_title=Microcirculation.; citation_title=Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses; citation_author=R Salcedo, JJ Oppenheim; citation_volume=10; citation_publication_date=2003; citation_pages=359-370; citation_doi=10.1038/sj.mn.7800200; citation_id=CR76 citation_journal_title=Curr Opin Pharmacol; citation_title=Activity-triggered tetrapartite neuron–glial interactions following peripheral injury; citation_author=K Ren, R Dubner; citation_volume=26; citation_publication_date=2016; citation_pages=16-25; citation_doi=10.1016/j.coph.2015.09.006; citation_id=CR77