A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents

Cancer Detection and Prevention - Tập 31 - Trang 237-243 - 2007
Jeff W. Hill1, Michele K. Evans1
1Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224-6825, United States

Tài liệu tham khảo

Shibutani, 1991, Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG, Nature, 349, 431, 10.1038/349431a0 Soussi, 2003, Significance of TP53 mutations in human cancer: a critical analysis of mutations at CpG dinucleotides, Hum Mutat, 21, 192, 10.1002/humu.10189 Nishimura, 2002, Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA, Free Radic Biol Med, 32, 813, 10.1016/S0891-5849(02)00778-5 Weiss, 2005, Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature, Mol Carcinog, 42, 127, 10.1002/mc.20067 Luna, 2005, Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant, Nucleic Acids Res, 33, 1813, 10.1093/nar/gki325 Hill, 2006, Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase, Nucleic Acids Res, 34, 1620, 10.1093/nar/gkl060 Hyun, 2000, Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1, Oncogene, 19, 4476, 10.1038/sj.onc.1203787 Hyun, 2002, Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines, Free Radic Biol Med, 32, 212, 10.1016/S0891-5849(01)00793-6 Hyun, 2003, 8-hydroxydeoxyguanosine causes death of human leukemia cells deficient in 8-oxoguanine glycosylase 1 activity by inducing apoptosis, Mol Cancer Res, 1, 290 Rachek, 2002, Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria, J Biol Chem, 277, 44932, 10.1074/jbc.M208770200 Choi, 1999, Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation, Free Radic Biol Med, 27, 848, 10.1016/S0891-5849(99)00141-0 Sakumi, 2003, Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption, Cancer Res, 63, 902 Xie, 2004, Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors, Cancer Res, 64, 3096, 10.1158/0008-5472.CAN-03-3834 Russo, 2004, Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases, Cancer Res, 64, 4411, 10.1158/0008-5472.CAN-04-0355 Sunaga, 2001, OGG1 protein suppresses G:C-->T:A mutation in a shuttle vector containing 8-hydroxyguanine in human cells, Carcinogenesis, 22, 1355, 10.1093/carcin/22.9.1355 Avkin, 2002, Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells, Mutat Res, 510, 81, 10.1016/S0027-5107(02)00254-3 Rosenquist, 2003, The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death, DNA Repair (Amst), 2, 581, 10.1016/S1568-7864(03)00025-9 Morgan, 1992, Quinone-induced DNA single strand breaks in rat hepatocytes and human chronic myelogenous leukaemic K562 cells, Biochem Pharmacol, 44, 215, 10.1016/0006-2952(92)90003-2 Piedade, 2006, Voltammetric determination of γ radiation-induced DNA damage, Anal Biochem, 355, 39, 10.1016/j.ab.2006.05.022 Kim, 2006, Exogenous 8-oxo-dG is not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua in DNA through error-prone DNA synthesis, Mutat Res, 596, 128, 10.1016/j.mrfmmm.2005.12.004 Lu, 2004, Gene regulation and DNA damage in the ageing human brain, Nature, 429, 883, 10.1038/nature02661 Yang, 2006, Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells, DNA Repair (Amst), 5, 43, 10.1016/j.dnarep.2005.07.003 Chatterjee, 2006, Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress, BMC Cancer, 6, 235, 10.1186/1471-2407-6-235